Skip to main content
SpringerLink
Log in

Is There a Rational Basis for the Different Spectra of Adverse Effects of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)?

  • Section 2: Symposium on NSAIDs
  • Published:
Drugs Aims and scope Submit manuscript

Summary

NSAIDs, particularly those related to aspirin, are all known to cause adverse effects, notably in the gastrointestinal tract, blood, liver and kidney, in addition to allergic and pseudo-allergic reactions. In the past decade, there have been many attempts to elucidate the cause(s) of these adverse effects so that new NSAIDs which are widely devoid of them can be developed. As a result, a number of concepts have been formulated which may well have considerable influence upon the future development of NSAIDs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Baer PG. Renal physiology. In Curtis-Prior PB (Ed.) Prostaglandins: biology and chemistry of prostaglandins and related eicosanoids, pp. 269–282, Churchill Livingstone, Edinburgh, 1988

    Google Scholar 

  • Bowen BK, Krause WJ, Ivey KJ. Effect of sodium bicarbonate on aspirin-induced damage and potential difference changes in human gastric musosa. British Medical Journal 2: 1052–1055, 1977

    Article  PubMed  CAS  Google Scholar 

  • Brune K, Aehringhaus U, Peskar BA. Pharmacological control of leukotriene and prostaglandin production from mouse peritoneal macrophages. Agents and Actions 14: 729–734, 1984

    Article  PubMed  CAS  Google Scholar 

  • Brune K, Dietzel K, Nürnberg B, Schneider TTh. Recent insight into the mechanism of gastrointestinal tract ulceration. Scandinavian Journal of Rheumatism (Suppl. 65): 135-140, 1987

  • Brune K, Lanz R. Pharmacokinetics of non-steroidal anti-inflammatory drugs. In Bonta IL et al (Eds) Handbook of inflammation: the pharmacology of inflammation, p. 413, Elsevier Science Publishers, 1985

  • Brune K, Schweitzer A, Eckert H. Parietal cells of the stomach trap salicylates during absorption. Biochemical Pharmacology 26: 1735–1740, 1977

    Article  PubMed  CAS  Google Scholar 

  • Chen CE, Seckman M, Rack F. A comparative endoscopic evaluation of the damaging effects of non-steroidal anti-inflammatory agents on the gastric and duodenal mucosa. American Journal of Gastroenterology 75: 17–21, 1981

    PubMed  Google Scholar 

  • CSM Update: non-steroidal anti-inflammatory drugs and serious gastro-intestinal adverse reactions — 1 and 2. British Medical Journal 292: 1190-1191, 1986

    Google Scholar 

  • Deby C. Metabolism of polyunsaturated fatty acids, precursors of eicosanoids. In Curtis-Prior PB (Ed.) Prostaglandins: biology and chemistry of prostaglandins and related eicosanoids, pp. 11–36, Churchill Livingstone, Edinburgh, 1985

    Google Scholar 

  • Del Favero A. Anti-inflammatory analgesics and drugs used in rheumatoid arthritis and gout. In Dukes MNG & Beeley L (Eds) Side effects of drugs annual, Vol. 12, pp. 79–100, Elsevier Science Publishers, Amsterdam, 1988

    Google Scholar 

  • Duggan DE, Kwan KG. Enterohepatic recirculation of drugs as a determinant of therapeutic ratio. Drug Metabolism Reviews 9: 21–41, 1979

    Article  PubMed  CAS  Google Scholar 

  • Laufen H, Leitold M. The effect of activated charcoal on the bioavailability of piroxicam in man. International Journal of Clinical Pharmacology, Therapy and Toxicology 24: 48–52, 1986

    CAS  Google Scholar 

  • Lombardino JG, Otterness IG, Wiseman EH. Acidic antiinflammatory agents — correlations of some physical pharmacological and clinical data. Arzneimittel-Forschung 25: 1629–1635, 1975

    PubMed  CAS  Google Scholar 

  • Martin BK. Accumulation of drug anions in gastric mucosal cells. Nature 198: 896, 1963

    Article  CAS  Google Scholar 

  • Nürnberg B, Schneider HTh, Brune K. Auswirkungen der Galenik auf die Absorptionskinetik von Diflunisal. Pharmazeutische Industrie 47: 763–769, 1985

    Google Scholar 

  • Paulus HE. FDA Arthritis Advisory Committee meeting: postmarketing surveillance of nonsteroidal antiinflammatory drugs. Arthritis and Rheumatism 28: 1168–1169, 1985

    Article  PubMed  CAS  Google Scholar 

  • Rainsford KD, Schweitzer A, Brune K. Autoradiographic and biochemical observations on the distribution of non-steroid anti-inflammatory drugs. Archive of International Pharmacodynamics 250: 180–194, 1981

    CAS  Google Scholar 

  • Schneider TTh, Nürnberg B, Dietzel K, Brune K. Differences in biliary elimination of non-steroidal anti-inflammatory drugs in patients with percutaneous transhepatic cholangiodrainage. British Journal of Clinical Pharmacology 129: 127–131, 1990

    Article  Google Scholar 

  • Settipane GA. Aspirin and allergic diseases: a review. American Journal of Medicine 74: 102, 1983

    Article  PubMed  CAS  Google Scholar 

  • Somerville K, Faulkner G, Langman M. Non-steroidal antiinflammatory drugs and bleeding peptic ulcer. Lancet 1: 462–464, 1986

    Article  PubMed  CAS  Google Scholar 

  • Von Brett MA, Greb WH, Kurth HJ, Rulander G, Haddock RE, et al. Fehlende enterohepatische Zirkulation des aktiven metaboliten von Nabumeton. Fortschritte der Medizin 106: 736–738, 1988

    PubMed  CAS  Google Scholar 

  • Zurier RB. Prostaglandins and inflammation. In Curtis-Prior PB (Ed.) Prostaglandins: biology and chemistry of prostaglandins and related eicosanoids, pp. 595–607, Churchill Livingstone, Edinburgh, 1988

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology and Toxicology, University of Erlangen-Nürnberg, Universitätsstrasse 22, D-8520, Erlangen, Federal Republic of Germany

    K. Brune

Authors
  1. K. Brune
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brune, K. Is There a Rational Basis for the Different Spectra of Adverse Effects of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)?. Med Toxicol Adverse Drug Exp 40 (Suppl 5), 12–15 (1990). https://doi.org/10.2165/00003495-199000405-00004

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00003495-199000405-00004

Keywords

Search

Navigation