Skip to main content
SpringerLink
Log in

The Treatment of Photoaged Human Skin by Topical Tretinoin

  • Leading Article
  • Published:
Drugs Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Bangham AD, Dingle JT, Lucy JA. Studies on the mode of action of excess vitamin A: IX. Penetration of lipid monolayers by compounds in the vitamin A series. Biochemical Journal 90: 133–140, 1964

    PubMed  CAS  Google Scholar 

  • Bollag W. Prophylaxis of chemically induced benign and malignant epithelial tumors by vitamin A acid (retinoic acid). European Journal of Cancer 8: 689–693, 1972

    Article  PubMed  CAS  Google Scholar 

  • Bollag W, Ott F. Vitamin A acid in benign and malignant epithelial tumors of the skin. Acta Dermato-Venereologica (Stockholm) 55 (Suppl.): 163–166, 1975

    Google Scholar 

  • Braverman IM, Fonferko E. Studies in cutaneous aging. I. The elastic fiber network. Journal of Investigative Dermatology 78: 434–444, 1982

    Article  PubMed  CAS  Google Scholar 

  • Connor MJ. Evaluation of retinoids (vitamin A derivatives) by their effects on epidermal histology. In Maibach HI & Lowe NJ (Eds) Models in dermatology, Vol. 3, S. Karger AG, Basel, 1986

    Google Scholar 

  • Connor MJ, Lowe NJ. Retinoid stimulation of epidermal cell growth in vivo. In Saurat J (Ed.) Retinoids, pp. 198–201, S. Karger AG, Basel, 1985

    Google Scholar 

  • Ehrlich HP, Hunt TK. Effects of cortisone and vitamin A on wound healing. Annals of Surgery 167: 324–329, 1976

    Article  Google Scholar 

  • Elias PM, Williams ML. Retinoid effects on epidermal differentiation. In Saurat JH (Ed.) Retinoids: new trends in research and therapy, pp. 138–158, S. Karger AG, Basel, 1985

    Google Scholar 

  • Gilchrest BA (Ed.). Skin and aging processes, pp. 97–103, CRC Press, Boca Raton, FL, 1984

    Google Scholar 

  • Grove GL, Grove MJ, Zerweck CR, Leyden JJ. Computerized laser doppler velocimetry assessment of cutaneous microcirculation: effects of topical tretinoin treatment in photoaged skin. In Program and Abstracts of the 46th Meeting of the American Academy of Dermatology, San Antonio, December 1987

  • Haas AA, Arndt KA. Selected therapeutic applications of topical tretinoin. Journal of the American Academy of Dermatology 15 (Suppl.): 870–877, 1986

    Article  PubMed  CAS  Google Scholar 

  • Keddie F. Use of vitamin A in the treatment of cutaneous diseases. Archives of Dermatology and Syphilology 58: 64–73, 1954

    Article  Google Scholar 

  • Kligman AM. Early destructive effects of sunlight on human skin. Journal of the American Medical Association 210: 2377–2380, 1969

    Article  PubMed  CAS  Google Scholar 

  • Kligman AM. Perspectives and problems in cutaneous gerontology. Journal of Investigative Dermatology 73: 39–46, 1979

    Article  PubMed  CAS  Google Scholar 

  • Kligman AM. Therapeutic aspects of retinoic acid in photoaging. Seminars in Dermatology 6: 136–140, 1987

    Google Scholar 

  • Kligman AM, Fulton Jr JE, Plewig G. Topical vitamin A acid in acne vulgaris. Archives of Dermatology 99: 469–476, 1969

    Article  PubMed  CAS  Google Scholar 

  • Kligman AM, Grove GL, Hirose R, Leyden JJ. Topical tretinoin for photoaged skin. Journal of the American Academy of Dermatology 15 (Suppl.): 836–859, 1986

    Article  PubMed  CAS  Google Scholar 

  • Kligman LH, Chen HD, Kligman AM. Topical retinoic acid enhances the repair of ultraviolet damaged dermal connective tissue. Connective Tissue Research 12: 139–150, 1984

    Article  PubMed  CAS  Google Scholar 

  • Kligman LH, Kligman AM. Photoaging in dermatology. In Fitzpatrick et al. (Eds) Dermatology in general medicine. 3rd ed., pp. 1470–1474, McGraw-Hill, New York, 1986

    Google Scholar 

  • Lavker RM, Kligman AM. Chronic heliodermatitis: a morphologic evaluation of chronic actinic dermal damage with emphasis on the role of mast cells. Journal of Investigative Dermatology 90: 325–330, 1988

    Article  PubMed  CAS  Google Scholar 

  • Lawrence D, Bern H. On the specificity of the response of mouse epidermis to vitamin A. Journal of Investigative Dermatology 31: 313–325, 1958

    PubMed  CAS  Google Scholar 

  • Mandy S. Tretinoin in the preoperative and postoperative management of dermabrasion. Journal of the American Academy of Dermatology 15 (Suppl.): 878–879, 1986

    Article  PubMed  CAS  Google Scholar 

  • Sams WM, Smith JG. The histochemistry of chronically sun damaged skin. Journal of Investigative Dermatology 37: 447–452, 1961

    Article  PubMed  CAS  Google Scholar 

  • Schumaker A, Stüttgen F. Vitamin A-saure bei Hyperkeratosen, epithelialen Tumoren und Akne. Deutsche Medizinische Wochenschrift 40: 1547–1551, 1971

    Article  Google Scholar 

  • Smith JG, Davidson EA, Sams WM, Clark RD. Alterations in human dermal connective tissue with age and chronic sun damage. Journal of Investigative Dermatology 39: 347–350, 1962

    Article  PubMed  CAS  Google Scholar 

  • Sporn MB, Dunlop NM, Newton DL, Smith JM. Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids). Federation Proceedings 35: 1332–1338, 1976

    PubMed  CAS  Google Scholar 

  • Sporn MB, Newton DL. Chemoprevention of cancer with retinoids. Federation Proceedings 38: 84–90, 1979

    Google Scholar 

  • Stüttgen G. Zur Lokalbehandlung von Keratosen mit Vitamin Asaure. Dermatologica 124: 65–80, 1962

    Article  Google Scholar 

  • Thomas JR. The therapeutic uses of topical vitamin A acid. Journal of the American Academy of Dermatology 4: 505–513, 1981

    Article  PubMed  Google Scholar 

  • Urbach F. Geographic pathology of skin cancers. In Urbach F (Ed.) The biologic effects of ultraviolet radiation, pp. 635–650, Pergamon Press, Oxford, 1969

    Google Scholar 

  • Weiss JS, Ellis CN, Headington JT, Tincoff T, Hamilton TA, et al. Topical tretinoin improves photoaged skin. Journal of the American Medical Association 259: 527–532, 1988

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, University of Pennsylvania, 244 Medical Education Building, 36th and Hamilton Walk, Philadelphia, Pennsylvania, 19104-6065, USA

    Albert M. Kligman

Authors
  1. Albert M. Kligman
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kligman, A.M. The Treatment of Photoaged Human Skin by Topical Tretinoin. Drugs 38, 1–8 (1989). https://doi.org/10.2165/00003495-198938010-00001

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00003495-198938010-00001

Search

Navigation