Sports Medicine

, Volume 35, Issue 6, pp 461–471 | Cite as

Exercise and the Lymphatic System

Implications for Breast-Cancer Survivors
  • Kirstin LaneEmail author
  • Dan Worsley
  • Don McKenzie
Leading Article


This article summarises the current research on the lymphatic system related to exercise and critically evaluates the implications for exercise performance by breast-cancer survivors. The primary role of the lymphatic system during exercise is to assist in the regulation of tissue volume and pressure by carrying fluid and plasma proteins that have leaked into the interstitial space from tissues back to the cardiovascular system. During steady-state exercise in humans, lymph flow has been shown to increase to levels approximately 2- to 3-fold higher than at rest. Although the lymphatic system does not typically limit exercise performance in the normal population, the function of this system can be impaired in 27–49% of women who have survived breast cancer.

Breast cancer-related lymphoedema (BCRL) is a chronic swelling that can occur in the ipsilateral hand or arm of women treated for breast cancer and results in a number of physical and psychological sequelae. Exercise was once believed to be a factor in the development of BCRL as it was thought that the damage to the axillary lymphatics from breast-cancer treatment resulted in a primary obstruction to lymph flow. However, the exact aetiology and pathophysiology of BCRL appears to be multi-factorial and not as simple as a ‘stop-cock’ effect. Furthermore, recent studies have shown that participating in vigorous, upper-body exercise is not related to an increase in arm volume, which would indicate the development of BCRL. It is still not known, though, how long-term exercise affects lymphatic system function in breast-cancer survivors with and without BCRL.


Lymphatic System Lymphatic Function Lymph Flow Lymphatic Capillary Initial Lymphatic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



K. Lane was supported by the Michael Smith Foundation for Health Research (MSFHR) and the Canadian Institutes of Health Research. The authors have no conflicts of interest that are directly relevant to the content of this review.


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Copyright information

© Adis Data Information BV 2005

Authors and Affiliations

  1. 1.School of Human KineticsUniversity of British ColumbiaVancouverCanada
  2. 2.Department of RadiologyUniversity of British ColumbiaVancouverCanada
  3. 3.Division of Sports MedicineUniversity of British ColumbiaVancouverCanada

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