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Drugs

, Volume 64, Issue 18, pp 2091–2097 | Cite as

Brivudin (Bromovinyl Deoxyuridine)

  • Susan J. Keam
  • Therese M. Chapman
  • David P. Figgitt
Adis Drug Profile

Abstract

  • ▴ Brivudin is an oral thymidine analogue indicated for the early treatment of acute herpes zoster in immunocompetent adults. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage.

  • ▴ In a large, 7-day, phase III trial in immunocompetent patients with herpes zoster, once-daily brivudin 125mg was significantly more effective than oral acyclovir 800mg five times daily in reducing the mean time from start of treatment to last vesicular eruption, and was as effective as acyclovir at healing lesions and alleviating acute zoster-related pain.

  • ▴ The likelihood of developing post-herpetic neuralgia (PHN) in immunocompetent patients aged ≥50 years was significantly lower with brivudin than with acyclovir.

  • ▴ Brivudin was as effective as oral famciclovir 250mg three times daily in terms of the prevalence of PHN, the time to last vesicular eruption and lesion healing in another large, 7-day, phase III study in immunocompetent patients with herpes zoster.

  • ▴ Oral brivudin is generally well tolerated, with a similar tolerability profile to those of oral acyclovir or famciclovir. Nausea was the most commonly reported adverse event.

Keywords

Herpes Zoster Acyclovir Varicella Zoster Virus Immunocompetent Patient Famciclovir 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Adis Data Information BV 2004

Authors and Affiliations

  • Susan J. Keam
    • 1
  • Therese M. Chapman
    • 1
  • David P. Figgitt
    • 1
  1. 1.Adis International LimitedMairangi Bay, AucklandNew Zealand

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