Skip to main content
SpringerLink
Log in

Use of Calciferol and its Metabolites and Analogues in Osteoporosis

Current Status

  • Leading Article
  • Published:
Drugs Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Aloia J, Vaswani A, Yeh J, Ellis K, Cohn S. Calcitriol in the treatment of postmenopausal osteoporosis. In Cohn et al. (Eds) Calcium regulation and bone metabolism: basic and clinical aspects, pp. 113–118, Elsevier Science Publishers, Amsterdam, 1987a

    Google Scholar 

  • Aloia JF, Vaswani A, Yeh J, Ellis K, Cohn SH. Treatment of postmenopausal osteoporosis with calcitriol. In Christiansen et al. (Eds) Osteoporosis 1987, Vol. 2, pp. 850–852, Osteopress ADS, Copenhagen, 1987b

    Google Scholar 

  • Bouillon R, Auwerx JH, Lissens WD, Pelemans WK. Vitamin D status in the elderly: seasonal substrate deficiency causes 1,25-dihydroxycholecalciferol deficiency. American Journal of Clinical Nutrition 45: 755–763, 1987

    PubMed  CAS  Google Scholar 

  • Brautbar N. Osteoporosis: is 1,25-(OH)2D3 of value in treatment? Nephron 44: 161–166, 1986

    Article  PubMed  CAS  Google Scholar 

  • Caniggia A, Nuti R, Lore’ F, Vattimo A. 1,25 (OH)2 Vitamin D3 in the long-term treatment of post-menopausal osteoporosis. In Norman et al. (Eds) Vitamin D: a chemical, biochemical and clinical update, pp. 986–995, Walter de Gruyter & Co, Berlin, 1985

    Google Scholar 

  • Christiansen C, Christensen MS, McNair P, Hagen C, Stocklund K-E, et al. Prevention of early postmenopausal bone loss: controlled 2-year study in 315 normal females. European Journal of Clinical Investigation 10: 273–279, 1980

    Article  PubMed  CAS  Google Scholar 

  • Christiansen C, Christensen MS, Rodbro P, Hagen C, Transbol I. Effect of 1,25-dihydroxy vitamin D3 itself or combined with hormone treatment in preventing post-menopausal osteoporosis. European Journal of Clinical Investigation 11: 305–309, 1981

    Article  PubMed  CAS  Google Scholar 

  • Conference Report. Consensus development conference: prophylaxis and treatment of osteoporosis. British Medical Journal 295: 914–915, 1987

    Article  Google Scholar 

  • Crilly RG, Horsman A, Peacock M, Nordin BEC. The vitamin D metabolites in the pathogenesis and management of osteoporosis. Current Medical Research and Opinion 7: 337–348, 1981

    Article  PubMed  CAS  Google Scholar 

  • Davies M, Mawer EB, Adams PH. Vitamin D metabolism and the response to l,25-dihydroxycholecalciferol in osteoporosis. Journal of Clinical Endocrinology and Metabolism 45: 199–208, 1977

    Article  PubMed  CAS  Google Scholar 

  • DeLuca HF. Recent advances in our understanding of the vitamin D endocrine system. Journal of Laboratory and Clinical Medicine 87: 7–26, 1976

    CAS  Google Scholar 

  • Duda JJ, Kumar R, Nelson KI, Zinsmeister AR, Mann KG, et al. 1,25-Dihydroxyvitamin D stimulation test for osteoblast function in normal and osteoporotic postmenopausal women. Journal of Clinical Investigation 79: 1249–1253, 1987

    Article  PubMed  Google Scholar 

  • Dykman TR, Haralson KM, Gluck OS, Murphy WA, Teitelbaum SL, et al. Effect of oral 1,25-dihydroxyvitamin D and calcium on glucocorticoid-induced osteopenia in patients with rheumatic diseases. Arthritis and Rheumatism 27: 1336–1343, 1984

    Article  PubMed  CAS  Google Scholar 

  • Editorial. Osteoporosis. Lancet 2: 833–872, 1987

  • Falch JA, Odegaard OR, Finnanger AM, Matheson I. Postmenopausal osteoporosis: no effect of three years treatment with l,25-dihydroxycholecalciferol. Acta Medica Scandinavica 221: 199–204, 1987a

    Article  PubMed  CAS  Google Scholar 

  • Falch JA, Oftebro H, Haug E. Early postmenopausal bone loss is not associated with a decrease in circulating levels of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, or vitamin D-binding protein. Journal of Clinical Endocrinology and Metabolism 64: 836–841, 1987b

    Article  PubMed  CAS  Google Scholar 

  • Forero MS, Klein RF, Nissenson RA, Nelson K, Heath H, et al. Effect of age on circulating immunoreactive and bioactive parathyroid hormone levels in women. Journal of Bone and Mineral Research 2: 363–366, 1987

    Article  PubMed  CAS  Google Scholar 

  • Francis RM, Peacock M, Aaron JE, Selby PL, Taylor GA, et al. Osteoporosis in hypogonadal men: role of decreased plasma 1,25-dihydroxyvitamin D, calcium malabsorption, and low bone formation. Bone 7: 261–268, 1986

    Article  PubMed  CAS  Google Scholar 

  • Francis RM, Peacock M, Barkworth SA. Renal impairment and its effects on calcium metabolism in elderly women. Age and Ageing 13: 14–20, 1984a

    Article  PubMed  CAS  Google Scholar 

  • Francis RM, Peacock M, Gibbs CJ, Barkworth SA. Malabsorption of calcium in elderly osteoporotic women. In Norman et al. (Eds) Vitamin D: a chemical, biochemical and clinical update, pp. 1049–1050, Walter de Gruyter & Co., Berlin, 1985

    Google Scholar 

  • Francis RM, Peacock M, Storer JH, Davies AEJ, Brown WB, et al. Calcium malabsorption in the elderly: the effect of treatment with oral 25-hydroxyvitamin D3. European Journal of Clinical Investigation 13: 391–396, 1983

    Article  PubMed  CAS  Google Scholar 

  • Francis RM, Peacock M, Taylor GA, Storer JH, Nordin BEC. Calcium malabsorption in elderly women with vertebral fractures: evidence for resistance to the action of vitamin D metabolites on the bowel. Clinical Science 66: 103–107, 1984b

    PubMed  CAS  Google Scholar 

  • Frost HM. Coherence treatment of osteoporosis. Orthopaedic Clinics of North America 12: 649–669, 1981

    CAS  Google Scholar 

  • Gallagher JC, Jerpbak CM, Jee WSS, Johnson KA, DeLuca HF, et al. 1,25-Dihydroxyvitamin D3: short- and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis. Proceedings of the National Academy of Sciences 79: 3325–3329, 1982

    Article  CAS  Google Scholar 

  • Gallagher JC, Recker RR. A comparison of the effects of calcitriol or calcium supplements on bone in postmenopausal osteoporosis. In Norman et al. (Eds) Vitamin D: a chemical, biochemical and clinical update, pp. 971–975, Walter de Gruyter &Co., Berlin, 1985

    Google Scholar 

  • Heaney RP. Calcium bone health, and osteoporosis. In Peck (Ed.) Bone and mineral research, pp. 255–301, Elsevier Science Publishers, Amsterdam, 1986

    Google Scholar 

  • High WB, Capen CC, Black HE. Histomorphometric evaluation of the effects of intermittent l,25-dihydroxycholecalciferol administration on cortical bone remodeling in adult dogs. American Journal of Pathology 104: 41–49, 1981

    PubMed  CAS  Google Scholar 

  • Holtrop ME, Cox KA, Clark MB, Holick MF, Anast CS. 1,25-Dihydroxycholecalciferol stimulates osteoclasts in rat bones in the absence of parathyroid hormone. Endocrinology 108: 2293–2301, 1981

    Article  PubMed  CAS  Google Scholar 

  • Jackson JA, Kleerekoper M, Parfitt AM, Rao DS, Villanueva AR, et al. Bone histomorphometry in hypogonadal and eugonadal men with spinal osteoporosis. Journal of Clinical Endocrinology and Metabolism 65: 53–58, 1987

    Article  PubMed  CAS  Google Scholar 

  • Jensen GF, Christiansen C, Transbol I. Treatment of post menopausal osteoporosis: a controlled therapeutic trial comparing oestrogen/gestagen, 1,25-dihydroxy-vitamin D3 and calcium. Clinical Endocrinology 16: 515–524, 1982

    Article  PubMed  CAS  Google Scholar 

  • Jensen GF, Meinecke B, Boesen J, Transbol I. Does 1,25(OH)2D3 accelerate spinal bone loss? A controlled therapeutic trial in 70-year-old women. Clinical Orthopaedics and Related Research 192: 215–221, 1985

    PubMed  Google Scholar 

  • Lawoyin S, Zerwekh JE, Glass K, Pak CYC. Ability of 25-hydroxyvitamin D3 therapy to augment serum 1,25- and 24,25-dihydroxyvitamin D in postmenopausal osteoporosis. Journal of Clinical Endocrinology and Metabolism 50: 593–596, 1980

    Article  PubMed  CAS  Google Scholar 

  • Lindsay R, Hart DM, Forrest C, Baird C. Prevention of spinal osteoporosis in oophorectomised women. Lancet 2: 1151–1153, 1980

    Article  PubMed  CAS  Google Scholar 

  • Lund B, Sorenson OH, Andersen RB, Lund B, Mosekilde L, et al. Long term treatment of senile osteopenia with 1α-hydroxycholecalciferol. In Norman et al. (Eds) Vitamin D: a chemical, biochemical and clinical update, pp. 1039–1040, Walter de Gruyter & Co., Berlin, 1985

    Google Scholar 

  • Marder HK, Tsang RC, Hug G, Crawford AC. Calcitriol deficiency in idiopathic juvenile osteoporosis. American Journal of Diseases of Children 136: 914–917, 1982

    PubMed  CAS  Google Scholar 

  • Martin AD, Houston CS. Osteoporosis, calcium and physical activity. Canadian Medical Association Journal 136: 587–593, 1987

    PubMed  CAS  Google Scholar 

  • Meller Y, Kestenbaum RS, Galinsky D, Shany S. Seasonal variation in serum levels of vitamin D metabolites and parathormone in geriatric patients with fractures in southern Israel. Israel Journal of Medical Science 22: 8–11, 1986

    CAS  Google Scholar 

  • Need AG, Horowitz M, Philcox JC, Nordin BEC. 1,25-Dihydroxycalciferol and calcium therapy in osteoporosis with calcium malabsorption: dose response relationship of calcium absorption and indices of bone turnover. Mineral Electrolyte Metabolism 11: 35–40, 1985

    CAS  Google Scholar 

  • Olah AJ, Reutter FW, Haas HG, Schulz W, Kovarik J. Histological bone changes in postmenopausal osteoporosis treated with sodium fluoride and 1,25(OH)2D3. Abstract. Journal of Bone and Mineral Research 1: 149, 1986

    Google Scholar 

  • Orwoll ES, Meier DE. Alterations in calcium, vitamin D, and parathyroid hormone physiology in normal men with aging: relationship to the development of senile osteopenia. Journal of Clinical Endocrinology and Metabolism 63: 1262–1269, 1986

    Article  PubMed  CAS  Google Scholar 

  • Ott SM, Chesnut CH. Calcitriol treatment in patients with postmenopausal osteoporosis. In Christiansen et al. (Eds) Osteoporosis 1987, Vol. 2, pp. 844–849, Osteopress ADS, Copenhagen, 1987

    Google Scholar 

  • Parfitt AM. The morphologic basis of bone mineral measurements: transient and steady state effects of treatment in osteoporosis. Editorial. Mineral Electrolyte Metabolism 4: 273–287, 1980

    Google Scholar 

  • Parfitt AM. The cellular basis of bone remodeling: the quantum concept re-examined in light of recent advances in cell biology of bone. Calcified Tissue International 36: S37–S45, 1984

    Article  PubMed  Google Scholar 

  • Parfitt AM. Accelerated cortical bone loss: primary and secondary hyperparathyroidism. In Uhthoff & Jaworski (Eds) Current concepts of bone fragility, pp. 279–285, Springer-Verlag, Berlin, 1986

    Chapter  Google Scholar 

  • Parfitt AM. Pathogenesis of vertebral fracture: qualitative abnormalities in bone architecture and bone age. In Roche AF (Ed.) Osteoporosis: current concepts. Report of the 7th Ross Conference on Medical Research, Ross Laboratories, Columbus, Ohio, April 1986, pp. 18–22, 1987a

    Google Scholar 

  • Parfitt AM. Bone remodeling and bone loss: understanding the pathophysiology of osteoporosis. Clinical Obstetrics and Gynecology 30: 789–811, 1987b

    Article  PubMed  CAS  Google Scholar 

  • Parfitt AM. Osteomalacia and related disorders. In Avioli & Krane (Eds) Metabolic bone disease, 2nd ed., Grune and Stratum, New York, in press, 1988

    Google Scholar 

  • Parfitt AM, Frame B. Drug treatment of rickets and osteomalacia. Seminars on Drug Treatment 2: 83–115, 1972

    CAS  Google Scholar 

  • Parfitt AM, Gallagher JC, Heaney RP, Johnston CC, Neer R, et al. Vitamin D and bone health in the elderly. American Journal of Clinical Nutrition 36: 1014–1031, 1982

    PubMed  CAS  Google Scholar 

  • Parfitt AM, Kleerekoper M. Diagnostic value of bone histomorphometry and comparison of histologic measurements and biochemical indices of bone remodeling. In Christiansen et al. (Eds) Osteoporosis. Proceedings of the Copenhagen International Symposium on Osteoporosis, Aalborg Stiftsbogtrykkeri, June 1984, pp. 111–120, 1984

    Google Scholar 

  • Parfitt AM, Mathews CHE, Brommage R, Jarnagin K, DeLuca HF. Calcitriol but no other metabolite of vitamin D is essential for normal bone growth and development in the rat. Journal of Clinical Investigation 73: 576–586, 1984

    Article  PubMed  CAS  Google Scholar 

  • Parfitt AM, Simon LS, Villanueva AR, Krane SM. Procollagen type carboxy-terminal extension peptide in serum as a marker of collagen biosynthesis in bone: correlation with iliac bone formation rates and comparison with total alkaline phosphatase. Journal of Bone and Mineral Research 2: 427–437, 1987

    Article  PubMed  CAS  Google Scholar 

  • Recker RR, Gallagher JC, Heaney RP. The metabolic effects of treatment with calcitriol in patients with postmenopausal osteoporosis. Abstract. Clinical Research 32: 406A, 1984

    Google Scholar 

  • Riggs BL. Treatment of osteoporosis with sodium fluoride: an appraisal. In Peck WA (Ed.) Bone and mineral research, Annual 2, pp. 366–393, Elsevier Science Publishers BV, Amsterdam, 1983

    Google Scholar 

  • Riggs BL. Vitamin D and involutional osteoporosis. In Kumar R (Ed.) Vitamin D, pp. 555–577, Martinus Nijhoff Publishing, Boston, 1984

    Google Scholar 

  • Riggs BL. Role of the vitamin D-endocrine system in pathogenesis of involutional osteoporosis. In Norman et al. (Eds) Vitamin D: a chemical, biochemical and clinical update, pp. 976–985, Walter de Gruyter & Co., Berlin, 1985

    Google Scholar 

  • Riggs BL, Gallagher JC, DeLuca HF, Edis AJ, Lambert PW, et al. A syndrome of osteoporosis, increased serum immunoreactive parathyroid hormone, and inappropriately low serum 1,25-dihydroxyvitamin D. Mayo Clinic Proceedings 53: 701–706, 1978

    PubMed  CAS  Google Scholar 

  • Riggs BL, Hamstra A, DeLuca HF. Assessment of 25-hydroxyvitamin D 1α-hydroxylase reserve in postmenopausal osteoporosis by administration of parathyroid extract. Journal of Clinical Endocrinology and Metabolism 53: 833–835, 1981

    Article  PubMed  CAS  Google Scholar 

  • Riggs BL, Melton LJ. Medical progress: involutional osteoporosis. New England Journal of Medicine 314: 1676–1686, 1986

    Article  PubMed  CAS  Google Scholar 

  • Santora AC. Role of nutrition and exercise in osteoporosis. American Journal of Medicine 82(Suppl. 1B): 73–79, 1987

    Article  PubMed  Google Scholar 

  • Schwartzman MS, Franck WA. Vitamin D toxicity complicating the treatment of senile, postmenopausal, and glucocorticoidinduced osteoporosis. American Journal of Medicine 82: 224–230, 1986

    Article  Google Scholar 

  • Slovik DM. The vitamin D endocrine system, calcium metabolism, and osteoporosis. Special Topics in Endocrinology and Metabolism 5: 83–148, 1983

    PubMed  CAS  Google Scholar 

  • Slovik DM, Rosenthal DI, Doppelt SH, Potts JT, Daly MA, et al. Restoration of spinal bone in osteoporotic men by treatment with human parathyroid hormone (1-34) and 1,25-dihydroxyvitamin D. Journal of Bone and Mineral Research 1: 377–381, 1986

    Article  PubMed  CAS  Google Scholar 

  • Sorensen OH, Lumholtz B, Lund B, Hjelmstrand IL, Mosekilde L, et al. Acute effects of parathyroid hormone on vitamin D metabolism in patients with the bone loss of aging. Journal of Clinical Endocrinology and Metabolism 54: 1258–1261, 1982

    Article  PubMed  CAS  Google Scholar 

  • Tsai K-S, Heath H, Kumar R, Riggs BL. Impaired vitamin D metabolism with aging in women: possible role in pathogenesis of senile osteoporosis. Journal of Clinical Investigation 73: 1668–1672, 1984

    Article  PubMed  CAS  Google Scholar 

  • Tsai K-S, Wahner HW, Offord KP, Melton LJ, Kumar R, et al. Effect of aging on vitamin D stores and bone density in women. Calcified Tissue International 40: 241–243, 1987

    Article  PubMed  CAS  Google Scholar 

  • Woolf AD, Dixon ASJ. Osteoporosis, an update on management. Drugs 28: 565–576, 1984

    Article  PubMed  CAS  Google Scholar 

  • Young G, Marcus R, Minkoff JR, Kim LY, Segre GV. Age-related rise in parathyroid hormone in man: the use of intact and mid molecule antisera to distinguish hormone secretion from retention. Journal of Bone and Mineral Research 2: 367–374, 1987

    Article  PubMed  CAS  Google Scholar 

  • Zerwekh JE, Sakhalee K, Glass K, Pak CYC. Long term 25-hydroxyvitamin D3 therapy in postmenopausal osteoporosis: demonstration of responsive and nonresponsive subgroups. Journal of Clinical Endocrinology and Metabolism 56: 410–413, 1983

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Bone and Mineral Research Laboratory, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, Michigan, 48202, USA

    A. M. Parfitt

Authors
  1. A. M. Parfitt
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Parfitt, A.M. Use of Calciferol and its Metabolites and Analogues in Osteoporosis. Drugs 36, 513–520 (1988). https://doi.org/10.2165/00003495-198836050-00001

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00003495-198836050-00001

Keywords

Search

Navigation