Sports Medicine

, Volume 13, Issue 2, pp 93–98 | Cite as

Some Central and Peripheral Factors Affecting Human Motoneuronal Output in Neuromuscular Fatigue

  • S. C. Gandevia
Issues in Fatigue in Sport and Exercise


Fatigue may be defined as a reduction in the maximal force-generating capacity of a muscle. It may result from peripheral processes distal to the neuromuscular junction and from central processes controlling the discharge rate of motoneurons. When assessed with a sensitive test using twitch interpolation, most “maximal” voluntary contractions approach but do not attain optimal muscle output. During fatigue, reflex inputs from intramuscular receptors may contribute to a decline in motor unit discharge rate — a decline which optimises force production during maximal efforts. Further studies should investigate how the central nervous system controls the discharge rate of motor units during fatigue produced by different forms of exercise.


Motor Unit Maximal Voluntary Contraction Chronic Fatigue Syndrome Central Fatigue Muscle Spindle Afferents 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Adis International Limited 1992

Authors and Affiliations

  • S. C. Gandevia
    • 1
  1. 1.Prince of Wales Medical Research Institute and Faculty of MedicineUniversity of New South WalesSydneyAustralia

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