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Talipexole

Abstract

  • ▲ Talipexole is a dopamine D2 receptor agonist, with activity at both pre- and postsynaptic D2 receptors. The drug also has α2-adrenoceptor agonist activity.

  • ▲ In a primate model of Parkinson’s disease, talipexole dose-dependently improved motor activity and parkinsonian symptoms, and beneficial effects were additive when combined with levodopa.

  • ▲ Clinical trials with talipexole in patients with Parkinson’s disease demonstrated statistically significant improvements from baseline for parkinsonian symptoms including akinesia, rigidity, tremor and gait disturbances.

  • ▲ In a large comparative trial in patients with Parkinson’s disease, talipexole was associated with a higher response rate and a lower incidence of gastrointestinal adverse events than bromocriptine, although drowsiness was more common among talipexole recipients.

  • ▲ The most frequently reported adverse events associated with talipexole are drowsiness, dizziness, hallucinations and minor gastrointestinal complaints such as nausea, gastrointestinal discomfort and loss of appetite.

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Correspondence to Greg L. Plosker.

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Plosker, G.L., Benfield, P. Talipexole. CNS Drugs 7, 410–416 (1997). https://doi.org/10.2165/00023210-199707050-00007

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  • DOI: https://doi.org/10.2165/00023210-199707050-00007

Keywords

  • Bromocriptine
  • Quinpirole
  • Parkinsonian Symptom
  • Droxidopa
  • Caudate Nucleus Neuron