Sports Medicine

, Volume 13, Issue 2, pp 108–115 | Cite as

Exercise, Muscle Damage and Fatigue

  • H.-J. Appell
  • J. M. C. Soares
  • J. A. R. Duarte
Issues in Fatigue in Sport and Exercise


Fatigue as a functional sign and muscle damage as a structural sign can be observed after prolonged exercise like marathon running or after strenuous exercise, especially with the involvement of eccentric contractions. For fatigue due to prolonged exercise, hypoxic conditions and the formation of free oxygen radicals seem to be of aetiological importance, resulting in an elevated lysosomal activity. Eccentric exercise of high intensity rather results in a mechanical stress to the fibres. Although these different mechanisms can be discerned experimentally, both result in similar impairments of muscle function. A good training status may attenuate the clinical signs of fatigue and muscle damage. The symptoms and events occurring during delayed onset of muscle soreness (DOMS) can be explained by a cascade of events following structural damage to muscle proteins.


Muscle Damage Eccentric Exercise Apply Physiology Prolonged Exercise Muscle Soreness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Adis International Limited 1992

Authors and Affiliations

  • H.-J. Appell
    • 1
  • J. M. C. Soares
    • 2
  • J. A. R. Duarte
    • 2
  1. 1.Institute for Experimental MorphologyGerman Sports UniversityCologne 41Federal Republic of Germany
  2. 2.Department of Sport BiologyUniversity of PortoPortugal

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