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Esomeprazole 20mg Provides More Effective Intragastric Acid Control than Maintenance-Dose Rabeprazole, Lansoprazole or Pantoprazole in Healthy Volunteers

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Abstract

Objective

A high proportion of patients with gastro-oesophageal reflux disease experience recurrence of symptoms within a year of initial treatment. The key to preventing relapse is an effective maintenance therapy that maintains intragastric pH >4. This study was conducted to compare the effects on intragastric pH of maintenance doses of four proton pump inhibitors: esomeprazole 20mg, lansoprazole 15mg, rabeprazole 10mg and pantoprazole 20mg.

Study participants and methods

Three standardised, randomised, two-way crossover studies were performed in a total of 108 Helicobacter pylori-negative healthy subjects. Intragastric pH was monitored on day 5 of once-daily oral dosing. The percentage of time of a 24-hour period with intragastric pH >4 and 24-hour median pH were measured on day 5.

Results

The mean percentage of time with intragastric pH >4 on day 5 was significantly longer following esomeprazole 20mg compared with either lansoprazole 15mg (esomeprazole 50.4% vs lansoprazole 43.0%, p = 0.026), rabeprazole 10mg (esomeprazole 59.8% vs rabeprazole 51.7%, p = 0.011) or pantoprazole 20mg (esomeprazole 59.6% vs pantoprazole 39.5%, p < 0.0001).

Conclusions

Maintenance dose esomeprazole 20mg provided greater acid control and maintained intragastric pH >4 for a longer period of time than maintenance dose lansoprazole 15mg, rabeprazole 10mg and pantoprazole 20mg in healthy subjects.

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Acknowledgements

This study was supported by a grant from AstraZeneca R&D Mölndal, Mölndal, Sweden.

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Authors and Affiliations

  1. AstraZeneca R&D, Pepparedsleden 1, S-431, Mölndal, Sweden

    Kerstin Röhss, Emma Nauclér & Lennart Jansson

  2. Gastroenterology Group Practice, Berne, Switzerland

    Clive Wilder-Smith

Authors
  1. Kerstin Röhss
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  2. Clive Wilder-Smith
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  3. Emma Nauclér
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  4. Lennart Jansson
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Correspondence to Kerstin Röhss.

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Röhss, K., Wilder-Smith, C., Nauclér, E. et al. Esomeprazole 20mg Provides More Effective Intragastric Acid Control than Maintenance-Dose Rabeprazole, Lansoprazole or Pantoprazole in Healthy Volunteers. Clin. Drug Investig. 24, 1–7 (2004). https://doi.org/10.2165/00044011-200424010-00001

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