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Current Concepts in the Treatment of Immune Thrombocytopenia

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Summary

Platelet destruction by antibodies is a common cause, of thrombocytopenia. In this review, various treatments for immune thrombocytopenia are discussed, with emphasis on corticosteroids, splenectomy, danazol, high-dose immunoglobulin G, anti-Rhesus globulin, colchicine and cytotoxic, immuftosuppressive agents such as cyclophosphamide and azathioprine. An approach to the treatment of adult idiopathic thrombocytopenic purpura (ITP) is reviewed in detail and the treatments for several other immune thrombocytopenic disorders are summarised.

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Authors and Affiliations

  1. Department of Pathology, McMaster University Medical Centre, Hamilton, Ontario, Canada

    Theodore E. Warkentin & John G. Kelton

  2. McMaster University Medical Centre, Room 2N34, P.O. Box 2000, Station A, Hamilton, Ontario, L8N 3Z5, Canada

    Theodore E. Warkentin & John G. Kelton

  3. Canadian Red Cross Blood Transfusion Service, Hamilton Centre, Hamilton, Ontario, Canada

    Theodore E. Warkentin & John G. Kelton

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  1. Theodore E. Warkentin
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Warkentin, T.E., Kelton, J.G. Current Concepts in the Treatment of Immune Thrombocytopenia. Drugs 40, 531–542 (1990). https://doi.org/10.2165/00003495-199040040-00004

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