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Postcoital Contraceptive Effects of an Alcoholic Extract of the Daucus carota Linn Seed in Rats


The alcoholic extract of Daucus carota Linn (carrot) seed was administered at different doses ranging from 50 to 250 mg/kg. Bodyweight after coitus showed a significant antifertility effect, which was dose dependent. The administration of this extract at a lower dose showed anti-implantational activity, whereas higher doses caused fetus resorption. The main effect of the extract appears to be an abortifacient activity. At higher dose levels the extract demonstrated an estrogenic nature with a prolonged estrous phase, whereas lower doses showed an antiestrogenic nature and an increase in the percentage duration of the diestrous phase of the estrous cycle. This extract is neither progestational nor antiprogestational. A uterine mast cell study directly reflected the hormonal nature of the extract and the mode of antifertility activity in rats.

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  1. 1.

    Norton SP. Studies on the variations in uterine mast cells in relation to antitrypsin agents and histamine depleters [thesis]. Bhopal: Bhopal University, 1975; 140–1

    Google Scholar 

  2. 2.

    Edgren RA, Calhoun DW. The chemical control of fertility. In: Edgren RA, editor. Contraception. New York: Marcel Dekker, 1957: 437

    Google Scholar 

  3. 3.

    Ohta Y. Deciduema fermation in rats. Ovariectomized at different ages. Biol Reprod 1982; 27: 308

    PubMed  Article  CAS  Google Scholar 

  4. 4.

    Cochrane RL, Meyer RK. Delayed nidation in the rat induced by progesterone. Endocrinology 1957: 96; 155

    CAS  Google Scholar 

  5. 5.

    Shelesnyak MC, Kraicer SP, Zeilmaker GH. Studies on the mechanism of decidualization-I. The estrogen surge of pseudoprenancy and progravidity and its role in the process of decidualization. Acta Endocr Kbh 1964; 42: 225–32

    Google Scholar 

  6. 6.

    Chang MC, Yanagimachi R. Effect of estrogens and other compounds as an oral antifertility agent on the development of rabbit ova and hamster embrye. Fertil Steril 1965; 16: 181–91

    Google Scholar 

  7. 7.

    Briggas MH, Christie GA. Antifertility substances in plants — Adv. steroid. Biochem Pharmacol 1977; 6: 11–9

    Article  Google Scholar 

  8. 8.

    Bingel AS, Farnsworth NR. Botanical sources of regulating agents, chemistry and pharmacology. Prog. Harm. Biochem Pharmacol 1980; 1: 149–225

    Article  CAS  Google Scholar 

  9. 9.

    Morris JM, Van Magenen B, McCann T, et al. Compounds interfering with ovum implantation and development — II. Synthetic estrogens and antiestrogens. Fertil Steril 1967; 18: 18–34

    PubMed  CAS  Google Scholar 

  10. 10.

    Sethi N, Nath D, Singh RK. Abortifacient activity of an ayurvedic compound narikela Kshar in rats and its teratological evaluation in non responses. J Res Ayurveda & Siddha 1990; 11: 72–7

    Google Scholar 

  11. 11.

    Chaudhury D, Adhikary P, Banerji J, et al. Pregnancy interceptive effect of Piper bitla. Fitoterapia 1991; 62: 397

    Google Scholar 

  12. 12.

    Burdick HO, Whitney R, Pincus G. The fate of mouse ova, tube lacked by injections of oestrogenic substances. Anat Rec 1937; 67: 5131

    Article  Google Scholar 

  13. 13.

    Greenwald GS. Hormonal regulation of egg transport through the mammalin oviaduct. In: Behrman SJ, Kistner B, editors. Prog Infertil 1968; 157

    Google Scholar 

  14. 14.

    Garg SK, Garg GP. Antifertility screening of plants (pt VIII). Effect on pregnancy in albine rats. Indian J Med Res 1971; 59: 302–6

    PubMed  CAS  Google Scholar 

  15. 15.

    Sharma MM, Lal G, Jacob D. Estrogenic and pregnancy interceptory effects of carrot Daucus carota seeds. Indian J Exp Biol 1976; 14: 506

    PubMed  CAS  Google Scholar 

  16. 16.

    Lerner LJ, Helthaus Jr FJ, Thompson CR. A nonsteroidal estrogen antagonist l-(P-2 diethylamine thesyphenyl)-1-Phenyl-1-1-2-P methoxy phenyl ethanol. Endocrinology 1958; 63: 295

    PubMed  Article  CAS  Google Scholar 

  17. 17.

    Leavitt WW, Wright PA. The plant estrogen coumestrol, as an agent affecting hypophysical gonadetrophic function. J Exp Zool 1956; 160: 319–28

    Article  Google Scholar 

  18. 18.

    Shutt DA. Interception of genistein with oestradiol in the reproductive tract of the ovariectemized mouse. Endocrinology 1967; 37: 231–2

    Article  CAS  Google Scholar 

  19. 19.

    Prakash AO. Antifertility investigation on embelinan oral contraceptive of plant origin. Biological properties. Planta Med 1981; 37 (Pt I): 259–66

    Article  Google Scholar 

  20. 20.

    Maraspin LE, Bo WJ. Effect of hormones pregnancy and pseudopregnancy on the mast cell count in the rat uterus. Life Sci 1971; 10: 111–20

    Article  CAS  Google Scholar 

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Correspondence to Upendra Bhatnagar.

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Bhatnagar, U. Postcoital Contraceptive Effects of an Alcoholic Extract of the Daucus carota Linn Seed in Rats. Clin. Drug Invest. 9, 30–36 (1995).

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