Skip to main content
SpringerLink
Log in

The Use and Potential of Serum Tumour Markers, New and Old

  • Leading Article
  • Published:
Drugs Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Ahmann FR, Schifman RB. Prospective comparison between serum monoclonal prostate specific antigen and acid phosphatase measurements in metastatic prostatic cancer. Journal of Urology 137: 431–434, 1987

    CAS  PubMed  Google Scholar 

  • Altug MU, Akdas A, Ruacan S, Ozen AH, Remzi D. Tissue alpha-fetoprotein and human chorionic gonadotrophin in nonseminomatous testicular tumours. British Journal of Urology 59: 458–462, 1987

    Article  CAS  PubMed  Google Scholar 

  • Anderson T, Waldmann TA, Javadpour N, Glatstein E. Testicular germ cell neoplasms: recent advances in diagnosis and therapy. Annals of Internal Medicine 90: 373–385, 1979

    Google Scholar 

  • Atack DB, Nisker JA, Allen HH, Tustanoff ER, Levin L. CA 125 surveillance and second-look laparotomy in ovarian carcinoma. American Journal of Obstetrics and Gynecology 154: 287–289, 1986

    CAS  PubMed  Google Scholar 

  • Attiyeh FF, Stearns M. Second-look laparotomy based on CEA elevations in colorectal cancer. Cancer 47: 2119–2125, 1981

    Article  CAS  PubMed  Google Scholar 

  • August DA, Ottow RT, Sugarbaker PH. Clinical perspective of human colorectal cancer metastasis. Cancer Metastasis Review 3: 303–324, 1984

    Article  CAS  Google Scholar 

  • Bast RC. Antigens associated with epithelial ovarian cancer. In Mitchell M (Ed.) Immunity to cancer II, pp. 73–83, Alan R. Liss, Inc., 1989

    Google Scholar 

  • Bast Jr RC, Klug TL, St John E, Jenison E, Niloff J, et al. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. New England Journal of Medicine 309: 883–887, 1983

    Article  PubMed  Google Scholar 

  • Bates SE, Longo DL. Use of serum tumor markers in cancer diagnosis and management. Seminars in Oncology 14: 102–138, 1987

    CAS  PubMed  Google Scholar 

  • Beard DB, Haskell CM. Carcinoembryonic antigen in breast cancer. American Journal of Medicine 80: 241–245, 1986

    Article  CAS  PubMed  Google Scholar 

  • Berek JS, Knapp RC, Malkasian GD, Lavin PT, Whitney C. CA 125 serum levels correlated with second-look operations among ovarian cancer patients. Obstetrics and Gynecology 67: 685–689, 1986

    Article  CAS  PubMed  Google Scholar 

  • Beretta E, Malesci A, Zerbi A, Mariani A, Carlucci M, et al. Serum CA 19-9 in the postsurgical follow-up of patients with pancreatic cancer. Cancer 60: 2428–2431, 1987

    Article  CAS  PubMed  Google Scholar 

  • Bosl GJ, Lange PH, Fraley EE, Goldman A, Nochomovite LE, et al. Human chorionic gonadotropin and alphafetoprotein in the staging of nonseminomatous testicular cancer. Cancer 47: 328–332, 1981

    Article  CAS  PubMed  Google Scholar 

  • Brioschi PA, Irion O, Bischof P, Bader M, Forni M, et al. Serum CA 125 in epithelial ovarian cancer: a longitudinal study. British Journal of Obstetrics and Gynaecology 94: 196–201, 1987

    Article  CAS  PubMed  Google Scholar 

  • Buamah PK, Cornell C, Venables CW, Skillen AW. An initial appraisal of the value of serum carbohydrate antigenic determinant (CA 19-9) levels in patients with pancreatic cancer. European Journal of Cancer and Clinical Oncology 23: 87–91, 1987

    Article  CAS  Google Scholar 

  • Catalona WJ. Tumor markers in testicular cancer. Urologic Clinics of North America 6: 613–628, 1979

    CAS  PubMed  Google Scholar 

  • Chen DS, Sung JL, Sheu JC, Lai MY, How SW, et al. Serum α-fetoprotein in the early stage of human hepatocellular carcinoma. Gastroenterology 86: 1404–1409, 1984

    CAS  PubMed  Google Scholar 

  • Civardi G, Cerri L, Cavanna L, Fornari F, Di Stasi M, et al. Diagnostic accuracy of a new tumor serologic marker, CA 19-9: comparison with CEA. Tumori 72: 621–624, 1986

    CAS  PubMed  Google Scholar 

  • Colomer R, Sole LA, Navarro M, Encabo G, Ruibal A, et al. Ca 15-3: early results of a new breast cancer marker. Anticancer Research 6: 683–684, 1986

    CAS  PubMed  Google Scholar 

  • Cruickshank DJ, Fullerton WT, Klopper A. The clinical significance of pre-operative serum CA 125 in ovarian cancer. British Journal of Obstetrics and Gynaecology 94: 692–695, 1987

    Article  CAS  PubMed  Google Scholar 

  • Cullen KJ, Stevens DP, Frost MA, Mackay IR. Carcinoembryonic antigen (CEA), smoking, and cancer in a longitudinal population study. Australian and New Zealand Journal of Medicine 6: 279–283, 1976

    Article  CAS  PubMed  Google Scholar 

  • Del Favero G, Fabris C, Plebani M, Panucci A, Piccoli A, et al. CA 19-9 and carcinoembryonic antigen in pancreatic cancer diagnosis. Cancer 57: 1576–1579, 1986

    Article  PubMed  Google Scholar 

  • Doos WG, Wolff WI, Shinya H, De Chabon A, Stenger RJ, et al. CEA levels in patients with colorectal polyps. Cancer 36: 1996–2003, 1975

    Article  CAS  PubMed  Google Scholar 

  • Einhorn LH, Williams SD, Mandelbaum I, Donohue JP. Surgical resection in disseminated testicular cancer following chemotherapeutic cytoreduction. Cancer 48: 904–908, 1981

    Article  CAS  PubMed  Google Scholar 

  • Evans JT, Mittelman A, Chu M, Holyoke ED. Pre-and postoperative uses of CEA. Cancer 42: 1419–1421, 1978

    Article  CAS  PubMed  Google Scholar 

  • Ferro MA, Barnes I, Roberts JBM, Smith PJB. Tumour markers in prostatic carcinoma: a comparison of prostate-specific antigen with acid phosphatase. British Journal of Urology 60: 69–73, 1987

    Article  CAS  PubMed  Google Scholar 

  • Foti AG, Cooper JF, Herschman H, et al. Detection of prostatic cancer by solid-phase radioimmunoassay of serum prostatic acid phosphatase. New England Journal of Medicine 297: 1357–1361, 1977

    Article  CAS  PubMed  Google Scholar 

  • Fowler JE, Taylor G, Blom J, Stuteman RE. Experience with serum alpha-fetoprotein and human chorionic gonadotropin in nonseminomatous testicular tumors. Journal of Urology 124: 365–368, 1980

    PubMed  Google Scholar 

  • Fucini C, Tommasi SM, Rosi S, Malatantis G, Cardona G, et al. Follow-up of colorectal cancer resected for cure: an experience with CEA, TPA, CA 19-9 analysis and second-look surgery. Diseases of the Colon and Rectum 30: 273–277, 1987

    Article  CAS  PubMed  Google Scholar 

  • Fujino N, Haga Y, Sakamoto K, Egami H, Kimura M, et al. Clinical evaluation of an immunoradiometric assay for CA 15-3 antigen associated with human mammary carcinomas: comparison with carcinoembryonic antigen. Japanese Journal of Clinical Oncology 16: 335–346, 1986

    CAS  PubMed  Google Scholar 

  • Ganz PA, Yeung Ma P, Wang HJ, Elashoff RM. Evaluation of three biochemical markers for serially monitoring the therapy of small-cell lung cancer. Journal of Clinical Oncology 5: 472–479, 1987

    CAS  PubMed  Google Scholar 

  • Germa-Lluch JR, Begent RHJ, Bagshawe KD. Tumor-marker levels and prognosis in malignant teratoma of the testis. British Journal of Cancer 42: 850, 1980

    Article  CAS  PubMed  Google Scholar 

  • Gibb I, Wilson LA, Powell PH, Tarbit I, Pratt D, et al. Immunological and colorimetric determination of prostatic acid phosphatase: technical and clinical reappraisal in symptomatic patients. Clinical Chemistry 32: 1760–1766, 1986

    CAS  PubMed  Google Scholar 

  • Gion M, Mione R, Dittadi R, Fasan S, Pallini A, et al. Evaluation of Ca 15/3 serum levels in breast cancer patients. Journal of Nuclear Medicine and Allied Sciences 30: 29–36, 1986

    CAS  PubMed  Google Scholar 

  • Gold P, Freedman SO. Demonstration of tumor specific antigens in human colonic carcinomata by immunologic tolerance and absorption techniques. Journal of Experimental Medicine 121: 439–462, 1965

    Article  CAS  PubMed  Google Scholar 

  • Goslin RH, Skarin AT, Zamcheck N. Carcinoembryonic antigen: a useful monitor of therapy of small cell lung cancer. Journal of the American Medical Association 246: 2173–2176, 1981

    Article  CAS  PubMed  Google Scholar 

  • Grem JL, Trump DL. Reversible increase in serum α-fetoprotein content associated with hepatic dysfunction during chemotherapy for seminoma. Journal of Clinical Oncology 4: 41–45, 1986

    CAS  PubMed  Google Scholar 

  • Gutman AB, Gutman EB. An ‘acid’ phosphatase occurring in the serum of patients with metastasizing carcinoma of the prostate gland. Journal of Clinical Investigation 17: 473–478, 1938

    Article  CAS  PubMed  Google Scholar 

  • Haglund C, Roberts PJ, Kuusela P, Jalanko H. Tumour markers in pancreatic cancer. Scandinavian Journal of Gastroenterology 21 (Suppl. 126): 75–78, 1986

  • Hayes DF, Zurawski VR, Kufe DW. Comparison of circulating CA15-3 and carcinoembryonic antigen levels in patients with breast cancer. Journal of Clinical Oncology 4: 1542–1550, 1986

    CAS  PubMed  Google Scholar 

  • Heyward WL, Lanier AP, McMahon BJ, Fitzgerald MA, Kilkenny S, et al. Early detection of primary hepatocellular carcinoma: screening for primary hepatocellular carcinoma among persons infected with hepatitis B virus. Journal of the American Medical Association 254: 3052–3054, 1985

    Article  CAS  PubMed  Google Scholar 

  • Horwich A, Peckham MJ. Transient tumor marker elevation following chemotherapy for germ cell tumors of the testis. Cancer Treatment Reports 70: 1329–1331, 1986

    CAS  PubMed  Google Scholar 

  • Jalanko H, Kuusela P, Roberts P, Sipponen P, Haglund C, et al. Comparison of a new tumour marker, CA 19-9, with α-fetoprotein and carcinoembryonic antigen in patients with upper gastrointestinal diseases. Journal of Clinical Pathology 37: 218–222, 1984

    Article  CAS  PubMed  Google Scholar 

  • Javadpour N. Misconceptions and source of errors in interpretation of cellular and serum markers in testicular cancer. Journal of Urology 135: 879, 1986

    CAS  PubMed  Google Scholar 

  • Khoo SK, Hurst T, Webb MJ, Dickie GJ, Kearsley JH, et al. Predictive value of serial CA 125 antigen levels in ovarian cancer evaluated by second-look laparotomy. European Journal of Cancer and Clinical Oncology 23: 765–771, 1987

    Article  CAS  Google Scholar 

  • Kobayashi K, Sugimoto T, Makino H, Kumagai M, Unoura M, et al. Screening methods for early detection of hepatocellular carcinoma. Hepatology 5: 1100–1105, 1985

    Article  CAS  PubMed  Google Scholar 

  • Koprowski H, Herlyn M, Steplewise Z, Sears HF. Specific antigen in serum of patients with colon carcinoma. Science 212: 53–55, 1981

    Article  CAS  PubMed  Google Scholar 

  • Krebs HB, Goplerud DR, Kilpatrick SJ, Myers MB, Hunt A. Role of CA 125 as tumor marker in ovarian carcinoma. Obstetrics and Gynecology 67: 473–477, 1986

    CAS  PubMed  Google Scholar 

  • Kuhbock J, Aiginger P, Kuzmits R, Spona J. Prognostic value of tumor marker determinations in testicular cancer patients. Cancer Detection and Prevention 10: 389–392, 1987

    CAS  PubMed  Google Scholar 

  • Kurman RJ, Scardino PT, McIntire KR, Waldmann TA, Javadpour N. Cellular localization of alpha-fetoprotein and human chorionic gonadotropin in germ cell tumors of the testis using an indirect immunoperoxidase technique: a new approach to classification utilizing tumor markers. Cancer 40: 2136–2152, 1977

    Article  CAS  PubMed  Google Scholar 

  • Laberge F, Fritsche HA, Umsawasdi T, Carr DT, Welch S, et al. Use of carcinoembryonic antigen in small cell lung cancer: prognostic value and relation to the clinical course. Cancer 59: 2047–2052, 1987

    Article  CAS  PubMed  Google Scholar 

  • Lambert J. The value of CA 125 serum assay in the management of ovarian cancer. British Journal of Obstetrics and Gynaecology 94: 193–195, 1987

    Article  CAS  PubMed  Google Scholar 

  • Lange PH, Nochomovitz LE, Rosai J, Fraley EE, Kennedy BJ, et al. Serum alpha-fetoprotein and human chorionic gonadotropin in patients with seminoma. Journal of Urology 124: 472–478, 1980

    CAS  PubMed  Google Scholar 

  • Loewenstein MS, Zamcheck N. Carcinoembryonic antigen (EA) levels in benign gastrointestinal disease states. Cancer 42: 1412–1418, 1978

    Article  CAS  PubMed  Google Scholar 

  • Lokich JJ, Zamcheck N, Lowenstein M. Sequential carcinoembryonic antigen levels in the therapy of metastatic breast cancer. Annals of Internal Medicine 89: 902–906, 1978

    CAS  PubMed  Google Scholar 

  • Loprinzi CL, Ahmann DL. Carcinoembryonic antigen: a routine test in patients with breast carcinoma? Archives of Internal Medicine 146: 2125–2126, 1986

    Article  CAS  PubMed  Google Scholar 

  • Loprinzi CL, Tormey DC, Rasmussen P, Falkson G, Davis TE, et al. Prospective evaluation of carcinoembryonic antigen levels and alternating chemotherapeutic regimens in metastatic breast cancer. Journal of Clinical Oncology 4: 46–56, 1986

    CAS  PubMed  Google Scholar 

  • Martin EW, Minton JP, Carcy LC. CEA-directed second-look surgery in the asymptomatic patient after primary resection of colorectal carcinoma. Annals of Surgery 202: 310–317, 1985

    Article  PubMed  Google Scholar 

  • Medical Research Council Working Party of Testicular Tumours. Prognostic factors in advanced non-seminomatous germ-cell testicular tumours: results of a multicentre study. Lancet 1: 8–11, 1985

    Google Scholar 

  • Moertel CG, O’Fallon JR, Go VLW, O’Connell MJ, Thynne GS. The preoperative carcinoembryonic antigen test in the diagnosis, staging and prognosis of colorectal cancer. Cancer 58: 603–610, 1986

    Article  CAS  PubMed  Google Scholar 

  • Mohler JL, Siami PF, Flanigan RC. False positive beta-human chorionic gonadotropin in testicular cancer. Urology 30: 252–254, 1987

    Article  CAS  PubMed  Google Scholar 

  • Newlands ES, Rustin GJS, Begent RHJ, Parker D, Bagshawe KD. Further advances in the management of malignant teratomas of the testis and other sites. Lancet 1: 948–951, 1983

    Article  CAS  PubMed  Google Scholar 

  • Pons-Anicet DMF, Krebs BP, Mira P, Namer M. Value of CA 15:3 in the follow-up of breast cancer patients. British Journal of Cancer 55: 567–569, 1987

    Article  CAS  PubMed  Google Scholar 

  • Robertson EA, Zweig MH, Steirteghem AC. Evaluating the clinical efficacy of laboratory tests. American Journal of Clinical Pathology 79: 78–86, 1983

    CAS  PubMed  Google Scholar 

  • Schmidt-Rhode P, Schulz KD, Sturm G, Raab-Frick A, Prinz H. CA 15.3 as a tumour marker in breast cancer. International Journal of Biological Markers 2: 135–142, 1987

    CAS  PubMed  Google Scholar 

  • Seamonds B, Yang N, Anderson K, Whitaker B, Shaw LM, et al. Evaluation of prostate-specific antigen and prostatic acid phosphatase as prostatic cancer markers. Urology 28: 472–479, 1986

    Article  CAS  PubMed  Google Scholar 

  • Shinkai T, Saijo N, Tominaga K, Eguchi K, Shimizu E, et al. Serial plasma carcinoembryonic antigen measurement for monitoring patients with advanced lung cancer during chemotherapy. Cancer 57: 1318–1323, 1986

    Article  CAS  PubMed  Google Scholar 

  • Sox HC. Probability theory in the use of diagnostic tests: an introduction to critical study of the literature. Annals of Internal Medicine 104: 60–66, 1986

    PubMed  Google Scholar 

  • Stamey TA, Yang N, Hay AR, McNeal JE, Freiha FS, et al. Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. New England Journal of Medicine 317: 909–916, 1987

    Article  CAS  PubMed  Google Scholar 

  • Steele G, Zamcheck N, Wilson R. Results of CEA-initiated second-look surgery for recurrent colorectal cancer. American Journal of Surgery 139: 544–549, 1980

    Article  PubMed  Google Scholar 

  • Steinberg WM, Gelfand R, Anderson KK, Glenn J, Kurtzman SH, et al. Comparison of the sensitivity and specificity of the CA 19-9 and carcinoembryonic antigen assays in detecting cancer of the pancreas. Gastroenterology 90: 343–349, 1986

    CAS  PubMed  Google Scholar 

  • Stevens DP, Mackay IR. Increased carcinoembryonic antigen in heavy cigarette smokers. Lancet 2: 1238–1239, 1973

    Article  CAS  PubMed  Google Scholar 

  • Tang ZY, Yang B. Early detection of subclinical hepatocellular carcinoma. In Tang ZY (Ed.) Subclinical hepatocellular carcinoma, pp. 12–21, China Academic Publishers, Beijing, and Springer Verlag, New York, 1985

    Google Scholar 

  • Tatsuta M, Yamamura H, Iishi H, Kasugai H, Okuda S. Value of serum alpha-fetoprotein and ferritin in the diagnosis of hepatocellular carcinoma. Oncology 43: 306–310, 1986

    Article  CAS  PubMed  Google Scholar 

  • Vecchio TJ. Predictive value of a single diagnostic test in unselected populations. New England Journal of Medicine 274: 1171–1173, 1966

    Article  CAS  PubMed  Google Scholar 

  • Vergote IB, Bormer OP, Abeler VM. Evaluation of serum CA 125 levels in the monitoring of ovarian cancer. American Journal of Obstetrics and Gynecology 157: 88–92, 1987

    CAS  PubMed  Google Scholar 

  • Virgi MA, Mercer DW, Herberman RB. Tumor markers in cancer diagnosis and prognosis. CA — A Cancer Journal for Clinicians 38: 104–126, 1988

    Article  Google Scholar 

  • Vogelzang NJ, Lange PH, Goldman A, Vessela RH, Fraley EE, et al. Acute changes of α-fetoprotein and human chorionic gonadotropin during induction chemotherapy of germ cell tumors. Cancer Research 42: 4855–4861, 1982

    CAS  PubMed  Google Scholar 

  • Vrba R, Alpert E, Isselbacher KJ. Immunological heterogeneity of serum carcinoembryonic antigen (CEA). Immunochemistry 13: 87–89, 1976

    Article  CAS  PubMed  Google Scholar 

  • Wanebo HJ, Stearns M, Schwartz MK. Use of CEA as an indicator of early recurrence and as a guide to a selected second-look procedure in patients with colorectal cancer. Annals of Surgery 188: 481–493, 1978

    Article  CAS  PubMed  Google Scholar 

  • Warnes TW, Smith A. Tumour markers in diagnosis and management. Bailliere’s Clinical Gastroenterology 1: 63–89, 1987

    Article  CAS  PubMed  Google Scholar 

  • Wilking N, Petrelli NJ, Herrera L, Holyoke ED, Mittelman A. Abdominal exploration for suspected recurrent carcinoma of the colon and rectum based upon elevated carcinoembryonic antigen alone or in combination with other diagnostic methods. Surgery, Gynecology and Obstetrics 162: 465–468, 1986

    CAS  PubMed  Google Scholar 

  • Zarate A, MacGregor C. Beta-subunit hCG and the control of trophoblastic disease. Seminars in Oncology 9: 187–190, 1982

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medicine Branch, National Cancer Institute, Bldg 10 Rm 12N226, Bethesda, Maryland, 20892, USA

    Susan E. Bates (Senior Staff Fellow)

Authors
  1. Susan E. Bates
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bates, S.E. The Use and Potential of Serum Tumour Markers, New and Old. Drugs 38, 9–18 (1989). https://doi.org/10.2165/00003495-198938010-00002

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00003495-198938010-00002

Keywords

Search

Navigation