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Metastatic Prostate Cancer

Optimal Management Strategies

  • Therapy in Practice
  • Published:
American Journal of Cancer

Abstract

The treatment of metastatic prostate cancer is based upon the principle that prostate cancer growth is stimulated by androgens. Androgen ablation therapy is an effective treatment for metastatic prostate cancer. The timing of initiation of androgen ablation and the role of combined androgen blockade have been investigated. The utilization of intermittent androgen suppression offers the potential for improved quality of life. Intermittent therapy for metastatic disease is being compared with continuous therapy in an ongoing cooperative group trial. Recent studies have defined the evolving role of cytotoxic chemotherapy in hormone-refractory disease.

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Acknowledgments

Dr Vaughn receives research funding from Bristol-Myers Squibb Oncology and is on the speakers bureau of the Bristol-Myers Oncology and Eli Lilly and Company.

Dr Malkowicz is a consultant to AstraZeneca, Novartis, and Merck.

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Authors and Affiliations

  1. Division of Urology, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

    Brian M. Levin & Bruce S. Malkowicz

  2. Division of Hematology/Oncology, Department of Medicine and the Abramsom Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

    David J. Vaughn

  3. Abramson Cancer Center of the University of Pennsylvania, 16 Penn Tower, 3400 Spruce Street, Philadelphia, PA, 19104, USA

    David J. Vaughn

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  1. Brian M. Levin
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  2. David J. Vaughn
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  3. Bruce S. Malkowicz
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Correspondence to David J. Vaughn.

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Levin, B.M., Vaughn, D.J. & Malkowicz, B.S. Metastatic Prostate Cancer. Am J Cancer 2, 87–94 (2003). https://doi.org/10.2165/00024669-200302020-00002

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  • DOI: https://doi.org/10.2165/00024669-200302020-00002

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