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Double-Blind Multicentre Isradipine Dose-Confirmation Study in Pakistan

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Conclusions

Isradipine 2.5mg twice daily was more effective than the 1.25mg twice daily dose in achieving normalisation of blood pressure and overall response. Larger reductions in blood pressure occurred sooner after starting isradipine 2.5mg twice daily than after the 1.25mg twice daily dose. Thus, this study confirms the results of European and American studies. Isradipine 2.5mg twice daily appears to be the optimal dosage for Pakistani patients with hypertension.

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References

  • British Isradipine Hypertension Group. Evaluation of the safety and efficacy of isradipine in elderly patients with essential hypertension. American Journal of Medicine 86(Suppl. 4A): 110–114, 1989

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  • Simonsen K, Sundstedt CD. Dose-response relationship and incidence of adverse drug reactions with isradipine in patients with essential hypertension. American Journal of Medicine 86(Suppl. 4A): 91–93, 1989

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Authors and Affiliations

  1. Department of Medicine, Jinnah Postgraduate Medical Centre, Hospital Road, Karachi, West Pakistan

    S. M. Rab

  2. Department of Medicine, Dow Medical College, Karachi, West Pakistan

    Mukhtar Azeem Mirza & Masood Hameed Khan

  3. National Institute of Cardiovascular Diseases, Karachi, West Pakistan

    Abdus Samad

  4. Department of Cardiology, Liaquat National Hospital, Karachi, West Pakistan

    Mansoor Ahmed

Authors
  1. S. M. Rab
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  2. Mukhtar Azeem Mirza
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  3. Masood Hameed Khan
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  4. Abdus Samad
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  5. Mansoor Ahmed
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Rab, S.M., Mirza, M.A., Khan, M.H. et al. Double-Blind Multicentre Isradipine Dose-Confirmation Study in Pakistan. Drugs 40 (Suppl 2), 30–32 (1990). https://doi.org/10.2165/00003495-199000402-00009

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  • DOI: https://doi.org/10.2165/00003495-199000402-00009

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