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Captopril Does Not Influence the Components of Free Radical Activity Following Acute Myocardial Infarction

A Substudy of ISIS-4

  • Clinical Pharmacodynamics
  • Published:
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Abstract

Objective: Free radical scavenging and/or inhibition of free radical generation may be a therapeutically useful property of sulfhydryl (SH)-containing angiotensin converting enzyme (ACE) inhibitors. In vitro studies on the anti-free radical activity of captopril, an SH-containing ACE inhibitor, brought conflicting results. The purpose of this study was to assess the antioxidant effects of captopril in the clinical setting of myocardial infarction.

Patients and Methods: 63 patients with acute myocardial infarction who entered the International Study on Infarct Survival-4 were randomised to receive oral captopril (50mg twice daily) or placebo. Plasma lipid peroxides (measured as thiobarbituric acid-reactive substances) and free radical production by isolated leucocytes (measured by chemiluminescence) were determined before the start of the study treatment and on days 7 and 14 of captopril/placebo.

Results: The values of plasma lipid peroxides and leucocyte free radical production were not altered by captopril treatment. Initial values of lipid peroxides (mean, nmol/L × ml−1) were 3.6 in the placebo group, 3.8 in the captopril group, and increased to 4.5 and 4.9 (day 7) and to 4.3 and 4.7 (day 14), respectively, showing no significant differences between the groups. Furthermore, leucocyte chemiluminescence in the placebo and captopril groups showed no significant changes from baseline either on day 7 or on day 14.

Conclusions: The results of the present study do not provide support for the antioxidant properties of captopril in the clinical setting of myocardial infarction.

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Acknowledgements

The authors are indebted to Professor Rory Collins for his valuable comments. We are grateful to Dr Bogna Kresowska for the measurements of lipid peroxides and to Mrs Ewa Buszko for her expert secretarial assistance. Funding was provided by the Postgraduate Medical School, Warsaw, Poland.

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Authors and Affiliations

  1. Medical Research Centre, Polish Academy of Sciences, Pawinskiego, 5, 02-106, Warsaw, Poland

    Krystyna Herbaczynska-Cedro

  2. Department of Cardiology, Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland

    Beata Klosiewicz-Wasek

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  1. Krystyna Herbaczynska-Cedro
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  2. Beata Klosiewicz-Wasek
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Correspondence to Krystyna Herbaczynska-Cedro.

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Herbaczynska-Cedro, K., Klosiewicz-Wasek, B. Captopril Does Not Influence the Components of Free Radical Activity Following Acute Myocardial Infarction. Clin. Drug Investig. 19, 441–445 (2000). https://doi.org/10.2165/00044011-200019060-00006

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  • DOI: https://doi.org/10.2165/00044011-200019060-00006

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