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Prevention of Propofol-Induced Injection Pain by Sufentanil

A Placebo-Controlled Comparison with Remifentanil

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Abstract

Background and objective: Propofol produces anaesthesia with rapid recovery but also causes pain or discomfort on injection. The effect of remifentanil in prevention of propofol-induced injection pain has been demonstrated in earlier studies. However, sufentanil, an opioid analgesic, has not been evaluated as an agent for managing pain on injection of propofol. In this study we aimed to compare the efficacy of remifentanil and sufentanil for the prevention of propofol-induced pain.

Methods: This double-blind, placebo-controlled clinical study was carried out from July 2006 to February 2007, and included patients who were candidates for elective surgery in a university hospital. From 92 American Society of Anesthesiologists (ASA) status I–II adult patients, 80 were randomly assigned to four groups of 20 each. Patients received 2 mL of sufentanil 0.01 mg, 2 mL of remifentanil 0.01 mg, 2 mL of remifentanil 0.02 mg, or 2 mL of saline 60 seconds prior to administration of 5 mL of propofol 1%. Patients were asked prior to losing consciousness whether they felt any pain due to propofol injection, and their pain scores were evaluated on the four-point scale of Ambesh et al.

Results: The incidence of pain was significantly lower in the remifentanil 0.02-mg group, remifentanil 0.01-mg group and sufentanil group compared with the saline group (40%, 70%, 75% and 100%, respectively, p < 0.05). Median pain intensity scores were significantly lower in the group receiving remifentanil 0.02 mg than in the sufentanil group (0 and 1 respectively, p < 0.05). The median intensity of propofol-induced pain was statistically similar between the groups receiving sufentanil or remifentanil 0.01 mg and the placebo group (1, 1 and 1, respectively, p > 0.05).

Conclusion: Remifentanil 0.02 mg administered over 60 seconds before propofol administration is more effective than sufentanil 0.01 mg, remifentanil 0.01 mg or placebo administered 1 minute prior to propofol in reducing the incidence and intensity of injection pain.

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Acknowledgements

The authors gratefully acknowledge the assistance of Dr Parvin Sajedy and Dr Zeinab Rajabi for data collection. No sources of funding were used to assist in the preparation of this study. The authors have no conflicts of interest that are directly relevant to the content of this study.

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  1. Department of Anaesthesiology and Intensive Care Medicine, Isfahan University of Medical Sciences, Sofeh Street, Isfahan, Iran

    Azim Honarmand &  Mohammadreza Safavi

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  1. Azim Honarmand
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  2. Mohammadreza Safavi
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Correspondence to Mohammadreza Safavi.

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Honarmand, A., Safavi, M. Prevention of Propofol-Induced Injection Pain by Sufentanil. Clin. Drug Investig. 28, 27–35 (2008). https://doi.org/10.2165/00044011-200828010-00004

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