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Injectable Contraception with Depot Medroxyprogesterone Acetate

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References

  • Belsey EM. Vaginal bleeding patterns among women using one natural and eight hormonal methods of contraception. Contraception 38: 181–206, 1988

    Article  CAS  PubMed  Google Scholar 

  • Ceulaer K, Gruber C, Hayes R, Serjeant GR. Medroxyprogesterone acetate and homozygous sickle-cell disease. Lancet 2: 229–231, 1982

    Article  PubMed  Google Scholar 

  • Gundy T, Reid OR, Roberts H. Bone density in women receiving depot medroxyprogesterone acetate for contraception. British Medical Journal 303: 13–16, 1991

    Article  Google Scholar 

  • El Etreby MF. Comparative aspects of the influence of contraceptive steroids on tumorigenesis in the reproductive organs of experimental animals and man. In Serio & Martini (Eds) Animal models in human reproduction, pp. 443–453, Raven Press, New York, 1980

    Google Scholar 

  • Fahmy K, Khairy M, Allam G, Gobran F, Alloush M. Effect of depot-medroxyprogesterone acetate on coagulation factors and serum lipids in Egyptian women. Contraception 44: 431–444, 1991

    Article  CAS  PubMed  Google Scholar 

  • Fotherby K, Koetsawang S, Mathrubutham M. Pharmacokinetic study of different doses of Depo Provera. Contraception 22: 527–536, 1980

    Article  CAS  PubMed  Google Scholar 

  • Garza-Flores J, De la Cruz DL, Valles de Bourges V, Sanchez-Nuncio R, Martinez, et al. Long-term effects of depot-medroxyprogesterone acetate on lipoprotein metabolism. Contraception 44: 61–71, 1991

    Article  CAS  PubMed  Google Scholar 

  • Gray RH. Reduced risk of pelvic inflammatory disease with injectable contraceptives. Lancet 1: 1046, 1985

    Article  CAS  PubMed  Google Scholar 

  • Gwinn ML, Lee NC, Rhodes PH, Layde PM, Rubin GL. Pregnancy, breast feeding, and oral contraceptives and the risk of epithelial ovarian cancer. Journal of Clinical Epidemiology 43: 559–568, 1990

    Article  CAS  PubMed  Google Scholar 

  • Heber KR. Medroxyprogesterone acetate as an injectable contraceptive. Australian Family Physician 17: 199–204, 1988

    CAS  PubMed  Google Scholar 

  • Jarman H, Kovacs GT, Westcott M. Depo Provera: a profile of current users. Australian and New Zealand Journal of Obstetrics and Gynaecology 30: 74–76, 1990

    Article  CAS  PubMed  Google Scholar 

  • Jeppson S, Gershagen S, Johansson EDB, Rannevik G. Plasma levels of medroxyprogesterone acetate (MPA), sex-hormone binding globulin, gonadal steroids, gonadotrophins and prolactin in women during long-term use of depo-MPA (Depo-Provera®) as a contraceptive agent. Acta Endocrinologica 99: 339–343, 1982

    Google Scholar 

  • Jones JR, Lonky S. Use of injectable contraceptive immediately post partum. New York State Journal of Medicine 71: 2279–2282, 1971

    CAS  PubMed  Google Scholar 

  • Kamau RK, Maina FW, Kigondu C, Mati JKG. The effect of low-oestrogen combined pill, progestogen-only pill and medroxy-progesterone acetate on oral glucose tolerance test. East African Medical Journal 67: 550–555, 1990

    CAS  PubMed  Google Scholar 

  • Kaunitz AM. Injectable contraception. Clinical Obstetrics and Gynecology 32: 356–368, 1989

    Article  CAS  PubMed  Google Scholar 

  • Kirton KT, Cornette JC. Return of ovulatory cyclicity following an intramuscular injection of medroxyprogesterone acetate (Provera®). Contraception 10: 39, 1974

    Article  CAS  PubMed  Google Scholar 

  • Koetsawang S, Shrimanker K, Fotherby K. Blood levels of medroxyprogesterone acetate after multiple injections of depo-provera or cycloprovera. Contraception 20: 1–4, 1979

    Article  CAS  PubMed  Google Scholar 

  • Koetsawang S. The effects of contraceptive methods on the quality and quantity of breast milk. International Journal of Gynecology and Obstetrics 25 (Suppl.): 115–127, 1987

    Article  PubMed  Google Scholar 

  • Laukaran VH. The effects of contraceptive use on the initiation and duration of lactation. International Journal of Gynecology and Obstetrics 25 (Suppl.): 129–142, 1987

    Article  PubMed  Google Scholar 

  • Liskin L, Blackburn R: Hormonal Contraception: new long-acting methods. Populations Reports. Series K: Injectibles and Implants 15: 57–87, 1987

    Google Scholar 

  • Mark I. Medroxyprogesterone acetate as a contraceptive for female drug addicts. Scandinavian Journal of Social Medicine 11: 75–80, 1983

    CAS  PubMed  Google Scholar 

  • Mattson RH, Cramer JA, Caldwell BV, Siconolfi BC. Treatment of seizures with medroxyprogesterone acetate: preliminary report. Neurology 34: 1255–1258, 1984

    Article  CAS  PubMed  Google Scholar 

  • Mishell DR, El-Habashy MA, Good RG, Moyer DL. Contraception with an injectable progestin: a study of its use in postpartum women. American Journal of Obstetrics and Gynecology 101: 1046–1053, 1968

    Article  PubMed  Google Scholar 

  • Mishell DR, Kletzky OA, Brenner PF, Roy S, Nicoloff J. The effect of contraceptive steroids on hypothalamic-pituitary function. American Journal of Obstetrics and Gynecology 128: 60–74, 1977

    Article  CAS  PubMed  Google Scholar 

  • Ortiz A, Hiroi M, Stanczyk FZ, Goebelsmann U, Mishell DR Jr. Serum medroxyprogesterone acetate (MPA) concentrations and ovarian function following intramuscular injection of Depo-MPA. Journal of Clinical Endocrinology and Metabolism 44: 32–38, 1977

    Article  CAS  PubMed  Google Scholar 

  • Pardthaisong T. Return of fertility after use of the injectable contraceptive Depo-Provera: updated analysis. Journal of Biosocial Science 16: 23–34, 1984

    Article  CAS  PubMed  Google Scholar 

  • Paul C, Skegg DCG, Spears GFS. Contraceptive practice in New Zealand. New Zealand Medical Journal 101: 809–813, 1988

    CAS  PubMed  Google Scholar 

  • Paul C, Skegg DCG, Spears GFS. Depot medroxyprogesterone acetate (Depo-Provera®) and risk of breast cancer. British Medical Journal 299: 759–762, 1989

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Richard BW, Lasagna L. Drug regulation in the United States and the United Kingdom: the Depo-Provera story. Annals of Internal Medicine 106: 886–891, 1987

    Article  CAS  PubMed  Google Scholar 

  • Rosenfield A. Injectable long-acting progestogen contraception: a neglected modality. American Journal of Obstetrics and Gynecology 120: 537–548, 1974

    Article  CAS  PubMed  Google Scholar 

  • Rosenfield A, Maine D, Rochat R, Shelton J, Hatcher RA. The Food and Drug Administration and medroxyprogesterone acetate. What are the issues? Journal of the American Medical Association 249: 2922–2928, 1983

    Article  CAS  PubMed  Google Scholar 

  • Rosenfield, A. Injectable Contraception. In Corson et al. (Eds.) Fertility regulation, 1st ed., pp. 187–195, Little Brown and Co., Boston, 1985

    Google Scholar 

  • Schwallie PC, Assenzo JR. Contraceptive use-efficacy study utilizing Depo-Provera administered as an injection once every six months. Contraception 6: 315–327, 1972

    Article  CAS  PubMed  Google Scholar 

  • Schwallie PC, Assenzo JR. Contraceptive use-efficacy study utilizing medroxyprogesterone acetate administered as an intramuscular injection once every 90 days. Fertility and Sterility 24: 331, 1973

    Article  CAS  PubMed  Google Scholar 

  • Simpson JL. Mutagenicity and teratogenicity of injectable and implantable progestins: probable lack of effect. In Zatuchni et al. (Eds) Long-acting contraceptive delivery systems, pp. 334–361, Harper & Row, Philadelphia, 1984

    Google Scholar 

  • Siriwongse T, Snidvongs W, Tantayaporn P, Leepipatpaiboon S. Effect of depo-medroxyprogesterone acetate on serum progesterone levels when administered on various cycle days. Contraception 26: 487–493, 1982

    Article  CAS  PubMed  Google Scholar 

  • Sotaniemi EA, Hynnynen T, Ahlqvist J, Ahokas JT, Puoskari U, et al. Effects of medroxyprogesterone on the liver function and drug metabolism of patients with primary biliary cirrhosis and chronic active hepatitis. Journal of Medicine 9: 117–128, 1978

    CAS  PubMed  Google Scholar 

  • Speroff L, Glass RH, Kase NG. Dysfunctional uterine bleeding. In Brown (Ed.) Clinical gynecologic endocrinology and infertility, 4th ed, pp. 265–282, Williams & Wilkins, Baltimore, 1989

    Google Scholar 

  • Toppozada M, Onsy FA, Fares E, Amir S, Shaala S. The protective influence of progestogen only contraception against vaginal moniliasis. Contraception 20: 99–103, 1979

    Article  CAS  PubMed  Google Scholar 

  • Trussel J, Kost K. Contraceptive failure in the United States: a critical review of the literature. Studies in Family Planning 18: 237–283, 1987

    Article  Google Scholar 

  • Van Deijk WA, Blijham GH, Mellink WAM, Meulenberg PMM. Influence of aminoglutethimide on plasma levels of medroxyprogesterone acetate: its correlation with serum cortisol. Cancer Treatment Reports 69: 85–90, 1985

    PubMed  Google Scholar 

  • Virutamasen P, Wongsrichanalai C, Tangkeo P, Nitichai Y, Rienprayoon D. Metabolic effects of depot-medroxyprogesterone acetate in long-term users: a cross-sectional study. International Journal of Gynecology and Obstetrics 24: 291–296, 1986

    Article  CAS  PubMed  Google Scholar 

  • WHO Collaborative Study of Neoplasia and Steroid Contraceptives. Breast cancer. Lancet 338: 833–838, 1991a

    Article  Google Scholar 

  • WHO Collaborative Study of Neoplasia and Steroid Contraceptives. Endometrial cancer. International Journal of Cancer 49: 186–190, 1991b

    Article  Google Scholar 

  • WHO Collaborative Study of Neoplasia and Steroid Contraceptives. Epithelial ovarian cancer. International Journal of Cancer 49: 191–195, 1991c

    Google Scholar 

  • WHO Collaborative Study of Neoplasia and Steroid Contraceptives. Squamous cervical cancer. Contraception 45: 299–312, 1992

    Article  Google Scholar 

  • WHO Task Force on Long-Acting Systemic Agents for Fertility Regulation. Special programme of research, development and research training in human reproduction. A multicentered phase III comparative clinical trial of depot medroxyprogesterone acetate given three-monthly at doses of 100mg or 150mg. 1. Contraceptive efficacy and side effects. Contraception 34: 223–235, 1986

    Google Scholar 

  • WHO Task Force on Long-Acting Systemic Agents for Fertility Control. A multicentered phase III comparative study of two hormonal contraceptive preparations given one-a-month by intramuscular injection. I. Contraceptive efficacy and side effects. Contraception 37: 1–20, 1988

    Google Scholar 

  • Wingo PA, Lee NC, Ory HW, Beral V, Peterson HB, et al. Age-specific differences in the relationship between oral contraceptive use and breast cancer. Obstetrics and Gynecology 78: 161–170, 1991

    CAS  PubMed  Google Scholar 

  • Wright CE, Antal EJ, Gillespie WR, Albert KS. Effect of injection volume on the bio-availability of sterile medroxyprogesterone acetate suspension. Clinical Pharmacology 2: 435–438, 1983

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Florida Health Science Center, 653 West 8th Street, Jacksonville, Florida, 32209, USA

    Andrew M. Kaunitz (Associate Professor)

  2. Columbia School of Public Health, and Department of Obstetrics and Gynecology, Columbia Presbyterian Medical Center, New York, New York, USA

    Allan Rosenfield

Authors
  1. Andrew M. Kaunitz
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  2. Allan Rosenfield
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Kaunitz, A.M., Rosenfield, A. Injectable Contraception with Depot Medroxyprogesterone Acetate. Drugs 45, 857–865 (1993). https://doi.org/10.2165/00003495-199345060-00001

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  • DOI: https://doi.org/10.2165/00003495-199345060-00001

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