Skip to main content
Log in

Clinical Relevance of Reducing Triglycerides

Implications for Ischaemic Heart Disease Treatment

  • Leading Article
  • Published:
Drugs Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Havel RJ, Kane JP. Structure and metabolism of plasma lipoproteins. In: Scriver CR, Beaudet AL, Sly WS, et al., editors. The metabolic basis of inherited disease. New York: McGraw-Hill, 1989: 1129–38

    Google Scholar 

  2. Mann CJ, Yen FT, Grant AM, et al. Mechanism of plasma cholesteryl ester transfer in hypertriglyceridemia. J Clin Invest 1991; 88: 2059–66

    Article  PubMed  CAS  Google Scholar 

  3. Kraemer FB, Chen Y-DI, Lopez RD, et al. Effects of non insulin-dependent diabetes mellitus on the uptake of very low density lipoproteins by thioglycolate-elicited mouse peritoneal macrophages. J Clin Endocrinol Metab 1985; 61: 335–42

    Article  PubMed  CAS  Google Scholar 

  4. Hiramatsu K, Rosen H, Heinecke JW, et al. Superoxide initiates oxidation of low density lipoprotein by human monocytes. Arteriosclerosis 1987; 7: 55–60

    Article  PubMed  CAS  Google Scholar 

  5. de Gruijter M, Hoogerbrugge N, van Rijn MA, et al. Patients with combined hypercholesterolemia-hypertriglyceridemia show an increased monocyte-endothelial cell adhesion in vitro: triglyceride level as a major determinant. Metabolism 1991; 40: 1119–21

    Article  PubMed  Google Scholar 

  6. Hiramatsu K, Arimori S. Increased superoxide production by mononuclear cells of patients with hypertriglyceridemia and diabetes. Diabetes 1988; 37: 832–7

    Article  PubMed  CAS  Google Scholar 

  7. Castelli WP. Epidemiology of triglycerides: A view from Framingham. Am J Cardiol 1992; 70: 3H–9H

    Article  PubMed  CAS  Google Scholar 

  8. Austin MA, Breslow JL, Hennekens CH, et al. Low density lipoprotein subclass patterns and risk of myocardial infarction. JAMA 1988; 260: 1917–21

    Article  PubMed  CAS  Google Scholar 

  9. NIH Consensus Development Panel on Triglyceride, High-Density Lipoprotein, and Coronary Heart Disease. Triglyceride, high-density lipoprotein, and coronary heart disease. JAMA 1993; 269: 505–10

    Article  Google Scholar 

  10. Pathogenesis of alcohol-induced hypertriglyceridemia. Nutrition Reviews 1987; 45: 215–16

  11. Sheu WH-H, Shieh S-M, Fuh MM-T, et al. Insulin resistance, glucose intolerance, and hyperinsulinemia: hypertriglyceridemia versus hypercholesterolemia. Arterioscler Thromb 1993; 13: 367–70

    Article  PubMed  CAS  Google Scholar 

  12. Schiitz E, Schuff-Werner P, Giittner Y, et al. Investigations into the haemorheological significance of postprandial and fasting hypertriglyceridaemia. Eur J Clin Invest 1993; 23: 270–6

    Article  Google Scholar 

  13. de Sousa JC, Bruckert E, Giral P, et al. Coagulation factor VII and plasma triglycerides. Haemostasis 1989; 19: 125–30

    Google Scholar 

  14. Burns P, Hoffman CJ, Katz JP, et al. Vitamin K-dependent clotting factors are elevated in young adults who have close relatives with ischemic heart disease. J Lab Clin Med 1993; 122: 720–7

    PubMed  CAS  Google Scholar 

  15. Ooi TC, Simo IE, Yakichuk JA. Delayed clearance of postprandial chylomicrons and their remnants in the hypoalphalipoproteinemia and mild hypertriglyceridemia syndrome. Arterioscler Thromb 1992; 12: 1184–90

    Article  PubMed  CAS  Google Scholar 

  16. Karpe F, Steiner G, Olivecrona T, et al. Metabolism of triglyceride-rich lipoproteins during alimentary lipemia. J Clin Invest 1993; 91: 748–58

    Article  PubMed  CAS  Google Scholar 

  17. Assman G, Schulte H. The importance of triglycerides: results from the Prospective Cardiovascular Munster (PROCAM) Study. Eur J Epidemiol 1992; 8 (Suppl. 2): 99–103

    Article  Google Scholar 

  18. Assman G, Schulte H. Relation of high-density lipoprotein cholesterol and triglycerides to incidence of atherosclerotic coronary artery disease (the PROCAM experience). Am J Cardiol 1992; 70: 733–7

    Article  Google Scholar 

  19. Carlson LA, Bottiger LE. Risk factors for ischaemic heart disease in men and women. Acta Med Scand 1985; 218: 207–11

    Article  PubMed  CAS  Google Scholar 

  20. Fontbonne A, Eschwege E, Cambien F, et al. Hypertriglyceridaemia as a risk factor of coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes. Diabetologia 1989; 32: 300–4

    Article  PubMed  CAS  Google Scholar 

  21. Criqui MH, Heiss G, Cohn R, et al. Plasma triglyceride level and mortality from coronary heart disease. N Engl J Med 1993; 328: 1220–5

    Article  PubMed  CAS  Google Scholar 

  22. Bass KM, Newschaffer CJ, Klag MJ, et al. Plasma lipoprotein levels as predictors of cardiovascular death in women. Arch Intern Med 1993; 153: 2209–16

    Article  PubMed  CAS  Google Scholar 

  23. Simons LA, Friedlander Y, McCallum J, et al. The Dubbo Study of the health of elderly: correlates of coronary heart disease at study entry. J Am Geriatr Soc 1991; 39: 584–90

    PubMed  CAS  Google Scholar 

  24. Simons LA. Triglyceride levels and the risk of coronary artery disease: a view from Australia. Am J Cardiol 1992; 70: 14H–8H

    Article  PubMed  CAS  Google Scholar 

  25. Welin L, Eriksson H, Larsson B, et al. Triglycerides, a major coronary risk factor in elderly men: a study of men born in 1913. Eur Heart J 1991; 12: 700–4

    PubMed  CAS  Google Scholar 

  26. Campbell AJ, Busby WJ, Robertson MC. Over 80 years and no evidence of coronary heart disease: characteristics of a survivor group. J Am Geriatr Soc 1993; 41: 1333–8

    PubMed  CAS  Google Scholar 

  27. Austin MA. Plasma triglyceride as a risk factor for coronary heart disease. Am J Epidemiol 1989; 129: 249–59

    PubMed  CAS  Google Scholar 

  28. Manninen V, Tenkanen L, Koskinen P, et al. Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Circulation 1992; 85: 37–45

    Article  PubMed  CAS  Google Scholar 

  29. Carlson LA, Rosenhamer G. Reduction of mortality in the Stockholm Ischemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid. Acta Med Scand 1988; 223: 405–18

    Article  PubMed  CAS  Google Scholar 

  30. Frick MH, Elo O, Haapa K, et al. Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. N Engl J Med 1987; 317: 1237–45

    Article  PubMed  CAS  Google Scholar 

  31. Study Group of the European Atherosclerosis Society. The recognition and management of hyperlipidemia in adults: a policy statement of the European Atherosclerosis Society. Eur Heart J 1988; 9: 571–600

    Google Scholar 

  32. NIH Consensus Development Conference Summary. Treatment of hypertriglyceridemia. JAMA 1984; 251: 1196–1200

    Article  Google Scholar 

  33. International Committee for the Evaluation of Hypertriglyceridemia as a Vascular Risk Factor. The hypertriglyceridemias: risk and management. Am J Cardiol 1991; 68: 1A–42A

    Article  Google Scholar 

  34. Carroll M, Sempos C, Briefel R, et al. Serum lipids of adults 20-74 years, United States, 1976-80. National Center for Health Statistics. Vital Health Stat 11(242), 1993. DHHS Publication No. (PHS) 93–1692

  35. Williams RR, Hopkins PN, Hunt SC, et al. Population-based frequency of dyslipidemia syndromes in coronary-prone families in Utah. Arch Intern Med 1990; 150: 582–8

    Article  PubMed  CAS  Google Scholar 

  36. Morrison JA, Namboodiri K, Green P, et al. Familial aggregation of lipids and lipoproteins and early identification of dys-lipoproteinemia. JAMA 1983; 250: 1860–8

    Article  PubMed  CAS  Google Scholar 

  37. Reaven GM. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595–1607

    Article  PubMed  CAS  Google Scholar 

  38. Wood PD, Stefanick ML, Dreon DM, et al. Changes in plasma lipids and lipoproteins in overweight men during weight loss through dieting as compared with exercise. N Engl J Med 1988; 319: 1173–9

    Article  PubMed  CAS  Google Scholar 

  39. Ullmann D, Connor WE, Hatcher LF, et al. Will a high-carbohydrate, low-fat diet lower plasma lipids and lipoproteins without producing hypertriglyceridemia?. Arterioscler Thromb 1991; 11: 1059–67

    Article  PubMed  CAS  Google Scholar 

  40. Lampman RM, Schteingart DE. Effects of exercise training on glucose control, lipid metabolism, and insulin sensitivity in hypertriglyceridemia and non-insulin dependent diabetes mellitus. Med Sci Sports Exerc 1991; 23: 703–12

    PubMed  CAS  Google Scholar 

  41. Todd PA, Ward A. Gemfibrozil: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in dyslipidaemia. Drugs 1988; 36: 314–39

    Article  PubMed  CAS  Google Scholar 

  42. Gotto AM, Pownall HJ. Manual of lipid disorders. Baltimore: Williams & Wilkins, 1992

    Google Scholar 

  43. Simo IE, Yakichuk J, Ooi TC. Effect of gemfibrozil and lovastatin on postprandial lipoprotein clearance in the hypoalphalipoproteinemia and hypertriglyceridemia syndrome. Atherosclerosis 1993; 100: 55–64

    Article  PubMed  CAS  Google Scholar 

  44. Pearson TA, Davidson L, Nafziger AN, et al. Marked reduction of postprandial triglyceride-rich lipoproteins with slow-release gemfibrozil in normotriglyceridemic patients. Circ 1992; 86: 1–144

    Article  Google Scholar 

  45. Vega GL, Grundy SM. Gemfibrozil therapy in primary hypertriglyceridemia associated with coronary heart disease. JAMA 1985; 253: 2398–403

    Article  PubMed  CAS  Google Scholar 

  46. Steiner G. Altering triglyceride concentrations changes insulin-glucose relationships in hypertriglyceridemic patients. Diabetes Care 1991; 14: 1077–81

    Article  PubMed  CAS  Google Scholar 

  47. Steiner G. Hypertriglyceridemia and carbohydrate intolerance: Interrelations and therapeutic implications. Am J Cardiol 1986; 57: 27G–30G

    Article  PubMed  CAS  Google Scholar 

  48. Squires RW, Allison TG, Gau GT, et al. Low-dose, time-release nicotinic acid: effects in selected patients with low concentrations of high density lipoprotein cholesterol. Mayo Clin Proc 1992; 67: 855–60

    Article  PubMed  CAS  Google Scholar 

  49. Tornvall P, Hamsten A, Johansson J, et al. Normalisation of the composition of very low density lipoprotein in hypertriglyceridemia by nicotinic acid. Atherosclerosis 1990; 84: 219–27

    Article  PubMed  CAS  Google Scholar 

  50. Bradford RH, Shear CL, Chremos AN, et al. Expanded clinical evaluation of lovastatin (EXCEL) study results. Arch Intern Med 1991; 151: 43–9

    Article  PubMed  CAS  Google Scholar 

  51. Gianturco SH, Bradley WA, Nozaki S, et al. Effects of lovastatin on the levels, structure, and atherogenicity of VLDL in patients with moderate hypertriglyceridemia. Arterioscler Thromb 1993; 13: 472–81

    Article  PubMed  CAS  Google Scholar 

  52. Connor WE, DeFrancesco CA, Connor SL. N-3 fatty acids from fish oil: effects on plasma lipoproteins and hypertriglyceridemic patients. Ann NY Acad Sci 1993; 683: 16–34

    Article  PubMed  CAS  Google Scholar 

  53. Borkman M, Chisholm DJ, Furler SM, et al. Effects of fish oil supplementation on glucose and lipid metabolism in NIDDM. Diabetes 1989; 38: 1314–19

    Article  PubMed  CAS  Google Scholar 

  54. Schmidt EB, Dyerberg J. Omega-3 fatty acids: current status in cardiovascular medicine. Drugs 1994; 47: 405–24

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nafziger, A.N. Clinical Relevance of Reducing Triglycerides. Drugs 48, 1–8 (1994). https://doi.org/10.2165/00003495-199448010-00001

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00003495-199448010-00001

Navigation