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The Role of Serotonin in Eating Disorders

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Summary

Recent pharmacological studies have more precisely characterised the nature of the inhibitory effect of brain serotonin (5-hydroxytryptamine) on feeding behaviour. Thus, the brain sites and receptors involved have been identified, and a possible physiological role of endogenous serotonin in controlling natural patterns of eating and nutrient selection has been defined. The medial hypothalamus is believed to be a critical location in the mediation of serotonin’s action. Specifically, the paraventricular and ventromedial nuclei are known to be involved in controlling energy balance, while the suprachiasmatic nucleus determines circadian patterns of eating. Serotonergic stimulation of these 3 nuclei with exogenous serotonin or drugs that release endogenous serotonin, preferentially reduces carbohydrate intake in naturally feeding animals through satiety mechanisms involved in the termination of feeding. This phenomenon is mediated by serotonin and possibly serotonin receptors, in contrast to serotonin autoreceptors which potentiate feeding possibly by inhibiting serotonin release. The activity of serotonergic function in the medial hypothalamus exhibits a circadian rhythm which is characterised by a peak at the beginning of the active cycle when the motivation to eat is strongest and is triggered by deficits in energy stores. At this time, carbohydrate is found to be the naturally preferred macronutrient, and it appears that serotonin becomes most activated under these conditions to terminate the carbohydrate-rich meal, possibly by activating satiety neurons localised in the medial hypothalamus. In this process, serotonin may interact antagonistically with noradrenaline (norepinephrine) and its α2-noradrenergic receptors that normally function to enhance carbohydrate intake at the onset of the natural feeding cycle. Moreover, while inducing satiety for carbohydrate, serotonin may also play a role in switching the animal’s preference towards protein. The regulation of this macronutrient is closely linked to that of carbohydrate, and it is normally preferred in the second meal of the natural feeding cycle.

Most of the pharmacological evidence to date generally supports the hypothesis that disturbances in serotonin function occur in eating disorders. Decreases in plasma tryptophan, urinary 5-hydroxyindoleacetic acid (5-HIAA), platelet serotonin binding and basal cerebrospinal fluid 5-HIAA in anorexia nervosa normalise upon weight restoration and appear to be starvation effects. These alterations in serotonergic function may however perpetuate the symptomatology of anorexia nervosa once the illness is set in motion. Some drugs which in part affect serotonergic function facilitate weight gain in conjunction with an integrated psychotherapeutic and behavioural programme. Patients with bulimia nervosa, regardless of the presence of anorexia nervosa or major depression, who have been relatively weight stable and free of binge/vomit episodes for at least 3 weeks, have significantly blunted prolactin responses to the serotonin agonists. These findings indicate that post-synaptic responsiveness in hypothalamic-pituitary serotonergic pathways is reduced in bulimia. Similar alterations in other serotonin pathways at or above the level of the hypothalamus may contribute to binge eating and other behavioural symptoms in bulimic patients. The clinical response to several psychotropic agents known to potentiate serotonergic transmission further substantiates a serotonin dysregulation hypothesis of bulimia nervosa. Serotonergic function is subject to seasonal alterations and may also be implicated in changes of mood and eating behaviour which accompany the seasonal affective disorder. Serotonin agonists such as dexfenfluramine are effective in suppressing excessive caloric intake in carbohydrate cravers.

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References

  • Agras WS, Dorian B, Kirkley BG. Imipramine in the treatment of bulimia: a double-blind controlled study. International Journal of Eating Disorders 6: 29–38, 1987

    Google Scholar 

  • Angel I, Taranger MA, Claustre Y, Scatton B, Longer SZ. Anorectic activities of serotonin uptake inhibitors: correlation with their potencies at inhibiting serotonin uptake in vivo and 3H-mazindol binding in vitro. Life Sciences 43: 651–658, 1988

    PubMed  CAS  Google Scholar 

  • Arora RC, Kregel L, Meltzer HY. Seasonal variation of serotonin uptake in normal controls and depressed patients. Biological Psychiatry 19: 795–804, 1984

    PubMed  CAS  Google Scholar 

  • Ashley DV. Factors affecting the selection of protein and carbohydrate from a dietary choice. Nutrition Research 5: 555–571, 1985

    CAS  Google Scholar 

  • Ashley DVM, Liardon R, Leathwood PD. Breakfast meal composition influences plasma tryptophan to large neutral amino acid ratios of healthy lean young men. Journal of Neural Transmission 63: 271–283, 1985

    PubMed  CAS  Google Scholar 

  • Barlow J, Blouin J, Blouin A. Treatment of bulimia with desipramine: a double-blind crossover study. Canadian Journal of Psychiatry 33: 129–133, 1988

    CAS  Google Scholar 

  • Bendotti C, Samanin R. 8-Hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) elicits eating in free-feeding rats by acting on central serotonin neurons. European Journal of Pharmacology 121: 147–150, 1986

    PubMed  CAS  Google Scholar 

  • Bernstein JG. Induction of obesity by psychotropic drugs. Annals of the New York Academy of Sciences 499: 203–215, 1987

    PubMed  CAS  Google Scholar 

  • Blundell JE. Serotonin and appetite. Neuropharmacology 23: 1537–1551, 1984

    PubMed  CAS  Google Scholar 

  • Blundell JE. Serotonin manipulations and the structure of feeding behaviour. Appetite 7 (Suppl.): 39–56, 1986

    PubMed  CAS  Google Scholar 

  • Blundell JE, Hill AJ. Nutrition, serotonin and appetite: case study in the evolution of a scientific idea. Appetite 8: 183–194, 1987a

    PubMed  CAS  Google Scholar 

  • Blundell JE, Hill AJ. Influence of tryptophan on appetite and food selection in man. In Kaufman (Ed.) Amino acids in health and disease: new perspectives, pp. 403–419, Alan R. Liss, New York, 1987b

    Google Scholar 

  • Blundell JE, Tombros E, Rogers PH, Latham CJ. Behavioural analysis of feeding: implications for the pharmacological manipulation of food intake in animals and man. Progress in Neuropharmacology 4: 319–326, 1980

    CAS  Google Scholar 

  • Borsini F, Bendotti C, Samanin R. Salbutamol d-amphetamine and d-fenfluramine reduce sucrose intake in freely feeding rats by acting on different neurochemical mechanisms. International Journal of Obesity 9: 277–283, 1985

    PubMed  CAS  Google Scholar 

  • Brewerton TD, Brandt HA, Lesem MD, Murphy DL, Jimerson DC. Serotonin in eating disorders. In Coccaro EF & Murphy DL (Eds) Serotonin in major psychiatric disorders. Progress in Psychiatry monograph series, Spiegel D (Ed.), American Psychiatric Association Press, in press

  • Brewerton TD, Mueller EA, Brandt HA. Evidence for serotonin dysregulation in anorexia. New Research Abstracts of the 140th Annual Meeting of the American Psychiatric Association, Chicago, p. 123, 1987a

  • Brewerton TD, Mueller EA, Murphy DL. Neuroendocrine effects of 5-HT agents in bulimia. CME Syllabus & Proceedings Summary of the 140th Annual Meeting of the American Psychiatric Association, Chicago, p. 85, 1987b

  • Carlsson A, Svennerholm L, Winblad B. Seasonal and circadian monoamine variations in human brains examined by postmortem. Acta Psychiatrica Scandinavica 61(Suppl. 280): 75–85, 1980

    CAS  Google Scholar 

  • Carruba MO, Mantegazza P, Memo M, Missale C, Pizzi M, et al. Peripheral and central mechanisms of action of serotonergic anorectic drugs. Appetite 7 (Suppl.): 105–113, 1986

    PubMed  CAS  Google Scholar 

  • Chaouloff F, Danguir J, Elghozi J-L. Dextrofenfluramine, but not 8-OH-DPAT affects the decrease in food consumed by rats submitted to physical exercise. Pharmacology Biochemistry and Behaviour 32: 573–576, 1989

    CAS  Google Scholar 

  • Clineschmidt BV. 5,6-Dihydroxytryptamine: suppression of the anorexigenic action of fenfluramine. European Journal of Pharmacology 24: 405–409, 1973

    PubMed  CAS  Google Scholar 

  • Coppen A, Wood K. 5-hydroxytryptamine in the pathogenesis of affective disorders. In Ho et al. (Eds) Serotonin in biological psychiatry, Raven Press, New York, 1982

    Google Scholar 

  • Coppen AJ, Gupta RK, Eccleston EG, Wood KM, Wakeling A, et al. Plasma-tryptophan in anorexia nervosa. Lancet 1: 961, 1976

    PubMed  CAS  Google Scholar 

  • Cowen PJ, Charig EM. Neuroendocrine responses to intravenous tryptophan in major depression. Archives of General Psychiatry 44: 958–966, 1987

    PubMed  CAS  Google Scholar 

  • Davies RF, Rossi J, Panksepp J, Bean NJ, Zobvick AJ. Fenfluramine anorexia: a peripheral locus of action. Physiology and Behaviour 30: 723–730, 1983

    CAS  Google Scholar 

  • Dourish CT, Clark ML, Fletcher A, Iversen SD. Evidence that blockade of post-synaptic 5-HT1 receptors elicits feeding in satiated rats. Psychopharmacology 97: 54–58, 1989

    PubMed  CAS  Google Scholar 

  • Dourish CT, Hutson PH, Curzon G. Low doses of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicit feeding in the rat. Psychopharmacology 86: 197–204, 1985

    PubMed  CAS  Google Scholar 

  • Dourish CT, Hutson PH, Kennett GA, Curzon G. 8-OH-DPAT-induced hyperphagia: its neural basis and possible therapeutic relevance. Appetite 7 (Suppl.): 127–140, 1986

    PubMed  CAS  Google Scholar 

  • Faradji H, Despuglio R, Jouvet M. Voltammetric measurements of 5-hydroxyindole compounds in the suprachiasmatic nuclei: circadian fluctuations. Brain Research 279: 111–119, 1983

    PubMed  CAS  Google Scholar 

  • Fernstrom JD. Role of precursor availability in the control of monoamine biosynthesis in brain. Physiological Reviews 63: 484–546, 1983

    PubMed  CAS  Google Scholar 

  • Fernstrom JD. Food-induced changes in brain serotonin synthesis: is there a relationship to appetite for specific macronutrients? Appetite 8: 163–182, 1987

    PubMed  CAS  Google Scholar 

  • Fletcher PJ, Burton MJ. Effects of manipulations of peripheral serotonin on feeding and drinking in the rat. Pharmacology Biochemistry and Behaviour 20: 835–840, 1984

    CAS  Google Scholar 

  • Freeman CPL, Morris JE, Cheshire KE. A double-blind controlled trial of fluoxetine versus placebo for bulimia nervosa. Abstracts of the Third International Conference on Eating Disorders, New York, Abstract no. 129, 1988

  • Galzin AM, Moret C, Langer SZ. Evidence that exogenous but not endogenous norepinephrine activates the presynaptic alpha-2 adrenoceptor on serotonergic nerve endings in rat hypothalamus. Journal of Pharmacology and Experimental Therapy 228: 725–732, 1984

    CAS  Google Scholar 

  • Garattini S, Bizzi A, Caccia S, Mennini T, Samanin R. Progress in assessing the role of serotonin in the control of food intake. Clinical Neuropharmacology 11(Suppl. 1): S8–S32, 1988

    PubMed  CAS  Google Scholar 

  • Garattini S, Mennini T, Bendotti C, Invernizzi R, Samanin R. Neurochemical mechanism of action of drugs which modify feeding via the serotinergic system. Appetite 7 (Suppl.): 15–38, 1986

    PubMed  CAS  Google Scholar 

  • Garattini S, Mennini T, Samanin R. Reduction of food intake by manipulation of central serotonin: current experimental results. British Journal of Psychiatry 155(Suppl. 8): 41–51, 1989

    Google Scholar 

  • Gardier AM, Trouvin JH, Orosco M, Nicolaidis S, Jacquot C. Effects of food intake and bodyweight on a serotonergic turnover index in rat hypothalamus. Brain Research Bulletin 22: 531–535, 1989

    PubMed  CAS  Google Scholar 

  • Garfinkel PE, Kaplan AS. Psychoneuroendocrine profiles of disorders of eating behaviour. In Ferrari & Brambilla (Eds) Disorders of eating behaviour. A psychoneuroendocrine approach, pp. 1–8, Pergamon Press, Oxford, 1986

    Google Scholar 

  • Goldbloom DS, Hicks LK, Garfinkel PE. Platelet serotonin uptake in bulimia nervosa. Abstracts of the Third International Conference on Eating Disorders, New York, Abstract no. 228, 1988a

  • Goldbloom DS, Hicks LK, Garfinkel PE. Platelet serotonin uptake in bulimia nervosa. American Psychiatric Association 141st Annual Meeting, Montreal, Quebec, New Research Abstract no. 281, 1988b

  • Goodwin GM, Fairburn CG, Cowen PJ. The effects of dieting and weight loss upon neuroendocrine responses to tryptophan, clonidine and apomorphine in volunteers: important implications for neuroendocrine investigations in depression. Archives of General Psychiatry 44: 952–957, 1987b

    PubMed  CAS  Google Scholar 

  • Goodwin GM, Fraser S, Stump K. Dieting and weight loss in volunteers increases the number of alpha-2-adrenoceptors and 5-HT receptors on blood platelets without effect on [3H]imipramine binding. Journal of Affective Disorders 12: 267–274, 1987a

    PubMed  CAS  Google Scholar 

  • Gwirtsman HE, Roy-Byrne P, Yager J, Gerner RH. Neuroendocrine abnormalities in bulimia. American Journal of Psychiatry 140: 559, 1983

    PubMed  CAS  Google Scholar 

  • Halmi KA, Eckert E, LaDu TJ. Anorexia nervosa treatment efficacy of cyproheptadine and amitriptyline. Archives of General Psychiatry 43: 177–181, 1986

    PubMed  CAS  Google Scholar 

  • Hery M, Faudon M, Dusticier G, Hery F. Daily variations in serotonin metabolism in the suprachiasmatic nucleus of the rat: influence of oestradiol impregnation. Journal of Endocrinology 94: 157–166, 1982

    PubMed  CAS  Google Scholar 

  • Hill AJ, Blundell JE. Model system for investigating the actions of anorectic drugs: effect of d-fenfluramine on food intake, nutrient selection, food preferences, meal patterns, hunger and satiety in healthy human subjects. In Ferrari & Brambilla (Eds) Disorders of eating behaviour. A psychoneuroendocrine approach, pp. 377–389, Pergamon Press, Oxford, 1986

    Google Scholar 

  • Hsu LKG. Treatment of bulimia with lithium. American Journal of Psychiatry 141: 1260–1262, 1984

    PubMed  CAS  Google Scholar 

  • Hudson JI, Laffer PS, Pope HG. Bulimia related to affective disorder by family history and response to the dexamethasone suppression test. American Journal of Psychiatry 139: 685, 1982

    PubMed  CAS  Google Scholar 

  • Hudson JI, Pope HG, Johns JM, Yurgelun-Todd D. Phenomenologic relationship of eating disorders to major affective disorder. Psychiatry Research 9: 345, 1983

    PubMed  CAS  Google Scholar 

  • Hughes PL, Wells LA, Cunningham CJ, Listrup DM. Treating bulimia with desipramine: a double-blind, placebo-controlled study. Archives of General Psychiatry 43: 182, 1986

    PubMed  CAS  Google Scholar 

  • Hutson PH, Donohoe TP, Curzon G. Infusion of the 5-hydyroxy-tryptamine agonists RU24969 and TFMPP into the paraventricular nucleus of the hypothalamus causes hypophagia. Psychopharmacology 95: 550–552, 1988

    PubMed  CAS  Google Scholar 

  • Huupponen R, Koulu M, Hänninen H, Pesonen U. Altered serotonin metabolism in hypothalamic paraventricular nucleus of obese Zucker rats. Acta Physiologica Scandinavica 154(Suppl. 157S): 111, 1988

    Google Scholar 

  • Johnston JL, Leiter LA, Burrow GN, Garfinkel PE, Anderson GH. Excretion of urinary catecholamine metabolites in anorexia nervosa: effect of body composition and energy intake. American Journal of Clinical Nutrition 40: 1001–1006, 1984

    PubMed  CAS  Google Scholar 

  • Kanarek RB. Neuropharmacological approaches to studying diet selection. In Kaufman (Ed.) Amino acids in health and disease: new perspectives, pp. 383–401, Alan R. Liss, New York, 1987

    Google Scholar 

  • Kaye WH, Ebert MH, Raleigh M, Lake R. Abnormalities in CNS monoamine metabolism in anorexia nervosa. Archives of General Psychiatry 41: 350–355, 1984

    PubMed  CAS  Google Scholar 

  • Kaye WH, Gwirtsman HE, Brewerton TD, George DT, Wurtman RJ. Bingeing behaviour and plasma amino acids: a possible involvement of brain serotonin in bulimia nervosa. Psychiatry Research 23: 31–43, 1988b

    PubMed  CAS  Google Scholar 

  • Kaye WH, Gwirtsman H, George DT, Obarzanek E, Brewerton TD, et al. Altered feeding behaviour in bulimia: is it related to mood and serotonin? In Walsh (Ed.) Eating behavior: in eating disorders, pp. 201–216, American Psychiatric Press, Washington, 1988a

    Google Scholar 

  • Kennett GA, Curzon G. Evidence that mCPP may have behavioural effects mediated by central 5-HT1C receptors. British Journal of Pharmacology 94: 137–147, 1988a

    PubMed  CAS  Google Scholar 

  • Kennett GA, Curzon G. Evidence that hypophagia induced by mCPP and TFMPP requires 5-HT1C and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors. Psychopharmacology 96: 93–100, 1988b

    PubMed  CAS  Google Scholar 

  • Kennett GA, Dourish CT, Curzon G. 5-HT1B agonists induce anorexia at a postsynaptic site. European Journal of Pharmacology 141: 429–435, 1987

    PubMed  CAS  Google Scholar 

  • Krahn D, Mitchell J. Use of L-tryptophan in treating bulimia. American Journal of Psychiatry 142: 1130, 1985

    PubMed  CAS  Google Scholar 

  • Le Fur G, Uzan A. Effects of 4-(3-indolyl-alkyl) piperidine derivatives on uptake and release of noradrenaline, dopamine and 5-hydroxytryptamine in rat brain synaptosomes, rat heart and human blood platelets. Biochemical Pharmacology 26: 497–503, 1977

    PubMed  Google Scholar 

  • Leibowitz SF. Hypothalamic paraventricular nucleus: interaction between α2-noradrenergic system and circulating hormones and nutrients in relation to energy balance. Neuroscience and Biobehavioral Reviews 12: 101–109, 1988

    PubMed  CAS  Google Scholar 

  • Leibowitz SF, Jhanwar-Uniyal M. 5-HT1A and 5-HT1B receptor binding sites in discrete hypothalamic nuclei: relation to feeding. Neuroscience Abstracts 15: 655, 1989

    Google Scholar 

  • Leibowitz SF, Shor-Posner G. Brain serotonin and eating behaviour. Appetite 7 (Suppl.): 1–14, 1986

    PubMed  CAS  Google Scholar 

  • Leibowitz SF, Shor-Posner G, Weiss GF. Serotonin in medial hypothalamic nuclei controls circadian patterns of macronutrient intake. In Paoletti, Vanhoutte, Brunello & Maggi (Eds) Serotonin: from cell biology to pharmacology and therapeutics, pp. 203–211, Kluwer Academic Publishers Dordrecht, 1990

    Google Scholar 

  • Leibowitz SF, Weiss GF, Shor-Posner G. Hypothalamic serotonin: pharmacological, biochemical and behaviour analyses of its feeding-suppressive action. Clinical Neuropharmacology 11(Suppl. 1): S51–S71, 1988

    PubMed  CAS  Google Scholar 

  • Leibowitz SF, Weiss GF, Walsh UA, Viswanath D. Medial hypothalamic serotonin: role in circadian patterns of feeding and macronutrient selection. Brain Research 503: 132–140, 1989

    PubMed  CAS  Google Scholar 

  • Li ETS, Anderson GH. 5-hydroxytryptamine: a modulator of food composition but not quantity? Life Science 34: 2453–2460, 1984

    CAS  Google Scholar 

  • Lieberman HR, Wurtman JJ, Chew B. Changes in mood after carbohydrate consumption among obese individuals. American Journal of Clinical Nutrition 44: 772–778, 1986

    PubMed  CAS  Google Scholar 

  • Lucki I, Kreider MS, Simansky KJ. Reduction of feeding behaviour by the serotonin uptake inhibitor sertraline. Psychopharmacology 96: 289–295, 1988

    PubMed  CAS  Google Scholar 

  • Martin KF, Marsden CA. In vivo diurnal variations of 5HT release in hypothalamic nuclei. In Redfern et al. (Eds) Circadian rhythms in the central nervous system, pp. 81–92, Macmillan Press, London 1985

    Google Scholar 

  • Mason R. Circadian variation in sensitivity of suprachiasmatic and lateral geniculate neurones to 5-hydroxytryptamine in the rat. Journal of Physiology 377: 1–13, 1986

    PubMed  CAS  Google Scholar 

  • Massi M, Marini S. Effect of the 5-HT2 antagonist ritanserin on food intake and on 5-HT-induced anorexia in the rat. Pharmacology Biochemistry and Behaviour 26: 333–340, 1987

    CAS  Google Scholar 

  • Meyer DC, Quay WB. Hypothalamic and suprachiasmatic uptake of serotonin in vitro: twenty-four-hour changes in male and proestrous female rats. Endocrinology 98: 1160–1165, 1976

    PubMed  CAS  Google Scholar 

  • Mitchell JE, Groat R. A placebo-controlled, double-blind trial of amitriptyline in bulimia. Journal of Clinical Psychopharmacology 4: 186–193, 1984

    PubMed  CAS  Google Scholar 

  • Mitchell JE, Hatsukami K, Pyle RL. The bulimia syndrome: course of the illness and associated problems. Comprehensive Psychiatry 27: 165–170, 1986

    PubMed  CAS  Google Scholar 

  • Murphy DL, Campbell I, Costa JL. Current status of the indoleamine hypothesis of affective disorders. In Lipton et al. (Eds) Psychopharmacology: a generation of progress, Raven Press, New York, 1978

    Google Scholar 

  • Neill JC, Cooper SJ. Evidence that d-fenfluramine anorexia is mediated by 5-HT1 receptors. Psychopharmacology 97: 213–218, 1989

    PubMed  CAS  Google Scholar 

  • Pazos A, Palacios JM. Quantative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Research 346: 205–230, 1985

    PubMed  CAS  Google Scholar 

  • Peroutka SJ. 5-hydroxytryptamine receptor subtypes. Annual Review of Neuroscience 11: 45–60, 1988

    PubMed  CAS  Google Scholar 

  • Pope HG, Hudson JI, Jonas JM, Yurgelun-Todd D. Bulimia treated with imipramine: a placebo-controlled double-blind study. American Journal of Psychiatry 140: 554, 1983

    PubMed  Google Scholar 

  • Robinson PH, Checkley SA, Russell GFM. Suppression of eating by fenfluramine in patients with bulimia nervosa. British Journal of Psychiatry 146: 169–176, 1985

    PubMed  CAS  Google Scholar 

  • Rogacki N, Weiss GF, Fueg A, Suh JS, Pal S, et al. Impact of hypothalamic serotonin on macronutrient intake. Annals of the New York Academy of Sciences 575: 619–621, 1989

    Google Scholar 

  • Rogers PJ, Blundell JE. Effects of anorexic drugs on food intake and the micro-structure of eating in human subjects. Psychopharmacology 66: 159–165, 1979

    PubMed  CAS  Google Scholar 

  • Rosenthal NE, Genhart M, Jacobsen FM, Skwerer RG, Wehr TA. Disturbances of appetite and weight regulation in seasonal affective disorder. Annals of the New York Academy of Sciences 499: 216–230, 1987

    PubMed  CAS  Google Scholar 

  • Russell GFM. Bulimia revisited. International Journal of Eating Disorders 4: 681–692, 1985

    Google Scholar 

  • Sabine EJ, Yonace A, Farrington AJ. Bulimia nervosa: a placebo controlled double-blind therapeutic trial of mianserin. British Journal of Clinical Pharmacology 15: 195S–202S, 1983

    PubMed  Google Scholar 

  • Samanin R. Drugs affecting serotonin and feeding. In Curtis-Prior (Ed.) Biochemical pharmacology of obesity, pp. 339–351, Elsevier, Amsterdam, 1983

    Google Scholar 

  • Samanin R, Caccia S, Bendotti C, Borsini F, Borroni E, et al. Further studies on the mechanism of serotonin-dependent anorexia in rats. Psychopharmacology 68: 89–104, 1980a

    Google Scholar 

  • Samanin R, Ghezzi D, Valzelli L, Garratini S. The effects of selective lesioning of brain serotonin or catecholamine containing neurons on the anorectic activity of fenfluramine and amphetamine. European Journal of Pharmacology 19: 318–322, 1972

    PubMed  CAS  Google Scholar 

  • Samanin R, Mennini T, Bendotti C, Barone D, Caccia S, et al. Evidence that central 5-HT2 receptors do not play an important role in the anorectic activity of d-fenfluramine in the rat. Neuropharmacology 28: 465–469, 1989

    PubMed  CAS  Google Scholar 

  • Samanin R, Mennini T, Garratini S. Evidence that it is possible to cause anorexia by increasing release and/or directly stimulating postsynaptic serotonin receptors in the brain. Progress in Neuro-Psychopharmacology 4: 363–369, 1980b

    PubMed  CAS  Google Scholar 

  • Sclafani A, Aravich PF. Macronutrient self-selection in three forms of hypothalamic obesity. American Journal of Physiology 244: R686–R694, 1983

    PubMed  CAS  Google Scholar 

  • Shor-Posner G, Azar AP, Insinga S, Leibowitz SF. Deficits in the control of food intake after hypothalamic paraventricular nucleus lesions. Physiology and Behaviour 35: 883–890, 1985

    CAS  Google Scholar 

  • Shor-Posner G, Grinker JA, Marinescu C, Brown O, Leibowitz SF. Hypothalamic serotonin in the control of meal patterns and macronutrient selection. Brain Research Bulletin 17: 663–671, 1986

    PubMed  CAS  Google Scholar 

  • Silverstone T, Goodall E. Serotoninergic mechanisms in human feeding: the pharmacological evidence. Appetite 7 (Suppl.): 85–97, 1986

    PubMed  CAS  Google Scholar 

  • Smythe GP. The role of serotonin and dopamine in hypothalamic-pituitary function. Clinical Endocrinology 7: 325, 1977

    PubMed  CAS  Google Scholar 

  • Stallone D, Nicolaidis S. Increased food intake and carbohydrate preference in the rat following treatment with the serotonin antagonist metergoline. Neuroscience Letters 102: 319–324, 1989

    PubMed  CAS  Google Scholar 

  • Stallone D, Nicolaidis S, Gibbs J. Cholecystokinin-induced anorexia depends on serotinergic function. American Journal of Physiology 256: R1138–1141, 1989

    PubMed  CAS  Google Scholar 

  • Stanley BG, Schwartz DH, Hernandes L, Leibowitz SF, Hoebel BG. Patterns of extracellular 5-hydroxyindoleacetic acid (5-HIAA) in the paraventricular hypothalamus (PVN): relation to circadian rhythm and deprivation-induced eating behaviour. Pharmacology Biochemistry and Behavior 33: 257–260, 1989

    CAS  Google Scholar 

  • Swade C, Coppen A. Seasonal variations in biochemical factors related to depressive illness. Journal of Affective Disorders 2: 249–255, 1980

    PubMed  CAS  Google Scholar 

  • Tempel DL, Shor-Posner G, Swyer D, Leibowitz SF. Nocturnal patterns of macronutrient intake in freely feeding and food deprived rats. American Journal of Physiology 256: R541–R548, 1989

    PubMed  CAS  Google Scholar 

  • Vigersky RA, Loriaux DL. The effect of cyproheptadine in anorexia nervosa: double-blind trial. In Vigersky (Ed.) Anorexia nervosa, pp. 349–356, New York, Raven Press, 1977

    Google Scholar 

  • Walsh BT, Stewart JW, Roose SP, Gladis M, Glassman AH. Treatment of bulimia with phenelzine: a double-blind placebo-controlled study. Archives of General Psychiatry 41: 105, 1984

    Google Scholar 

  • Weiss GF, Buchen D, Hsieh H, Leibowitz SF. Effect of central d-norfenfluramine injection on macronutrient selection: a hypothalamic mapping study. Proceedings of the Eastern Psychology Association 60: 9, 1989

    Google Scholar 

  • Weiss GF, Leibowitz SF. The impact of serotonergic agonists on nocturnal patterns of macronutrient selection. Neuroscience Abstracts 14: 613, 1988

    Google Scholar 

  • Weiss GF, Papadakos P, Knudson K, Leibowitz SF. Medial hypothalamic serotonin: effects on deprivation and norepinephrine-induced eating. Pharmacology Biochemistry and Behaviour 25: 1223–1230, 1986

    CAS  Google Scholar 

  • White PJ, Cybulski KA, Primus R, Johnson DF, Collier GH, et al. Changes in macronutrient selection as a function of dietary tryptophan. Physiology and Behaviour 43: 73–77, 1988

    CAS  Google Scholar 

  • Wirz-Justice A, Richter R. Seasonality in biochemical determinations: a source of variance and a clue to the temporal incidence of affective illness. Psychiatry Research 1: 53–60, 1979

    PubMed  CAS  Google Scholar 

  • Wong DT, Reid LR, Threlkeld PG. Suppression of food intake in rats by fluoxetine: comparison of enantiomers and effects of serotonin antagonists. Pharmacology Biochemistry and Behaviour 31: 475–479, 1988

    CAS  Google Scholar 

  • Wurtman JJ. Carbohydrate cravings: a disorder of food intake and mood. Clinical Neuropharmacology 11(Suppl. 1): S139–S145, 1988

    PubMed  Google Scholar 

  • Wurtman JJ, Wurtman RJ. Drugs that enhance central serotonergic transmission diminish elective carbohydrate consumption by rats. Life Sciences 24: 895–904, 1979

    PubMed  CAS  Google Scholar 

  • Wurtman JJ, Wurtman RJ. Suppression of carbohydrate consumption as snacks and at mealtimes by d-fenfluramine on tryptophan. In Garattini & Samanin (Eds) Anorectic agents: mechanisms of action and tolerance, pp. 169–182, Raven Press, New York, 1981

    Google Scholar 

  • Wurtman JJ, Wurtman RJ. D-fenfluramine selectively decreases carbohydrate but not protein intake in obese subjects. International Journal of Obesity 8: 79–84, 1984

    PubMed  Google Scholar 

  • Wurtman RJ, Wurtman JJ. Carbohydrates and depression. Scientific American 260: 68–75, 1989

    PubMed  CAS  Google Scholar 

  • Wurtman JJ, Wurtman RJ, Mark S, Tsay R, Gilbert W, et al. d-Fenfluramine selectively suppresses carbohydrate snacking by obese subjects. International Journal of Eating Disorders 4: 89, 1985

    PubMed  CAS  Google Scholar 

  • Yokogoshi H, Wurtman RJ. Meal composition and plasma amino acid ratios: effect of various proteins or carbohydrates, and of various protein concentrations. Metabolism 35: 837–842, 1986

    PubMed  CAS  Google Scholar 

  • Young SN, Tourjman SV, Teff KL, Pihl RO, Anderson HG. The effect of lowering tryptophan on food selection in normal males. Pharmacology Biochemistry and Behaviour 31: 149–152, 1988

    CAS  Google Scholar 

  • Zohar J, Insel TR. Obsessive-compulsive disorder, psychobiological approaches to diagnosis, treatment and pathophysiology. Biological Psychiatry 22: 667–687, 1987

    PubMed  CAS  Google Scholar 

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  1. The Rockefeller University, 1230 York Avenue, New York, NY, 10021, USA

    Sarah F. Leibowitz

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  1. Sarah F. Leibowitz
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Leibowitz, S.F. The Role of Serotonin in Eating Disorders. Drugs 39 (Suppl 3), 33–48 (1990). https://doi.org/10.2165/00003495-199000393-00005

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