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Efficacy and Tolerability of Fleroxacin Compared with Ciprofloxacin in the Treatment of Bacterial Exacerbation of Chronic Bronchitis

A Pilot Study

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Summary

The aim of this multicentre pilot study was to compare the clinical efficacy and safety of fleroxacin and ciprofloxacin in patients with bacterial exacerbation of chronic bronchitis. A total of 39 patients were enrolled, 20 in the fleroxacin group and 19 in the ciprofloxacin group. The 2 parallel groups received either fleroxacin 400mg once daily or ciprofloxacin 500mg twice daily, for 7 days. According to the clinical efficacy ratings, 90% of patients in both groups were either cured or improved and bacteriological outcome appeared to be better for fleroxacin than for ciprofloxacin (eradication 45 vs 32%). Both drugs were well tolerated and fleroxacin appears to have a lower propensity to cause theophylline intoxication than ciprofloxacin. However, fleroxacin is favoured over ciprofloxacin for the treatment of patients with bacterial exacerbation of chronic bronchitis because bacteriological outcome appeared to be better for fleroxacin.

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Authors and Affiliations

  1. Chest Hospital TSH, Davos, Switzerland

    Jörg D. Leuppi, F. Schwarz & B. Villiger

  2. Department of Internal Medicine, University Hospital, Zürich, Switzerland

    T. C. Medici

Authors
  1. Jörg D. Leuppi
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  2. T. C. Medici
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  3. F. Schwarz
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  4. B. Villiger
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Leuppi, J.D., Medici, T.C., Schwarz, F. et al. Efficacy and Tolerability of Fleroxacin Compared with Ciprofloxacin in the Treatment of Bacterial Exacerbation of Chronic Bronchitis. Clin. Drug Invest. 12, 279–286 (1996). https://doi.org/10.2165/00044011-199612060-00001

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  • DOI: https://doi.org/10.2165/00044011-199612060-00001

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