Skip to main content
Log in

Monoclonal Antibodies

Future Potential in Cancer Chemotherapy

  • Leading Article
  • Published:
Drugs Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Bagshawe KD, Searle F, Springer C, Boden J, Melton R, et al. Tumour site activation of cytotoxic agent. Advances in the applications of monoclonal antibodies in clinical oncology meeting, London, May 25–27, 1988, p. 38, 1988

  • Baldwin RW. Design and development of drug-monoclonal antibody 791T/36 for cancer therapy. In Foon K & Morgan AC (Eds) Monoclonal antibody therapy of human cancer, pp. 23–56, Martinus Nijhoff Publishing, Boston 1985

    Chapter  Google Scholar 

  • Baldwin RW, Byers VS (Eds). Monoclonal antibodies for cancer detection and therapy, Academic Press, London, 1985

    Google Scholar 

  • Baldwin RW, Embleton MJ, Garnett MC, Pimm MV. Conjugates of monoclonal antibody 791T/36 with methotrexate in cancer therapy. NCI Monographs 3: 95–99, 1987

    PubMed  Google Scholar 

  • Berche C, Mach JP, Lumbroso JD. Tomoscintigraphy for detecting gastrointestinal and medullary thyroid cancer: first clinical results using radiolabelled monoclonal antibodies against carcinoembryonic antigen. British Medical Journal 285: 1449–1451, 1982

    Article  Google Scholar 

  • Bernstein ID, Nowinski RC. Monoclonal antibody treatment of transplanted and spontaneous murine leukemia. In Oettgen H & Mitchell M (Eds) Hybridomas in the diagnosis and treatment of cancer, pp. 97–112, Raven Press, New York, 1982

    Google Scholar 

  • Blakey BJP, Watson GJ, Knowles PP, Thorpe PT. Effect of chemical deglycosylation of ricin A chain on the in vivo fate and cytotoxic activity of an immunotoxin composed of ricin A chain and anti-Thy-1.1 antibody. Cancer Research 47: 947–952, 1987

    PubMed  CAS  Google Scholar 

  • Blakey DC, Thorpe PE. An overview of therapy with immunotoxins containing ricin or its A chain. Antibody Immunoconjugates and Radiopharmaceuticals 1: 1–16, 1988

    CAS  Google Scholar 

  • Blakey DC, Wawrzynczak EJ, Wallace PM, Thorpe PE. Antibody toxin conjugates: a perspective. In Waldmann H. (Ed.) Monoclonal antibody therapy: progress in allergy, Vol. 45, pp. 50–90, Karger, Basel, 1988

    Chapter  Google Scholar 

  • Bourrie BJP, Casellas P, Blythman HE, Janse FK. Study of the plasma clearance of antibody ricin A chain immunotoxins: evidence for specific recognition sites on the A chain that mediate rapid clearance of the immunotoxin. European Journal of Biochemistry 155: 1–10, 1986

    Article  PubMed  CAS  Google Scholar 

  • Burchell J, Gendler S, Taylor-Papadimitriou J, Girling A, Lewis A, et al. Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk fat globule. Cancer Research 47: 5476–5482, 1987

    PubMed  CAS  Google Scholar 

  • Carrasquillo JA, Krohn KA, Beaumier P, McGuffin RW, Brown JP, et al. Diagnosis and therapy for solid tumours with radiolabelled antibodies and immune fragments. Cancer Treatment Reports 68: 317–328, 1984

    PubMed  CAS  Google Scholar 

  • Carrasquillo JA, Sugarbaker P, Colcher D, Reynolds JC, Esteban J, et al. Peritoneal carcinomatosis: imaging with intraperitoneal injection of I-131-labelled B72.3 monoclonal antibody. Radiology 167: 35–40, 1988

    PubMed  CAS  Google Scholar 

  • Casellas P, Bourie BJP, Gross P, Jansen FK. Kinetics of cytotoxicity induced by immunotoxins. Journal of Biological Chemistry 259: 9359–9384, 1984

    PubMed  CAS  Google Scholar 

  • Casson AG, Ford CHJ, Marsden CH, Gallant ME and Bartlett SE. Efficacy and selectivity of vindesine monoclonal anti-CEA antibody conjugates on human tumour xenografts in nude mice. NCI Monographs 3: 117–124, 1987

    PubMed  Google Scholar 

  • Clark M, Gilliland L, Waldmann H. The potential of hybrid antibodies secreted by hybrid-hybridomas in tumour therapy. International Journal of Cancer (Suppl. 2): 15–17, 1988

    Google Scholar 

  • Clark M, Waldmann H. Therapy with hybrid antibodies. British Journal of Cancer 59: 304, 1989

    Google Scholar 

  • Cote RJ, Morrissey DM, Houghton AN, Beattie EJ, Oettgen HF, et al. Generation of human monoclonal antibodies reactive with cellular antigens. Proceedings of the National Academy of Sciences of USA 80: 2026–2030, 1983

    Article  CAS  Google Scholar 

  • Delaloye B, Bischof-Delaloye A, Buchegger F. Detection of colorectal carcinoma by emission computerised tomography after injection of 123I-labelled Fab′ and F(ab′)2 fragments from monoclonal anti-CEA antibodies. Journal of Clinical Investigation 77: 301–311, 1986

    Article  PubMed  CAS  Google Scholar 

  • Dillman, RO, Shawler DL, Johnson DE, Meyer DL, Koziol JA, et al. Preclinical trials with combinations and conjugates of T101 monoclonal antibody and doxorubicin. Cancer Research 46: 4886–4891, 1986

    PubMed  CAS  Google Scholar 

  • Doney KC, Weiden PL, Storb R, Thomas ED. Treatment of graft-versus-host disease in human allogeneic marrow graft recipients and randomized trial comparing antithymocyte globulin and corticosteroids. American Journal of Hematology 11: 1–8, 1981

    Article  PubMed  CAS  Google Scholar 

  • Embleton MJ, Garnett MC. Antibody targeting of anticancer agents. In Baldwin RW & Byers VS (Eds) Monoclonal antibodies for cancer detection and therapy, pp. 317–344, Academic Press, London, 1985

    Google Scholar 

  • Embleton MJ, Gunn B, Byuers VS, Baldwin RW. Antitumour reactions of monoclonal antibody against a human osteogenic sarcoma cell line. British Journal of Cancer 43: 582–587, 1981

    Article  PubMed  CAS  Google Scholar 

  • Epenetos AA, Courtenay-Luck NS, Dhokia B, Snook D, Hooker G, et al. Antibody-guided irradiation of hepatic metastases using introhepatically administered radiolabelled anti-CEA antibodies with simultaneous and reversible hepatic blood flow stasis using biodegradable starch microspheres. Nuclear Medicine Communications 8: 1047–1058, 1987

    Article  PubMed  CAS  Google Scholar 

  • Epenetos AA, Courtenay-Luck NS, Pickering D, Hooker G, Durbin H, et al. Antibody-guided irradiation of brain glioma by arterial infusion of radioactive monoclonal antibody against epidermal growth factor receptor and blood group A antigen. British Medical Journal 290: 1463–1466, 1985

    Article  PubMed  CAS  Google Scholar 

  • Epenetos AA, Ganti G, Taylor-Papadimitriou J, Curling M, Bodmer WF. Use of two epithelium specific monoclonal antibodies for diagnosis of malignancy in serious effusions. Lancet 2: 1004, 1982

    Article  PubMed  CAS  Google Scholar 

  • Epenetos AA, Munro AJ, Stewart S, Rampling R, Lambert HE, et al. Antibody-guided irradiation of advanced ovarian cancer with intraperitoneally administered radiolabelled monoclonal antibodies. Journal of Clinical Oncology 5: 1890–1899, 1987

    PubMed  CAS  Google Scholar 

  • FIGO. Report presented by the Cancer Committee to the General Assembly of FIGO, New York, 1970. International Journal of Gynaecology and Obstetrics 9: 172–180, 1971

    Google Scholar 

  • Fillipovich AH, McGlave PB, Ramsay NKC, Goldstein G, Warkentin PI, et al. Pretreatment of donor bone marrow with monoclonal antibody OKT3 for prevention of acute graft-versus-host disease in allogeneic histocompatible bone marrow transplantation. Lancet 1: 1266–1269, 1982

    Article  Google Scholar 

  • Finkler NJ, Mutom MG, Muto G, Kassis A, Griffiths CT, et al. A phase I study using 131-Iodine labelled OC 125 in the treatment of epithelia ovarian carcinoma. Abstract. Advances in the applications of monoclonal antibodies in clinical oncology meeting, London, May 25–27th, 1988, p.43, 1988

  • Fulton RJ, Uhr JW, Vitetta ES. The effects of antibody valency and lysosomotropic amines on the synergy between ricin-A chain and ricin-B chain containing immunotoxins. Journal of Immunology 136: 3103–3109, 1986

    CAS  Google Scholar 

  • Gansow OA, Brechbiel MW, Kumar K, Mirzadehs S, McMurray T, et al. Polyazamacrocyclic chelating agents for radioimmunoimaging and radioimmunotherapy. British Journal of Cancer 59: 308, 1989

    Google Scholar 

  • Garnett MC, Baldwin RW. An improved synthesis of methotrexate-albumin-791T/36 monoclonal antibody conjugate cytotoxic to human osteogenic sarcoma cell lines. Cancer Research 46: 2407–2412, 1986

    PubMed  CAS  Google Scholar 

  • Garnett MC, Embleton MJ, Jacobs E, Baldwin RW. Preparation and properties of a drug carrier antibody conjugate showing selective antibody directed cytotoxicity in vitro. International Journal of Cancer 31: 661–670, 1983

    Article  CAS  Google Scholar 

  • Gendler SJ, Burchell JM, Duhig T, White R, Parker M, et al. Cloning the cDNA coding for the differentiation and tumour associated mucin glycoproteins expressed by human mammary epithelium. Proceedings of the National Academy of Sciences of USA 84: 6060–6064, 1987

    Article  CAS  Google Scholar 

  • Ghetie MA, May RD, Till M, Uhr JW, Ghetie V, et al. Evaluation of ricin A chain-containing immunotoxins directed against CD19 and CD22 antigens on normal and malignant human B-cells as potential reagents for in vivo therapy. Cancer Research 48: 2610–2617, 1988

    PubMed  CAS  Google Scholar 

  • Goldenberg DM, Kim EE, Deland FH, Bennet S, Primius FJ. Radioimmunodetection of cancer with radioactive antibodies to CEA. Cancer Research 46: 2984–2992, 1980

    Google Scholar 

  • Goldenberg DM, Preston DF, Primus FJ, Hausen HJ. Photoscan localisation of GW-39 tumours in hamsters using radiolabelled anti-CEA immunoglobulin G. Cancer Research 34: 1–9, 1974

    PubMed  CAS  Google Scholar 

  • Hand PH, Colcher Q, Salomen D, Ridge J, Noguchi P, et al. Influence of spatial configuration of carcinoma cell populations on the expression of a tumour associated glycoprotein. Cancer Research 45: 833–840, 1985

    Google Scholar 

  • Herlyn DM, Steplewski Z, Herlyn MF, Koprowski H. Inhibition of growth of colorectal carcinoma in nude mice by monoclonal antibody. Cancer Research 40: 717–721, 1980

    PubMed  CAS  Google Scholar 

  • Hnatowich DJ, Virtzi F, Doherty PW. DTPA-coupled antibodies labelled with yttrium-90. Journal of Nuclear Medicine 5: 503–509, 1985

    Google Scholar 

  • Hurwitz E, Maron R, Bernstein A, Wilchek M, Sela M, et al. The effect in vivo of chemotherapeutic drug-antibody conjugates in two murine experimental tumour systems. International Journal of Cancer 21: 747–755, 1978

    Article  CAS  Google Scholar 

  • Johnson DA, Laguzza BC. Antitumour xenograft activity with a conjugate of a vinca derivative and the squamous carcinoma reactive monoclonal antibody PF1/D. Cancer Research 47: 3118–3122, 1987

    PubMed  CAS  Google Scholar 

  • Kalofonos HP, Stewart S, Epenetos AA. Antibody-guided diagnosis and therapy of malignant lesions. International Journal of Cancer (Suppl. 2): 74–80, 1988

    Google Scholar 

  • Kanellos J, Pietersz GA, McKenzie I. Studies of methotrexate monoclonal antibody conjugates for immunotherapy. Journal of the National Cancer Institute 75: 319–333, 1985

    PubMed  CAS  Google Scholar 

  • Kersey J, Le Bien T, Valerra D, Nesbit M, Weisdorf D. et al. Allogeneic and autologous marrow transplantation: ex vivo purging with monoclonal antibody or immunotoxins to remove leukemic cells or to prevent graft versus host disease. In Hazenbeek H & Lowenberg B (Eds) Minimal residual disease in acute leukemia, pp. 275–281, Martinus Nijhoff, Dordrecht, 1986

    Chapter  Google Scholar 

  • Knowles PP, Thorpe PE. Purification of immunotoxins containing ricin A chain and abrin A chain using Blue sepharose CL-6B. Analytical Biochemistry 160: 440–443, 1987

    Article  PubMed  CAS  Google Scholar 

  • Kohler G, Milstein C. Continuous culture of fused cells secreting antibody of predefined specificity. Nature 248: 465, 1975

    Google Scholar 

  • Larson SM. Radiolabelled monoclonal anti-tumour antibodies in diagnosis and therapy. Journal of Nuclear Medicine 26(5): 538–545, 1985

    PubMed  CAS  Google Scholar 

  • Laurent G, Pris J, Farcet JP, Garayon P, Blythman H. et al. Effects of therapy with T101 ricin A chain immunotoxin in two leukemia patients. Blood 67: 1680–1687, 1986

    PubMed  CAS  Google Scholar 

  • Mach JP, Buchegger F, Forni M, Ritschard J, Berche C, et al. Use of radiolabelled monoclonal anti-CEA antibodies for the detection of human carcinomas by external photoscanning and tomoscintigraphy. Immunology Today 2: 239–249, 1981

    Article  Google Scholar 

  • Mach JP, Carrel S, Forni M, Ritschard J, Donath A, et al. Tumor localization of radiolabeled antibodies against carcinoembryonic antigen in patients with carcinoma: a critical evaluation. New England Journal of Medicine 303: 5–10, 1980

    Article  PubMed  CAS  Google Scholar 

  • Mach JP, Carrel S, Merenda C, Sorbat B, Gerottini JC. In vivo localisation of radiolabelled antibodies to CEA in human colon carcinoma grafted into nude mice. Nature 248: 704–706, 1974

    Article  PubMed  CAS  Google Scholar 

  • Meeker TC, Lowder J, Cleary ML, Stewart S, Warnke R, et al. Emergence of idiotype variants during treatment of B-cell lymphoma with anti-idiotype antibodies. New England Journal of Medicine 312: 1658, 1985a

    Article  PubMed  CAS  Google Scholar 

  • Meeker TC, Lowder J, Maloney DG, Miller RA, Thielemans K, et al. A clinical trial of anti-idiotype therapy for B cell malignancies. Blood 65: 1349, 1985b

    PubMed  CAS  Google Scholar 

  • Miller RA, Maloney DG, Warnke R, Levy R. Treatment of B-cell lymphoma with monoclonal anti-idiotype antibody. New England Journal of Medicine 306: 517, 1982

    Article  PubMed  CAS  Google Scholar 

  • Miller RA, Oseroff AR, Stratte PT, Levy R. Monoclonal antibody therapeutic trials in seven patients with T-cell lymphoma. Blood 62: 988, 1983

    PubMed  CAS  Google Scholar 

  • Minowada J, Onuma T, Moore GE. Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes. Journal of the National Cancer Institute 49: 891–895, 1972

    PubMed  CAS  Google Scholar 

  • Miotti S, Canevari S, Menard S, Mezzanzanica D, Porro G, et al. Characterization of human ovarian carcinoma-associated antigens defined by novel monoclonal antibodies with tumour restricted specificity. International Journal of Cancer 39: 297–303, 1987

    Article  CAS  Google Scholar 

  • Moore GE, Woods LK, Minowada J. Establishment of leukemia cell lines with T cell characteristics. In Vitro (Rockville), 8: 434, 1973

    Google Scholar 

  • Muirhead M, Martin PJ, Torok-Storb B, Uhr J, Vitetta ES. Use of an antibody-Ricin A chain conjugate to deplete neoplastic B cells from human bone marrow. Blood 42: 327–332, 1983

    Google Scholar 

  • Myers CD. The use of immunotoxins to eliminate tumour cells from human leukaemic marrow autografts. In Baldwin RW & Byers VS (Eds) Monoclonal antibodies for cancer detection and therapy, pp. 345–367, Academic Press, London, 1985

    Google Scholar 

  • Nadler LM, Stashenko P, Hardy R, Kaplan WD, Button LN, et al. Serotherapy of a patient with a monoclonal antibody directed against a human lymphoma associated antigen. Cancer Research 40: 3147, 1980

    PubMed  CAS  Google Scholar 

  • Olsnes S, Refsnes K, Pihl A. Mechanism of action of toxic lectins abrin and ricin. Nature (London) 249: 627–631, 1974

    Article  CAS  Google Scholar 

  • Order SE. Monoclonal antibodies: potential role in radiation therapy and oncology. International Journal of Radiation, Oncology, Biology, Physics 8(97): 1193–1201, 1982

    Article  CAS  Google Scholar 

  • Order SE. Antibody guided irradiation of cancer. British Journal of Cancer 52: 641, 1985

    Article  Google Scholar 

  • Order SE, Klein JL, Ettinger D, Anderson P, Siegelman S, et al. Use of isotopic immunoglobulin in therapy. Cancer Research 40: 801, 1980

    Google Scholar 

  • Order SE, Klein JL, Leichner PK, Frincke J, Lollo C, et al. 90-Yttrium antiferritin: a new therapeutic radiolabelled antibody. International Journal of Radiation, Oncology, Biology, Physics 12: 277–281, 1986

    Article  CAS  Google Scholar 

  • Pectasides D, Stewart S, Courtenay-Luck NS, Rampling R, Munro AJ. Antibody-guided irradiation of malignant pleural and pericardial effusions. British Journal of Cancer 53: 727–732, 1986

    Article  PubMed  CAS  Google Scholar 

  • Poels LG, Peters D, van Megen Y, Vooijs GP, Verheyen RNM, et al. Monoclonal antibody against human ovarian tumour-associated antigens. Journal of the National Cancer Institute 76: 781, 1986

    PubMed  CAS  Google Scholar 

  • Powles RL, Barrett AJ, Clink HM, Sloane J, Kay HEM, et al. Cyclosporin A for the treatment of graft-versus-host disease in man. Lancet 2: 1327–1331, 1978

    Article  PubMed  CAS  Google Scholar 

  • Powles RL, Clink HM, Spence D, Morgestern G, Watson JG, et al. Cyclosporin A to prevent graft versus host disease in man after allogeneic bone marrow transplantation. Lancet 1: 327–329, 1980

    Article  PubMed  CAS  Google Scholar 

  • Prentice H, Janossy G, Skeggs D, Blacklock HA, Bradstck KF, et al. Use of anti-T-cell monoclonal antibody OKT3 to prevent graft-versus-host disease in allogeneic bone marrow transplantation for acute leukaemia. Lancet 1: 700–703, 1982

    Article  PubMed  CAS  Google Scholar 

  • Price MR, Campbell DG, Robins RA, Baldwin RW. Immunolocalisation of the murine monoclonal antibody, 791/T36, within primary human colorectal carcinomas and identification of the target antigen. European Journal of Cancer and Clinical Oncology 19: 81–90, 1983

    Article  CAS  Google Scholar 

  • Racadot E, Herve P, Beaujean F, Vernant JP, Flesch M, et al. Prevention of graft-versus-host disease in HLA-matched bone marrow transplantation for malignant disease: a multicentric study of 62 patients using 3-pan-T monoclonal antibodies and rabbit complement. Journal of Clinical Oncology 5: 426–435, 1987

    PubMed  CAS  Google Scholar 

  • Raffeld M, Neckers L, Longo DL, Cossman J. Spontaneous alteration of idiotype in a monoclonal B-cell lymphoma: escape from detection by anti-idiotype. New England Journal of Medicine 312: 1653–1658, 1985

    Article  PubMed  CAS  Google Scholar 

  • Ramsay NKC, Kersey JH, Robinson LL, McClave PB, Woods WG, et al. A randomized study of the prevention of acute graft-versus-host disease. New England Journal of Medicine 306: 392–397, 1982

    Article  PubMed  CAS  Google Scholar 

  • Reichman L, Clark M, Waldmann H, Winter G. Reshaping human antibodies for therapy. Nature 332: 323–327, 1988

    Article  Google Scholar 

  • Reinhertz EL, Hussey RE, Schlossman SF. A monoclonal antibody blocking human T cell function. European Journal of Immunology 10: 758–762, 1980

    Article  Google Scholar 

  • Reisner Y, Kapoor N, Kirkpatrick D, Pollack MS, Cunningham-Rundles S, et al. Transplantation for severe combined immunodeficiency with HLA-A, B,C,Dr: incompatible parental marrow cells fractionated by soybean agglutinin and sheep red blood cells. Blood 61: 391–398, 1983

    Google Scholar 

  • Ritz J, Sallan SE, Bast RCJ, Lipton JM, Clavell LA, et al. Autologous bone marrow transplantation in CALLA-positive acute lymphoblastic leukaemia after in vitro treatment with J5 monoclonal antibody and complement. Lancet 2: 60–63, 1982

    Article  PubMed  CAS  Google Scholar 

  • Riva P, Lazari S. Therapeutic application of radiolabelled monoclonal antibodies: preliminary experiences in 25 patients with solid tumours. Abstract. Advances in the applications of monoclonal antibodies in clinical oncology meeting, London, May 25–27, 1988, p. 44, 1988

  • Rowland GF, Axton CA, Baldwin RW, Brown JP, Caorvalan JR, et al. Antitumour properties of vindesine-monoclonal antibody conjugates. Cancer Immunology Immunotherapy 19: 1–7, 1985

    Article  CAS  Google Scholar 

  • Royston I, Majda JA, Baird SM, Meserve BL, Griffiths JC. Human T cell antigens defined by monoclonal antibodies: the 65000-dalton antigen of T cells (T65) is also found on chronic lymphocytic leukaemia cells bearing surface immunoglobulin. Journal of Immunology 57: 553–564, 1980

    Google Scholar 

  • Sands H, Jones PL, Brown BA, Nason T. Uptake of radiolabel in rat liver cells after administration of radiolabelled B72.3 adn it F(ab′)2 fragments. British Journal of Cancer 59: 306, 1989

    Google Scholar 

  • Schlom J. Innovations in monoclonal antibody tumour targeting: diagnostic and therapeutic implications. Journal of the American Medical Association 261: 744–746, 1989

    Article  PubMed  CAS  Google Scholar 

  • Sears HF, Atkinson B, Mattis J, Ernst C, Herlyn D, et al. Phase I clinical trial of monoclonal antibody in treatment of gastrointestinal tumours. Lancet 1: 762–765, 1982

    Article  PubMed  CAS  Google Scholar 

  • Sears HF, Herlyn D, Steplewski Z, Koprowskitt. Phase II clinical trial of a murine monoclonal antibody cytotoxic for gastrointestinal adenocarcinoma. Cancer Research 45(II): 5910–5913, 1985

    PubMed  CAS  Google Scholar 

  • Shin HS, Johnson RS. Antibody-mediated tumour suppression: some recent developments and possible role in natural resistance to tumours. Clinics in Immunology and Allergy 3: 457–464, 1983

    Google Scholar 

  • Speck B, Grathwohl A, Nissen C. Cyclosporin A for prophylaxis of GVHD in clinical bone marrow transplantation. In Baum SJ & Ledney GD (Eds) Experimental hematology today, pp. 117–120, Springer-Verlag, New York, 1981

    Google Scholar 

  • Spitler LE, del Rio M, Khentigan A, Wedel NI, Brophy NA, et al. Therapy of patients with malignant melanoma using a monoclonal antimelanoma antibody-ricin A chain immunotoxin. Cancer Research 47: 1717–1723, 1987

    PubMed  CAS  Google Scholar 

  • Stewart S, Hird V, Epenetos AA. Intraperitoneal radio-immunotherapy for ovarian cancer. Abstract. Advances in the applications of monoclonal antibodies in clinical oncology meeting, London, May 25–27, p.44, 1988

  • Storb R, Deeg HJ, Whitehead J, Appelbaum F, Beatty P, et al. Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft verus host disease after marrow transplantation for leukaemia. New England Journal of Medicine 314(12): 729–735, 1986

    Article  PubMed  CAS  Google Scholar 

  • Takahashi Y, Masayashi M, Umento N, Kao Y, Harra T, et al. Conjugates of mitomycin with anti-aFP antibody: anti-tumour effect against mice. NCI Monographs 3: 101–105, 1987

    PubMed  Google Scholar 

  • Takvorian T, Canellos GP, Ritz J, Freedman AS, Anderson KC, et al. Prolonged disease-free survival after autologous bone marrow transplantation in patients with non-Hodgkin’s lymphoma with a poor prognosis. New England Journal of Medicine 316(24): 1499–1505, 1987

    Article  PubMed  CAS  Google Scholar 

  • Takvorian T, Sallan S, Ritz J. Monoclonal antibody purged autologous bone marrow transplantation for relapsed non-T-cell acute lymphoblastic leukaemia. In Hazenbeek H & Lowenberg B (Eds) Minimal residual disease in acute leukaemia, pp. 266–274, Martinus Nijhoff, Dordrecht, 1986

    Chapter  Google Scholar 

  • Thomas ED, Storb R, Clift RA, Fefer A, Johnson L, et al. Bone marrow transplantation. New England Journal of Medicine 292: 832–843, 895-902, 1975

    Article  PubMed  CAS  Google Scholar 

  • Thorpe PE, Detre SI, Foxwell BMJ, Brown ANF, Skilleter DN, et al. Modification of the carbohydrate in ricin with metaperiodate-cyanoborohydride mixtures: effector toxicity and in vivo distribution. European Journal of Biochemistry 147: 197–209, 1985

    Article  PubMed  CAS  Google Scholar 

  • Thorpe PE, Wallace PM, Knowles PP, Reif MG, Brown AN, et al. New coupling agents for the synthesis of immunotoxins containing a hindered disulfide bond with improved stability in vivo. Cancer Research 47: 5924–5931, 1987

    PubMed  CAS  Google Scholar 

  • Vallera D, Soderling C, Carlson G, Kersey JH. Bone marrow transplantation across major histocompatibility complex barriers in mice. Transplantation 33(3): 243–248, 1982

    Article  PubMed  CAS  Google Scholar 

  • Vallera DA, Youle R, Neville Jr DM, Soderling CC, Kersey JH. Monoclonal antibody toxin conjugates for experimental graft-versus-host disease prophylaxis. Transplantation 36(1): 73–80, 1983

    Article  PubMed  CAS  Google Scholar 

  • Verhoeyen M, Milstein G, Winter G. Reshaping human antibodies: grafting an antilysozyme activity. Science 239: 1534–1536, 1988

    Article  PubMed  CAS  Google Scholar 

  • Vitetta ES, Fulton RJ, May RD, Till M, Uhr JW. Redesigning nature’s poisons to create anti-tumour reagents. Science 239: 1098–1104, 1987

    Article  Google Scholar 

  • Wessels BW, Rogus RD. Radionuclide selection and model absorbed dose calculations for radiolabelled tumour associated antibodies. Medical Physics 11: 638–645, 1984

    Article  PubMed  CAS  Google Scholar 

  • Worrell NR, Cumber AJ, Parnell GD, Ross WCJ, Forrester JA. Fate of an antibody-ricin A chain conjugate administered to normal rats. Biochemical Pharmacology 35: 417–423, 1986

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kosmas, C., Kalofonos, H. & Epenetos, A.A. Monoclonal Antibodies. Drugs 38, 645–657 (1989). https://doi.org/10.2165/00003495-198938050-00001

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00003495-198938050-00001

Keywords

Navigation