References
Amann FW, Bolli P, Kiowski W, Bühler FR. Enhanced alpha-adrenoceptor-mediated vasoconstriction in essential hypertension. Hypertension 3(Suppl. I): I119–I123, 1981
Ames RP, Hill P. Increase in serum lipids during treatment of hypertension with chlorthalidone. Lancet 1: 721, 1976
Amodeo C, Kobrin I, Ventura HO, Messerli FH, Fröhlich ED. Immediate and short-term hemodynamic effects of diltiazem in patients with hypertension. Circulation 73: 108–113, 1986
Ashley CC, Castell LM, Ledingham JGG, Osborn C, Pritschard K, et al. Relationships between lymphocyte and platelet intracellular free calcium concentrations, plasma-ionized calcium, and blood pressure in essential hypertension in humans. Journal of Physiology (London) 86P: 106, 1986
Astrand PO, Rodahl K. Textbook of work physiology, McGraw Hill, New York, 1970
Bertel O, Bühler FR, Kiowski K, Lütold BE. Decreased beta-adrenoceptor responsiveness as related to age, blood pressure and plasma catecholamines in essential hypertension. Hypertension 2: 130–138, 1980
Bolli P, Amann FW, Bühler FR. Antihypertensive response to postsynaptic alpha-blockade with prazosin in low and normal renin hypertension. Journal of Cardiovascular Pharmacology 2: 399S–405S, 1980
Bolli P, Bühler FR. Risk and risk minimization of drug induced adversity in hypertension. Progress in Pharmacology 6: 33–44, 1985
Bolli P, Erne P, Ji BH, Block LH, Kiowski W, et al. Adrenaline induces vasoconstriction through postjunctional α2-adrenoceptors and this response is enhanced in patients with essential hypertension. Journal of Hypertension 1(Suppl. 2): 257–259, 1983
Brouwer RML, Bolli P, Erne P, Conen D, Kiowski W, et al. Antihypertensive treatment using calcium antagonists in combination with captopril rather than diuretics. Journal of Cardiovascular Pharmacology 7(Suppl. 4): S88–S91, 1985a
Brouwer RML, Follath F, Bühler FR. Review of the cardiovascular adversity of the calcium antagonist betablocker combination: implications for antihypertensive therapy. Journal of Cardiovascular Pharmacology 7(Suppl. 4): S38–S44, 1985b
Brunner HR, Sealey JE, Laragh JH. Renin subgroups in essential hypertension. Circulation Research 32(Suppl. 1): 99–105, 1973
Bruschi G, Bruschi ME, Caroppo M, Orlandini G, Spaggiari M, et al. Cytoplasmic free calcium is increased in the platelets of spontaneously hypertensive rats and essential hypertensive patients. Clinical Science 68: 179–184, 1985
Bühler FR. Antihypertensive action of beta-blockers. In Laragh et al. (Eds) Frontiers in hypertension research, pp. 423–436, Springer, New York, 1981
Bühler FR, Bertel O, Lütold BE. Simplified and age-stratified antihypertensive therapy based on betablockers. Cardiovascular Medicine 3: 135–148, 1978
Bühler FR, Bolli P, Kiowski W, Erne P, Hulthén UL, et al. Renin profiling to select antihypertensive baseline drugs. American Journal of Medicine 20: 36–42, 1984
Bühler FR, Burkart F, Lütold BE, Küng M, Marbet G, et al. Antihypertensive betablocking action as related to renin and age: a pharmacological tool to identify pathogenic mechanisms in essential hypertension. American Journal of Cardiology 36: 653–669, 1975
Bühler FR, Hulthén UL, Kiowski W, Bolli P. The place of the calcium antagonist verapamil in antihypertensive therapy. Journal of Cardiovascular Pharmacology 4: S350–S357, 1982
Bühler FR, Kiowski W, van Brummelen P, Amann FW, Bertel O, et al. Plasma adrenoceptor mediated and cardiac, renal and peripheral vascular adrenoceptor mediated responses in different age groups of normal and hypertensive subjects. Clinical Experimental Hypertension 2: 409–426, 1980
Bühler FR, Laragh JH, Vaughan Jr ED, Brunner HR, Gavras H, et al. The antihypertensive action of propranolol: specific anti-renin responses in high and normal renin essential, renal, renovascular and malignant hypertension. American Journal of Cardiology 32: 511–522, 1973
Burger RA, Carter DG, Gardiner DG, Higgins AJ. Amlodipine: a new dihydropyridine calcium channel blocker with slow onset and long duration of action. British Journal of Pharmacology 85: 281P, 1985
Burkart F, Bühler FR, Pfisterer M, Lütold BE, Küng M. Hemodynamic responses to exercise and acute betablockade in renin subtypes of essential hypertension. Clinical Science 51(Suppl. 3): 493s–496s, 1976
Campbell BC, Sturani A, Reid JL. Evidence of parasympathetic activity of angiotensin converting enzyme inhibitors, captopril, in normotensive man. Clinical Science 68: 49–56, 1985
Carvalho AC, Colman RW, Lees RS. Platelet function in hyper-lipoproteinaemia. New England Journal of Medicine 290: 434, 1974
Crane MG, Harris JJ, Johus VJ. Hyporeninemic hypertension. American Journal of Medicine 52: 457–466, 1972
Croog SH, Levine S, Testa MA, Brown B, Bulpitt CJ, et al. The effects of antihypertensive therapy on the quality of life. New England Journal of Medicine 314: 1657–1664, 1986
Dustan HP. Nitrendipine in Black US patients. Journal of Cardiovascular Pharmacology 9(Suppl. 4): S267–S271, 1987
Erne P, Bolli P, Bertel O, Hulthén UL, Kiowski W, et al. Factors influencing the hypotensive effects of calcium antagonists. Hypertension 5(Suppl. II): 97–102, 1983
Erne P, Bolli P, Bürgisser E, Bühler FR. Correlation of platelet calcium with blood pressure: effect of antihypertensive therapy. New England Journal of Medicine 310: 1084–1088, 1984
European Working Party on High Blood Pressure in the Elderly. Mortality and morbidity results from the European Working Party on high blood pressure in the elderly. Lancet 1: 1349–1354, 1985
Fleisch JH. Age-related changes in the sensitivity of blood vessels to drugs. Pharmacology and Therapeutics 8: 477–487, 1980
Fritschka E. Crossover comparison of nitrendipine with propranolol in patients with essential hypertension. Journal of Cardiovascular Pharmacology 9(Suppl. 4)
Gribbin B, Pickering TG, Sleight P, Peto R. Effect of age and high blood pressure on baroreflex sensitivity in man. Circulation Research 29: 424–429, 1971
Hall WD. Pharmacologic therapy of hypertension in blacks. In Hall et al. (Eds) Epidemiology, pathophysiology and treatment, pp. 31–47, Year Book Medical Publishers, Chicago, 1985
Hulthén UL, Bolli P, Amann FW, Kiowski W, Bühler FR. Enhanced vasodilatation in essential hypertension by calcium channel blockade with verapamil. Hypertension 4(Suppl. II): 26–31, 1982
IPPPSH Collaborative Group. Cardiovascular risks and risk factors in a randomized trial of treatment based on the beta-blocker Oxprenolol: The International Prospective Primary Prevention Study in Hypertension (IPPPSH). Journal of Hypertension 3: 379–392, 1985
Kenneth J, van Brummelen P, Vermey P, Timmermanns PBMWM, van Zwieten PA. Alpha-1- and alpha-2-adrenoceptor mediated vasoconstriction in the forearm of normotensive and hypertensive subjects. Journal of Cardiovascular Pharmacology 8: 190–196, 1986
Kiowski W, Bertel O, Erne P, Hulthén UL, Bolli P, et al. Haemodynamic and reflex mechanisms of acute and chronic antihypertensive therapy with the calcium channel blocker nifedipine. Hypertension 5(Suppl. 1): 170–174, 1983
Kiowski W, Bühler FR, Fadayomi MO, Erne P, Müller FB, et al. Age, race, blood pressure and renin: predictors for antihypertensive treatment with calcium antagonists. American Journal of Cardiology 56: 81H–85H, 1985
Kiowski W, Julius S. Renin response to stimulation of cardiopulmonary mechanoreceptors in man. Journal of Clinical Investigation 62: 656–663, 1978
Kohner EM, Dollery CT, Lowy C, Schumber B. Effect of diuretic therapy on glucose tolerance in hypertensive patients. Lancet 1: 986, 1971
Langer SZ. Presynaptic receptors and their role in the regulation of transmitter release: sixth Gaddum memorial lecture. British Journal of Pharmacology 60: 481–497, 1977
Leary WP, Asmal AC. Treatment of hypertension with verapamil. Current Therapeutic Research 25: 747–752, 1979
Le Quan-Sang KH, Montenay-Garestier T, Devynck MA. Platelet cytosolic free calcium concentration in essential hypertension. Nouvelle Revue Française d’Hématologie 27: 279–283, 1985
Lijnen P, M’Buyamba JR, Fagard R, Staessen J, Amery A. Age-related hypotensive response to captopril in hypertensive patients. Methods and Findings in Experimental and Clinical Pharmacology 5(9): 655–660, 1983
Management Committee of the Australian National Blood Pressure Study. Prognostic factors in the treatment of mild hypertension. Circulation 69: 668–676, 1984
May GS, Eberlin KA, Furberg CD, Passamani ER, DeMets DL. Secondary prevention after myocardial infarction: a review of long-term trials. Progress in Cardiovascular Diseases 24: 331–352, 1982
M’Buyamba-Kabangu JR, Fagard R, Lijnen P, Amery A. Nitrendipine and acebutolol in hypertensive African blacks. Journal of Cardiovascular Pharmacology 9(Suppl. 4): S263–S266, 1987
Moser M, Cunn J. Comparative effects of pindolol and hydrochlorothiazide in black hypertensive patients. Angiology 32: 561, 1981
Moser M, Cunn J. Responses to captopril and hydrochlorothiazide in black patients with hypertension. Clinical Pharmacology and Therapeutics 32: 307, 1982
Moser M, Cunn J, Materson BJ. Comparative effects of diltiazem and hydrochlorothiazide in Blacks with systemic hypertension. American Journal of Cardiology 56: 101H–104H, 1985
Moser M, Cunn J, Nash DT, Burris JF, Winer N, et al. Nitrendipine in the treatment of mild to moderate hypertension. Journal of Cardiovascular Pharmacology 6(Suppl. 7): S1085–S1089, 1984
MRC trial of treatment of mild hypertension: principal results. British Medical Journal 291: 89–90, 1985
MRFIT (Multiple Risk Factor Intervention Trial Research Group). Multiple risk factor intervention trial, risk factor changes and mortality results. Journal of the American Medical Association 248: 1465–1477, 1982
Müller FB, Bolli P, Erne P, Block LH, Kiowski W, et al. Antihypertensive therapy with the long-acting calcium-antagonist nitrendipine. Pharmacology 6: S1073–S1076, 1984
Müller FB, Bolli P, Linder L, Kiowski W, Erne P, et al. Calcium antagonists and the second drug for antihypertensive therapy. American Journal of Medicine 81(6A): 25–29, 1986a
Müller FB, Ha HR, Hotz H, Schmidlin O, Follath F, et al. Once a day verapamil in essential hypertension. British Journal of Clinical Pharmacology 21(Suppl. 2): 143S–147S, 1986b
Müller FB, Sealey JE, Case DB, Atlas SA, Pickering TG, et al. The captopril-test for identifying renovascular disease in hypertensive patients. American Journal of Medicine 80: 633–644, 1986c
Oliver MF, Kurien VA, Greenwood TW. Relation between serum-free-fatty-acids and arrhythmias and death after acute myocardial infarction. Lancet 1: 710, 1968
Pedrinelli R, Fonad FM, Tarazi RC, Bravo EL, Textor SC. Nitrendipine, a calcium-entry blocker: renal and humoral effects in human arterial hypertension. Archives of Internal Medicine 146: 62–65, 1986
Resink TJ, Dimitrov D, Zschauer A, Erne P, Tkachuk VA, et al. Platelet calcium-linked abnormalities in essential hypertension. Annals of the New York Academy of Sciences 488: 252–265, 1986a
Resink TJ, Tkachuk VA, Erne P, Bühler FR. Platelet membrane calmodulin-stimulated calcium-adenosine triphosphatase: altered activity in essential hypertension. Hypertension 8: 159–166, 1986b
Resnick LM, Nicholson JP, Laragh JH. Calcium metabolism and the renin-aldosterone system in essential hypertension. Journal of Cardiovascular Pharmacology 7(Suppl. 6): S187–S193, 1985
Ribstein J, de Treglode D, Mimran A. Acute effect of nifedipine on arterial pressure in healthy subjects and hypertensives. Archives de Maladies du Coeur et des Vaisseaux 78: 29–32, 1985
Robinson BF, Dobbs RJ, Kelsey CR. Effects of nifedipine on resistance vessels, arteries and veins in man. British Journal of Clinical Pharmacology 10: 433–438, 1980
Swales JD, Bing RF, Swart S, Thurston H. Diuretics, sodium intake, and renin in the management of hypertension. Journal of Cardiovascular Pharmacology 6: S250–S255, 1984
Sweet CS, Kadowitz PJ, Brody MJ. Arterial hypotension elicited by prolonged intravertebral infusion of angiotensin II in conscious dogs. American Journal of Physiology 221: 1640–1641, 1971
Ueda A, Uchida Y, Ueda K, Gondaira T, Katayama S. Centrally mediated vasopressor effects of angiotensin II in man. Japanese Heart Journal 10: 243–247, 1969
van Brummelen P, Bühler FR, Kiowski W, Amann FW. Age-related decrease in cardiac and peripheral vascular responsiveness to isoproterenol. Clinical Science 60: 571–577, 1981
Vaughan Jr ED, Laragh JH, Gavras I, Bühler FR, Gavras H, et al. The volume factor in low and normal renin essential hypertension: its treatment with either spironolactone or chlorthalidone. American Journal of Cardiology 32: 523–532, 1973
Veterans Administration Cooperative Study Group on Antihypertensive Agents. Effects of treatment on morbidity in hypertension: III. Influence of age, diastolic pressure, and prior cardiovascular disease; further analysis of side effects. Circulation 45: 991–995, 1972
Veterans Administration Cooperative Study Group on Antihypertensive Agents. Comparison of propranolol and hydrochlorothiazide for the initial treatment of hypertension. I. Results of short-term titration with emphasis on racial differences in response. II. Results of long-term therapy. Journal of the American Medical Association 248: 1996–2011, 1982
Weinberger MH. The role of age, race and plasma renin activity in influencing the blood pressure response to nitrendipine or hydrochlorothiazide. Journal of Cardiovascular Pharmacology 9(Suppl. 4): S272–S275, 1987
WHO. 1986 guidelines for the treatment of mild hypertension: memorandum from a WHO/ISH meeting. Journal of Hypertension 4: 383–386, 1986
Yusuf S, Peto R, Lewis J, Pollius R, Sleight P. Betablockade during and after myocardial interaction: an overview of the randomized trials. Progress in Cardiovascular Diseases 27: 335–371, 1985
Zachariah PK, Schwartz GL, Ritter SG, Strong CG. Plasma predictors of calcium channel blocker efficacy in hypertension. Journal of Cardiovascular Pharmacology 9(Suppl. 4): S148–S153, 1987
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Bühler, F.R. Antihypertensive Treatment According to Age, Plasma Renin and Race. Drugs 35, 495–503 (1988). https://doi.org/10.2165/00003495-198835050-00001
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DOI: https://doi.org/10.2165/00003495-198835050-00001