Summary
Streptogramin antibiotics represent a unique class of antibacterials in that each member of the class consists of at least 2 structurally unrelated molecules: group A streptogramins (macrolactones) and group B streptogramins (cyclic hexadepsipeptides). Both group A and group B streptogramins inhibit protein synthesis at the ribosomal level, and they act synergistically against many isolates, their combination generating bactericidal activities and reducing the possibility of emergence of resistant strains. The mechanisms of acquired resistance to group B streptogramins are similar to those induced by erythromycin, but group A streptogramins remain unaffected by target modifications and active efflux. The pharmacokinetic parameters of group A and group B streptogramins in blood are quite similar. In addition, both the A and B groups penetrate and accumulate in macrophages and in the bacterial vegetations of experimental endocarditis. There are important structural and biological differences between the streptogramins and the macrolides. The main differentiating features are the rapid antibacterial killing of streptogramins and the rarity of cross-resistance between the 2 groups of antibiotics.
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References
Aumercier M, Le Goffic F. Mechanisms of action of the macrolide and streptogramin antibiotics. In: Bryskier AJ, Butzler JP, Neu HC et al., editors. Macrolides chemistry, pharmacology and clinical use. Paris: Arnette Blackwell, 1993: 115–23.
Cocito C. Antibiotics of the virginiamycin family, inhibitors which contain synergistic components. Microbiol Rev 1979; 43: 145–98.
Paris JM, Barrière JC, Smith C, et al. The chemistry of pristinamycin. In: Recent progress in the chemical synthesis of antibiotics. Berlin: Heidelberg, 1990: 183–248
Barrière JC, Bouanchaud DH, Paris JM, et al. Antimicrobial activity against Staphylococcus aureus of semisynthetic injectable streptogramins: RP 59500 and related compounds. J Antimicrob Chemother 1992; 30 Suppl. A: 1–8.
Di Giambattista M, Chinali G, Cocito C. The molecular basis of the inhibitory activities of type A and type B synergimycins and related antibiotics on ribosomes. J Antimicrob Chemother 1989; 24: 485–507.
Neu HC, Chin NX, Gu JW. The in vitro activity of new streptogramins RP 59500, RP 57669 and RP 54476, alone and in combination. J Antimicrob Chemother 1992; 30 Suppl. A: 83–94.
Bouanchaud DH. In vitro and in vivo synergic activity and fractional inhibitory concentration (FIC) of the components of a semisynthetic streptogramin RP 59500. J Antimicrob Chemother 1992; 30 Suppl. A: 95–100.
Videau D. Etude de l’activité bactéricide de la pristinamycine. Pathol Biol 1982; 30: 529–34.
Pankuch GA, Jacobs MR, Appelbaum PC. Study of comparative antipneumococcal activities of penicillin G, RP 59500, erythromycin, sparfloxacin, ciprofloxacin, and vancomycin by using time-kill methodology. Antimicrob Agents Chemother 1994; 38: 2065–72.
Hoban DJ, Weshnoweski B, Palatnick L, et al. In vitro activity of streptogramin RP 59500 against staphylococci, including bactericidal kinetic studies. J Antimicrob Chemother 1992; 30 Suppl. A: 59–66.
Verbist L, Verhaegen J. Comparative activity of RP 59500. J Antimicrob Chemother 1992; 30 Suppl. A: 39–44.
Pechère J-C. In vitro activity of RP 59500, a semisynthetic streptogramin, against staphylococci and streptococci. J Antimicrob Chemother 1992; 30 Suppl. A: 15–8.
Inoue M, Okamoto R, Okubo T, et al. Comparative in vitro activity of RP 59500 against clinical bacterial isolates. J Antimicrob Chemother 1992; 30 Suppl. A: 45–52.
Goto S, Miyazaki S, Kaneko Y. The in vitro activity of RP 59500 against Gram-positive isolates. J Antimicrob Chemother 1992; 30 Suppl. A: 25–8.
Nougayrede A, Berthaud N, Bouhanchaud DH. Post-antibiotic effects of RP 59500 with Staphylococcus aureus. J Antimicrob Chemother 1992; 30 Suppl. A: 101–6.
Leclercq R, Courvalin P. Mechanisms of resistance to macrolides and functionally related antibiotics. In: Bryskier AJ, Butzler JP, Neu HC et al., editors. Macrolides chemistry, pharmacology and clinical use. Paris: Arnette Blackwell, 1993: 125–42.
Leclercq R, Nantas L, Soussy C, et al. Activity of RP 59500, a new parenteral semisynthetic streptogramin, against staphylococci with various mechanisms of resistance to macrolide-lincosamide-streptogramin antibiotics. J Antimicrob Chemother 1992; 30 Suppl. A: 67–75.
Koechlin C, Kempf JF, Jehl F, et al. Single oral dose pharmacokinetics of the two main components of pristinamycin in humans. J Antimicrob Chemother 1990; 25: 651–6.
Etienne SD, Montay G, Le Riboux A, et al. A phase I, double blind, placebo controlled study of the tolerance and pharmacokinetic behaviour of RP 59500. J Antimicrob Chemother 1992; 30 Suppl. A: 123–31.
Desnottes JF, Diallo N. Cellular uptake and intracellular bactericidal activity of RP 59500 in murine macrophages. J Antimicrob Chemother 1992; 30 Suppl. A: 25–8.
Fantin B, Leclercq R, Ottaviani M, et al. In vitro activities and penetration of the two components of the streptogramin RP 59500 in cardiac vegetation of experimental endocarditis. Antimicrob Agents Chemother 1994; 38: 432–7.
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Pechère, JC. Streptogramins. Drugs 51 (Suppl 1), 13–19 (1996). https://doi.org/10.2165/00003495-199600511-00005
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DOI: https://doi.org/10.2165/00003495-199600511-00005