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Antihypertensive Effect of Manidipine

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Abstract

Manidipine is a lipophilic, third-generation, highly vasoselective, dihydropyridine (DHP) calcium channel antagonist, which, when given on a once-daily basis, effectively reduces blood pressure (BP) in patients with mild-to-moderate essential hypertension. Manidipine has a gradual onset and a long duration of action, effectively maintaining reduced BP levels throughout the 24-hour dosing period, and is effective in the long term with no evidence of intolerance. The BP-lowering capacity of manidipine is similar to that of other established DHPs and of angiotensin-converting enzyme inhibitors. Diabetic patients and very elderly patients with mild-to-moderate hypertension also respond favourably to treatment with manidipine. Manidipine has neutral effects on glucose and lipid metabolism and is generally well tolerated. Manidipine thus represents a first-line option for lowering BP in patients with mild-to-moderate hypertension.

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Authors and Affiliations

  1. Internal Medicine Department, Hospital Santa Creu i Sant Pau, and School of Medicine, Universitat Autónoma de Barcelona, Barcelona, Spain

    Alex Roca-Cusachs

  2. Department of Cardiology, Larissa University Hospital, Larissa, Greece

    Filippos Triposkiadis

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  1. Alex Roca-Cusachs
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  2. Filippos Triposkiadis
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Correspondence to Alex Roca-Cusachs.

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Roca-Cusachs, A., Triposkiadis, F. Antihypertensive Effect of Manidipine. Drugs 65 (Suppl 2), 11–19 (2005). https://doi.org/10.2165/00003495-200565002-00003

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