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Diosmectite for Ulcerative Colitis

A Pilot Trial

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References

  1. Allen A, Hoskins LC. In: Kirsner JB, Shorter RG, editors. Diseases of the colon and rectum. Baltimore: Williams & Wilkins, 1988: 65–92

    Google Scholar 

  2. Hutton DA, Pearson JP, Allen A, et al. Mucolysis of the colonic mucus barrier by faecal proteinases: inhibition by interacting polyacrylate. Clin Sci 1990; 78: 265–71

    PubMed  CAS  Google Scholar 

  3. Corfield AP, Williams AJK, Clamp J, et al. Degradation by bacterial enzymes of colonie mucus from normal subjects and patients with IBD: role of sialic acid metabolism and the detection of a novel O-acetyl sialic acid esterase. Clin Sci 1988; 74: 71–8

    PubMed  CAS  Google Scholar 

  4. Samson HJ, Allen A, Pearson JP, et al. Faecal proteinase activity: raised values in patients with ulcerative colitis. Gut 1991; 32(10): 1235–6

    Google Scholar 

  5. Pullan RD, Rhodes M, Allen A, et al. Adherent layer of colonic mucus in mucosal protection and IBD. Br J Surg 1992; 79(11): 1229

    Google Scholar 

  6. Allen A, Leonard A. Mucus structure. Gastroenterol Clin Biol 1985; 9: 9–12

    PubMed  CAS  Google Scholar 

  7. Mahraoui L, Heyman M, Plique O, et al. Apical effect of diosmectite on damage to the intestinal barrier induced by basal tumour necrosis factor-alfa. Gut 1997; 40: 339–43

    PubMed  CAS  Google Scholar 

  8. Madkour AA, Madina EMH, El-Azouni OEZ, et al. Smectite in acute diarrhoea of children: a double-blind placebo controlled clinical trial. J Pediatr Gastroenterol Nutr 1993; 17: 176–81

    Article  PubMed  CAS  Google Scholar 

  9. Leber W. A new suspension form of smectite for the treatment of acute diarrhea: a randomized comparative study. Pharmacoterapeutica 1988; 5: 256–60

    CAS  Google Scholar 

  10. Rachmilewitz D. Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of active ulcerative colitis: a randomised trial. BMJ 1989; 298: 82–6

    Article  PubMed  CAS  Google Scholar 

  11. Rhodes J, Thomas G. Nicotine treatment in ulcerative colitis: current status. Drugs 1995; 49: 157–60

    Article  PubMed  CAS  Google Scholar 

  12. Finnie IA, Campbell BJ, Taylor BA, et al. Stimulation of colonic mucin synthesis by corticosteroids and nicotine. Clin Sci 1996; 91: 359–64

    PubMed  CAS  Google Scholar 

  13. Ilnyckyj A, Shanahan F, Anton PA, et al. Quantification of the placebo response in ulcerative colitis. Gastroenterology 1997; 112: 1854–8

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Gastroenterology Unit, S. Raffaele Hospital, Via Olgettina 60, 20132, Milano, Italy

    M. Guslandi

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  1. M. Guslandi
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Correspondence to M. Guslandi.

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Guslandi, M. Diosmectite for Ulcerative Colitis. Clin. Drug Investig. 16, 411–412 (1998). https://doi.org/10.2165/00044011-199816050-00010

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  • DOI: https://doi.org/10.2165/00044011-199816050-00010

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