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Drugs

, Volume 45, Supplement 3, pp 65–72 | Cite as

Fluoroquinolones: Interaction Profile during Enteral Absorption

  • Karl-Matthias Deppermann
  • Hartmut Lode
State-of-The-Art Presentations

Summary

Fluoroquinolones are used worldwide in the treatment of severe infections. These drugs, however, can interact with other agents. This paper is a review of drug interactions with different quinolone derivatives at the absorption phase; the review deals mainly with the prototype quinolones, ciprofloxacin and ofloxacin, and also with some of the newer agents. The concomitant agents considered are food, H2-receptor antagonists, anticholinergic drugs and metallic cationcontaining compounds.

Food (standard breakfast), H2-receptor antagonists and anticholinergic drugs had no major effect on the bioavailability of the quinolones. However, antacids, ferrous sulfate and other metallic cation-containing compounds impaired the bioavailability of the quinolones. This effect is due to chelation between the functional groups of the quinolone molecule and the metallic cations, resulting in insoluble complexes that can not be absorbed. The degree of impairment varied between different quinolone derivatives.

Keywords

Ranitidine Ofloxacin Ferrous Sulfate Sucralfate Enoxacin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© ADIS International Limited 1993

Authors and Affiliations

  • Karl-Matthias Deppermann
    • 1
  • Hartmut Lode
    • 2
  1. 1.Medical Department, Klinikum SteglitzFreie Universität BerlinBerlin 45Germany
  2. 2.Department of Pulmonary and Infectious DiseasesCity Hospital Berlin-ZehlendorfBerlinGermany

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