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Appetite Suppressants

A Review

Drugs volume 43, pages 820–836 (1992)Cite this article

Summary

Centrally acting appetite suppressant drugs used in the treatment of obesity fall into 2 broad pharmacological categories; those which act via brain catecholamine pathways and those which act via serotonin pathways. Of the former group, amphetamine and phenmetrazine are no longer recommended because of their stimulant properties and addictive potential. The remaining drugs in this class include amfepramone (diethylpropion), phentermine, mazindol and phenylpropanolamine. All have been shown to reduce appetite and lower food intake, thereby helping obese patients more easily keep to a low-calorie diet and lose weight. They all have some sympatho-mimetic and stimulant properties. Anorectic drugs which promote serotonin neurotransmission have no such stimulant or sympathomimetic properties. They are fenfluramine, together with its recently introduced dextrorotatory stereoisomer dexfenfluramine, and fluoxetine. They reduce appetite and food intake and are effective in the treatment of obesity.

Anorectic drugs should be reserved for those who are clinically at risk from being overweight, and then only as part of a comprehensive weight-reducing programme including regular dietary counselling. Although current licensing regulations only allow their use over a relatively short period (12 to 16 weeks), clinical trials have shown them to be effective over longer periods, particularly in preventing weight regain. Of the compounds currently indicated for use in obesity, dexfenfluramine appears to have the most suitable pharmacological profile, although it should not be given to patients with a history of depression.

When used appropriately, appetite suppressants can be of real therapeutic benefit, and pose little risk.

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References

  • Allen GS. A double-blind trial of diethylproprion hydrochloride, mazindol and placebo in the treatment of exogenous obesity. Current Therapy Research 22: 678–683, 1977

    Google Scholar 

  • Altschuler S, Conte A, Sebok M, Marlin R, Winick C. Three controlled trials of weight loss with phenylpropanolamine. International Journal of Obesity 6: 549–556, 1982

    PubMed  CAS  Google Scholar 

  • Altschuler S, Frazer DL. Double-blind clinical evaluation of the anorectic activity of phenylpropanolamine hydyrochloride drops and placebo drops in the treatment of exogenous obesity. Current Therapy Research 40: 211–217, 1986

    Google Scholar 

  • American Medical Association. Drugs used in obesity. Drug Evaluations Subscriptions 3(6): 1–616, 1990

    Google Scholar 

  • Angel I. Central receptors and recognition sites mediating the effects of monoamines and anorectic drugs on feeding behaviour. Clinical Neuropharmacology 13: 361–391, 1990

    PubMed  CAS  Google Scholar 

  • Ashwell M. A survey of patients’ views on doctors’ treatment of obesity. Practitioner 211: 653–661, 1973

    PubMed  CAS  Google Scholar 

  • Atkinson RL, Greenway FL, Bray GA, Dahms WT, Molitch ME. Treatment of obesity: comparison of physician and non-physician therapists using placebo and anorectic drugs in a double-blind trial. International Journal of Obesity 1: 113–120, 1977

    PubMed  CAS  Google Scholar 

  • Blackburn G, Morgan J, Lavin P, Noble R, Funder Burk F. Determinants of the pressor effect of phenylpropanolamine in healthy subjects. Journal of the American Medical Association 261: 3267–3272, 1989

    PubMed  CAS  Google Scholar 

  • Blundell JE, Latham EM, McArthur RA. Structural analysis of the actions of amphetamine and fenfluramine on food intake and feeding behaviour in animals and in man. Current Medical Research and Opinion 6 (Suppl. 1): 34–54, 1979

    CAS  Google Scholar 

  • Bolding OT. Diethylproprion hydrochloride: an effective appetite suppressant. Current Therapy Research 16: 40–43, 1974

    CAS  Google Scholar 

  • Bradley MJ, Blum NJ, Scheib RK. Mazindol in obesity with known cardiac disease. Journal of International Medical Research 2: 347–354, 1974

    CAS  Google Scholar 

  • Bradley MH, Raines J. The effects of phenylpropanolamine hydrochloride in overweight patients with controlled stable hypertension. Current Therapy Research 46: 74–84, 1989

    Google Scholar 

  • Breum L, Astrup A, Anderson T, Lammert O, Nielsen E. The effect of long-tern) dexfenfluramine treatment on 24 hour energy expenditure in man, a double-blind placebo controlled study. International Journal of Obesity 13 (Suppl. 1): 150, 1989

    Google Scholar 

  • Breum L, Moller S, Bjerre U, Jacobsen S. Effect of fluoxetine on amino acids and macro-nutrient selection in obese patients. International Journal of Obesity 14 (Suppl. 2): 141, 1990

    Google Scholar 

  • British National Formulary. Appetite suppressants. British Medical Association and the Royal Pharmaceutical Society of Great Britain, 1991

  • Caccia S, Ballabio M, Guiso G, Rocchetti M, Garattini S. Species differences in the kinetics and metabolism of fenfluramine isomers. Archives of International Pharmacology 258: 15–28, 1982

    CAS  Google Scholar 

  • Campbell C, Bhalla IP, Steel JM, Duncan LJP. A controlled trial of phentermine in obese diabetic patients. Practitioner 218: 851–855, 1977

    PubMed  CAS  Google Scholar 

  • Campbell DB. Plasma concentration of fenfluramine and its metabolite, norfenfluramine, following single and repeated oral administration. British Journal of Pharmacology 43: 465–469, 1971

    Google Scholar 

  • Carabillo EA. USA drug abuse warning network. In Garattini S & Samanin S (Eds) Central mechanisms of anorectic drugs, p. 461, Raven Press, New York, 1978

    Google Scholar 

  • Carlsson A. Amphetamine and brain catecholamines. In Costa E & Garattini S (Eds) Amphetamine and related compounds, pp. 289–300, Raven Press, New York, 1970

    Google Scholar 

  • Chait LD, Uhlenhuth EH, Johanson CE. Reinforcing and subjective effects of several anorectics on normal human volunteers. Journal of Pharmacology and Experimental Therapeutics 242: 777–783, 1987

    PubMed  CAS  Google Scholar 

  • Craighead LW, Stunkard A, O’Brien RM. Behaviour therapy and pharmacotherapy for obesity. Archives of General Psychiatry 38: 763–768, 1981

    PubMed  CAS  Google Scholar 

  • Enzi G, Crepaldi G, Inelmen EM, Bruni R, Baggio E. Efficacy and safety of dexfenfluramine in obese patients. Clinical Neuropharmacology 11 (Suppl. 1): 5173–5178, 1988

    Google Scholar 

  • Douglas A, Douglas JG, Robertson CE, Munro JF. Plasma phentermine levels, weight loss and side-effects. International Journal of Obesity 7 (Suppl. 6): 591–595, 1983

    PubMed  CAS  Google Scholar 

  • Ferguson JM, Feighner JP. Fluoxetine induced weight loss in overweight non-depressed subjects. International Journal of Obesity 11 (Suppl. 3): 163–170, 1987

    PubMed  Google Scholar 

  • Finer N, Craddock D, Lavielle R, Keen H. Dextrofenfluramine in the treatment of refractory obesity. Current Therapy Research 38: 847–854, 1985

    Google Scholar 

  • Finer N, Craddock D, Lavielle R, Keen H. Prolonged weight loss with dexfenfluramine treatment in obese patients. Diabetes and Metabolism 13: 598–602, 1987

    CAS  Google Scholar 

  • Finer N, Finer S, Naoumova R. Dexfenfluramine after successful weight reduction on a very low calorie diet (VLCD). International Journal of Obesity 13 (Suppl. 2): 91–93, 1989

    PubMed  Google Scholar 

  • Fink M, Shapiro DM, Itil TM. EEG profiles of fenfluramine, amobarbital and dextroamphetamine in normal volunteers. Psychopharmacologia 22: 369–383, 1971

    PubMed  CAS  Google Scholar 

  • Fuller RW, Wong DT. Fluoxetine and serotoninergic appetite suppressant drugs. Drug Development Research 17: 1–15, 1989

    CAS  Google Scholar 

  • Gagnon M, Bordileau J, Tetrault L. Fenfluramine: study of its central action through its effects on sleep. International Journal of Clinical Pharmacology 1: 74–82, 1969

    Google Scholar 

  • Garattini S, Bizzi A, Caccia S, Mennini T, Samanin R. Progress in assessing the role of serotonin in the control of food intake. Clinical Neuropharmacology 11 (Suppl. 1): 58–532, 1988

    Google Scholar 

  • Garrow JS. Obesity and related diseases, pp. 169–173, Churchill Livingstone, Edinburgh, 1988

    Google Scholar 

  • Giordano G, Marago M, Bompiani G, Descovich GC, Papalia D. Efficacy and treatment of dexfenfluramine in the treatment of simple obesity: multicentre Italian study. Clinical Diabetology 17: 81–89, 1990

    Google Scholar 

  • Goodall E, Corney R, Stanton R, Browne PB. Changes in food preference in premenstrual syndrome. 1st European Congress on Obesity, Stockholm, 1988

  • Goodall E, Feeney S, McGuirk J, Silverstone T. A comparison of the effects of d- and 1-fenfluramine and d-amphetamine on energy and macronutrient intake in human subjects. Psycho-pharmacology 106: 221–227, 1992

    CAS  Google Scholar 

  • Goodall E, Oxtoby C, Richards R, Watkinson G, Brown D, et al. A clinical trial of the efficacy and acceptability of d-fenfluramine in the treatment of neuroleptic-induced obesity. British Journal of Psychiatry 153: 208–213, 1988

    PubMed  CAS  Google Scholar 

  • Goodall E, Silverstone T. Differential effect of d-fenfluramine and metergoline on food intake in human subjects. Appetite 11: 215–228, 1988

    PubMed  CAS  Google Scholar 

  • Goodman R, Wright J, Barlascini C, McKenney J, Lambert C. The effect of phenylpropanolamine on ambulatory blood pressure. Clinical Pharmacology and Therapeutics 40: 144–147, 1986

    PubMed  CAS  Google Scholar 

  • Gotestam KG, Gunne LM. Subjective effects of two anorexigenic agents fenfluramine and AN 448 in amphetamine dependent subjects. British Journal of Addiction 67: 39–44, 1972

    CAS  Google Scholar 

  • Grapin B, Cohen A. Drug therapy in simple obesity: controlled trial of mazindol. Internal Medical Digest 9: 15–21, 1974

    Google Scholar 

  • Greenway F. A double-blind clinical evaluation of the anorectic activity of phenylpropanolamine versus placebo. Clinical Therapeutics 11: 584–589, 1989

    PubMed  CAS  Google Scholar 

  • Guy-Grand B, Apfelbaum M, Crepaldi G, Gries A, Lefebvre P, et al. International trial of long-term dexfenfluramine in obesity. Lancet 2: 1142–1145, 1989

    PubMed  CAS  Google Scholar 

  • Guy-Grand B, Apfelbaum M, Crepaldi G, Gries A, Lefebvre P, et al. Effect of withdrawal of dexfenfluramine on bodyweight and food intake after one year’s administration. International Journal of Obesity 14 (Suppl. 2): 48, 1990

    Google Scholar 

  • Hedges A. AN 448 on critical flicker frequency and heart rate in man. South African Medical Journal 46: 139, 1972

    PubMed  CAS  Google Scholar 

  • Hill AJ, Blundell JE. Food selection, body weight and the premenstrual syndrome (PMS) — effect of d-fenfluramine. Appetite 12: 215, 1989

    Google Scholar 

  • Hill AJ, Blundell JE. Sensitivity of the appetite control system in obese subjects to nutritional and serotoninergic challenges. International Journal of Obesity 14: 219–233, 1990

    PubMed  CAS  Google Scholar 

  • Hoebel BG, Cooper J, Kamin MC, Willard D. Appetite suppression by phenylpropanolamine in humans. Obesity/Bariatric Medicine 4: 192–197, 1975

    Google Scholar 

  • Hoekenga MT, O’Dillon RH, Leyland HM. A comprehensive review of diethylpropion hydrochloride. In Garattini S & Samanin R (Eds) Central mechanisms of anorectic drugs, Raven Press, New York, 1978

    Google Scholar 

  • Holmstrand J, Jonsson J. Subjective effects of two anorexogenic agents — fenfluramine and AN 448 in normal subjects. Postgraduate Medical Journal 57: 183–186, 1975

    Google Scholar 

  • Innes JA, Watson ML, Ford MJ, Munro JF, Stoddart M. Plasma fenfluramine levels, weight loss and side effects. British Medical Journal 2: 1322–1325, 1977

    PubMed  CAS  Google Scholar 

  • Kalb SW. The effect of amphetamine (Benzadrine) sulfate pro-padrine hydrochloride and propadrine hydrochloride in combination with sodium devinai on the appetite of obese patients. Journal of the Medical Society of New Jersey 39: 584–586, 1942

    Google Scholar 

  • Kolanowski J, Younis L, Vanbutsele R, Detry JM. Effects of d-fenfluramine treatment on body weight, blood pressure and adrenergic activity in obese subjects with moderate hypertension. 1st European Congress on Obesity, 288, Stockholm, 1988

  • Kutnowski M, Daubresse J, Friedman H, Kolanowski J, Krzentowski G. Eight weeks fluoxetine therapy in obese patients with impaired glucose tolerance. International Journal of Obesity 14 (Suppl. 2): 48, 1990

    Google Scholar 

  • Kyriakides M, Silverstone T. Comparison of the effects of d-amphetamine and fenfluramine on hunger and food intake in man. Neuropharmacology 18: 1007–1008, 1979

    PubMed  CAS  Google Scholar 

  • Lasagna L. Anorectic activity: phenylpropanolamine — a review, pp. 132–146, Wiley — Interscience, New York, 1988

    Google Scholar 

  • Lawson AAH, Strong JA, Roscoe P, Gibson A. Comparison of fenfluramine and metformin in treatment of obesity. Lancet 1: 437–441, 1970

    Google Scholar 

  • Leibowitz SF. The role of serotonin in eating disorders. Drugs 39 (Suppl. 3): 33–48, 1990

    PubMed  CAS  Google Scholar 

  • Levine L, Enas G, Thompson W, Byyny R, Daver A. Use of fluoxetine, a selective serotonin-uptake inhibitor in the treatment of obesity: a dose-response study (with a commentary by Michael Weintraub). International Journal of Obesity 13: 635–645, 1989

    PubMed  CAS  Google Scholar 

  • Liebson I, Bigelow G, Griffiths R, Funderburk F. Phenylpropanolamine: effects on subjective and cardiovascular variables at recommended over the counter dose levels. Journal of Clinical Pharmacology 27: 685–693, 1987

    PubMed  CAS  Google Scholar 

  • McGuirk J, Silverstone T. The effect of the 5-HT reuptake inhibitor fluoxetine on food intake and body weight in healthy male subjects. International Journal of Obesity 14: 361–372, 1990a

    PubMed  CAS  Google Scholar 

  • McGuirk J, Silverstone T. Effects of fluoxetine on appetite, food intake and body weight in obese subjects. International Journal of Obesity 14 (Suppl. 2): 141, 1990b

    Google Scholar 

  • McKay RHG. Long-term use of diethylpropion in obesity. Current Medical Research 1: 489–493, 1973

    CAS  Google Scholar 

  • McQuarrie HGD. Clinical assessment of the use of an anorectic drug in a total weight reduction programme. Current Therapy Research 17: 437–445, 1975

    CAS  Google Scholar 

  • McTavish D, Heel RC. Dexfenfluramine: a review of its pharmacological properties and therapeutic potential in obesity. Drugs 43: 713–733, 1992

    PubMed  CAS  Google Scholar 

  • Marcus MD, Wing RR, Ewing L, Kern E, McDermott M. A double-blind, placebo controlled trial of fluoxetine plus behaviour modification in the treatment of obese binge-eaters and non-binge eaters. American Journal of Psychiatry 147: 876–881, 1990

    PubMed  CAS  Google Scholar 

  • Miach P, Thomson W, Doyle A, Louis W. Double-blind crossover evaluation of mazindol in the treatment of obese hypertensive patients. Medical Journal of Australia 2: 378, 1976

    PubMed  CAS  Google Scholar 

  • Morgan JP, Funderburg FR, Blackburn GL, Noble R. Subjective profile of phenylpropanolamine: absence of stimulant or euphorigenic effects at recommended dose levels. Journal of Clinical Psychopharmacology 9: 33–38, 1989

    PubMed  CAS  Google Scholar 

  • Munger R, Lamelle R, Arnaud O, Schutz O, Jecquier E. Enhanced diet induced thermogenesis in humans after administration of dexfenfluramine. 1st European Congress on Obesity, Stockholm, 1988

  • Munro JF. The clinical use of anti-obesity agents. In Munro JF (Eds) The treatment of obesity, pp. 85–121, MTP, Lancaster, 1979

    Google Scholar 

  • Munro JF, Ford M. Drug treatment of obesity. In Silverstone T (Eds) Drugs and appetite, pp. 125–157, Academic Press, London, 1982

    Google Scholar 

  • Munro JF, Seaton DA, Duncan LJP. Treatment of refractory obesity with fenfluramine. British Medical Journal 11: 624–625, 1966

    Google Scholar 

  • National Institutes of Health Consensus Development Panel. Health implications of obesity. Annals of Internal Medicine 103: 1073–1077, 1985

    Google Scholar 

  • Noble R. A six-month study of the effects of dexfenfluramine on partially successful dieters. Current Therapy Research 47: 612–619, 1990

    Google Scholar 

  • Onishi T. Clinical evaluation of mazindol, an anorexiant, on obesity. International Journal of Obesity 14 (Suppl. 2): 34, 1990

    Google Scholar 

  • Oswald I, Jones HS, Mannerheim JE. Effects of two slimming drugs on sleep. British Medical Journal 1: 796–799, 1968

    PubMed  CAS  Google Scholar 

  • Pietrusko R, Stunkard A, Brownell K, Campbell DB. Plasma fenfluramine levels, weight loss and side effects: a failure to find a relationship. International Journal of Obesity 6(6): 567–572, 1982

    PubMed  CAS  Google Scholar 

  • Pijl H, Koppeschaar H, Meinders A, Willekens F, Op De Kamp I. Fluoxetine and dietary intake and composition. International Journal of Obesity 13 (Suppl. 1): 131–145, 1989

    Google Scholar 

  • Pinder RM, Brogden RN, Sawyer PR, Speight TM, Avery GS. Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity and diabetes mellitus. Drugs 10: 241–323, 1975

    PubMed  CAS  Google Scholar 

  • Richard BW, Lasagna L. Anorectic drugs: drug policy making at the state level. Journal of Clinical Pharmacology 28: 395–400, 1988

    Google Scholar 

  • Rosenstock J, Cercone S, Koffler M, Ramirez L, Raskin P. The effects of the serotonin reuptake inhibitor fluoxetine on weight loss, glycaemic control and lipid levels in non-insulin dependent diabetes mellitus. Diabetes 36 (Suppl. 1): 66A, 1987

    Google Scholar 

  • Royal College of Physicians. Obesity. Journal of the Royal College of Physicans 17: 3–58, 1983

    Google Scholar 

  • Samanin R, Garattini S. Neuropharmacology of feeding. In Silverstone T (Eds) Drugs and appetite, pp. 23–39, Academic Press, London, 1982

    Google Scholar 

  • Scalfi L, D’Arrigo E, Carandente V, Coztorti A, Contaldo F. The effect of d-fenfluramine on BMR and post prandial thermogenesis in obese subjects. International Journal of Obesity 13 (Suppl. 1): 142, 1989

    Google Scholar 

  • Scheen AJ, Paolisso G, Salvatore T, Lefebvre PJ. Dexfenfluramine reduces insulin resistance independently of weight reduction in obese type 2 (non-insulin-dependent) diabetic patients. Diabetologica 31: 640A 1988

    Google Scholar 

  • Schteingart D. Effectiveness of phenylpropanolamine as an adjunct in the dietary management of obesity. International Journal of Obesity 14 (Suppl. 2): 48, 1990

    Google Scholar 

  • Silverstone T. The anorectic effect of a long-acting preparation of phentermine (Duromine). Psychopharmacoligia 25: 315–320, 1972

    CAS  Google Scholar 

  • Silverstone JT. Intermittent treatment with anorectic drugs. Practitioner 212: 245–252, 1974

    Google Scholar 

  • Silverstone JT, Buckle RM. Obesity in diabetes: some considerations on treatment. American Journal of Clinical Nutrients 19: 158–167, 1966

    CAS  Google Scholar 

  • Silverstone JT, Cooper-RM, Begg RR. A comparative trial of fenfluramine and diethylpropion in obesity. British Journal of Clinical Practitioners 24 (Suppl. 10): 423–425, 1970

    CAS  Google Scholar 

  • Silverstone JT, Fincham J, Campbell DB. The anorectic activity of fenfluramine. Postgraduate Medical Journal 51 (Suppl. 1): 171–174, 1975

    PubMed  Google Scholar 

  • Silverstone T, Kyriakides M. Clinical Pharmacology of appetite. In Silverstone T (Eds) Drugs and appetite, pp. 93–123, Academic Press, London, 1982

    Google Scholar 

  • Silverstone T, Smith G, Richards R. A comparative evaluation of dextrofenfluramine and dl-fenfluramine on hunger, food intake, psychomotor function and side effects in normal human subjects. In Bender A & Brookes L (Eds) Body weight control, pp. 240–246, Churchill Livingstone, Edinburgh, 1987

    Google Scholar 

  • Silverstone JT, Turner P, Humpherson PL. Direct measurement of the anorectic activity of diethylpropion (Tenuate Dospan). Journal of Clinical Pharmacology 8 (Suppl. 3): 172–179, 1968

    CAS  Google Scholar 

  • Striwatanakul K, Yuthavong K, Kominor S. Double-blind study to determine the efficacy and safety of dexfenfluramine in the treatment of obesity. European Journal of Clinical Pharmacology 36 (Suppl): A322, 1989

    Google Scholar 

  • Steel JM, Munro JF, Duncan LJP. A comparative trial of different regimes of fenfluramine and phentermine in obesity. Practitioner 211: 232–236, 1973

    PubMed  CAS  Google Scholar 

  • Stunkard A, Rickeis K, Hesbacher P. Fenfluramine in the treatment of obesity. Lancet 1: 503–505, 1973

    PubMed  CAS  Google Scholar 

  • Sullivan AC, Cornai K. Pharmacological treatment of obesity. International Journal of Obesity 2: 167–189, 1978

    PubMed  CAS  Google Scholar 

  • Tauber-Lassen E, Damsbo P, Enrikson JE, Palmvig B, Beck-Bielsen H. Improvement of glycaemic control and weight loss in type 2 (non-insulin-dependent diabetics) after one year of dexfenfluramine treatment. Diabetologica 33: A230, 1990

    Google Scholar 

  • Truant AP, Olon LP, Cobb S. Phentermine resin as an adjunct in medical weight reduction: a controlled randomised double-blind prospective study. Current Therapy Research 14: 726–738, 1972

    CAS  Google Scholar 

  • Tuominen S, Hietula M, Kuusankoski M. Double-blind trial comparing fenfluramine, phentermine and dietary advice on treatment of obesity. International Journal of Obesity 14 (Suppl. 2): 138, 1990

    Google Scholar 

  • Turner P. Peripheral mechanisms of action of fenfluramine. Current Medical Research and Opinion 6 (Suppl. 1): 101–106, 1979

    CAS  Google Scholar 

  • Turner P. Dexfenfluramine: its place in weight control. Drugs 39 (Suppl. 3): 53–62, 1990

    PubMed  Google Scholar 

  • Van Gaal L, Vansant G, Vandevoorde K, Biasi B, De Leevw I. Long-term evaluation of dex-fenfluramine treatment in obese women. International Journal of Obesity 13 (Suppl. 1): 141, 1989

    Google Scholar 

  • Weintraub M, Ginsberg G, Stein E, Sundaresan P, Schuster B. Phenylpropanolamine OROS (Acutrim) vs placebo in combination with calorie restriction and physician managed behaviour modification. Clinical Pharmacology and Therapeutics 39: 501–509, 1986

    PubMed  CAS  Google Scholar 

  • Weintraub M, Sriwatanakul K, Sundaresan PR, Weis OF, Dorn IM. Extended release fenfluramine: patient acceptance and efficacy of evening dose. Clinical Pharmacology and Therapeutics 33: 621–627, 1983

    PubMed  CAS  Google Scholar 

  • Weintraub M, Taves D, Hasday J, Mushlin A, Lockwood DH. Determinants of response to anorexiants. Clinical Pharmacology and Therapeutics 30: 528–535, 1981

    PubMed  CAS  Google Scholar 

  • Wing RR, Jeffrey RW. Outpatient treatments of obesity: a comparison of methodology and clinical results. International Journal of Obesity 3: 261–279, 1979

    PubMed  CAS  Google Scholar 

  • Wise S. Fluoxetine, efficacy and safety in treatment of obese type 2 (non-insulin-depeendent) diabetes. Diabetologica 32: 557A, 1989

    Google Scholar 

  • Wurtman J, Wurtman R, Reynolds S, Tsay R, Chew B. Fenfluramine suppresses snack intake among carbohydrate cravers but not among non-carbohydrate cravers. International Journal of Eating Disorders 6: 687–699, 1987

    Google Scholar 

  • Zerbe RL. Safety of fluoxetine in the treatment of obesity. International Journal of Obesity 11 (Suppl. 3): 191–199, 1987

    PubMed  Google Scholar 

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    Trevor Silverstone

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Silverstone, T. Appetite Suppressants. Drugs 43, 820–836 (1992). https://doi.org/10.2165/00003495-199243060-00003

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Keywords

  • Obese Patient
  • Fluoxetine
  • Fenfluramine
  • Dexfenfluramine
  • Phentermine