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Historical Perspective of Gastric Acid Inhibition

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Abstract

The inhibition of gastric secretion has been a therapeutic objective for decades. A variety of pharmacologic and non-pharmacologic approaches have been proposed throughout history. Among the non-pharmacologic proposals, gastric surgery was widely used until effective drugs were available. Initially antacids and later anti-cholinergics, H2 blockers and proton pump inhibitors took the predominant position. Finally, Helicobacter pylori eradication has been the milestone for the cure of peptic ulcers.

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Authors and Affiliations

  1. Department of Medical Pathology, Gastroenterology Service, ‘San Carlos’ Clinical University Hospital, Complutense University, calle Martín Lagos s/n, 28040, Madrid, Spain

    Manuel Díaz-Rubio

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  1. Manuel Díaz-Rubio
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Correspondence to Manuel Díaz-Rubio.

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Díaz-Rubio, M. Historical Perspective of Gastric Acid Inhibition. Drugs 65 (Suppl 1), 1–6 (2005). https://doi.org/10.2165/00003495-200565001-00002

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  • DOI: https://doi.org/10.2165/00003495-200565001-00002

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