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Drug Therapy of Renovascular Hypertension

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Summary

The renin-angiotensin system is responsible for renovascular hypertension resulting from narrowing of the renal arteries. Inhibitors of angiotensin-converting enzyme (ACE) interrupt the conversion of angiotensin I to angiotensin II, causing a reduction in blood pressure.

Several drugs of this family have been introduced since captopril was launched, including enalapril, lisinopril, ramipril and others. While they are effective antihypertensive agents, they can in some cases lead to deterioration of renal function, especially in patients with bilateral renal artery stenosis or stenosis of a solitary kidney. ACE inhibitors must also be administered with caution to sodium-depleted patients.

Calcium antagonists, presumed to be ideal for the treatment of low renin hypertension, have also proved to be effective in patients with renal artery stenosis, many of whom have severe refractory hypertension. These agents, in common with ACE inhibitors, may be useful for determining the lateralisation index used to establish the kidney responsible for hypertension.

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References

  • al-Qattan KK, Johns EJ. A comparison of the actions of cilazapril in normal, dietary sodium-depleted and two-kidney, one clip Goldblatt hypertensive anesthetised rats. Journal of Hypertension 10: 423–429, 1992

    Article  CAS  PubMed  Google Scholar 

  • Aldigier JC, Plouin PF, Guyene TT, Thibonnier M, Corvol P, et al. Comparison of the hormonal and renal effects of captopril in severe essential and renovascular hypertension. American Journal of Cardiology 49: 1447–1450, 1982

    Article  CAS  PubMed  Google Scholar 

  • Andreucci VE, Conte G, Dai-Canton A, Di-Mino G, Usberti M. The causal role of salt depletion in acute renal failure due to captopril in hypertensive patients with a single functioning kidney and renal artery stenosis. Renal Failure 10: 9–20, 1987

    Article  CAS  PubMed  Google Scholar 

  • Atkinson AB, Brown JJ, Cumming AMM, Fraser R, Lever AF, et al. Captopril in renovascular hypertension long-term use in predicting surgical outcome. British Medical Journal 284: 689–692, 1982

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Azizi M, Houillier P, Chauveau D, Guyenne TT, Plouin PF, et al. Single intravenous nicardipine dose: a new diagnostic test in renovascular hypertension. Abstract. Proceedings of the International Meeting of Hypertension, Madrid, 1992

  • Bell AJ, Lindner A. Effects of verapamil and felodipine on renal function and hemodynamics in the dog. Renal Physiology 7: 329–343,1984

    CAS  PubMed  Google Scholar 

  • Bender W, La France N, Gordon Walker W. Mechanism of deterioration in renal function patients with renovascular hypertension treated with enalapril. Hypertension (Suppl. 1): 193–197, 1984

  • Bengis RG, Coleman TG. Antihypertensive effect of prolonged blockade of angiotensin formation in benign and malignant one and two kidney Goldblatt hypertensive rats. Clinical Science 57: 53–62, 1979

    Article  CAS  PubMed  Google Scholar 

  • Bertel O, Conen D, Radu EW, Lang C, Dubach UC. Nifedipine in hypertensive emergencies. British Medical Journal 283: 19, 1983

    Article  Google Scholar 

  • Blythe WB. Captopril and renal autoregulation. New England Journal of Medicine 308: 390–391, 1983

    Article  CAS  PubMed  Google Scholar 

  • Brittinger WD, Schwarzbeck A, Wittenmeier KW, Twittenhoss WD, Stegaru B, et al. Klinisch-experimentelle Unlersuchungerr über die blutkdruchsekende Wirkung von Verapamil. Deutsche Medizinische Wochenschrift 95: 1871–1877, 1970

    Article  CAS  PubMed  Google Scholar 

  • Brunner HR, Nussberger J, Waeber B. Effects of angiotensin converting enzyme inhibition: a clinical point of view. Journal of Cardiovascular Pharmacology 7 (Suppl. 4): 73–81, 1985

    Article  Google Scholar 

  • Buhler FR, Hulthen L. Calcium blockers: a pathophysiologically based antihypertensive treatment concept for future? European Journal of Clinical Investigations 12: 1–3, 1982

    Article  CAS  Google Scholar 

  • Buhler FR, Laragh JH, Vaughan ED, Brunner HR, Gavras H, et al. The antihypertensive action of propranolol specific antirenin responses in high and normal renin forms of essential renal, renovascular and malignant hypertension. In Laragh (Ed.) Hypertension manual, pp. 873–898, Yorke Medical Books, New York, 1973

    Google Scholar 

  • Burnier M, Waeber B, Nussberger J, Brunner HR. Effect of angiotensin converting-enzyme inhibitor in renovascular hypertension. Journal of Hypertension 7 (Suppl. 7): S27–S31, 1989

    Article  CAS  PubMed  Google Scholar 

  • Bursztyn M, Grossman E, Rosenthal T. Long-acting nifedipine in moderate and severe hypertensive patients with serious concomitant diseases. American Heart Journal 110: 96–101, 1985a

    Article  CAS  PubMed  Google Scholar 

  • Bursztyn M, Grossman E, Rosenthal T. Nifedipine as a substitute for converting enzyme inhibitors in the treatment of renovascular hypertension. Clinical and Experimental Hypertension A7: 1187–1197, 1985b

    Google Scholar 

  • Bussien JP, Schaller MD, Nusberger J, Waeber B, Brunner HR. Acute renal insufficiency after angiotensin converting enzyme inhibition by different agents. Schweizerische Medizinische Wochenschrift 114: 236–239, 1984

    CAS  PubMed  Google Scholar 

  • Camaiti A, Del Rosso A, Federichi G. Insufficienza renale acuta da trathamento con diuretici ed ACE inhibitori in assenza di stenosi delle arterie renali. Minerva Medica 83: 371–375, 1992

    CAS  PubMed  Google Scholar 

  • Canzanello VJ, Madaio MP, Madias NE. Enalapril in the management of hypertension associated with renal artery stenosis. Journal of Clinical Pharmacology 27: 32–40, 1987

    Article  CAS  PubMed  Google Scholar 

  • Case DB, Atlas SA, Sullivan PA, Laragh JH. Acute and chronic treatment of severe and malignant hypertension with the oral angiotensin-converting enzyme inhibitor captopril. Circulation 64: 756–771, 1981

    Article  Google Scholar 

  • Case DB, Atlas SA, Marion RM, Laragh JH: Long-term efficacy of captopril in renovascular and essential hypertension. American Journal of Cardiology 49: 1440–1446, 1982

    Article  CAS  PubMed  Google Scholar 

  • Chrysant SG, Dunn M, Marples D, DeMasters K. Severe reversible azotemia from captopril therapy: report of three cases and review of the literature. Archives of Internal Medicine 143: 437–441,1983

    Article  CAS  PubMed  Google Scholar 

  • Cody RJ, Tarazi RC, Bravo EL, Fouad FM. Haemodynamics of orally-active converting enzyme inhibitor (SQ 14225) in hypertensive patients. Clinical Science and Molecular Medicine 55: 453–459, 1978

    PubMed  Google Scholar 

  • Collste P, Danielsson M, Elmfeldt D, Feleke E, Gelin A, et al. Long term experience with felodipine in combination with B-blockade and diuretics in refractory hypertension. Drugs 29 (Suppl. 2): 124–130, 1985

    Article  PubMed  Google Scholar 

  • Curtis JJ, Lure RG, Whelchel JD, Diethelm AG, Jone P, Dunstan H. Inhibition of angiotensin converting enzyme in renal transplant recipients with hypertension. New England Journal of Medicine 308: 377–381, 1983

    Article  CAS  PubMed  Google Scholar 

  • Davidson RA, Wilcox CS. Newer tests for the diagnosis of renovascular disease. Journal of the American Medical Association 16: 3353–3358, 1992

    Article  Google Scholar 

  • Davis BA, Crook JE, Vestal RE, Oates JA. Prevalence of renovascular hypertension in patients with grade II or IV hypertensive retinopathy. New England Journal of Medicine 301: 1273–1276, 1979

    Article  CAS  PubMed  Google Scholar 

  • Dean RH. Comparison of medical and surgical treatment of renovascular hypertension. Nephron 44 (Suppl. 1): 101–104, 1986

    Article  PubMed  Google Scholar 

  • Dean RH, Kiefer RH, Smith BW, Oates JA, Nadeau GHG, et al. Renovascular hypertension: anatomic and renal functional changes during drug therapy. Archives of Surgery 116: 1408–1415,1981

    Article  CAS  PubMed  Google Scholar 

  • Diamond JR, Cheung JY, Fang JST. Nifedipine-induced renal dysfunction. Alterations in renal hemodynamics. American Journal of Medicine 77: 905–909, 1984

    CAS  PubMed  Google Scholar 

  • Dilmen U, Caglar MK, Senses DA. Nifedipine in hypertensive emergencies in children. American Journal of Diseases of Children 137: 1162–1165, 1983

    CAS  PubMed  Google Scholar 

  • Ding YA, Chang ST, Shieh SM, Huang WC. Antihypertensive and renal effects of cilazapril and their reversal by angiotensin in renovascular hypertensive rats. Clinical Science 74: 365–372, 1988

    Article  CAS  PubMed  Google Scholar 

  • Donker AJM. Nephrotoxicity of angiotensin converting enzyme inhibitors. Kidney International 31 (Suppl. 20): 132–137, 1987

    Google Scholar 

  • Dubovsky EV, Russell CD. Diagnosis of renovascular hypertension after renal transplantation. American Journal of Hypertension 4: 724S–730S, 1991

    Article  CAS  PubMed  Google Scholar 

  • Durand D, Van TT, Adler JL, Suc JM. Renal insufficiency does not necessarily occur following the administration of captopril in single or bilateral renal artery stenosis. Archives des Maladies du Coeur 77: 1272–1277, 1984

    CAS  Google Scholar 

  • Dustan HP, Page IH, Poutasse EF, Wilson L. An evaluation of treatment of hypertension associated with occlusive renal arterial disease. Circulation 27: 1018–1027, 1963

    Article  Google Scholar 

  • Fagard R, Amery A, Lijnen P, Staessen J. First dose effect of the oral angiotensin converting enzyme inhibitor captopril: factors determining adverse hypotension. Archives Internationales de Pharmacodynamie et de Thérapie (Suppl.): 178–187, 1980

  • Farrow PR, Wilkinson R. Reversible renal failure during treatment with captopril. British Medical Journal 1: 1680, 1979

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fiorentini C, Galli C, Tamborini G, Tosi E, Riva S. Hemodynamic and renin responses to nifedipine in renovascular hypertension. American Heart Journal 119: 353–356, 1990

    Article  CAS  PubMed  Google Scholar 

  • Franklin SS, Smith RD. Comparison of effects of enalapril plus hydrochlorothiazide versus standard triple therapy on renal function in renovascular hypertension. American Journal of Medicine 79 (Suppl. 3C): 14–21, 1985

    Article  CAS  PubMed  Google Scholar 

  • Franklin SS, Smith RD. A comparison of enalapril plus hydrochlorothiazide with standard triple therapy in renovascular hypertension. Nephron 44 (Suppl. 1): 73–82, 1986

    Article  PubMed  Google Scholar 

  • Fyhrquist F, Gronhagen-Riska C, Tikkanen I, Junggren IL. Long term monotherapy with linisopril in renovascular hypertension. Journal of Cardiovascular Pharmacology 9 (Suppl. 3): S61–S65, 1987

    Article  PubMed  Google Scholar 

  • Gagnadoux MF, Niaudet P, Bacri JL, Antignac C, Broyer M. Captopril and transplant renal artery stenosis in children. Transplant 17: 187–188, 1985

    Google Scholar 

  • Gavras H, Brunner HR, Thurston H, Laragh JH. Reciprocation of renin dependency in renal hypertension. Science 188: 1316–1317, 1979

    Article  Google Scholar 

  • Given BD, Lee TH, Stone PH, Dzau VJ. Nifedipine in severely hypertensive patients with congestive heart failure and preserved ventricular systolic function. Archives of Internal Medicine 145: 281, 1985

    Article  CAS  PubMed  Google Scholar 

  • Greminger P, Vetter H, Steurer J, Seigenthaler W, Vetter W. Captopril and kidney function in renovascular and essential hypertension. Nephron 44 (Suppl. 1): 91–95, 1986

    Article  PubMed  Google Scholar 

  • Grim EC, Luft FC, Grim CM, Klotman PE, Van Hysse JW, et al. Rapid blood pressure control with minoxidil. Archives of Internal Medicine 139: 529–533, 1979

    Article  CAS  PubMed  Google Scholar 

  • Grossman A, Eckland D, Price P, Edwards CRW. Captopril: reversible renal failure with severe hyperkalemia. Lancet 1: 712–713, 1980

    Article  CAS  PubMed  Google Scholar 

  • Grossman E, Morag B, Nussinovitch N, Boichis H, Knecht A, et al. Clinical use of captopril in Takayasu’s disease. Archives of Internal Medicine 144: 95–96, 1984

    Article  CAS  PubMed  Google Scholar 

  • Grossman E, Rosenthal T. The hypotensive effect of nisoldipine in renovascular hypertensive rats. Journal of Hypertension 4 (Suppl. 5): S141–144, 1986

    CAS  PubMed  Google Scholar 

  • Haegerty AM, Bing FR, Thurston H, Swales JD. Nifedipine substituted for minoxidil in the treatment of refractory hypertension. Journal of Human Hypertension 1: 83–86, 1987

    Google Scholar 

  • Hall JE, Guyton AC, Coleman TG, Lohmeier TI, Tripods NC. Control of glomerular filtration rate by renin angiotensin system. American Journal of Physiology 233: F366–F372, 1977

    CAS  PubMed  Google Scholar 

  • Hall JE, Guyton AC, Smith MJ, Coleman TG. Blood pressure and renal function during changes in sodium intake: role of angiotensin. American Journal of Physiology 239: F271–F280, 1980

    CAS  PubMed  Google Scholar 

  • Halperin AK, Cubeddu LX. The role of calcium channel blockers in the treatment of hypertension. American Heart Journal 111: 363–382, 1986

    Article  CAS  PubMed  Google Scholar 

  • Hannedouche T, Godin M, Fries D, Fillastre JP. Acute renal thrombosis induced by angiotensin-converting enzyme inhibitors in patients with renovascular hypertension. Nephron 57: 230–231, 1991

    Article  CAS  PubMed  Google Scholar 

  • Herlitz H, Aurell M, Bjorck S, Granerus G. Renal effects of felodipine in hypertensive patients with reduced renal function. Drugs 29 (Suppl. 2): 192–197, 1985

    Article  PubMed  Google Scholar 

  • Herlitz H, Bjorck S, Granerus G, Aurell M. Clinical evaluation of felodipine in patients with refractory hypertension. Drugs 34 (Suppl. 3): 151–155, 1987

    Article  PubMed  Google Scholar 

  • Hodsman GP, Brown JJ, Davies DL, Fraser R, Lever AF, et al. Converting enzyme inhibitor enalapril (MK421) in treatment of hypertension with renal artery stenosis. British Medical Journal 285: 1697–1696, 1982

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hodsman GP, Brown JJ, Cumming AMM. Enalapril in the treatment of hypertension with renal artery stenosis. British Medical Journal 287: 1413–1417, 1983a

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hodsman GP, Brown JJ, Cumming AMM, Davies DL, East BW, et al. Enalapril in treatment of hypertension with renal artery stenosis: changes in blood pressure, renin, angiotensin I and II, renal function, and body composition. American Journal of Medicine 77: 52–60, 1984

    Article  CAS  PubMed  Google Scholar 

  • Hodsman GP, Isles CG, Murray GD, Usherwood TP, Webb DJ, et al. Factors related to first dose hypotensive effect of captopril: prediction and treatment. British Medical Journal 286: 832–834, 1983b

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hoefnagels WHL, Thien T. Renal artery occlusion in patients with renovascular hypertension treated with captopril. British Medical Journal 292: 24–25, 1986

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hollenberg NK. Medical therapy of renovascular hypertension: efficacy and safety of captopril in 269 patients. Cardiovascular Reviews and Reports 4: 852–878, 1983

    Google Scholar 

  • Hollenberg NK. Angiotensin-converting enzyme inhibition: renal aspects. Journal of Cardiovascular Pharmacology 7: S40–S44, 1985

    Article  PubMed  Google Scholar 

  • Hollenberg NK. The treatment of renovascular hypertension: surgery, angioplasty and medical therapy with converting-enzyme inhibitors. American Journal of Kidney Disease 10 (Suppl. 1): 52–60, 1987

    Article  CAS  Google Scholar 

  • Hollenberg NK. Medical therapy for renovascular hypertension: a review. American Journal of Hypertension 1: 338S–343S, 1988

    Article  CAS  PubMed  Google Scholar 

  • Hollifield JW, Moore LC, Winn SD, Marshall MA, McCombs C, et al. Angiotensin converting enzyme inhibition in renovascular hypertension. Cardiovascular Reviews and Reports 3: 673–676, 1982

    Google Scholar 

  • Hricik DE, Browning PJ, Kopelman R, Goorno EW, Madias NE, et al. Captopril-induced functional renal insufficiency in patients with bilateral renal artery stenoses or renal artery stenosis in a solitary kidney. New England Journal of Medicine 308: 373–376, 1983

    Article  CAS  PubMed  Google Scholar 

  • Hricik DE. Captopril-induced renal insufficiency and the role of sodium balance. Annals of Internal Medicine 103: 222–223, 1985

    Article  CAS  PubMed  Google Scholar 

  • Huang WC, Ploth DW, Bell PD, Work J, Varar LG. Bilateral renal function responses to converting enzyme inhibitor (SQ20881) in two-kidney one-clip Goldblatt hypertensive rats. Hypertension 3: 285–293, 1981

    Article  CAS  PubMed  Google Scholar 

  • Huddle KR, Doodha MI, Mackenzie M,. Captopril in the treatment of renovascular hypertension secondary to Takayasu’s arteritis: a case report. South African Medical Journal 4: 58–60, 1986

    Google Scholar 

  • Hunt JC, Sheps SG, Harrison EG, Strong CG, Bernatz PE. Renal and renovascular hypertension: a reasoned approach to diagnosis and management. Archives of Internal Medicine 133: 988–999, 1974

    Article  CAS  PubMed  Google Scholar 

  • Ideishi M, Sasaguri M, Ikeda M, Arakaw K. Effects of the angiotensin converting enzyme inhibitor captopril, rentiapril and alcepril in patients with essential and renovascular hypertension. Clinical Therapeutics 11: 441–451, 1989

    CAS  PubMed  Google Scholar 

  • Imanishi M, Kawamura M, Akabane S, Matsushima Y, Kuramochi M, et al. Aspirin lowers blood pressure in patients with renovascular hypertension. Hypertension 14: 461–468, 1989

    Article  CAS  PubMed  Google Scholar 

  • Jackson B, Franze L, Sumithran E, Johnston CI. Pharmacologic nephrectomy with chronic angiotensin converting enzyme inhibitor treatment in renovascular hypertension in the rat. Journal of Laboratory and Clinical Medicine 115: 21–27, 1990

    CAS  PubMed  Google Scholar 

  • Jackson B, Johnston CI. Angiotensin-converting enzyme inhibition in renal disease; contrasting effects on renal function in renal artery stenosis and progressive renal injury. Journal of Human Hypertension 3 (Suppl. 1): 107–115, 1989

    PubMed  Google Scholar 

  • Jackson B, Matthews PG, McGrath BP, Johnston CI. Angiotensin converting enzyme inhibition in renovascular hypertension: frequency of reversible renal failure. Lancet 1: 225–226, 1984

    Article  CAS  PubMed  Google Scholar 

  • Jackson B, McGrath BP, Matthews G, Wong C, Johnston CI. Differential renal function during angiotensin converting enzyme inhibition in renovascular hypertension. Hypertension 8: 650–654, 1986a

    Article  CAS  PubMed  Google Scholar 

  • Jackson B, Murphy BF, Johnston CI, Kincaid-Smith P, Whitworth JA. Renovascular hypertension: treatment with the oral angiotensin-converting enzyme inhibitor enalapril. American Journal of Nephrology 6: 182–186, 1986b

    Article  CAS  PubMed  Google Scholar 

  • Jeunemaitre X, Valenta-de-Almeid L, Sassano P, Farge D, Guyene TT, et al. Acute response to calcium inhibitors in secondary hypertension: does renin play a role? Archives des Maladies du Coeur 81: 141–144, 1988

    Google Scholar 

  • Kalra AP, Mamtora H, Holmes AM, Waldek S. Renovascular disease and renal complications of angiotensin-converting enzyme inhibitor therapy. American Journal of Medicine 77: 1013–1018, 1990

    CAS  Google Scholar 

  • Kamper AL. Irreversible renal failure during treatment with angiotensin I converting enzyme inhibitor in bilateral renal stenosis. Ugeskrift foer Laeger 151: 2984–2985, 1992

    Google Scholar 

  • Karlberg BE, Rosenquist U. Antihypertensive and hormonal effects of lisinopril, a new angiotensin converting enzyme (ACE) inhibitor in patients with renovascular hypertension. Acta Medica Scandinavica 714 (Suppl.): 33–42, 1986

    CAS  PubMed  Google Scholar 

  • Kincaid-Smith P. Comment: role of ACE inhibitors in treatment of hypertension- experience with renovascular hypertension. In Doyle AE & Beam AG (Eds) Hypertension and angiotensin system: therapeutic approaches, pp. 233–240, Raven Press, New York, 1983

    Google Scholar 

  • Kjellbo H, Lund N, Bergentz S-E, Hood B. Renal artery stenosis and hypertension. Scandinavian Journal of Urology and Nephrology 4: 43–47, 1970

    Article  CAS  PubMed  Google Scholar 

  • Knecht E, Grossman E, Rosenthal T. Enalapril in the treatment of renovascular hypertension. Clinical and Experimental Hypertension A7: 1377–1393, 1985

    Google Scholar 

  • Kuwajima I, Ueda K, Kamata C. A study of the effects of nifedipine in hypertensive crisis and severe hypertension. Japanese Heart Journal 19: 455–467, 1987

    Article  Google Scholar 

  • Levenson D, Dzau V. Effects on angiotensin-converting enzyme inhibition on renal hemodynamics in renal artery stenosis. Kidney International 31: SI73–179, 1987

    Google Scholar 

  • Lin H, Young DB. The antihypertensive mechanism of verapamil: alteration of glomerular filtration rate regulation. Hypertension 11: 639–644, 1988

    Article  CAS  PubMed  Google Scholar 

  • Loutzenhiser R, Epstein M. Effects of calcium antagonists on renal hemodynamics. American Journal of Physiology 249: F619–F629, 1985

    CAS  PubMed  Google Scholar 

  • Luna RL, Carrasco RM. Efficacy of verapamil in patients resistant to other antihypertensive therapy. American Journal of Cardiology 57: 64D–68D, 1986

    Article  CAS  PubMed  Google Scholar 

  • Madeddu P, Rubattu S, Spanu MA, Pala FM, Dessi-Fulgheri P, et al. Short term efficacy of nifedipine in essential and renovascular hypertension. American Journal of Nephrology 6 (Suppl. 1): 105–107, 1986

    Article  PubMed  Google Scholar 

  • Mann SJ, Pickering TG. Detection of renovascular hypertension. State of the art: 1992. Annals of Internal Medicine 117: 845–853, 1992

    CAS  PubMed  Google Scholar 

  • Martinez Vea A, Garcia Ruiz C, Carrera M, Oliver JA, Richart C. Effect of captopril in nephrotic-range proteinuria due to renovascular hypertension. Nephron 45: 162–163, 1987

    Article  CAS  PubMed  Google Scholar 

  • Michel JP, Dussaule JC, Choudat L, Auzan C, Nochy D, et al. Effects of antihypertensive treatment in one-clip two-kidney hypertension in rats. Kidney International 29: 1011–1020, 1985

    Article  Google Scholar 

  • Michel JP, Dussaule JC, Choudat L, Nochy D, Corvol P, et al. Renal damage induced in the clipped kidney of one-clip two-kidney hypertensive rats during normalization of blood pressure by converting enzyme enhibition. Kidney International 31: S168–172, 1987

    Google Scholar 

  • Mimran A, Ribstein J, DuCailar G. Converting enzyme inhibitors and renal function in essential and renovascular hypertension. American Journal of Hypertension 4: 75–145, 1991

    Article  Google Scholar 

  • Miyamori I, Yasuhare S, Takeda R, Koshida H, Ikeda M, et al. Effects of converting enzyme inhibition on split renal function in renovascular hypertension. Hypertension 8: 415–421, 1936

    Article  Google Scholar 

  • Miyamori I, Yashuhare S, Matsubara T, Takasaki H, Takeda R. Comparative effects of captopril and nifedipine on split renal function in renovascular hypertension. American Journal of Hypertension 1: 359–363, 1988

    Article  CAS  PubMed  Google Scholar 

  • Murphy BF, Whitworth JA, Kincaid-Smith P. Renal insufficiency with combination of angiotensin converting enzyme enhibitors and diuretics. British Journal of Medicine 288: 844–845, 1984

    Article  CAS  Google Scholar 

  • Novick AC. Atherosclerotic renovascular disease. Journal of Urology 126: 567–572, 1981

    CAS  PubMed  Google Scholar 

  • O’Donnell D. Renal failure due to enalapril and captopril in bilateral renal artery stenosis: greater awareness needed. Medical Journal of Australia 148: 525–527, 1988

    PubMed  Google Scholar 

  • Ogborn MR, Crocker JFS. Captopril and transplant renal artery stenosis. Nephron 48: 333–334, 1988

    Article  CAS  PubMed  Google Scholar 

  • Ogihara T, Kaneko Y, Ikeda M, Yamada K, Omae T, et al. Clinical evaluation of delapril in Japan. Report from Japan Study Group on Delapril. American Journal of Hypertension 4: 42S–45S, 1991

    CAS  Google Scholar 

  • Opie LH, Jennings A. Sublingual captopril versus nifedipine in hypertensive crises. Lancet 2: 555, 1985

    Article  CAS  PubMed  Google Scholar 

  • Pickering TG. Renovascular hypertension medical evaluation and nonsurgical treatment. In Laragh JH & Brenner BM (Eds) Hypertension, pathophysiology, diagnosis and management, pp. 1554–1559, Raven Press, New York, 1990

    Google Scholar 

  • Plouin PF, Darne B, Chatellier G, Pannier I, Battaglia C, et al. Restenosis after a first percutaneous transluminal renal angioplasty. Hypertension 21: 89–96, 1993

    Article  CAS  PubMed  Google Scholar 

  • Pohl MA, Novick AC. Natural history of atherosclerotic and fibrous renal artery disease: clinical implications. American Journal of Kidney Diseases 5 (Suppl.): A120–A130, 1985

    Article  CAS  PubMed  Google Scholar 

  • Postma CT, Hoefnagles WH, Barentsz JO, de Boo T, Thien T. Occlusion of unilateral stenosed renal arteries — relation to medical treatment. Journal of Human Hypertension 3: 185–190, 1989

    CAS  PubMed  Google Scholar 

  • Postma CT, Dennesen PJW, de Boo T, Thien T. First dose hypotension after captopril; can it be predicted? A study of 240 patients. Journal of Human Hypertension 6: 205–209, 1992

    CAS  PubMed  Google Scholar 

  • Raine AE, Ledingham JG. Clinical experience with captopril in the treatment of severe drug resistant hypertension. American Journal of Cardiology 49: 1475–1479, 1982

    Article  CAS  PubMed  Google Scholar 

  • Ram CVS. Southwestern internal medicine conference: current concepts in renovascular hypertension. American Journal of the medical Sciences 304: 53–71, 1992

    Article  CAS  PubMed  Google Scholar 

  • Reams GP, Bauer JH. Enalapril versus triple-drug therapy in the treatment of renovascular hypertension. Drugs 30 (Suppl. 1): 59–69,1985

    Article  PubMed  Google Scholar 

  • Reams GP, Bauer JH, Gaddy P. Use of the converting enzyme inhibitor enalapril in renovascular hypertension: effect on blood pressure, renal function and the fenin angiotentin-aldosterone system. Hypertension 8: 290–297, 1986

    Article  CAS  PubMed  Google Scholar 

  • Ribstein J, Mourad G, Mimran A. Determinant factors in the acute functional deterioration caused by the inhibition of the conversion enzyme in renovascular arterial hypertension. Archives des Maladies du Coeur 80: 866–869, 1987

    CAS  Google Scholar 

  • Ribstein J, Mourad G, Mimran A. Contrasting acute effects of captopril and nifedipine on renal function in renovascular hypertension. American Journal of Hypertension 1: 239–244, 1988

    Article  CAS  PubMed  Google Scholar 

  • Ritter SG, Bentley MD, Fisken-Olsen MJ, Brown ML, Romero JC, et al. Effect of captopril on renal function in hypertensive dogs with unilateral renal artery stenosis studied with radionuclide dynamic scintigraphy. American Journal of Hypertension 3: 591–598, 1990

    Article  CAS  PubMed  Google Scholar 

  • Sakuri T, Kurita T, Nagano S, Sonoda T. Antihypertensive vasodilating and sodium diuretic actions of cis-isomer of benzothazepine derivative (CRD-401). Acta Urological Japanica 18: 695–707, 1972

    Google Scholar 

  • Salahudeen AK, Pingle A. Reversibility of captopril-induced renal insufficiency after prolonged use in an unusual case of renovascular hypertension. Journal of Human Hypetension 2: 57–59, 1988

    CAS  Google Scholar 

  • Scanu P, Hurault-de-Ligny B, Ryckelynck JP. Reversible acute renal insufficiency with combination of enalapril and diuretic in a patient with a single renal artery stenosis. Nephron 45: 321–322, 1987

    Article  CAS  PubMed  Google Scholar 

  • Schneider E, Jennings AA, Opie LH. Captopril, nifedipine and their combination for therapy of hypertensive urgencies. South African Medical Journal 80: 265–270, 1991

    CAS  PubMed  Google Scholar 

  • Schorer K, Alatas H, Bein G. Die Behandlung der renalen Hypertension mit verapamil im Kindesalter. Abstract. Monatsschrift Kinderheilkunde 125: 706–712, 1977

    Google Scholar 

  • Schreiber MJ, Polh MA, Novick AC. The natural history of atherosclerotic and fibrous renal artery disease. Urology Clinics of North America 11: 383–391, 1984

    CAS  Google Scholar 

  • Staessen J, Bulpitt C, Fagard R, Lijren P, Amery A. Long-term converting enzyme inhibition as a guide to surgical curability of hypertension associated with renovascular disease. American Journal of Cardiology 51: 1317–1322, 1983

    Article  CAS  PubMed  Google Scholar 

  • Takeda R, Morimoto S, Uchida K, Kigoshi T, Sumitani T, et al. Effects of captopril on both hypertension and proteinuria. Report of a case of renovascular hypertension associated with nephrotic syndrome. Archives of Internal Medicine 140: 1531–1533, 1980

    CAS  PubMed  Google Scholar 

  • Textor SC. ACE inhibitors in renovascular hypertension. Cardiovascular Drugs and Therapy 4: 229–235, 1990

    Article  CAS  PubMed  Google Scholar 

  • Textor SC, Novick AC, Tarazi RC, Klimas V, Vidt DG, et al. Critical perfusion pressure for renal function in patients with bilateral atherosclerotic renal vascular disease. Annals of Internal Medicine 102: 308–314, 1985

    Article  CAS  PubMed  Google Scholar 

  • Textor SC, Tarazi RC, Novick AC, Bravo E, Fouad FM. Regulation of renal hemodynamics and glomerular filtration in patients with renovascular hypertension during converting enzyme inhibition with captopril. American Journal of Medicine 76: 29–37, 1984

    Article  CAS  PubMed  Google Scholar 

  • Tillman DM, Adams FG, Gillen G, Morton JJ, Robertson GIS. Ramipril for hypertension secondary to renal artery stenosis: changes in blood pressure, the renin-angiotensin system and total and divided renal function. American Journal of Cardiology 59: 133D–142D, 1987

    Article  CAS  PubMed  Google Scholar 

  • Tillman DM, Malatino LS, Cumming AMM, Hodsman GP, Leckie BJ, et al. Enalapril in hypertension with renal artery stenosis: long-term follow-up and effects on renal function. Journal of Hypertension 2 (Suppl. 2): 93–100, 1984

    Google Scholar 

  • Trachtman H, Butt KMH, Gordon D, Tejani A. The use of captopril to control hypertension in post transplant renal artery stenosis. Clinical Nephrology 23: 203–206, 1985

    CAS  PubMed  Google Scholar 

  • Van der Woude FJ, van Son WJ, Tegzess AM, Donker Ab JM, Sloff MJH, et al. Effect of captopril on blood pressure and renal function in patient with transplant renal artery stenosis. Nephron 39: 184–188, 1985

    Article  PubMed  Google Scholar 

  • Vidt DG. Advances in the medical management of renovascular hypertension. Urology Clinics of North America 2: 417–424, 1984

    Google Scholar 

  • Vidt DG. Geriatric hypertension of renovascular origin: diagnosis and management. Geriatrics 42: 59–69, 1987

    CAS  PubMed  Google Scholar 

  • Waeber B, Nussberger J, Brunner HR. Does renin determine the blood pressure response to calcium entry blockers? Hypertension 7: 223–227, 1985

    Article  CAS  PubMed  Google Scholar 

  • Weir MR. The effects of enalapril on blood pressure, renal hemodynamics and renal function. Clinical Therapeutics 11: 685–700, 1989

    CAS  PubMed  Google Scholar 

  • Wenting GJ, Derkx FHM, Tan-Tjiong HL, Van Seyen AJ, Manin’t Veld AJ, Schalekamp MADH. Risks of angiotensin converting enzyme inhibitor in renal artery stenosis. Kidney International 31 (Suppl. 20): 180–183, 1987

    Google Scholar 

  • White WB, Aydelotte ME. Clinical experience with labetalol and enalapril in combination in patients with severe essential and renovascular hypertension. American Journal of the Medical Sciences 296: 187–191, 1988

    Article  CAS  PubMed  Google Scholar 

  • Wiggelinkhuizen J. Reversible renal failure and captopril therapy in renovascular hypertension. South African Medical Journal 71: 332–333, 1987

    CAS  PubMed  Google Scholar 

  • Williams PS, Hendy MS, Ackrill P. Captopril induced acute renal artery thrombosis and persistent anuria in a patient with documented preexisting RAS and renal failure. Postgraduate Medical Journal 60: 561–563, 1984

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Working Group on Renovascular Hypertension. Detection, evaluation and treatment of renovascular hypertension: final report. Archives of Internal Medicine 147: 820–829, 1987

    Article  Google Scholar 

  • Ying Y, Tifft CP, Gavras H, Chobanian AV. Renal revascularization in the azotemic hypertensive patient resistant to therapy. New England Journal of Medicine 311: 1070–1075, 1984

    Article  CAS  PubMed  Google Scholar 

  • Zech P, Finaz de Villaine J, Pozet M, Sassard J, Vincent M, et al. Surgical versus medical treatment in renovascular hypertension. Nephron 44 (Suppl. 1): 105–108, 1986

    Article  PubMed  Google Scholar 

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  1. Chorley Institute of Research, Hypertension Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel

    Talma Rosenthal

  2. Hypertension Unit, Chaim Sheba Medical Center, Tel Aviv University, Sackler School of Medicine,, Tel Hashomer, 52621, Israel

    Talma Rosenthal

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  1. Talma Rosenthal
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Rosenthal, T. Drug Therapy of Renovascular Hypertension. Drugs 45, 895–909 (1993). https://doi.org/10.2165/00003495-199345060-00003

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