Summary
Sport can improve the quality of life of asthmatic children. However, athletic activity and even games are frequently disturbed by dyspnoeic events called exercise-induced asthma (EIA). The intensity and the type of the exercise that provokes EIA vary from one patient to another. The maximal intensity of these attacks occurs between 5 and 15 minutes after the end of the exercise. In some asthmatic children, there seems to be a late phase response. In 40 to 50% of asthmatics, EIA is followed by a refractory period that lasts 2 to 4 hours.
EIA is detected by exercise challenge testing. There are several types of tests involving different equipment: free running, treadmill or cycle ergometer. The conditions under which these tests are performed must be rigorously controlled.
Prevention of EIA must be adapted to the intensity and the frequency of EIA. Prevention may be nonpharmacological, pharmacological or both. Cromones and β2-agonists are the drugs of choice in the prevention of EIA. Sport training in specialised centres is sometimes necessary, especially for patients with severe asthma. The purpose of this training is to decrease exercise-induced hyperventilation for a given level of work. The resulting improved tolerance to effort will increase the threshold of appearance of EIA.
The choice of sport for an asthmatic child depends upon local possibilities, the child’s tastes, the intensity of his/her EIA and the potential of the sport to induce asthma. Thus, asthmatic children and adolescents can and should practice sports.
Similar content being viewed by others
References
Anderson SD, Silverman M, Konig P, et al. Exercise-induced asthma. Br Dis Chest 1975; 69: 1–39
Balfour-Lynn L, Tooley M, Godfrey S. Relationship of exercise-induced asthma to clinical asthma in childhood. Arch Dis Child 1981; 56: 450–4
Denjean A, Cerrina J, Lockhart A. Asthme post-exercice. Bull Eur Physiopathol Respir 1981; 17: 847–67
Rufin P. Les épreuves d’effort. In: Rufin P, editor. Les tests de provocation bronchique et nasale. Vol. I. Joinville-le-Pont: IFRA, 1986: 97–116
Souhrada JF, Kivity S. Exercise testing. In: Spector SL, editor. Provocative challenge procedures: bronchial, oral, nasal and exercise. Vol. 2. Boca Raton (FL): CRC Press, 1983: 75–101
Menardo JL, Mazeran G, Michel FB, et al. L’enfant asthmatique et le sport au collège: enquête auprès des professeurs d’éducation physique et sportive. Rev Mal Respir 1990; 7: 45–9
Pierson WE. Exercise-induced bronchospasm in children, and adolescents. Pediatr Clin North Am 1988; 38: 1031–9
Rufin P. Le sport chez l’enfant asthmatique. In: Paupe J, Scheinmann P, de Blic J, editors. Allergologie pédiatrique. Vol. I. Paris: Médecine Sciences Flammarion, 1994: 601–15
Beck KC, Offord KP, Scanion PD. Bronchoconstriction occuring during exercise in asthmatic subjects. Am J Respir Crit Care Med 1994; 149: 325–57
Boner AL, Vallone G, Chiesa M, et al. Reproducibility of late phase pulmonary response to exercise and its relationship to bronchial hyperreactivity in children with chronic asthma. Pediatr Pulmonol 1992; 14: 156–9
Crimi E, Balbo A, Milanese M, et al. Airway inflammation and occurrence of delayed bronchoconstriction in exercise-induced asthma. Am Rev Respir Dis 1992; 146: 507–12
Horn CR, Jones RM, Lee D, et al. Late response in exercise-induced asthma. Clin Allergy 1984; 14: 307–9
Likura Y, Inui H, Nagakura T, et al. Factors predisposing to exercise-induced late asthmatic responses. J Allergy Clin Immunol 1985; 75: 285–9
Rohuschi M, Riva E, Fucella LM, et al. Prevention of exercise-induced bronchoconstriction by a new leukotriene antagonist (SK&F 104353). Am Rev Respir Dis 1992; 145: 1285–8
Speelberg B, Panis EAH, Bijl D, et al. Late asthmatic responses after exercise challenge. J Allergy Clin Immunol 1991; 87: 1128–37
Karjalainen J. Exercise response in 404 young men with asthma: no evidence for a late asthmatic reaction. Thorax 1991; 46: 100–4
Hofstra WB, Sterk PJ, Neijens HJ, et al. Occurrence of a late response to exercise in asthmatic children: multiple regression approach using time-matched baseline and histamine control days. Eur Respir J 1996; 9: 1348–55
Koh YY, Lim HS, Min KU. Airway responsiveness to allergen is increased 24 hours after exercise challenge. J Allergy Clin Immunol 1994; 94: 507–16
Kidd JM, Cohen SH, Sosman AJ, et al. Food-dependent, exercise-induced anaphylaxis. J Allergy Clin Immunol 1983; 71: 407–11
Sheffer AL, Soter NA, McFadden Jr ER, et al. Exercise-induced anaphylaxis: a distinct form of physical allergy. J Allergy Clin Immunol 1983; 71: 311–6
Songsiridej V, Busse WW. Exercise-induced anaphylaxis. Clin Allergy 1983; 13: 317–21
Debavelaere C, de Blic J, Bodemer C, et al. Syndrome d’anaphylaxie induite par l’exercice. Arch Fr Pediatr 1989; 46: 281–3
Dohi D, Suko M, Sugiyama H, et al. Food-dependent, exercise-induced anaphylaxis: a study of 11 Japanese cases. J Allergy Clin Immunol 1991; 87: 34–40
Balfour-Lynn L, Tooley M, Godfrey S. Relationship of exercise-induced asthma to clinical asthma in childhood. Arch Dis Child 1981; 56: 450–4
Broide DH, Eisman S, Ramsdell JW, et al. Airway levels of mast cell-derived mediators in exercise-induced asthma. Am Rev Respir Dis 1990; 141: 563–8
Busse W. Exercise-induced asthma: a role for the eosinophil? J Allergy Clin Immunol 1991; 88: 696–8
Lee TH, Nagakura T, Cromwell O, et al. Neutrophil chemotactic activity and histamine in atopic and non-atopic subjects after exercise-induced asthma. Am Rev Respir Dis 1984; 129: 409–12
Schoeffel RE, Anderson SD, Gillam I, et al. Multiple exercise and histamine challenge in asthmatic patients. Thorax 1980; 35: 164–70
Ben-Dov I, Bar-Yishay E, Godfrey S. Refractory period after exercise-induced asthma unexplained by respiratory heat loss. Am Rev Respir Dis 1982; 125: 530–4
Irnell L, Swarting S. Maximal expiratory flow at rest and during muscular work in patient with bronchial asthma. Scand J Respir Dis 1966; 47: 103–13
Poppius M, Muttari A, Kreus KE, et al. Exercise-asthma and disodium cromoglycate. BMJ 1970; 4: 337–339
Laitinen LAJ. Histamine and methacholine challenge in the testing of bronchial reactivity. Scand J Respir Dis 1974; 55 Suppl.: 1–48
Bundgaard A. Incidence of exercise-induced asthma in adult asthmatics. Allergy 1981; 36: 23–6
Rufin P, Jean R, Benoist MR, et al. Course libre chez l’enfant asthmatique. Rev Fr Allergol 1976; 16: 151–5
Mellis CM, Kattan M, Keens TG, et al. Comparative study of histamine and exercise challenge in asthmatic children. Am Rev Respir Dis 1978; 117: 911–5
Cropp CJA. Exercise-induced asthma. Pediatr Clin N Amer 1975; 22: 63–76
Field J, Allegra J, Trautlein J, et al. Measurement of plasma prostaglandins during exercise-induced bronchospasm. J Allergy Clin Immunol 1976; 58: 581–5
Shapiro GG, Pierson WE, Furukawa CT, et al. A comparison of the effectiveness of free running and treadmill exercise for assessing exercise-induced bronchospasm in clinical practice. J Allergy Clin Immunol 1979; 64: 609–11
Silverman M, Anderson SD. The standardization of exercise tests in asthmatic children. Arch Dis Child 1972; 47: 882–9
Rufin P, Benoist MR, Jean R, et al. La détection du bronchospasme induit par l’exercice chez l’enfant asthmatique: comparaison entre la course libre et le cycloergomètre. Rev Fr Allergol 1979; 19: 137–43
Sterk PJ, Fabbri LM, Quanjer PH, et al. Airway responsiveness: standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults. Eur Respir J 1993; 6: 53–83
Maregiano A, Dhivert H, Bartholomé G, et al. Modalités pratiques de réhabilitation de l’enfant asthmatique par le sport. In: L’enfant, l’adolescent et le sport (actualité en médecine du sport). Vol. I. Paris: Masson, 1986: 170–7
Nickerson BG, Bautista DB, Namey MA, et al. Distance running improves fitness in asthmatic children without pulmonary complications or changes in exercise-induced bronchospasm. Pediatrics 1983; 71: 147–52
Terrai C, Menardo JL, Michel FB. Réhabilitation de l’enfant asthmatique par le sport. In: L’enfant, l’adolescent et le sport (actualités en médecine du sport). Vol. I. Paris: Masson, 1986: 165–9
Clark CJ. The role of physical training in asthma. Chest 1992; 101 Suppl.: 293S–8S
Varray A, Prefaut CG. Les bases physiopathologiques du réentraînement à l’effort des asthmatiques. Rev Mal Respir 1992; 9: 355–6
Nisar M, Spence DPS, West D, et al. A mask to modify inspired air temperature and humidity and its effect on exercise-induced asthma. Thorax 1992; 47: 446–50
Godfrey S, Konig P. Inhibition of exercise-induced asthma by different pharmacological pathways. Thorax 1976; 17: 137–43
Ben-Dov I, Bar-Yishay E, Godfrey S. Heterogeneity in the response of asthmatic patients to pre-exercise treatment with cromolyn sodium. Am Rev Respir Dis 1983; 127: 113–6
Bundgaard A, Bach-Mortensen N, Schmid T. The effect of sodium cromoglycate delivered by spinhaler and hyperpressurized aerosol on exercise-induced asthma in children. Clin Allergy 1982; 12: 601–5
Patel KR, Kerr JW. The dose duration effect of sodium cromoglycate in exercise-induced asthma. Clin Allergy 1984; 14: 87–91
Orenstein DM, Reed ME, Grogan FT, et al. Exercise conditioning in children with asthma. J Pediatr 1985; 106: 556–60
Roberts JA, Thomson NC. Attenuation of exercise-induced asthma by pretreatment with nedocromil sodium and minocromil. Clin Allergy 1985; 15: 377–81
Chudry N, Correa F, Silverman M. Nedocromil sodium and exercise-induced asthma. Arch Dis Child 1987; 62: 412–4
De Benedictis FM, Tuteri G, Bertotto A, et al. Comparison of the protective effects of cromolyn sodium and nedocromil sodium in the treatment of exercise-induced asthma in children. J Allergy Clin Immunol 1994; 94: 684–6
Pedersen S. Effect of terbutaline sulphate turbuhaler in children with exercise-induced bronchoconstriction. In: Newman SP, Moren F, Crompton GK, editors. A new concept in inhalation therapy. Vol. 1. Bussum: Medicom, 1987: 146–50
Patessio A, Podda A, Carone M, et al. Protective effect and duration of action of formoterol aerosol in exercise-induced asthma. Eur Respir J 1991; 4: 296–300
Anderson SD, Rodwell LT, Du Toit J, et al. Duration of protection by inhaled salmeterol in exercise-induced asthma. Chest 1991; 100: 1254–60
Carlsen KH, Roksund O, Olsholt K, et al. Overnight protection by inhaled salmeterol on exercise-induced asthma in children. Eur Respir J 1995; 8: 1852–5
Wooley M, Anderson SD, Quigley BM. Duration of protective effect of terbutaline sulfate and cromolyn sodium alone and in combination on exercise induced asthma. Chest 1990; 97: 39–45
Pollock J, Kiechel F, Cooper D, et al. Relationship of serum theophylline concentration to inhibition of exercise-induced bronchospasm and comparison with cromolyn. Pediatrics 1977; 60: 840–4
Smith CM, Anderson SD, Seale JP. The duration of action of the combination of fenoterol hydrobromide and ipratropium bromide in protecting against asthma provoked by hyperpnea. Chest 1988; 94: 709–17
Craps L, Martin V, Radielevic P. Démonstration pharmacologique et clinique d’un effet antihistaminique prophylactique illustré par le kétotifène. Rev Ther 1977; 36: 923–33
Doward AJ, Patel KR. A comparison of ketotifen with clemastine, ipratropium bromide and sodium cromoglycate in exercise-induced asthma. Clin Allergy 1982; 12: 355–61
Zielinski J, Chodosowska E. Exercise-induced bronchoconstriction in patients with bronchial asthma: its prevention with an antihistaminic agent. Respiration 1977; 34: 31–5
Waalkens HJ, Van Essen Zandvliet EEM, Gerritsen J, et al. The effect of an inhaled corticosteroid (budesonide) on exercise-induced asthma in children. Eur Respir J 1993; 6: 652–6
Henriksen JM, Dahl R. Effects of inhaled budesonide alone and in combination with low dose terbutaline in children with exercise-induced asthma. Am Rev Respir Dis 1983; 128: 993–7
Benoist MR, Brouard JJ, Rufin P, et al. Dissociation of symptom scores and bronchial hyperreactivity: study in asthmatic children on long-term treatment with inhaled beclomethasone dipropionate. Pediatr Pulmonol 1992; 13: 71–7
Finnerty JP, Wood Baker R, Thomson H, et al. Role of leukotrienes in exercise-induced asthma. Am Rev Respir Dis 1992: 145: 746–8
Melzer SS, Hasday JD, Cohn J, et al. Inhibition of exercise-induced bronchospasm by zileuton: a 5-lipoxygenase inhibitor. Am J Respir Crit Care Med 1996; 153: 931–5
Adelroth E, Inman MD, Summers E, et al. Prolonged protection against exercise-induced bronchoconstriction by the leukotriene D4 receptor antagonist cinalukast. J Allergy Clin Immunol 1997; 99: 210–5
Comis PA, Nariman S, Girson GJ. Nifedipine in the prevention of asthma induced by exercise and histamine. Am Rev Respir Dis 1983; 128: 991–2
Patel KR. The effect of calcium antagonist nifedipine in exercise-induced asthma. Clin Allergy 1981; 11: 429–32
Barnes PJ, Wilson NM, Vickers H. Prazosin, an alpha adrenoreceptor antagonist, partially inhibits exercise-induced asthma. J Allergy Clin Immunol 1977; 60: 163–8
Dinh-Xuan AT, Chaussain M, Regnard J, et al. Pretreatment with an inhaled alpha-1-adrenergic agonist, methoxamine, reduces exercise-induced asthma. Eur Respir J 1989; 2: 409–14
Novembre E, Frongia G, Lombardi E, et al. The preventive effect of nedocromil or furosemide alone in combination on exercise-induced asthma in children. J Allergy Clin Immunol 1994; 94: 201–6
Novembre E, Frongia G, Lombardi E, et al. The preventive effect and duration of action of two doses of inhaled furosemide on exercise-induced asthma in children. J Allergy Clin Immunol 1995; 96: 906–9
Melo RE, Sole D, Naspitz CK. Comparative efficacy of inhaled furosemide and disodium cromoglycate in the treatment of exercise-induced asthma in children. J Allergy Clin Immunol 1997; 99: 204–9
Bianco S, Vaghi A, Robuschi M, et al. Prevention of exercise-induced bronchoconstriction by inhaled furosemide. Lancet 1988; II: 252–5
Garrigo J, Danta I, Ahmed T. Time course of the predictive effect of inhaled heparin on exercise-induced asthma. Am J Respir Crit Care Med 1996; 153: 1702–7
Prefaut C, Savy Pacaux AM, Varray A. Principes et résultats du réentraînement à l’effort chez l’asthmatique. Rev Fr Allergol 1991; 31: 221–4
Reiff SB, Choudry NB, Pride NB, et al. The effect of prolonged submaximal warm-up exercise on exercise-induced asthma. Am Rev Respir Dis 1989; 139: 479–84
Varray A, Mercier JG, Terrai CM, et al. Individualized aerobic and high intensity training on asthmatic children in an exercise readaptation program: is training always helpful for better adaptation to exercise? Chest 1991; 99: 579–86
Fjelbirkeland L, Gulsvik A, Walloe A. Swimming-induced asthma. Tidsskr Nor Laegeforen 1995; 115: 2051–3
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Rufin, P., Scheinmann, P. & de Blic, J. Exercise-Induced Asthma. BioDrugs 8, 6–15 (1997). https://doi.org/10.2165/00063030-199708010-00002
Published:
Issue Date:
DOI: https://doi.org/10.2165/00063030-199708010-00002