Summary
The combined oral contraceptive pill is the most popular method of contraception worldwide, with modern low-dose formulations significantly improving tolerability. Breakthrough bleeding is the most significant adverse event associated with the low-dose combined oral contraceptives. Monophasic, biphasic, triphasic and progestogen-only preparations are available, and the choice of formulation should be tailored to best suit the patient. Any areas of uncertainty or concern that the patient has should be addressed, and the patient should be clearly informed of how to use the oral contraceptive effectively, the likely initial adverse effects and what to do if a pill is missed.
Similar content being viewed by others
References
Klitsch M. The new pills: waiting the next generation of oral contraceptives. Fam Plann Perspect 1992; 24 (5): 227–8.
Clinical and Scientific Advisory Committee Interim Guidelines for doctors following the pill scare. Br J Fam Plann 1984; 9: 120–2.
Rosenberg MJ, Long SC. Oral contraceptives and cycle control: the critical review of the literature. Adv Contracept 1992; 8 Suppl. 1: 35–45.
Jones ES, Forrest JD. Contraceptive failure in the United States: revised estimates from the 1982 National Survey of Family Growth. Fam Plann Perspect 1989; 21: 103–9.
The International Working Group on enhancing patient compliance and contraceptive efficacy. A consensus statement enhancing patient compliance and oral contraceptive efficiency. Br J Fam Plann 1983; 18: 126–9.
Belsey EM, Machin D, D’arcangues C. The analysis of vaginal bleeding patterns incidence by fertility regulating methods. Contraception 1986; 34: 253–60.
Shenfield GM. Oral contraceptives: are drug interactions of clinical significance? Drug Saf 1993; 9 (1): 21–37.
Adams Hillard PJ. Oral contraception non-compliance: the extent of the problem. Adv Contracept 1992; Suppl. 1: 13–20.
Davis AJ. The role of hormonal contraception in adolescents. Am J Obs Gynecol 1994; 170: 1581–4.
Perucca E, Hedges A, Makki KA, et al. A comparative study of the enzyme inducing properties of anti convulsant drugs in epileptic patients. Brit J Clin Pharmacol 1984; 18: 401–10.
Orm ML’E, Back DJ. Interactions between oral contraceptive steroids and broad spectrum antibiotics. Clin Exp Dermatol 1986; 11: 327–31.
Croft P, Hannaford PC. Risk factors for acute myocardial infarction in women: evidence from the Royal College of General Practitioners’ oral contraceptive study. BMJ 1989; 298: 165–68.
Gazpart UJ. CLinical relevance of plasma lipid changes during use of new low dose oral contraceptives. Adv Contracept 1991;Suppl. 3: 180–94.
Larsson G, Milson I, Linsted T, et al. The einfluence of a low dose combined oral contraceptive on menstrual blood loss and iron status. Contraception 1992; 46: 327–34.
Fotherby K. The progestogen only contraceptive pill. Br J Fam Plann 1982; 8 (7): 10.
WHO Technical Report Series. Oral contraception and neoplasia. Report of a WHO scientific committee. Geneva: WHO, 1992: 16–21.
Harlap S. Oral contraceptives, breast cancer and age. Adv Contracept 1991; 7 (Suppl. 1): 15–24.
Romieu I, Berlin JA, Coldix G. Oral contraceptive and breast cancer. Cancer 1990; 66: 2253.
The WHO Collaborative Study of Neoplasia and Steroid Contraceptives. Endometrial cancer and combined oral contraceptives. Int J Epidemiol 1988; 17: 263–9.
The WHO Collaborative Study of Neoplasia and Steroid Contraceptives. Epithelial ovarian cancer and combined oral contraceptives. Int J Epidemiol 1989; 18: 538–45.
Thomas DB. Oral contraceptives and cancer risk: comparing results from developing and developed countries. Outlook 1989; December: 2–6.
Guillebaud J. Oral contraception, the combined oral contraceptive. In: Contraception, your questions answered. London: Pitman Publishing Limited, 1985: 128.
Yuzpe AA, Lancee WJ. Ethinyl oestradiol and dl-norgestrel as a postcoital contraceptive. Fertil Steril 1977; 28 (9): 532.
Roland S, Guillebaud J, Bounds W, et al. Side effects of danazol compared with an ethinyl oestradiol/norgestrel combination when used for post coital contraception. Contraception 1983; 27: 29–39.
Rolands S, Kubba AA, Guillebaud J, et al. A possible mechanism of action of danazol and ethinyl oestradiol/norgestrel combination used as post coital contraception, contraceptive agents. Contraception 1986; 33: 539–45.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Weisberg, E. Prescribing Oral Contraceptives. Drugs 49, 224–231 (1995). https://doi.org/10.2165/00003495-199549020-00007
Published:
Issue Date:
DOI: https://doi.org/10.2165/00003495-199549020-00007