Conclusion
The neuroendocrine system plays an integral function in the development and maintenance of muscle tissue. Numerous investigations have confirmed the effects of both aerobic exercise and heavy resistance exercise upon the neuroendocrine system. Although there has been great progress in the area of exercise and neuroendocrinology, many questions regarding hormonal responses to exercise remain unanswered. In particular, there is a need for additional research that will reveal the specific mechanisms by which different exercise protocols induce hormonal responses.
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References
Abe H, Molitch M, VanWych J, Underwood L. Human growth hormone and somatomedin C suppresses the spontaneous release of growth hormone in anesthetized rats. Endocrinology 113: 1319–1324, 1983
Adams H, Nissley S, Kasuga M, Foley T, Rechler M. Receptors for insulin-like growth factors and growth effects of multiplication-stimulating activity (rat insulin-like growth factor II) in rat embryo fibroblasts. Endocrinology 112: 971–978, 1983
Aldercreutz H, Harkonen K, Kuoppasalmi H, Naveri I, Huhtaniemi H, et al. Effect of training on plasma anabolic and catabolic steroid hormones and their response during physical exercise. International Journal of Sports Medicine 7: 27–28, 1986
Aono T, Kurachi K, Mivata M, Nakashima A, Koshiyoma K, et al. Influence of surgical stress under general anaesthesia on serum gonadotrophin levels in male and female patients. Journal of Clinical Endocrinology and Metabolism 42: 144–148, 1976
Beguinot F, Kahn C, Moses A, Smith R. Distinct biologically active receptors for insulin, insulin-like growth factor-I and insulin-like growth factor-II cultured skeletal muscle cells. Journal of Biological Chemistry 260: 15892–15898, 1985
Beguinot F, Kahn C, Moses A, Smith R. The development of insulin receptors and responsiveness is an early marker of differentiation in the muscle cell line L6. Endocrinology 118: 447–455, 1986
Bloom S, Johnson R, Park D, Rennie M, Sulaiman W. Differences in the metabolic and hormonal response to exercise between racing cyclists and untrained individuals. Journal of Physiology 258: 1–18, 1976
Borer K. Characteristics of growth inducing exercise. Physiology of Behavior 24: 713–720, 1980
Borer K, Kelch R. Increased serum growth hormone and somatic growth in exercising adult hamsters. American Journal of Physiology 234: E611–E616, 1978
Borer K, Nicoski D, Owens V. Alteration of pulsatile growth hormone secretion by growth inducing exercise: involvement of endogenous opiates and somatostatin. Endocrinology 118: 844–850, 1986
Bunt J, Boileau R, Mahr J, Nelson R. Sex and training differences in human growth hormone levels during prolonged exercise. Journal of Applied Physiology 61: 1796–1801, 1986
Busso T, Haakinen K, Pakarinen A, Carasso C, Lacour J, et al. A systems model of training responses and its relationship to hormonal responses in elite weight-lifters. European Journal of Applied Physiology 61: 48–54, 1990
Cumming D, Wall S, Galbraith M, Beicastro A. Reproductive hormone responses to resistance training. Medicine and Science in Sports and Exercise 19: 234–238, 1987
Cuttler L, Walsh J, Szabo M. The effect of age on somatostatin suppression of basal, growth hormone (GH)-releasing factor-stimulated, and dibutyryl adenosine 3′, 5′-monophosphate-stimulated GH release from rat pituitary cells in monolayer culture. Endocrinology 119: 152–157, 1986
Daughaday W, Parker K, Borowsky S, Trivedi B, Kapadia M. Measurement of somatomedin-related peptides in fetal, neonatal, and maternal rat serum by insulin-like growth factor (IGF) 1 radio-immunoassay, IGF-II radioreceptor assay (RRA), and multiplication-stimulating activity RRA after acid-ethanol extraction. Endocrinology 110: 575–581, 1982
Daughaday WM, Rotwein P. Insulin-like growth factors I and II: peptide, messenger ribonnucleic acid and gene structures, serum, and tissue concentrations. Endocrine Reviews 10: 68–91, 1989
Donevan R, Andrew G. Plasma β-endorphin immunoreactivity during graded cycle ergometry. Medicine and Science in Sports and Exercise 119: 229–233, 1987
Ewton D, Falen S, Florini J. The type II insulin-like growth factor (IGF) receptor has low affinity for IGF-I analogs: pleiotypic actions of IGFs on myoblasts are apparently mediated by the type I receptor. Endocrinology 120: 115–123, 1987
Ewton D, Florini J. Relative effects of the somatomedins, multiplication-stimulating activity, and growth hormone on myoblasts and myotubes in culture. Endocrinology 106: 577–583, 1980
Ewton D, Florini J. Effects of the somatomedins and insulin on myoblast differentiation in vitro. Developmental Biology 86: 31–39, 1981
Farrell P, Gustafson A, Garthwaite T, Kalkhoff R, Cowley A, et al. Influence of endogenous opioids on the response of selected hormones to exercise in humans. Journal of Applied Physiology 61: 1051–1057, 1986
Florini J. Hormonal control of muscle growth. Journal of Animal Science (Suppl. 61): 21–37, 1985
Florini J, Ewton D, Falen S, VanWyck J. Biphasic concentration dependency of stimulation of myoblast differentiation by somatomedins. American Journal of Physiology 250: C771–C778, 1986
Florini J, Roberts A, Ewton D, Falen S, Flanders K, et al. Transforming growth factor-B. Journal of Biological Chemistry 261: 16509–16513, 1986
Frantz AG, Rabkin MT. Effects of estrogen and sex differences on secretion of human growth hormone. Journal of Clinical Endocrinology and Metabolism 25: 1470–1480, 1965
Galbo H. The hormonal response to exercise. Proceedings of the Nutrition Society 44: 257–266, 1985
Galbo H, Holst J, Christensen N. Glucagon and plasma catecholamine responses to graded and prolonged exercise in man. Journal of Applied Physiology 38: 70–76, 1975
Gambert SR, Garthwaite TL, Pontzer CH. Running elevates plasma beta-endorphin immunoreactivity and ACTH in untrained human subjects. Proceedings of the Society for Experimental Biology and Medicine 168: 1–4, 1981
Groesbeck M, Parlow A, Daughaday W. Stimulation of supra-normal growth in prepubertal, adult plateaued, and hypophy-sectomized female rats by large doses of rat growth hormone: physiological effects and adverse consequences. Endocrinology 120: 1963–1975, 1987
Grossman A, Bouloux P, Price P, Drury P, Lam K, et al. The role of opioid peptides in the hormonal responses to acute exercise in man. Clinical Science 67: 483–491, 1984
Guerrievo V, Florini J. Dexamethasone effects on myoblast proliferation and differentiation. Endocrinology 106: 1198–1202, 1980
Guezennec Y, Leger L, Lhoste F, Aymonod M, Pesquies PC. Hormone and metabolic response to weight-lifting training sessions. International Journal of Sports Medicine 7: 100–105, 1986
Haakinen K, Pakarinen A, Alen M, Kauhanen H, Komi P. Relationships between training volume, physical performance capacity, and serum hormone concentrations during prolonged training in elite weight lifters. International Journal of Sports Medicine 8 (Suppl.): 61–65, 1987
Haakinen K, Pakarinen A, Alen M, Kauhanen H, Komi P. Neuromuscular and hormonal adaptations in athletes to strength training in two years. Journal of Applied Physiology 65: 2406–2412, 1988
Haakinen K, Pakarinen A, Alen M, Komi P. Serum hormones during prolonged training of neuromuscular performance. European Journal of Applied Physiology 53: 287–293, 1985
Haakinen K, Pakarinen A, Kyrolainen H, Cheng S, Kim D, et al. Neuromuscular adaptations and serum hormones in females during prolonged power training. International Journal of Sports Medicine 11: 91–98, 1990
Hackney A, Sinning W, Bruot B. Hypothalamic-pituitary-testicular axis function in endurance-trained males. International Journal of Sports Medicine 11: 298–303, 1990
Hartley H, Mason J, Hogan R, Jones L, Kotchen T, et al. Multiple hormonal responses to prolonged exercise in relation to physical training. Journal of Applied Physiology 33: 607–610, 1972a
Hartley H, Mason J, Hogan R, Jones L, Kotchen T, et al. Multiple hormonal responses to graded exercise in relation to physical training. Journal of Applied Physiology 33: 603–606, 1972b
Hedge GA, Colby HD, Goodman RL. Clinical endocrine physiology, W.B. Saunders Co., Philadelphia, 1987
Janeczko R, Etlinger J. Inhibition of intracellular proteolysis in muscle cultures by multiplication-stimulating activity. Journal of Biological Chemistry 259: 6292–6297, 1984
Johannesen A, Hagen C, Galbo H. Prolactin, growth hormone, thyrotropin 3,5,3′-triiodothyrine, and thyroxine responses to exercise after fat and carbohydrate enriched diet. Journal of Clinical Endocrinology and Metabolism 52: 56–61, 1981
Keiser H. Exercise- and training-induced menstrual cycle irregularities (AMI). International Journal of Sports Medicine 7: 38–44, 1986
Kraemer WJ. Endocrine responses to resistance exercise. Medicine and Science in Sports and Exercise (Suppl. 20): S152–S157, 1988
Kraemer W, Gordon S, Heck S, Marchitelli L, Mello R, et al. Endogenous anabolic hormonal and growth factor responses to heavy resistance exercise in males and females. International Journal of Sports Medicine, in press, 1991
Kraemer W, Marchitelli L, Gordon S, Harman E, Dziados J, et al. Hormonal and growth factor responses to heavy resistance exercise protocols. Journal of Applied Physiology 69: 1442–1450, 1990
Kraemer WJ, Marchitelli L, McCurry D, Harmon EF, Frykman PN, et al. Endogenous anabolic hormone responses to weight training protocols. Medicine and Science in Sports and Exercise (Suppl. 20): S59, 1988
Kraemer WJ, Noble B, Clark M, Culver B. Physiological responses to heavy-resistance exercise with very short rest periods. International Journal of Sports Medicine 8: 247–252, 1987
Kraemer WJ, Noble B, Culver B, Lewis R. Changes in plasma proenkephalin peptide F and catecholamine levels during graded exercise in men. Proceedings of the National Academy of Sciences 82: 6349–6351, 1985
Kraemer W, Patton J, Knuttgen H, Marchitelli L, Cruthirds C, et al. Hypothalamic-pituitary-adrenal responses to short-duration high-intensity cycle exercise. Journal of Applied Physiology 66: 161–166, 1989
Kuoppasalmi K. Plasma testosterone and sex-hormone-binding globulin capacity in physical exercise. Scandinavian Journal of Clinical Laboratory Investigation 40: 411–418, 1980
Kuoppasalmi K, Naveri H, Harkonen M, Aldercreutz H. Plasma cortisol, androstenedione, testosterone, and luteinizing hormone in running exercise of different intensities. Scandinavian Journal of Clinical Laboratory Investigation 40: 403–409, 1980
Kurowski T, Capaccio J, Hickson R. Glucocoriticoids override androgen-induced growth. Medicine and Science in Sports and Exercise (Suppl. 18): S23, 1986
Leung DL, Spencer SA, Cachianes G, Hammonds RG, et al. Growth hormone receptor and serum binding protein: purification, cloning and expression. Nature 330: 537–540, 1987
Ljunhall S, Joborn H, Benson L, Fellstrom B, Wide L, et al. Effects of physical exercise on serum calcium and parathyroid hormone. Journal of Clinical Investigation 14: 469–473, 1984
Login I, Judd A, MacLeod R. Association of Ca mobilization with stimulation of growth hormone (GH) release by GH-releasing factor in dispersed normal male rat pituitary cells. Endocrinology 118: 239–243, 1986
Mandel J, Pearson J. Insulin stimulates myogenesis in a rat myoblast line. Nature 251: 618–620, 1974
Maresh CM, Cook MR, Cohen HD, Graham C, Gunn WS. Exercise testing in the evaluation of human responses to powerline frequency fields. Aviation, Space, and Environmental Medicine 59: 1139–1145, 1988
Martin CR. Endocrine physiology, Oxford University Press, New York, 1985
Miller J, Tannenbaum G, Colle E, Guyda H. Daytime pulsatile growth hormone secretion during childhood and adolescence. Journal of Clinical Endocrinology and Metabolism 55: 989–994, 1984
Minuto F, DelMonte P, Barveca A, Nicolen A, Giordano G. Partial characterization of somatomedin C-like immunoreactivity secreted by breast cancer cells in vitro. Molecular and Cellular Endocrinology 54: 179–184, 1987
Murphy L, Lazarus L. The effect of streptozotocin-induced diabetes mellitus on the ability of rat serum to stimulate human fibroblast proliferation. Endocrinology 112: 1026–1035, 1983
Nakashima A, Koshiyama K, Vozumi T, Monden T, Hamahaka Y, et al. Effects of general anesthesia and severity of surgical stress on serum LH and testosterone in males. Acta Endocrinologica 78: 258–269, 1975
Pearlman WH, Crepy O. Steroid protein interaction with particular reference to testosterone binding by human serum. Journal of Biological Chemistry 242: 182–189, 1967
Richman R, Benedict M, Florini J, Toly B. Hormonal regulation of somatomedin secretion by fetal rat hepatocytes in primary culture. Endocrinology 116: 180–188, 1985
Richman R, Weiss J, Roberts S, Florini J. The effect of serum and multiplication stimulating activity on L6 myoblast growth: the lack of correlation with cyclic nucleotide changes. Journal of Cellular Physiology 103: 63–93, 1980
Richter EA, Mikines KJ, Galbo H, Kiens B. Effects of exercise on insulin action in human skeletal muscle. Journal of Applied Physiology 66: 876–885, 1989
Roberts A, Anzano M, Meyers C, Wideman J, Blacher R, et al. Purification and properties of a type B transforming growth factor from bovine kidney. Biochemistry 22: 5692–5698, 1983
Sato Y, Hayamizu S, Yamamoto C, Onkuwa Y, Yamanouchi K, et al. Improved insulin sensitivity in carbohydrate and lipid metabolism after physical training. International Journal of Sports Medicine 7: 307–310, 1986
Schwarz L, Kindermann W. β-Endorphin, adrenocorticotrophic hormone, cortisol and catecholamines during aerobic and anaerobic exercise. European Journal of Applied Physiology 61: 165–171, 1990
Seidman D, Dolev E, Deuster P, Burnstein R, Arnon R, et al. Androgenic response to long-term physical training in male subjects. International Journal of Sports Medicine 11: 421–424, 1990
Shangold MM. Exercise and the adult female: hormonal and endocrine effects. In Terjung (Ed.) Exercise and sport sciences reviews, pp. 55–79, Collamore Press Inc., Lexington, MA, 1984
Shangold MM, Gatz ML, Thysen B. Acute effects of exercise on plasma concentrations of prolactin and testosterone in recreational women runners. Fertility and Sterility 35: 699–702, 1981
Strauss R, Lanese R, Malarkey W. Weight loss in amateur wrestlers and its effect on serum testosterone levels. Journal of the American Medical Association 254: 3337–3338, 1985
Tegelman R, Johansson C, Hemmingsson P, Eklof R, Carlstron K, et al. Endogenous anabolic and catabolic steroid hormones in male and female athletes during off season. International Journal of Sports Medicine 10: 103–106, 1990
VanHelder W, Casey K, Goode R, Radomski W. Growth hormone regulation in two types of aerobic exercise of equal oxygen uptake. European Journal of Applied Physiology 55: 236–239, 1986
Vora N, Kukreja S, York P, Bower E, Hargis G, et al. Effects of exercise on serum calcium and parathyroid hormone. Journal of Clinical Endocrinology and Metabolism 57: 1067–1069, 1983
Webster BA, Vigna SR, Paquette T. Acute exercise, epinephrine and diabetes enhance insulin binding to skeletal muscle. American Journal of Physiology 250: E198–E204, 1986
Wheeler G, Wall S, Beicastro A, Cumming D. Reduced serum testosterone and prolactin levels in male distance runners. Journal of American Medical Association 252: 514–516, 1984
Wilkerson J, Horvath S, Gutin B. Plasma testosterone during treadmill exercise. Journal of Applied Physiology 49: 249–253, 1980
Williams RH. Textbook of endocrinology, W.B. Saunders Co., Philadelphia, 1974
Wilmore D. Hormonal responses and their effect on metabolism. Surgical Clinics of North America 56: 999–1018, 1976
Yamashita S, Melmed S. Insulin-like growth factor I action on rat anterior pituitary cells: suppression of growth hormone secretion and messenger ribonucleic acid levels. Endocrinology 118: 176–182, 1986
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Deschenes, M.R., Kraemer, W.J., Maresh, C.M. et al. Exercise-Induced Hormonal Changes and their Effects upon Skeletal Muscle Tissue. Sports Med 12, 80–93 (1991). https://doi.org/10.2165/00007256-199112020-00002
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DOI: https://doi.org/10.2165/00007256-199112020-00002