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Treatment of the Anaemia of Chronic Renal Failure with Recombinant Human Erythropoietin

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References

  • Bommer J, Kugel M, Schoeppe W, Brunkhorst R, Samtleben W, et al. Dose related effects of recombinant erythropoietin on erythropoiesis: results of a multicenter trial in patients with end stage renal disease. Contributions to Nephrology 66: 85–93, 1988a

    PubMed  CAS  Google Scholar 

  • Bommer J, Ritz E, Weinreich T, Bommer G, Ziegler T. Subcutaneous erythropoietin. Correspondence. Lancet 2: 406, 1988b

    Article  PubMed  CAS  Google Scholar 

  • Canadian Erythropoietin Study Group. A prospective randomised double-blind study of recombinant human erythropoietin in chronic hemodialysis. Abstract. Kidney International 33: 218, 1988

    Google Scholar 

  • Casati S, Passerini P, Campise MR, Graziani G, Cesana B, et al. Benefits and risks of protracted treatment with human recombinant erythropoietin in patients having haemodialysis. British Medical Journal 295: 1017–1020, 1987

    Article  PubMed  CAS  Google Scholar 

  • Cotes PM, Pippard MJ, Reid CDL, Winearls CG, Oliver DO, et al. Characterisation of the anaemia of chronic renal failure and the mode of its correction by erythropoietin (r-HuEPO): an investigation of the pharmacokinetics of intravenous r-HuEPO and its effect on erythrokinetics. Quarterly Journal of Medicine, New Series 70: 113–137, 1989

    CAS  Google Scholar 

  • Edmunds ME, Walls J. Blood pressure and erythropoietin. Correspondence. Lancet 1: 352, 1988

    Google Scholar 

  • Egrie JC, Eschbach JW, McGuire TC, Adamson JW. Pharmacokinetics of recombinant human erythropoietin (r-HuEPO) administered to hemodialysis (HD) patients. Abstract. Kidney International 33: 152, 1988

    Google Scholar 

  • Egrie JC, Strickland TW, Lane J, Aoki K, Cohen AM, et al. Characterisation of the biological effects of recombinant human erythropoietin. Immunobiology 172: 213–224, 1986

    Article  PubMed  CAS  Google Scholar 

  • Eschbach JW. The anaemia of chronic renal failure: pathophysiology and the effects of recombinant erythropoietin. Kidney International 35: 134–148, 1989

    Article  PubMed  CAS  Google Scholar 

  • Eschbach JW, Adamson JW. Anemia of end-stage renal disease (ESRD). Kidney International 28: 1–5, 1985

    Article  PubMed  CAS  Google Scholar 

  • Eschbach JW, Adamson JW. Correction of anaemia of haemodialysis (HD) patients with recombinant human erythropoietin (r-HuEPO): results of a multicentre study. Kidney International 33: 189, 1988

    Google Scholar 

  • Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW. Correction of the anaemia of end-stage renal disease with recombinant human erythropoietin: results of a combined phase I and II clinical trial. New England Journal of Medicine 316: 73–78, 1987

    Article  PubMed  CAS  Google Scholar 

  • Eschbach JW, Funk D, Adamson JW, Kuhn I, Scribner BH, et al. Erythropoiesis in patients with renal failure undergoing chronic dialysis. New England Journal of Medicine 276: 653–658, 1967

    Article  PubMed  Google Scholar 

  • Frenken LAM, Coppens PJW, Tiggeler RGWL, Koene RAP. In-traperitoneal erythropoietin. Correspondence. Lancet 2: 1495, 1988

    Article  PubMed  CAS  Google Scholar 

  • Jacobs K, Shoemaker C, Rudersdorf R, Neill EF, Kaufman RJ, et al. Isolation and characterisation of genomic and cDNA clones of human erythropoietin. Nature 313: 806–810, 1985

    Article  PubMed  CAS  Google Scholar 

  • Lassere JJ, Gretz N, Strauch M. A flu-like syndrome in patients treated with erythropoietin. Abstract. Nephrology Dialysis and Transplantation 3: 498, 1988

    Google Scholar 

  • Lim VS, DeGowin RL, Zavala D, Kirchner PT, Abels R, et al. Recombinant human erythropoietin treatment in pre-dialysis patients: a double-blind placebo-controlled trial. Annals of Internal Medicine 110: 108–114, 1989

    PubMed  CAS  Google Scholar 

  • Lin FK, Suggs S, Lin CH, Browne JK, Smalling R, et al. Cloning and expression of the human erythropoietin gene. Proceedings of the National Academy of Sciences of the USA 82: 7580–7584, 1985

    Article  PubMed  CAS  Google Scholar 

  • Mayer G, Thum J, Cada EM, Stumvoll HK, Graf H. Working capacity is increased following recombinant human erythro-poietin treatment. Kidney International 34: 525–528, 1988

    Article  PubMed  CAS  Google Scholar 

  • McGonigle RJS, Parsons V. Aluminium-induced anaemia in haemodialysis patients. Nephron 39: 1–9, 1985

    Article  PubMed  CAS  Google Scholar 

  • Nonnast-Daniel B, Creutzig A, Kuhn K, Bahlman J, Reimers E, et al. Effect of treatment with recombinant human erythropoietin on peripheral hemodynamics and oxygenation. Contributions to Nephrology 66: 185–194, 1988

    PubMed  CAS  Google Scholar 

  • Raine AEG. Hypertension, blood viscosity and cardiovascular morbidity in renal failure: implications of erythropoietin therapy. Lancet 2: 97–100, 1988

    Article  Google Scholar 

  • Samtleben W, Baldamus CA, Bommer J, Fassbinder W, Nonnast-Daniel B, et al. Blood pressure changes during treatment with recombinant human erythropoietin. Contributions to Nephrology 66: 114–122, 1988

    PubMed  CAS  Google Scholar 

  • Sasaki H, Bothner B, Dell A, Fukuda M. Carbohydrate structure of erythropoietin expressed in Chinese Hamster Ovary cells by a human erythropoietin cDNA. Journal of Biological Chem-istry 262: 12059–12076, 1987

    CAS  Google Scholar 

  • Schooley JC, Kullgren B, Allison AC. Inhibition by interleukin-1 of the action of erythropoietin on erythroid precursors and its possible role in the pathogenesis of hypoplastic anaemias. British Journal of Haematology 67: 11–17, 1987

    Article  PubMed  CAS  Google Scholar 

  • Shinaberger JH, Miller JH, Gardner PW. Erythropoietin alert: risks of high hematocrit hemodialysis. Transactions of the American Society of Artificial Internal Organs 34: 179–184, 1988

    CAS  Google Scholar 

  • Stevens JM, Hughes RT, Cotes PM, Oliver DO, Strong C, et al. Subcutaneous administration of recombinant erythropoietin (r-HuEPO) to anaemic renal failure patients maintained by chronic ambulatory peritoneal dialysis (CAPD). Abstract, p. 214, XXVth i Congress of the European Dialysis and Transplant Association-European Renal Association, Madrid, 1988

  • Stone WJ, Graber SE, Krantz SB, Dessypris EN, Pincus TP. Treatment of the anemia of predialysis patients with recombinant human erythropoietin: a randomised, placebo-controlled trial. American Journal of the Medical Sciences 296: 171–179, 1988

    Article  PubMed  CAS  Google Scholar 

  • Swartz R, Drombrouski J, Burnatowska-Hledin M, Mayer G. Microcytic anaemia in dialysis patients: reversible marker of aluminum toxicity. American Journal of Kidney Diseases 9: 217–223,1987

    PubMed  CAS  Google Scholar 

  • Takeuchi M, Takasaki S, Miyazaki H, Kato T, Hoshi S, et al. Comparative study of the asparagine-linked sugar chains of human erythropoietins purified from urine and the culture medium of recombinant Chinese Hamster Ovary cells. Journal of Biological Chemistry 263: 3657–3663, 1988

    PubMed  CAS  Google Scholar 

  • Tomson CRV, Venning MC, Ward MK. Blood pressure and erythropoietin. Correspondence. Lancet 1: 351, 1988

    Article  Google Scholar 

  • Van Wyck DB, Stivelman JC, Ruiz J, Kirlin LF, Katz MA, et al. Iron status in patients receiving erythropoietin for dialysis-associated anemia. Kidney International 35: 712–716, 1989

    Article  PubMed  Google Scholar 

  • Wahlberg J, Jacobsson J, Odlind B, Tufveson G, Wikstrom B. Haemodilution in renal transplantation in patients on erythropoietin. Lancet 2: 1418, 1988

    Article  PubMed  CAS  Google Scholar 

  • Winearls CG. Erythropoietin and the anaemia of chronic renal failure. In Morris PJ & Tilney NJ (Eds) Transplantation reviews, Vol. 3, pp. 31–46, Grune and Stratton, London, 1989

    Google Scholar 

  • Winearls CG, Qliver DO, Pippard MJ, Reid C, Downing MR, et al. Effect of human erythropoietin derived from recombinant DNA on the anaemia of patients maintained by chronic haemodialysns. Lancet 2: 1175–1178, 1986

    Article  PubMed  CAS  Google Scholar 

  • Zaoui P, Bayle F, Maurizi J, Foret M, Dalsoglio S, et al. Early thrombosis in kidney grafted into patient treated with erythropoietin. Lancet 2: 956, 1988

    Article  PubMed  CAS  Google Scholar 

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  1. Renal Unit, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LJ, England

    Christopher G. Winearls (Consultant Nephrologist)

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  1. Christopher G. Winearls
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Winearls, C.G. Treatment of the Anaemia of Chronic Renal Failure with Recombinant Human Erythropoietin. Drugs 38, 342–345 (1989). https://doi.org/10.2165/00003495-198938030-00002

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  • DOI: https://doi.org/10.2165/00003495-198938030-00002

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