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Patient-Controlled Spinal Opiate Analgesia in Terminal Cancer

Has its Time Really Arrived?

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References

  • Abouleish E, Barmada MA, Nemoto EM, Tung A, Winter P. Acute and chronic effects of intrathecal morphine in monkeys. British Journal of Anaesthesia 53: 10 27–1032, 1981

    Article  Google Scholar 

  • Arner S, Amer B. Differential effects of epidural morphine in the treatment of cancer-related pain. Acta Anaesthesiologica Scandinavica 29: 32–36, 1985

    Article  PubMed  CAS  Google Scholar 

  • Behar M, Magora F, Olshwang D, Davidson JT. Epidural morphine in treatment of pain. Lancet 1: 527–529, 1979

    Article  PubMed  CAS  Google Scholar 

  • Carl O, Crawford ME, Ravlo O, Bach V. Long-term treatment with epidural opiates. Anaesthesia 41: 32–38, 1986

    Article  PubMed  CAS  Google Scholar 

  • Chrubasik J. Low-dose epidural morphine by infusion pump. Lancet 1: 738–739, 1984

    Article  PubMed  CAS  Google Scholar 

  • Chrubasik J, Meynadier J, Blond S, Scherpereel P, Ackerman E, et al. Somatostatin, a potent analgesic. Lancet 2: 1208–1209, 1984

    Article  PubMed  CAS  Google Scholar 

  • Chrubasik J. Spinal infusion of opiates and somatostatin, Hygiene Plan Publisher, Oberursel, 1985

  • Chrubasik J, Volk B, Wetterauer U, Trötschler H. Externe Opiat-Dosiergeräte bei unerträglichen Krebsschmerzen. Zeitschrift für Allgemeine Medizine 61: 17–21, 1985a

    Google Scholar 

  • Chrubasik J, Weigel K, Friedrich G. Ergänzende Information zur Anwendung extern tragbarer Dosiergeräte in der Behandlung unerträglicher Krebsschmerzen. Anaesthesist 34: 39–40, 1985b

    Google Scholar 

  • Chrubasik J, Falke KF, Zindler M, Volk B, Vitrac P, et al. Is calcitonin an analgesic agent? Pain 27: 273–276, 1986

    Article  PubMed  CAS  Google Scholar 

  • Chrubasik J, Magora F. Antinociceptive opioid activity ratio. Anesthesiology 72 (Suppl.): 1097, 1990

    Article  PubMed  CAS  Google Scholar 

  • Coombs DW. Continuous intraspinal morphine analgesia for relief of cancer pain, Shea Bros. Inc., Cambridge MA, 1985

  • Coombs DW, Saunders RL, Lachance D, Savage S, Ragnarsson TS, et al. Intrathecal morphine tolerance: use of intrathecal clonidine, DADLE, and intraventricular morphine. Anesthesiology 62: 358–363, 1985

    Article  PubMed  CAS  Google Scholar 

  • Crawford ME, Andersen HB, Augustenborg G, Bay J, Beck O, et al. Pain treatment on outpatient basis utilizing extradural opiates: a Danish multicentre study comprising 105 patients. Pain 16: 41–47, 1983

    Article  PubMed  CAS  Google Scholar 

  • Erdine S, Aldemir T. Long-term results of peridural morphine in 225 patients. Pain 45: 155–159, 1991

    Article  PubMed  CAS  Google Scholar 

  • Gustafsson LL, Wiesenfeld-Hallin Z. Spinal opioid analgesia: a critical update. Drugs 35: 597–603, 1988

    Article  PubMed  CAS  Google Scholar 

  • Hegelund K, Nielsen FM. Pain treatment on long-term basis with extradural opiates. Acta Anaesthesiologica Scandinavica 27 (Suppl. 78): 69, 1983

    Google Scholar 

  • Hernandez JLR, Padron FR, VeraReyes JA de. Administration intratecallumbar de morfina en al tratamiento del dolor del cancer avanzado. Revista Espanola Anestesiologica y Reanimacion 33: 253–256, 1986

    Google Scholar 

  • Jacobson L, Chabal C, Brody MC, Ward RJ. Intrathecal methadone 5mg and morphine 0.5mg for postoperative analgesia: a comparison of the efficacy, duration and side-effects. Anesthesia and Analgesia 68 (Suppl.): 132, 1989a

    Google Scholar 

  • Jacobson L, Chabal C, Brody MC, Ward RJ, Ireton RC. Intrathecal methadone and morphine for postoperative analgesia: a comparison of the efficacy, duration, and side-effects. Anesthesiology 70: 742–746, 1989b

    Article  PubMed  CAS  Google Scholar 

  • Jansen EC. Morphine pumps in the epidural treatment of pain. Acta Anaesthesiologica Scandinavica 26 (Suppl.): 68, 1983

    Google Scholar 

  • Krames ES, Gershow J, Glassberg A, Kenefick T, Lyons A, et al. Continuous infusion of spinally administered narcotics for the relief of pain due to malignant disorders. Cancer 56: 696–702, 1985

    Article  PubMed  CAS  Google Scholar 

  • Motsch J, Bleser W, Ismaily AJ, Distler L. Kontinuierliche intrathekale Opiattherapie mit tragbaren Medikamentenpumpen bei Karzinomschermerzen. Anaesthesie Intensivtherapie Not-fallmedizim 23; 271–275, 1988

    Article  CAS  Google Scholar 

  • Müller H, Aigner K, Worm I, Lobisch M, Bränler A, Hempelmann G. Langzeiterfahrungen mit der kontinuierlichen periduralen Opiatanalgesie mittels implantierter Pumpe. Anaesthesist 33: 433–439, 1984

    PubMed  Google Scholar 

  • Penn RD, Paice JA. chronic intrathecal morphine for intractable pain. Journal of Neurosurgery 67: 182–186, 1987

    Article  PubMed  CAS  Google Scholar 

  • Penn RD, Paice JA, Gottschalk W, Ivankovich AD. Cancer pain relief using chronic morphine infusion. Journal of Neurosurgery 61: 302–306, 1984

    Article  PubMed  CAS  Google Scholar 

  • Penn RD, Paice JA, Kroin JS. Intrathecal octreotide for cancer pain. Lancet 1: 738, 1990

    Article  Google Scholar 

  • Pert CB, Snyder SH. Opiate receptor: demonstration in nervous tissue. Science 179: 1011–1014, 1973

    Article  PubMed  CAS  Google Scholar 

  • Plummer JL, Cherry DA, Cousins MJ, Gourlay GK, Onley MM, et al. Long term spinal administration of morphine in cancer and non-cancer pain: a retrospective study. Pain 44: 215–220, 1991

    Article  PubMed  CAS  Google Scholar 

  • Porter J, Jick H. Addiction rare in patients treated with narcotics. New England Journal of Medicine 74: 123, 1980

    Google Scholar 

  • Shetter AG, Hadley MN, Wilkinson E. Administration of intraspinal morphine sulfate for the treatment of intractable cancer pain. Neurosurgery 18: 740–747, 1986

    Article  PubMed  CAS  Google Scholar 

  • Sjöberg M, Appelgren L, Einarsson S, Hultman E, Linder LE, et al. Long-term intrathecal morphine and bupivacaine in ‘refractory’ cancer pain. I. Results from the first series of 52 patients. Acta Anaesthesiologica Scandinavica 35: 30–43, 1991

    Article  PubMed  Google Scholar 

  • Tryba M, Zenz M, Strumpf M. Long-term epidural catheters in terminally ill patients — a prospective study of complications in 129 patients. Anesthesiology 73 (Suppl.): 784, 1990

    Google Scholar 

  • Verdenne JB, Esteve M, Guillaume A. Injection de morphine intrathecale dans le traitment ambulatoire dela douleur neo-plastique. Journal de Chirurgie (Paris) 123: 330–332, 1986

    Google Scholar 

  • Wang JK. Intrathecal morphine for intractable pain secondary to cancer of pelvic organs. Pain 21: 99–102, 1985

    Article  PubMed  CAS  Google Scholar 

  • Waldman SD, Feldstein GS, Allen ML, Turnage G. Selection of patients for implantable intraspinal narcotic delivery systems. Anesthesia and Analgesia 65: 883–885, 1986

    Article  PubMed  CAS  Google Scholar 

  • Wang JK, Nauss LA, Thomas JE. Pain relief by intrathecally applied morphine in man. Anesthesiology 50: 149–151, 1979

    Article  PubMed  CAS  Google Scholar 

  • Wells CJ, Lipton S, Lahuerta J. Respiratory despression after percutaneous cervical anterolateral cordotomy in patients on slow-release oral morphine. Lancet 1: 739, 1984

    Article  PubMed  CAS  Google Scholar 

  • Yaksh TL, Onofrio BM. Retrospective consideration of the doses of morphine given intrathecally by chronic infusion in 163 patients by 10 physicians. Pain 31: 211–223, 1987

    Article  PubMed  CAS  Google Scholar 

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Chrubasik, J., Chrubasik, S. & Martin, E. Patient-Controlled Spinal Opiate Analgesia in Terminal Cancer. Drugs 43, 799–804 (1992). https://doi.org/10.2165/00003495-199243060-00001

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