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A Pharmacological Approach to Gastric Acid Inhibition

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Abstract

Proton pump inhibitors have changed our approach to gastric acid-related diseases. They are much more potent acid inhibitors than H2-antagonists and exhibit a sophisticated mechanism of action. The present review analyses the general pharmacology of proton pump inhibitors and differentiates the specific characteristics of the various compounds that belong to this family. Special emphasis has been placed in describing the clinical implications of such differences and the potential importance for adverse effects.

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Table I

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, University of Valencia, Spain

    Juan V. Esplugues

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  1. Juan V. Esplugues
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Correspondence to Juan V. Esplugues.

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Esplugues, J.V. A Pharmacological Approach to Gastric Acid Inhibition. Drugs 65 (Suppl 1), 7–12 (2005). https://doi.org/10.2165/00003495-200565001-00003

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  • DOI: https://doi.org/10.2165/00003495-200565001-00003

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