Abstract
Epizoonoses such as scabies, lice and cimicosis are common, vexing disorders that occur worldwide. Historically, many treatment modalities have been employed in the management of these disorders, and most of the drugs described in this review are of historical interest and no longer recommended or in widespread use because of their wide spectrum of adverse effects. More recently, reports documenting resistance against various antiectoparasite drugs, complicated and severe courses of the diseases, and adverse effects of drug therapy have prompted the development of new treatment strategies and drugs for optimal disease management.
Because the strategies currently recommended for the treatment of ectoparasites differ worldwide, this review proposes a rational approach to selecting the best therapeutic agent by comparing the pharmacokinetics, pharmacodynamics, drug efficacy and adverse effects. A literature search of the currently Internet accessible libraries PubMed, Medline and Ideal library, of citations of articles found there, and from communications with the Federal Institute for Drugs and Medical Devices, Germany, was conducted based on this approach.
One major observation of this literature search is that permethrin is the treatment of choice for lice and scabies in the US and in Great Britain, whereas lindane is still recommended for scabies in most other European countries because of its longer-standing record of effectiveness. Although permethrin has not yet been proven to be more effective than lindane in treating infections with these ectoparasites, it currently appears to have the best efficacy versus safety profile of topical treatments for scabies and lice.
Ivermectin is a newer oral drug for the treatment of ectoparasites, which has been used with great success in the treatment of onchocercosis and other endoparasites. Although ivermectin appears to be a promising drug, its role in the treatment of ectoparasitic infections will be clarified as more study data become available.
Finally, it is important to emphasise the clinical aspects of ectoparasite therapy and that providing the patient with optimal instructions on the use of topical therapeutics is of great importance in avoiding adverse effects and assuring complete removal of the ectoparasite, thereby avoiding the development of drugresistance.
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References
Orkin M. Scabies in AIDS. Semin Dermatol 1993; 12(1): 9–14
Elgart ML. A risk-benefit assessment of agents used in the treatment of scabies. Drug Saf 1996; 14: 386–93
Hernandez-Perez E. Resistance to antiscabietic drugs. J Am Acad Dermatol 1983; 8: 121–2
Taplin D. Resistance to antiscabietic drugs [reply]. J Am Acad Dermatol 1983; 8: 122–3
Taplin D, Rivera A, Walter JG, et al. A comparative trial of three treatment schedules for the eradication of scabies. J Am Acad Dermatol 1983; 9(4): 550–4
Purvis RS, Tyring SK. An outbreak of lindane-resistant scabies treated successfully with permethrin 5% cream. J Am Acad Dermatol 1991; 25: 1015–6
Purvis RS, Tyring SK. Lindane resistant scabies [reply]. J Am Acad Dermatol 1991; 27: 648
Roth WI. Scabies resistant to lindane 1% lotion and crotaminon 10% cream. J Am Acad Dermatol 1991; 24(3): 502–3
Judd LE. Gamma benzene hexachloride resistant scabies. N Z Med J 1993; 106: 61–3
Boix V, Sanchez-Paya J, Portilla J, et al. Nosocomial outbreak of scabies clinically resistant to lindane [letter]. Infect Control Hosp Epidemiol 1997; 18(10): 677
Taplin D, Porcelain SL, Meinking TL, et al. Community control of scabies: a model based on use of permethrin cream. Lancet 1991; 337: 1016–8
Wolff HH, Kock S. Ivermectin als orale Einmalbehandlung der Skabies. Deutsches Ärzteblatt 1998; 95: B1717–9
Melnik B. Besonderheiten der Skabiestherapie. Schwangerschaft, Ivermectin, Resistenzprobleme. In: Plewig G, Wolff HH, editors. Fortschritte der praktischen Dermatologie und Venerologie. Berlin: Springer, 1998: 511–7
Ullmann E. Lindane, Monographie eines insektiziden Wirkstoffes. Verlag K. Schillinger, 1973: Freiburg I. Br.
Martindale’s health science guide. 28th ed. Newport Beach (CA): Martindale, 1982: 837
Merck index. 10th ed. Boca Raton: Chapman & Hall/CRC, 1983: 789
Remingtons pharmaceutical desk reference. New York (NY): Remington, 1988: 1664–6
Slade RE. The gamma isomer of hexachlorcyclohexane. Chem Ind 1945; 64: 314–9
Woolridge WE. The gamma isomer of hexachlorcyclohexane in the treatment of scabies. J Invest Dermatol 1948; 10: 363–6
Spühler H. Die Behandlung der Scabies und der Pediculosen mit gamma-Hexachlorcyclohexan. Schweiz Med Wochenschr 1954; 84: 701–4
Röchling H. Hexachlorcyclohexan und verwandte Stoffe. In: Wegler R (Hrsg), editor. Chemie der Pflanzenschutz- und Insektenbekämpfungsmittel. Berlin: Springer, 1970: 129–33
Brown S, Becher J, Brady W. Treatment of ectoparasitic infections: review of the English-language literature, 1982–1993. Clin Inf Dis 1995; 20 Suppl. 1: S104–S9
Feldmann RJ, Maibach HI. Percutaneous penetration of some pesticides and herbicides in man. Toxicol Appl Pharmacol 1974; 28: 126–32
Nitsche K, Lange M, Bauer E, et al. Quantitative distribution if locally applied lindane in human skin and subcutaneous fat in vitro. Dermatosen 1984; 32: 161–5
Moody RP, Ritter L. Dermal absorption of the insecticide lindane in rats and rhesus monkeys: effect of anatomical sites. J Toxicol Environ Health 1989; 28: 161–9
World Health Organization (WHO). Alpha- and beta-hexachlorcyclohexane. Geneva: WHO, 1992. (Environmental Health Criteria Series No. 123)
World Health Organization (WHO). Lindane. Geneva: WHO, 1991 (Environmental Health Criteria Series No. 124)
Franz TJ, Lehmann PA, Franz SF. Comparative percutaneous absorption of lindane and permethrin. Arch Dermatol 1996; 132: 901–5
Baumann K, Angerer J, Heinrich R, et al. Occupational exposure to hexachlorcyclohexane: I. Body burden of HCH-isomers. Int Arch Occup Environ Health 1980; 47: 119–27
Baumann K, Behling K, Brassow H-L, et al. Occupational exposure to hexachlorcyclohexane: II. Neurophysiological findings and neuromuscular function in chronically exposed workers. Int Arch Occup Environ Health 1981; 48: 165–72
Seifert B, Becker K, Helm D, et al. The German Environmental Survey 1990/1992 (GerES II): reference concentrations of selected environmental pollutants in blood, urine, hair, house dust, drinking water and indoor air. J Expo Anal Environ Epidemiol 2000 Nov–Dec; 10 (6 Pt 1): 552–65
Mortensen ML. Management of acute childhood poisonings caused by selected insecticides and herbicides. Pediatr Clin North Am 1986; 33(2): 421–5
Minton NA, Murray VS. A review of organophosphate poisoning. Med Toxicol 1988; 3: 350–75
Oesch F, Friedberg T, Herbst M et al. Effects of lindane treatment on drug metabolizing enzymes and liver weight of CFI mice in which is evoked hepatomas and in non-susceptible rodents. Chem Biol Interact 1982; 40: 1–40
Chang SK, Williams PL, Dauterman WC, et al. Percutaneous absorption, dermatopharmacokinetics and related bio-transformation studies on carbaryl, lindane, malathion, and parathion in isolated perfused porcine skin. Toxicology 1994; 91(3): 269–80
Centre International d’Etudes du Lindane (C.I.E.L.). Lindane: Information über einen Wirkstoff. Lindane -ja, HCH-Nein. Lindane Workshop Hannover. Freiburg: Schilinger, 1982
Jung D, Becher H, Edler L, et al. Elimination of betahexachlorocyclohexane in occupationally exposed persons. J Toxicol Environ Health 1997; 51: 23–34
Hertel JW. Bestimmung der Dosis letalis von Jacutin bei oraler Applikation an der Ratte. Bericht der Hermal-Chemie 1979; Hertel Reinbeck, Germany: Kurt Hermann vom 15.08.1979
Forth W, Henschler D. Pharmakologie und Toxikologie: Insektizide. 5. Ausgabe 1987: 776–9 Munich: Urbon & Fischer, 1987
UNO. IPCS. International Programme on chemical safety, environmental health criteria for Lindane. UNO, International Labour Organization. 2nd draft. Geneva: WHO, 1989
Oliveira-Filho EC, Paumgartten FJR. Comparative study in the acute toxicities of alpha, beta, gamma and delta isomers of hexachlorcyclohexane to freshwater fishes. Bull Environ Contain Toxicol 1997; 59: 984–8
Davies JE, Dedhia HV, Morgdale C, et al. Lindane poisonings. Arch Dermatol 1983; 119: 142–4
Moeschlin S. Klinik und Therapie der Vergiftungen. 7. Neu bearbeitete und erweiterte Auflage. Stuttgart: Thiere, 1991
Orkin M, Maibach HI. Scabies in children. Pediatr Clin North Am 1978; 25(2): 371–86
Herbst M, Weisse I, Köllmer H. A contribution to the question of the possible hepatocarcinogenic effects of lindane. Toxicology 1975; 4: 91–6
Herbst M. Toxizität von gamma HCH (Lindane). Hexachlorcyclohexan als Schadstoff in Lebensmitteln: Materialien aus zwei Kolloquien der Senatskomission zur Prüfung von Rückständen in Lebensmitteln am 28./29.11.1979 und 6.3. 1980. Weinheim: Verlag Chemie, 1983
Porting J, Schnorr C. The potency of gamma-1,2,3,4,5,6- hexachlorcyclo-hexane (lindane). Toxicology 1988; 52: 309–21
Surber C, Rufli T. Lindane. Hautarzt 1995; 46(8): 528–36
Solomon LM, Fahrner L, West DP. Gamma benzene hexachloride toxicity: a review. Arch Dermatol 1977; 113: 353–57
Rasmussen JE. The problem of lindane. J Am Acad Dermatol 1981; 5: 507–16
Shacter B. Treatment of scabies and pediculosis with lindane preparations: an evaluation. J Am Acad Dermatol 1981; 5: 517–27
Rasmussen JE. Lindane: a prudent approach. Arch Dermatol 1987; 123(8): 1008–10
Abalis IM, Eldefrawi ME, Eldefrawi AT. Effects of insecticides on GAB A-induced chloride influx into rat brain microsacs. J Toxicol Environ Health 1986; 18: 13–23
Joy RM, Albertson TE. Factors responsible for increased excitability of dentate gyrus granule cells during exposure to lindane. Neurotoxicology 1987; 8: 517–28
Fishman BE, Gianutsos G. CNS biochemical and pharmacological effects of the isomers of hexachlorcyclohexane (lindane) in the mouse. Toxicol Appl Pharmacol 1988; 93: 146–53
Uchida M, Kurihara N, Fujita T, et al. BHC isomers and related compounds. VIII. Inhibitory effects of BHC and nerve conduction. Pestic Biochem Physiol 1974; 4: 233–8
Publicover SJ, Duncan CJ. The action of lindane in accelerating the spontaneous release of neurotransmitter at the frog neuromuscular junction. Naunyn Schmiedebergs Arch Pharmacol 1979; 381: 179–82
Yamaguchi I, Matsumara F, Kadous AA. Inhibition of synaptic ATPase by rheptachlorepoxide in rat brain. Pestic Biochem Physiol 1979; 11: 285–93
Pandy RN, Zaidi SIM, Kidawi AM. Effects of pesticides on frog skeletal muscle sarcolemmam enzymes. J Environ Biol 1985; 6: 7–9
Hawkinson JE, Shull CR, Joy RM. Effects of lindane on calcium fluxes in synaptosomes. Neurotoxicology 1989; 10: 29–40
Rivera S, Rosa R, Martinez E, et al. Behavioral and monoaminergic changes after lindane exposure in developing rats. Neurotoxicol Teratol 1998; 29(2): 155–60
Suter R. 3 Month toxicity study in rats with lindane. Part 1 S. 2. Unpublished result of research and consulting company limited. Hingen, 1989. Celemarck Document No. 11AA-433-007/009
Van Velsen FL. Semichronische oral toxiciteitsinderzoek can lindane in the rat [unpublished report]. Bilthoven: Rijks Institute voor Volksezondheit en familienhygiene, 1984 Nov. Rapport Nr. 618209001, zitiert nach UNO 1989
Schnell U. Untersuchungen über die chronische Toxizität von Lindane für Schweine unter besonderer Berücksichtigung der Rückstandsuntersuchung in Fett und Leber [thesis]. Berlin: Humbolt Universität, Zitiert nach UNO 1989
Danapoulos E, Melissinos K, Katsas G. Serious poisoning by hexachlorohexane. Arch Industr Hyg Chicago 1953; 8: 582–7
Hayes WJ. Benzene hexachloride. In: Hayes WJ, editor. Pesticides studies in man. Baltimore (MD): Williams and Wilkins, 1982: 211–28
CIEL (Centre International d’Etudes du Lindane). Lindane-testing for teratogenic effects in mice following oral administration. Darmstadt: E. Merck, 1972. CIEL-Nr. 451-005
Siegmund OH, editor. The Merck veterinary manual. 4th ed. Rahaway (NJ): Merck & Co, 1973
CIEL (Centre International d’Etudes du Lindane). Teratology study in rats lindane (gamma benzene hexachloride USP) — final report. Fallschurch (VA): Hazleton Laboratories America, Inc., 1976. CIEL-Nr. 451-003
CIEL (Centre International d’Etudes du Lindane). Teratology study in rabbits lindane (gamma benzene hexachloride USP) — final report. Fallschurch (VA): Hazleton Laboratories America, Inc., 1976. CIEL-Nr. 451-004
Weisse J, Herbst M. Carcinogenicity study of lindane in the mouse. Toxicology 1977; 7(2): 233–8
Khera KS, Whalen C, Trivett G, et al. Teratogenicity studies on pesticide formulations of dimethoate diuron and lindane in rats. Bull Environ Contain Toxicol 1979; 22: 522–9
Palmer AK, Bottomley AM, Worden AN, et al. Effect of lindane on pregnancy in the rabbit and rat. Toxicology 1978; 9: 239–47
Hassoun EA, Stohs SJ. Comparative teratological studies on TCDD, endrin and lindane in C57BL/6J and DBA/2J mice. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 1996; 113(3): 393–8
Dalsenter PR, Faqi AS, Webb J, et al. Reproductive toxicity and toxicokinetics of lindane in the male offspring of rats exposed during lactation. Hum Exp Toxicol 1997; 16: 146–53
Dalsenter PR, Faqi AS, Chahoud I. Serum testosterone and sexual behavior in rats after prenatal exposure to lindane. Bull Environ Contain Toxicol 1997; 59: 37–45
Dzwonkowska A, Hübner H. Mutagenicity testing of commercial insecticides administered per os. Pol J Occup Med 1989; 2: 286–93
Pool-Zobel BL, Guigas C, Klein R, et al. Assessment of genotoxic effects by lindane. Food Chem Toxic 1993; 31: 271–83
Dich J, Zahm H, Hanberg A, et al. Pesticides and cancer. Cancer Causes Control 1997; 8: 420–43
Fitzhugh OG, Nelson AA, Frawly JP. The chronic toxicities of technical benzene hexachloride and its alpha, beta and gamma isomers. J Pharmacol Exp Ther 1950; 100: 59–66
Gotto M, Hattori M, Mizagawa T. Contributions to ecology II: hepatoma development in mice after administration of HCH isomers in high dosages. Chemosphere 1972; 1: 279–82
Hanada M, Yutani C, Miyajii T. Induction of hepatoma in mice by benzene hexachloride. Gann 1973; 64: 511–3
Thorpe E, Walker A. The toxicity of dieldrin II: comparative long-term oral toxicity studies in mice with dieldrin, DDT, phenobarbitone, beta-BHC, and gamma-BHC. Food Cosmet Toxicol Toxicol 1973; 11: 433–24
National Cancer Institute (NCI). Bioassay of lindane for possible carcinogenicity. Bethesda (MD): NCI, 1977. (Technical Report Series No. 14)
Kashyap SK, Nigam SK, Gupta RC. Carcinogenicity of hexachlorcyclohexane (beta-HCH) in pure inbred Swiss mice. J Environ Sci Health B 1979; 14(3): 305–18
Wolff GL, Morrissey RL. Increased responsiveness of lean pseudoagouti Avy/a female mice to lindane enhancement of lung and liver tumorgenesis [abstract]. Proc Am Assoc Cancer Res 1986; 27: 138
Schröter C, Parzevall W, Schröter W, et al. Dose-response studies on the effect of á-,â-, and ã-hexachlorocyclohexane on putative preneoplastic foci, monooxigenases, and growth in rat liver. Cancer Res 1987; 47: 80–8
Wolff GL, Roberts DW, Morrissey RL, et al. Tumorigenic responses in mice: potentiation by a dominant mutation. Carcinogenesis 1987; 8: 1889–97
Wolff GL. Multiple levels of response in carcinogenicity bioassays: regulational variation among viable yellow (Avy//-)mice. J Exp Animal Sci 1993; 35: 221–31
Pool-Zobel BL, Lotzmann N, Knoll M, et al. Detection of genotoxic effects in human gastric mucosa and nasal mucosa cells isolated from biopsy samples. Environ Mol Mutagen 1994; 24: 23–5
Tiemann U, Schneider F, Tuchscherer A. Effects of organochlorine pesticides on DNA synthesis of cultured oviductal and uterine cells and on estrogen receptor of uterine tissue from heifers. Arch Toxicol 1996; 70(8): 490–6
International Agency for Research Cancer (IARC). Some halogenated hydrocarbons. Lyon: IARC, 1979: 195–239. (IARC monographs on the evaluation on the carcinogenic risk chemicals to humans. Vol. 20)
International Agency for Research Cancer (IARC). Overall evaluation of carcinogenicity: an updating of IARC monographs vol 1 to 42. Lyon: IARC, 1987: 220–2. (IARC monographs on the evaluation on the carcinogenic risk chemicals to humans. Suppl. 7)
International Agency for Research Cancer (IARC). Genetic and related effects: an updating of selected IARC Monographs Vol. 1 to 42. Lyon: IARC, 1987: 333–5. (IARC monographs on the evaluation on the carcinogenic risk chemicals to humans. Suppl. 6)
Tsuda H, Matsumoto K, Ogino H, et al. Demonstration of initiation potential of carcinogens by induction of preneoplastic glutathione S-transferase P-form-positive liver cell foci: possible in vivo assay system for environmental carcinogens. Jpn J Cancer Res 1993; 84: 230–6
Mattioli F, Robbiano L, Adamo D, et al. Genotoxic effects of alpha-hexachlorocyclohexane in primary cultures of rodent and human hepatocytes. Mutagenesis 1996; 11(1): 79–83
Antunes-Madeira MC, Almeida LM, Madeira VMC. Effects of lindane on membrane fluidity: intramolecular excimerization of pyrene derivative and polarization of diphenylhexatriene. Biochem Biophys Acta 1990; 1022: 110–4
Barros SBM, Simizu K, Junqueira VBC. Liver lipid peroxidation-related parameters after short-term administration of hexachlorcyclohexane isomers to rats. Toxicol Lett 1991; 56: 137–44
Bainy ACD, Silva MAS, Kogake M, et al. Influence of lindane and paraquat on oxidative stress-related parameters of erythrocytes in vitro. Human Environ Toxicol 1994; 13: 461–5
Samanta L, Chainy GB. Comparison of hexachlorocyclohexanes-induced stress in the testis of immature and adultrats. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 1997; 118(3): 319–22
Brassow H-L, Baumann K, Lehnert G. Occupational exposure to hexachlorcyclohexane: III. Health conditions of chronically exposed workers. Int Arch Occup Environ Health 1981; 48: 81–7
Nigam SK, Karnik AB, Majumder SK, et al. Serum hexachlorcyclohexane residues in workers engaged at a HCH manufacturing plant. Int Arch Occup Environ Health 1986; 57: 315–20
Czegledi-Janko G, Avar P. Occupational exposure to lindane: clinical laboratory findings. Br J Ind Med 1979; 27: 283–6
Drummond L, Gillanders EM, Wilson HK. Plasma gamma-hexachlorcyclohexane concentrations in forestry workers exposed to lindane. Br J Ind Med 1988; 45: 493–7
Schüttmann W. Chronische Lebererkrankungen nach beruflicher Einwirkung von Dichlordiphenyltrichlorethan und Hexachlorcyclohexan (HCH). Int Arch Gewpath Gewhyg 1968; 24: 193–210
Rauch AE, Kowalsky SF, Lesar TS, et al. Gamma benzene hexachloride (Kwell-) induced aplastic anaemia. Arch Intern Med 1990; 150(11): 2393–5
Parent Massin D, Thouvenot D, Rio B, et al. Lindane haematotoxicity conformed by in vitro tests on human and rat progenitors. Hum Exp Toxicol 1994; 13: 103–6
Shouche S, Rathore HS. Hematological effects of hexachlorcyclohexane (HCH) in mice: results and possibilities. Ind J Med Sci 1998; 18: 120–2
Milby T, Samuels AJ. Human exposure to lindane: comparison of an exposed and an unexposed population. J Occup Med 1971; 13: 256–8
Samuels AJ, Milby T. Human exposure to lindane: clinical hematological and biochemical effects. J Occup Med 1971; 13: 147–51
Blair LS, Campbell WC. Efficacy of ivermectin against Dirofilaria immitis larvae in dogs 31, 60 and 90 days after infection. Am J Vet Res 1980; 41: 2108
Wang HH, Gruffermann S. Aplastic anaemia and occupational pesticide exposure: a case control study. J Occup Med 1981; 23(5): 364–6
Morgan DP, Roberts RJ, Walter AW, et al. Anaemia associated with exposure to lindane. Arch Environ Health 1980; 35(5): 307–10
Löffelmann G. Übergang von chlororganischen Verbindungen von der Mutter auf das Kind in der perinatalen Phase am Patientengut einer Frauenheilkundeklinik. Diplom-Arbeit Biologie, Medizinische Fakultät der Rur-Universität Bochum, 1987
Döllefeld E, Froreich A. Medizinische Laboratoriumsuntersuchungen. Alphabetisches Verzeichnis mit klinischen Indikationen. Gesellschaft für Laboratoriumsdiagnostik mbH & Co KG, 4. Auflage, 1993
Bundesanzeiger. Monographie: Lindan zur topischen Anwendung. Bundesanzeiger 1994; 86: 4854
Rote Liste, 1998. Aulendorf: ECV, Edito Cantor Verlag, 1998
Taplin D, Meinking TL. Scabies, lice, and fungal infections. Prim Care 1989; 16(3): 551–76
Kramer MS, Hutchinson TA, Rudnick SA, et al. Operational criteria for adverse drug reactions in evaluating suspect toxicity of a popular scabicide. Clin Pharmacol Ther 1980; 27: 149–55
Kramer MS. Adverse drug reactions in dermatologic therapy. Int J Dermatol 1981; 20: 438–84
Dick IP, Blain PG, Williams FM. The percutaneous absorption and skin distribution of lindane in man: I. In vivo studies. Hum Exp Toxicol 1997; 16: 645–51
Dick IP, Blain PG, Williams FM. The percutaneous absorption and skin distribution of lindane in man: II. In vitro studies. Hum Exp Toxicol 1997; 16: 652–7
Palier AS. Scabies in infants and small children. Semin Dermatol 1993; 12(1): 3–8
Lisi P, Caraffini S, Assalve D. A test series for pesticide dermatitis. Contact Dermatitis 1986; 15: 266–9
Lisi P, Caraffini S, Assalve D. Irritation and sensitization potential of pesticides. Contact Dermatitis 1986; 17: 212–8
Steigleder GK. Sogenannte postscabiöse Dermatitis [letter]. Hautarzt 1981; 32: 105
Gainsburg CM, Lowry W. Absorption of gamma benzene hexachloride following application of Kwell shampoo. Pediatr Dermatol 1983; 1: 74–6
Gainsburg CM, Lowry W, Reisch JS. Absorption of lindane (gamma benzene hexachloride) in infants and children. J Pediatr 1987; 91: 998–1000
Lange M, Nitzsche K, Zesch A. Percutaneous absorption of lindane in healthy volunteers and scabies patients. Arch Dermatol Res 1981; 271: 387–99
Lee B, Groth P. Transcutaneous poisoning during treatment [letter]. Pediatrics 1977; 59: 643
Pramanik AK, Hansen RC. Transcutaneous gamma benzene hexachloride absorption and toxicity in infants and children. Arch Dermatol 1979; 123: 1056–8
Zesch A, Nitzsche K, Lange M. Demonstration of percutaneous absorption of a lipophilic pesticide and its possible storage in the human body. Arch Dermatol Res 1986; 273: 43–9
Zesch A. Short and long-term risks of topical drugs. Br J Dermatol 1986; 115(S31): 63–70
Zesch A. Externa. Heidelberg: Springer, 1988
Orkin M, Maibach HI. Scabies therapy-1993. Semin Dermatol 1993; 12(1): 22–5
Orkin M, Maibach HI. Scabies treatment: current considerations. Curr Probl Dermatol 1996; 24: 151–6
Hosier J, Tschanz C, Hignite CE, et al. Topical application of lindane cream (Kwell) and antipyrine metabolism. J Invest Dermatol 1979; 74: 51–3
Vohland H, Koransky W. Zu Verhalten und Wirkungen des Hexachlorcyclohexan als Schadstoff in Lebensmitteln: Materialien aus zwei Kolloquien der Senatskomission zur Prüfung von Rückständen in Lebensmitteln am 28729.11 1979 und 6.3.1980. Weinheim: Verlag Chemie, 1983
Friedman SJ. Lindane reaction in nonbullous congenital ichthiosis form of erythroderma. Arch Dermatol 1987; 123(8): 1056–8
Senger E, Menzel I, Holzmann H. Therapiebedingte Lindan-konzentration in der Muttermilch. Dermatosen 1989; 37: 167–70
Burrage RH, Saha JG. Insecticide residues in pheasant after being on wheat seed treated with heptachlor and 14C-lindane. J Econ Entomol 1972; 65(4): 1013–7
Grosser V, Knoll W. Chlorierte Kohlenwasserstoffe im Blut des Menschen unter Bedingungen der Nahrungskarenz. Dtsch Gesundheitsw 1973; 28: 1998–2001
Haustein UF, Hlawa B. Treatment of scabies with permethrin versus lindane and benzyl benzoate. Acta Dermatol Venerol 1989; 69(4): 348–51
Schultz MW, Gomez M, Hansen RC, et al. Comparative study of 5% permethrin cream and 1 % lindane lotion for the treatment of scabies. Arch Dermatol 1990 Jul; 126(7): 966–7
Taplin D. Meinking TL, Chen JA, et al. Permethrin 5% dermal cream: a new treatment for scabies. J Am Acad Dermatol 1986; 15: 990–1001
Taplin D, Meinking TL, Chen JA, et al. Comparison of crotaminon 10% cream (Eurax) and permethrin 5% cream (Elimite) for the treatment of scabies in children. Pediatr Dermatol 1990; 7: 67–73
Amer M, el-Gharib I. Permethrin versus crotaminon and lindane in the treatment of scabies. Int J Dermatol 1992; 31(5): 357–8
Glaziou P, Cartel JL, Alzieu P. Comparison of ivermectin and benzylbenzoate for treatment of scabies. Trop Med Parasitai 1993; 44: 331–2
Alberici F, Pagani L, Ratti G, et al. Ivermectin alone or in combination with benzyl benzoate in the treatment of human immunodeficiency virus-associated scabies. Br J Dermatol 2000; 142(5): 969–72
Tausch I. Crotamiton — eine wirksame und sichere Substanz für die Therapie der Scabies. Ergebnisse einer kontrollierten klinischen Prüfung. Z Hautkr 1999; 3(74): 162–6
Chouela EN, Abeldano AM, Pellerano G, et al. Equivalent therapeutic efficacy and safety of ivermectin and lindane in the treatment of human scabies. Arch Dermatol 1999; 135(6): 651–5
Brandenburg K, Deinard AS, DiNapoli J, et al. 1% permethrin cream rinse vs 1% lindane shampoo in treating pediculosis capitis. Am J Dis Child 1986 Sep; 140(9): 894–6
Bowerman JG, Gomez MP, Austin RD, et al. Comparative study of permethrin 1 % creme rinse and lindane shampoo for the treatment of head lice. Pediatr Infect Dis J 1987 Mar; 6(3): 252–5
Kalter DC, Sperber J, Rosen T, et al. Treatment of pediculosis pubis. Clinical comparison of efficacy and tolerance of 1% lindane shampoo vs 1% permethrin creme rinse. Arch Dermatol 1987 Oct; 123(10): 1315–9
Fusia JF, Marek WJ, Puerini A Jr, et al. Nationwide comparative trial of pyrethrins and lindane for pediculosis in children: experience in northeastern United States. Curr Ther Res Clin Exp 1987; 41: 881–90
Carson DS, Tribble PW, Weart CW. Pyrethrins combined with piperonyl butoxide (RID) vs 1% permethrin (NIX) in the treatment of head lice. Am J Dis Child 1988 Jul; 142(7): 768–9
DiNapoli JB, Austin RD, Englender SJ, et al. Eradication of head lice with a single treatment. Am J Public Health 1988 Aug; 78(8): 978–80
Walker GJA, Johnstone PW. Interventions for treating scabies. Cochrane review [online]. Available from: URL: http://www.update-software.Com/abstra
Meinking TL. Safety of permethrin vs lindane for the treatment of scabies. Arch Dermatol 1996; 132: 959–62 cts/ab000320.htm [Accessed 2000] The Cochrane Library, Issue 2, 2001
Estes SA, Estes J. Therapy of scabies: nursing homes, hospitals and the homeless. Semin Dermatol 1993; 12(1): 26–33
Andrews EB, Joseph MC, Magenheim MJ, et al. Postmarketing surveillance study of pennethrin creme rinse. Am J Public Health 1992; 82: 857–61
Committee on Toxicology, National Research Council. Health effects of permethrin-impregnated army battle-dress uniforms. Washington, DC: National Academy Press, 1994
World Health Organization (WHO). Permethrin. Geneva: WHO, 1991 (Environmental Health Criteria Series No. 94)
American Academy of Pediatrics. Scabies. In: Peter G, editor. Red book: report of the Committee on Infectious Diseases. 23rd ed. Elk Groove Village (IL): American Academy of Pediatrics, 1994: 417–9
Department of Pesticide Regulation, California Environmental Protection Agency. Permethrin (parmone tick repellent): risk characterization document [revised]. Sacramento (CA): California Environmental Protection Agency, 1994
Ishmael J, Litchfield MH. Chronic toxicity and carcinogenic evaluation of permethrin in rats and mice. Fundam Appl Toxicol 1988; 11: 308–22
Miyamoto J. Degradation, metabolism and toxicity of synthetic pyrethroids. Environ Health Perspect 1976; 14: 15–28
Bucks DA, Maibach HI, Guy RH. Mass balance and dose accountability in percutaneous absorption studies: development of a nonocclusive application system. Pharm Res 1988 May; 5(5): 313–5
Elliott M, Farnham AW, Janes NF, et al. A photostable pyrethroid. Nature 1973; 246: 169–70
Elliott M, Janes NF, Pulmon DA, et al. Radiosynthesis and metabolism in rats of 1R isomers of the insecticide permethrin. J Agric Food Chem 1976; 24: 270–6
Gaughan LO, Unal T, Casida JE. Permethrin metabolism in rats. J Agric Food Chem 1977; 25: 9–17
Yacobi A, Baughman RA, Cosulich DB, et al. Method for determination of first-pass metabolism in human skin. J Pharm Sci 1984; 73(10): 1499–500
Sidon EW, Moody RP, Franklin CA. Percutaneous absorption of cis- and trans-permethrin in rhesus monkeys and rats: anatomic sites and interspecies variation. J Toxicol Environ Health 1988; 23: 207–16
Amer M, el Bayoumi M, Rizk MK. Treatment of scabies: preliminary report. Int J Dermatol 1991; 20(4): 289–90
Schultz MW, Gomez M, Hansen RC, et al. Comparative study of 5% permethrin cream and 1% lindane lotion for the treatment of scabies. Arch Dermatol 1990; 126(2): 167–70
Downs AM, Stafford KA, Harvey I, et al. Evidence for double resistance to permethrin and malathion in head lice. Br J Dermatol 1999; 141(3): 508–11
Hemingway J, Miller J, Mumcuoglu KY. Pyrethroid resistance mechanisms in the head louse Pediculus capitis from Israel: implications for control. Med Vet Entomol 1999; 13(1): 89–96
Pollack RJ, Kiszewski A, Armstrong P, et al. Differential permethrin susceptibility of head lice sampled in the United States and Borneo. Arch Pediatr Adolesc Med 1999; 153(9): 969–73
Spach DH, Fritsche TR. Images in clinical medicine: Norwegian scabies in a patient with AIDS. N Engl J Med 1994; 331(12): 777
Spach DH, Fritsche TR. Norwegian scabies in a patient with AIDS [reply]. N Engl J Med 1995; 332: 612
Quarterman MJ, Lesher JL. Neonatal scabies treated with permethrin 5% cream. Pediatr Dermatol 1994; 11: 264–6
Van der Rhee HJ, Farquhar JA, Vormeulen NPE. Efficacy and transdermal absorption of permethrin in scabies patients. Acta Derm Venerol 1989; 69: 170–3
Domejoz R. Über ein neues Antiscabiosum. Schweiz Med Wochenschr 1946; 47: 1210–3
Schuster O, Menke G, Czichowsky H, et al. Pharmacokinetics of crotaminon following topical application to healthy volunteers. J Dermatol Treat 1992; 3: 57–60
Results of unpublished controlled clinical trials. Hamburg: BioSkin Institut für Dermatologische Forschung und Entwicklung GmbH, 1997
Cubela V. Clinical experience with crotaminon cream and lotion in treatment of infants with scabies. Br JClin Pract 1978; 32: 229–31
Ippen H, Uter W. Alte und neue Dermatika: Verwendung von Antimikrobika und Antiparasitika in mitteleuropäischen Kliniken. Dermatosen 1991; 39: 7–11
Konstantinov D, Stanoeva L, Yawalkar SJ. Crotaminon cream and lotion in the treatment of infants and young children with scabies. J Int Med Res 1979; 7: 443–8
Karacic I, Yawalkar SJ. A single application of crotaminon in the treatment of patients with pediculosis capitis. Int J Dermatol 1982; 21: 611–3
Meinking TL, Taplin D. Advances in pediculosis, scabies and other mite infestations. Adv Dermatol 1990; 5: 131–50; discussion 151
Meinking TL, Taplin D, Hermida JL, et al. The treatment of scabies with ivermectin. N Engl J Med 1993; 333: 26–30
Bundesanzeiger. Monographie: Crotaminon. Bundesanzeiger 1993; 132
Farkas J. Irritative contact dermatitis to scabicides as a sort of postscabies dermatitis. Derm Beruf Umwelt 1983; 31(6): 189–90
Lin A, Reamer R, Carter D. Sulfur revisited. J Am Acad Dermatol 1988; 18: 553–8
Maibach H, Surber C, Orkin M. Sulfur revisited [letter]. J Am Acad Dermatol 1990; 23: 154–6
Moller KO. Pharmakologie. B. Basel/Stuttgart: Schwabe & Co Verlag, 1961: 64
Draize JH. Toxicological investigations of compounds proposed for use as insect repellents. J Pharmacol Exp Ther 1948; 93(26): 26–39
Hall RL, Osier BL. Recent progress in the consideration of flavouring ingredients under the food additives amendment III Gras substance FEMA-List. Washington, DC: Federal Emergency Management Agency, 1982
Opdyke DLJ. Monographs on fragrance raw materials. Food Cosmet Toxicol 1973; 11: 1011–181
Jimbo Z. Penetration of fragrance compounds through human epidermis. J Dermatol 1983; 10: 229–39
American Medical Association drug evaluations. Scabicides and pediculides. 5. Auflage, 1990: 1851
Pharmaceutical Codex. 11th ed. Pharmaceutical Press, 1979: 91
Hassan MMA, Mossa JS. Benzylbenzoate. Analytical profiles of drug substances 1981; 10: 55–74
McCaughey H. Poisoning of cats with benzyl benzoate. Aust Vet J 1968; 44(2): 82
Hogan DJ. Benzoyl peroxide. Int J Dermatol 1991; 30(7): 467–70
Lanfranchi C, Bavoux F. Difficulties in the treatment of scabies in infants. Arch Fr Pediatr 1982; 39(19): 845–9
Van der Stichle H. Systematic review of clinical efficacy of topical treatments for head lice. BMJ 1995; 311: 604–8
Pokorny M, Svec J, Hasek J. Use of hexachlorophene in the treatment and prevention of scabies. Czech Dermatol 1972; 47(6): 249–51
Bottoli A. Clinical study of the antiparasital activity of BPH 3004 (Mitigal Spray) in scabies and pubic pediculosis. G Ital Dermatol Venerol 1984; 119(2): I–III
Camassa F, Fania M, Ditano G, et al. Neonatal scabies. Cutis 1995; 56(4): 210–2
Hurwitz S. Insect bites and parasitic infestations. In: Hurwitz S, editor. Clinical paediatric dermatology. Philadelphia (PA): WB Saunders, 1993: 405–31
DeFelice J, Rumsfield J, Beinstein JE. Clinical evaluation of an after-pediculocide nit removal system. Int J Dermatol 1989; 28: 468–70
Campell WC. Ivermectin and abamectin. New York (NY): Springer Verlag, 1989: 149–161, 215–29
Greene BM, Taylor HR, Cupp EW. Comparison of ivermectin and dimethylcarbamazine in the treatment of onchocerciasis. N Engl J Med 1985; 313: 133–8
Greene BM, Brown KR, Taylor HR. Use of ivermectin in humans. In: Campbell WC, editor. Ivermectin and abamectin. New York (NY): Springer Verlag, 1989; 311–23
Encarnacion CF, Giordano MF, Murray HW. Onchocerciasis in New York City: the Moa-Manhattan connection. Arch Int Med 1994; 154: 1749–51
Cartel JL, Ngyen NL, Moulia-Peltat JP, et al. Mass chemoprophylaxis of lymphatic filariasis with a single dose of ivermectin in a Polynesian community with a high Wucheria bancrofti infection rate. Trans R Soc Trop Med Hyg 1992; 86: 537–40
Martin-Prevel Y, Cosnefroy JY, Tshipamba P. Tolerance and efficacy of single high-dose ivermectin for the treatment of loiasis. Am J Trop Med Hyg 1993; 48: 186–92
Kar SK, Mania J, Patnaik S. The use of ivermectin for scabies. Natl Med J India 1994; 7(1): 15–6
Quadripur SA, Schauder S. Orale Therapie einer lindanresistenten Skabies crustosa mit Ivermectin. Z Hautkr 1997; 72: 121–6
Schulz-Key H. Ivermectin. Arzneim Ther 1994; 4: 896–7
Tzenow I, Wjehmeier M, Melnik B. Orale Behandlung der Scabies mit Ivermectin. Hautarzt 1997; 48: 2–4
Merck, Sharp & Dohme International. Mectizan™ (Ivermectin, MSD). International physicians circular. Whitehouse Station (NJ): Merck Co Inc., 1988
Bennet DG. Clinical pharmacology of ivermectin. J Am Vet Med Assoc 1986; 189: 100–4
Edwards G, Dingsdale A, Helsby N, et al. The relative systemic availability of ivermectin after administration as capsule, tablet, and oral solution. Eur J Clin Pharmacol 1988; 35: 1–4
Barkwell R, Shields S. Deaths associated with ivemectin treatment of scabies. Lancet 1997; 349: 1144–5
Diazgranados JA, Costa JL. Deaths after ivermectin treatment [letter]. Lancet 1997; 349: 1698
Commens CA. We can get rid of scabies: new treatment available soon. Med J Aust 1994; 160: 317–8
Marty P, Gari-Toussaint M, Le Fichoux Y. Efficacy of ivermectin in the treatment of an epidemic of sarcoptic scabies. Ann Trop Med Parasitai 1994; 88(4): 453
Aubin F, Humbert P. Ivermectin for crusted (Norwegian) scabies [letter]. N Engl J Med 1995; 332(9): 612
Taplin D, Meinking TL. Treatment of HIV-related scabies with emphasis on the efficacy of ivermectin. Semin Cutan Med Surg 1997; 16(3): 235–40
Lawrence GW, Sheridan JW, Speare R. We can get rid of scabies: new treatment available soon [letter]. Med J Aust 1994; 161: 232
Fontan I, Taieb A, Klenc C. Critical review of scabies treatments [in French]. Ann Dermatol Venerol 1986; 113(6–7): 593–6
Centers for Disease Control (CDC). 1989 Sexually transmitted diseases: treatment guidelines. MMWR Morb Mortal Wkly Rep 1989; 38 Suppl. 8: 1–43
Drugs for sexually transmitted diseases. Med Lett Drugs Ther 1991; 33: 119–24
Dodd CS. Interventions for treating headlice. Cochrane Database Syst Rev 2000; (2): CD001165
Levot G. Resistance and the control of lice on humans and production animals. Int J Parasitai 2000; 30(3): 291–7
Arlian LG, Runyan RA, Vyszensky-Moher DL. Water balance and nutrient procurement of Sarcoptes scabiei var canis (Acari: Sarcoptidae). J Med Entomol 1988; 25: 64–8
Jones KL, Romanelli F. Pharmacist intervention to control lice resistance. J Am Pharm Assoc (Wash) 1999; 39(5): 611
Downs A. Comparing antiscabies treatments [comment; letter]. Arch Dermatol 1996; 133(4): 526
Hogan DJ, Schachner L, Tanglertsampen C. Diagnosis and treatment of childhood scabies and pediculosis. Ped Clin 1991; 38: 941–56
Peterson CM, Eichenfield LF. Scabies. Pediatr Ann 1996; 25(2): 97–100
Paasch U, Haustein UF. Treatment of endemic scabies with allethrin, permethrin and ivermectin. Evaluation of a treatment strategy. Hautarzt 2001 Jan; 52(1): 31–7
Bigby M. A systematic review of the treatment of scabies. Arch Dermatol 2000; 136: 387–9
Burkhart KM, Burkhart CN, Burkhart CG. Comparing topical scabietic treatments will soon become extinct [comment; letter]. Arch Dermatol 1997; 133(10): 1314
Andersen BM, Haugen H, Rasch M, et al. Outbreak of scabies in Norwegian nursing homes and home care patients: control and prevention. J Hosp Infect 2000; 45(2): 160–4
Walton SF, Myerscough MR, Currie BJ. Studies in vitro on the relative efficacy of current acaricides for Sarcoptes scabiei var. hominis. Trans R Soc Trop Med Hyg 2000; 94(1): 92–6
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This work was supported by a grant from the Interdisciplinary Center for Clinical Research (IZKF) of the Medical Faculty of the RWTH Aachen (T.C.R.).
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Roos, T.C., Roos, S., Merk, H.F. et al. Pharmacotherapy of Ectoparasitic Infections. Drugs 61, 1067–1088 (2001). https://doi.org/10.2165/00003495-200161080-00004
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DOI: https://doi.org/10.2165/00003495-200161080-00004