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Chemotherapy For Retinoblastoma

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Abstract

Retinoblastoma is the most common primary intraocular tumour in children, with an incidence of 1 in 15 000 live births. Treatment strategies for retinoblastoma have gradually evolved over the past few decades. There has been a trend way from enucleation (removal of the eye) and external beam radiation therapy toward focal ‘conservative’ treatments. Every effort has been made to save the child’s life with preservation of eye and sight, if possible.

Primary enucleation continues to be the commonly used method of treatment for retinoblastoma. It is employed in situations where eyes contain large tumours, long standing retinal detachments, neovascular glaucoma and suspicion of optic nerve invasion or extrascleral extension. Most of these eyes either have or are expected to have no useful vision. Radiation therapy continues to be an effective treatment option for retinoblastoma. However, external beam radiotherapy has unfortunately been associated with secondary non-ocular cancers in the field of radiation (primarily in children carrying the RB-1 germline mutation). Ophthalmic plaque brachytherapy has a more focal and shielded radiation field, and may carry less risk. Unfortunately, its applicability is limited to small to medium-sized retinoblastomas in accessible locations. Cryotherapy and transpupillary thermotherapy (TTT) have been used to provide control of selected small tumours. TTT is an advanced laser system adapted to the indirect ophthalmoscope which provides flexible nonsurgical treatment for small retinoblastomas.

Recent research in the treatment of retinoblastoma has concentrated on methods of combining chemotherapy with other local treatment modalities (TTT, radiotherapy, cryotherapy). This approach combines the principle of chemotherapeutic debulking in paediatric oncology with conservative focal therapies in ophthalmology. Termed chemoreduction, intravenous or subconjunctival chemotherapy is used to debulk the initial tumour volume and allow for focal treatment with TTT, cryotherapy and plaque radiotherapy. Cyclosporin has been added to the chemotherapy regimen in several centres.

Other clinical settings where chemotherapy is considered are situations where the histopathology suggests a high risk for metastatic disease and where there is extraocular extension. There is no consensus that chemotherapy is needed when choroidal invasion is observed on histopathology. However, in patients where the retinoblastoma is noted beyond the cut end of the optic nerve or if there is disruption of the sciera with microscopic invasion of the orbital tissue, treatment has been helpful. Systemic and intrathecal chemotherapy with local and cranial radiotherapy has improved the survival of these patients. Most recently, the use of new chemotherapy modalities with haematopoietic stem cell rescue or local radiotherapy has increased the survival of patients with distant metastasis. Nevertheless, the prognosis of patients with central nervous system involvement is still poor.

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Authors and Affiliations

  1. Department of Ophthalmology, The New York Eye and Ear Infirmary, New York City, New York, USA

    Paul T. Finger Director, Grazyna Czechonska & Hakan Demirci

  2. Department of Ophthalmology, New York University School of Medicine, New York City, New York, USA

    Paul T. Finger Director & Hakan Demirci

  3. Department of Ophthalmology, General Hospital, Kondratowicza, Warsaw, Poland

    Grazyna Czechonska

  4. Department of Nuclear Medicine, General Hospital, Kondratowicza, Warsaw, Poland

    Grazyna Czechonska

  5. Department of Paediatrics, New York University School of Medicine, New York City, New York, USA

    Aaron Rausen

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Finger, P.T., Czechonska, G., Demirci, H. et al. Chemotherapy For Retinoblastoma. Drugs 58, 983–996 (1999). https://doi.org/10.2165/00003495-199958060-00003

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