Objective: To determine whether exposure during pregnancy to two types of lozenges used for treatment of sore throat [Kalgaron® (Rafa Laboratories, Jerusalem, Israel) or Strepsils® (Boots Healthcare International, Nottingham, UK)] was associated with an increased risk of malformations, spontaneous abortions or decreased birthweight.
Design: Prospective, controlled, observational study.
Study participants: The study group included 54 women who received Kalgaron® or Strepsils® during the first trimester of pregnancy. The control group included 54 women exposed to non-teratogenic drugs.
Results: The rate of major malformations in the study group (3.84%) did not differ from that of the control group (3.92%) [p = 0.98; relative risk 0.98, 95% confidence interval 0.14 to 6.7]. The rate of minor malformations in the study group (1.92%) did not differ statistically from that of the control group (0%) [p = 0.32]. There were also no statistically significant differences in birthweight, rate of live births and rate of spontaneous abortions among the two groups.
Conclusions: The use of Kalgaron® or Strepsils® during pregnancy was not associated with an increased risk of malformations, spontaneous abortions or decreased birthweight. However, larger studies are needed to confirm the safety of these medications during pregnancy.
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Adams PF, Hendershot GE, Marano MA. Current estimates from the National Health Interview Survey, 1996. National Center for Health Statistics. Vital Health Stat 1999 Oct. Report no. 10 (200)
Heinonen OP, Slone D, Shapiro S. Birth defects and drugs in pregnancy. Littleton (MA): Publishing Sciences Group Inc., 1977
Nelson K, Holmes LB. Malformations due to presumed spontaneous mutation in newborn infants. N Engl J Med 1989 January; 320: 19–23
Holmes LB. Need for inclusion and exclusion criteria for the structural abnormalities recorded in children born from exposed pregnancies. Teratology 1999; 59: 1–2
Stevenson RE: Causes of human anomalies: an overview and historical perspective. In: Stevenson RE, editor. Human malformations and related anomalies. New York: Oxford University Press, 1993; 11: 3–20
Moore KI, Persand TVN. The developing human. Clinically oriented embryology. Philadelphia (PA): WB Saunders Company, 1993
Cheung M. Counselling the pregnant patient. Cont Pract 1988; 15: 7–14
Rudolph AM, Hoffman JIE, Rudolph CD, editors. Rudolph’s paediatrics. 20th ed. Norwalk, Connecticut: Appleton & Lange, 1996
Merlob P, Papier CM, Klinberg MA, et al. Incidence of congenital malformations in the newborn, particularly minor abnormalities. Prog Clin Biol Res 1985; 163C: 51–5
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Berkovitch, M., Greenberg, R., Gendler, L. et al. Sore Throat Treatment during Pregnancy. Clin. Drug Investig. 22, 135–139 (2002). https://doi.org/10.2165/00044011-200222020-00008
- Inguinal Hernia
- Sore Throat
- Apgar Score
- Spontaneous Abortion
- Common Cold