References
Amoux B, Denjean A, Page CP, Morley J, Benveniste J. Pulmonary effects of platelet-activating factor in a primate are inhibited by ketotifen. American Review of Respiratory Diseases 131: 2, 1985
Arnoux B, Joseph M, Simoes AH, Tonnel AB, Duroux P, et al. Antigenic release of PAF-acether and beta-glucuronidase from alveolar macrophages of asthmatics. Bulletin Européen de Physiopathologie Respiratoire 23: 119–124, 1987
Aursudkij B, Rogers DF, Evans TW, Alton EWFW, Chung KF, et al. Reduced tracheal mucus velocity in guinea-pig in vivo by platelet activating factor. American Review of Respiratory Diseases 35: 160, 1987
Barnes PJ. Cell receptors and airway function. In Flenley & Petty (Eds) Recent advances in respiratory medicine IV, pp. 25–44, Churchill Livingstone, London, 1986a
Barnes PJ. Asthma as an axon reflex. Lancet 1: 242–245, 1986b
Barnes PJ. The changing face of asthma. Quarterly Journal of Medicine 63: 359–365, 1987a
Barnes PJ, Chung KF, Page CP. Platelet-activating factor as a mediator of allergic disease. Journal of Allergy and Clinical Immunology. In press, 1987b
Barnes PJ, Cuss FMC, Palmer JBD. The effect of airway epithelium on smooth muscle contractility in bovine trachea. British Journal of Pharmacology 86: 685–691, 1985
Barnes NC, Piper PJ, Costello JF. Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjects. Thorax 39: 500–504, 1984
Basran GS, Page CP, Paul W, Morley J. Cromoglycate (DSCG) inhibits responses to platelet activating factor (Paf-acether) in man: an alternative mode of action for DSCG in asthma? European Journal of Pharmacology 86(1): 143–144, 1983
Benveniste J, Henson PM, Cochrane CG. Leucocyte dependent histamine release from rabbit platelets: the role of IgE, basophils and a platelet activating factor. Journal of Experimental Medicine 136: 1356–1377, 1972
Boulet LP, Cartier A, Thomson NC, Roberts RS, Dolovich J, et al. Asthma and increases in non-allergic bronchial responsiveness from seasonal pollen exposure. Journal of Allergy and / Clinical Immunology 71: 399–404, 1983
Boushey HA, Holtzman MJ, Sheller JR, Nadel JA. Bronchial hyperreactivity. American Review of Respiratory Diseases 121: 389–413, 1980
Braquet P, Spinnewyn B, Braquet M, Bourgain RH, Taylor JE, et al. BN 52021 and related compounds: a new series of highly specific PAF-receptor antagonists isolated from Ginkgo biloba. Blood Vessels 16: 559–572, 1985
Britton JR, Hanley SP, Tattersfield AE. The effect of an oral leukotriene D4 antagonist L-649, 923 on the response to inhaled antigen in asthma. Journal of Allergy and Clinical Immunology 79: 811–815, 1987
Burney PGJ. Asthma mortality in England and Wales: evidence for a further increase. Lancet 2: 323–326, 1986
Camussi G, Aglietta M, Malavasi F, Tetta C, Piacibello W, et al. The release of platelet activating factor from human endothelial cells in culture. Journal of Immunology 131: 2397–2403, 1983
Casals-Stenzel J. Protective effect of WEB 2086, a novel antagonist of platelet-activating factor, in endotoxin shock. European Journal of Pharmacology 135: 117–122, 1987
Casals-Stenzel J, Weber KH. Triazolobenzodiazepines: dissociation of their Paf (platelet-activating factor) antagonistic and CNS activity. British Journal of Pharmacology 90: 139–146, 1987
Chignard M, LeCouedic JP, Vargaftig BB, Benveniste J. Platelet-activating factor (PAF-acether) secretion from platelets: effect of aggregating agents. British Journal of Haematology 46: 455–464, 1980
Chung KF. Role of inflammation in the hyperreactivity of the airways in asthma. Thorax 41: 657–662, 1986
Chung KF, Aizawa H, Leikauf GD, Ueki IF, Evans TW, et al. Airway hyperresponsiveness induced by platelet-activating factor: role of thromboxane generation. Journal of Pharmacology and Experimental Therapeutics 236: 580–584, 1986
Chung KF, Barnes PJ. Bronchial hyperreactivity induced by platelet-activating factor (PAF): modification by a beta-agonist. Thorax 42: 220, 1987
Chung KF, Dent G, McCusker M, Guinot Ph, Page CP, et al. Effect of a ginkgolide mixture (BN 52063) in antagonising skin and platelet responses to platelet activating factor in man. Lancet 1: 248–251, 1987d
Chung KF, Dixon CMS, Barnes PJ. Platelet-activating factor (PAF) and asthmatic airways: effects of caliber, responsiveness and circulating cells. American Review of Respiratory Diseases 135: 159, 1987b
Chung KF, McCusker M, Minette P, Barnes PJ. Ketotifen inhibits the cutaneous responses but not the bronchoconstriction and bronchial hyperresponsiveness induced by PAF in man. Thorax 42: 220, 1987c
Clark RAF, Sandler JA, Gallin JI, Kaplan AP. Histamine modulation of eosinophil migration. Journal of Immunology 118: 137–145, 1977
Clay KL, Murphy RC, Andres JL, Lynch J, Henson PM. Structure elucidation of platelet activating factor derived from human neutrophils. Biochemical and Biophysical Research Communications 121: 815–825, 1984
Cockcroft DW, Ruffm RE, Dolovich J, Hargreave FE. Allergen-induced increase in non-allergic bronchial reactivity. Clinical Allergy 7: 503–513, 1977
Coyle A, Page CP, Touvay C, Villain B, Braquet P. Effect of the selective PAF antagonist BN 52021 on antigen-induced bronchial hyperreactivity in the guinea-pig. American Review of Respiratory Diseases 135: A161, 1987a
Coyle AJ, Sjoerdsma K, Page CP, Brown L, Metzger WJ. Modification of the late asthmatic response and bronchial hyperreactivity in the allergic rabbit by the specific PAF antagonist, BN 52063. Journal of Allergy and Clinical Immunology. In press, 1987b
Cuss FM, Dixon CMS, Barnes PJ. Effects of inhaled platelet activating factor on pulmonary function and bronchial responsiveness in man. Lancet 2: 189–192, 986
Dahlen S-E, Bjork J, Hedquist P, Arfors KE, Hammarstrom S, et al. Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response. Proceedings of the National Academy of Sciences (USA) 78: 3887–3891, 1981
Darius H, Lefer DJ, Smith B, Lefer AM. Role of platelet-activating factor — acether in mediating guinea pig anaphylaxis. Science 232: 58–60, 1986
Davidson AB, Lee TH, Scamon PD, Solway J, McFadden ER, et al. Bronchoconstrictor effects of leukotriene E4 in normal and asthmatic subjects. American Review of Respiratory Diseases 135: 333–337, 1987
Davies RJ, Green M, Schofield NM. Recurrent nocturnal asthma after exposure to grain dust. American Review of Respiratory Diseases 114: 1011–1019, 1976
De Monchy JGR, Kauffman HF, Venge P, Koeter GH, Jansen HM, et al. Bronchoalveolar eosinophils during allergen-induced late asthmatic reactions. American Review of Respiratory Diseases 131: 373–376, 1985
Denjean A, Arnoux B, Masse R, Lockhart A, Benveniste J. Acute effects of intratracheal administration of platelet-activating factor in baboons. Journal of Applied Physiology 55: 799–804, 1983
Doebber TW, Wu MS, Robbins JC, Choy BM, Chang MN, et al. Platelet-activating factor (PAF) involvement in endotoxin-induced hypotension in rats: studies with PAF-receptor antagonist Kadsurenone. Biochemical and Biophysical Research Communications 127: 799–808, 1985
Dunnill MS. The pathology of asthma with special reference to changes in the bronchial mucosa. Journal of Clinical Pathology 13: 27–33, 1960
Evans TW, Brokaw JJ, Chung KF, McDonald DM, Nadel JA. Ozone-induced bronchial hyperreactivity and airway inflammation in the rat. Clinical Science 70: 67P, 1985
Evans TW, Chung KF, Rogers DF, Barnes PJ. Effect of platelet-activating factor on airway vascular permeability: possible mechanisms. Journal of Applied Physiology 63: 479–484, 1987a
Evans TW, Rogers DF, Dent G, Aursudkij B, Chung KF, et al. Effects of platelet-activating factor (PAF) antagonist (WEB 2086) on airway microvascular leakage induced by PAF and antigen. American Review of Respiratory Diseases 135: A162, 1987c
Evans TW, Rogers DF, Roberts NM, Chung KF, Barnes PJ. Mediators of increased vascular permeability during anaphylaxis in sensitised guinea-pigs. Thorax 42: 221, 1987b
Fairfax AJ, Hanson JM, Morley J. The late reaction following bronchial provocation with house dust mite allergen: dependence on arachidonic acid metabolism. Clinical and Experimental Immunology 53: 393–398, 1983
Fitzgerald MF, Moncada S, Parente L. The anaphylactic release of platelet-activating factor from perfused guinea pig lungs. British Journal of Pharmacology 88: 149–153, 1986
Flavahan NA, Aarhus LL, Rimele TJ, Vanhoutte PM. Respiratory epithelium inhibits bronchial smooth muscle tone. Journal of Applied Physiology 58: 834–838, 1985
Fleming DM, Crombie DL. Prevalence of asthma and hay fever in England and Wales. British Medical Journal 294: 279–283, 1987
Flint KC, Leung KBP, Hudspith BN, Brostoff J, Pearce FL, et al. Bronchoalveolar mast cells in extrinsic asthma: a mechanism for the initiation of antigen specific bronchoconstriction. British Medical Journal 291: 923–926, 1985
Frigas E, Gleich GJ. The eosinophil and the pathology of asthma. Journal of Allergy and Clinical Immunology 77: 527–537, 1986
Fujimura M, Sasaki F, Nakatsumi Y, Takahashi Y, Hifumi S, et al. Effects of thromboxane synthetase inhibitor (OKY-046) and a lipoxygenase inhibitor (AA-861) on bronchial responsiveness to acetylcholine in asthmatic subjects. Thorax 41: 955–959,1986
Fuller RW, Dixon CMS, Dollery CT, Barnes PJ. Prostaglandin D2 potentiates airway responses to histamine and methacholine. American Review of Respiratory Diseases 133: 252–254, 1986
Gateau O, Arnoux B, Deriaz H, Viars P, Benveniste J. Acute effects of intratracheal administration of Paf-acether (platelet-activating factor) in humans. American Review of Respiratory Diseases 3: 129, 1984
Glynn AA, Michaels L. Bronchial biopsy in chronic bronchitis and asthma. Thorax 15: 142–153, 1960
Godard P, Chaintreuil J, Damon M, Coupe M, Flandre O, et al. Functional assessment of alveolar macrophages: comparison of cells from asthmatics and normal subjects. Journal of Allergy and Clinical Immunology 70: 88–93, 1982
Goetzl EJ, Austen KF. Purification and synthesis of eosinophil-otactic tetrapeptides of human lung tissue: identification as eosinophil chemotactic factor of anaphylaxis. Proceedings of the National Academy of Sciences (USA) 72: 4123–4127, 1975
Griffin M, Weiss JW, Leitch AG, McFadden ER, Corey EJ, et al. Effect of leukotriene D4 on the airways in asthma. New England Journal of Medicine 308: 436–439, 1983
Guinot Ph, Braquet P, Duchier J, Cournot A. Inhibition of PAF-acether induced wheal and flare reaction in man by a specific antagonist. Prostaglandins 32: 160–163, 1986
Halonen M, Lohman IC, Dunn AM, McManus LM, Palmer JD. Participation of platelets in the physiologic alterations of the AGEPC response and of IgE anaphylaxis in the rabbit. American Review of Respiratory Diseases 131: 11–17, 1985
Halonen M, Palmer JD, Lohman IC, McManus LM, Pinckard RN. Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorylcholine, a mediator of IgE anaphylaxis in the rabbit. American Review of Respiratory Diseases 122: 915–924, 1980
Hanahan DJ. Platelet activating factor: a biologically active phosphoglyceride. Annual Review of Biochemistry 55: 483–509, 1986
Hardy CC, Robinson C, Tattersfield AE, Holgate ST. The bronchoconstrictor effect of inhaled prostaglandin D2 in normal and asthmatic men. New England Journal of Medicine 311: 209–213, 1984
Haroldsen PE, Voelkel NF, Henson JE, Henson PM, Murphy RC. Metabolism of platelet-activating factor in isolated perfused rat lung. Journal of Clinical Investigation 79: 1860–1867, 1987
Henocq E, Vargaftig BB. Accumulation of eosinophils in response to intracutaneous PAF-acether and allergens in man. Lancet 1: 1378–1379, 1986
Houston JC, de Nevasquez S, Trounce JR. A clinical and pathologic study of fatal cases of status asthmaticus. Thorax 8: 207–213,1953
Hwang MN, Chang ML, Garcia QQ, Huang L, King VF, et al. L-652,469 — A dual antagonist of platelet activating factor and dihydropyridines from Tussilogo furfara. European Journal of Pharmacology, in press, 1987
Hwang SB, Lam MH, Biftu T, Beattie TR, Shen TY. Trans-2, 5-Bis-(3,4,5,-trimethotyphenyl) tetrahydrofuran: an orally active specific and competitive receptor antagonist of platelet activating factor. Journal of Biological Chemistry 260: 15639–15645, 1985b
Hwang S-B, Lam M-H, Shen TY. Specific binding sites for platelet activating factor in human lung tissues. Biochemical and Biophysical Research Communications 128: 972–979, 1985a
Inarrea P, Gumez-Cambronero J, Nieto M, Sanchez-Crespo M. Characteristics of binding of platelet activating factor to platelets of different animal species. European Journal of Pharmacology 105: 309–315, 1984
Irvin CG, Berend N, Henson PM. Airways hyperreactivity and inflammation produced by aerosolization of human C5A des arg. American Review of Respiratory Diseases 134: 777–783, 1986
Juniper EF, Frith PA, Hargreave FE. Airway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptoms of asthma. Thorax 36: 575–579,1981
Kornecki E, Garlich YH, Lenox RH. Platelet-activating factor-induced aggregation of human platelets specifically inhibited by triazolobenzodiazepines, Science 226: 1954–1956, 1985
Lagente V, Touvay C, Randon J, Desquand S, Cirino M, et al. Interference of the Paf-acether antagonist BN 52021 with passive anaphylaxis in the guinea-pig. Prostaglandins, in press, 1987
Laitinen LA, Heino M, Laitinen A, Kava T, Haahtela T. Damage of the airway epithelium and bronchial reactivity in patients with asthma. American Review of Respiratory Diseases 131: 599–606, 1985
Lam S, Wong R, Chan-Yeung M. Non-specific bronchial reactivity in occupational asthma. Journal of Allergy and Clinical Immunology 63: 28–34, 1979
Latrigue-Mattei C, Godeneche D, Chabard JL, Petie J, Berger JA. Pharmacokinetic study of 3H-labelled Paf-acether. II: comparison with 3H-labelled lyso-Paf-acether after intravenous administration in the rabbit and protein binding. Agent and Actions 15: 643–648, 1984
Lee TC, Lenihan DJ, Malone B, Roddy LL, Wasserman SI. Increased biosynthesis of platelet activating factor in activated human eosinophils. Journal of Biological Chemistry 259: 5526–5530, 1984
Lynch JM, Henson PM. The intracellular retention of newly-synthetized platelet-activating factor. Journal of Immunology 137: 2653–2661, 1986
Marom Z, Shelhamer JH, Bach MR, Morton DR, Kalinen M. Slow-reacting substances, leukotrienes C4 and D4, increase the release of mucus from human airways in vitro. American Review of Respiratory Diseases 126: 449–451, 1982
Mazzoni L, Morley J, Page CP, Sanjar S. Induction of airway hyper-reactivity by platelet activating factor in the guinea-pig. Journal of Physiology 365: 107P, 1985a
Mazzoni L, Morley J, Page CP, Sanjar S. Prophylactic anti-asthma drugs impair the airway hyperreactivity that follows exposure to platelet activating factor (PAF). British Journal of Pharmacology 86: 571P, 1985b
McIntyre TM, Zimmerman GA, Satoh K, Prescott SM. Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphate. Journal of Clinical Investigation 76: 271–280, 1985
Moreno RH, Hogg JC, Pare PD. Mechanics of airway narrowing. American Review of Respiratory Diseases 133: 1171–1180, 1986
Morley J, Page CP, Mazzoni L, Sanjar S. Effects of ketotifen upon responses to platelet activating factor: A basis for asthma prophylaxis. Annals of Allergy 56: 335–340, 1986
O’Bryne PM, Walters EH, Aizawa H, Fabbri LM, Holtzman MJ, et al. Indomethacin inhibits the airway hyperresponsiveness but not the neutrophil influx induced by ozone in dogs. American Review of Respiratory Diseases 130: 220–224, 1984
O’Flaherty JT, Surles JR, Redman J, Jacobson D, Piantadosi C, et al. Binding and metabolism of platelet-activating factor by human neutrophils. Journal of Clinical Investigation 78: 381–388, 1986
O’Flaherty JT, Wykle RL. Biology and biochemistry of platelet-activating factor. Clinical Review in Allergy 1: 353–367, 1983
Okamoto M, Yoshida K, Uchida I, Kohsaka M, Aoki H. Studies of platelet activating factor (PAF) antagonists from microbial products. II: pharmacological studies of FR-49175 in animal models. Chemical and Pharmaceutical Bulletin (Tokyo) 34: 345–348, 1986
Partridge MR, Saunders KB. Effect of inhaled antihistamine (clemastine) as a bronchodilator and as a maintenance treatment in asthma. Thorax 34: 771–776, 1979
Persson CGA, Erjefalt I. Inflammatory leakage of macromol-ecules from the vascular compartment into the tracheal lumen. Acta Physiologica Scandinavica 126: 615–616, 1986
Persson CGA, Erjefalt I, Sundler F. Airway microvascular and epithelial leakage of plasma induced by PAF-acether (PAF) and capsaicin (CAP). American Review of Respiratory Diseases 135: A401, 1987
Platts-Mills TAE, Mitchell EB, Nock P, Tovey ER, Moszoro H, et al. Reduction of bronchial hyperreactivity during prolonged allergen avoidance. Lancet 2: 675–677, 1982
Prescott SM, Zimmerman GA, Mclntyre TM. Human endothelial cells in culture produce platelet-activating factor (1-alkyl2-acetyl-sn-glycero-3-phosphocholine) when stimulated with thrombin. Proceedings of the National Academy of Science (USA) 81: 3534–3538, 1984
Roberts NM, Page CP, Chung KF, Barnes PJ. Effect of a PAF antagonist, BN52063, on antigen-induced acute and late-onset cutaneous responses in atopic subjects. Submitted, 1987
Rogers DF, Aursudkij B, Evans TW, Belvisi MG, Chung KF, et al. Platelet activating factor increases protein exudation but not mucus secretion in guinea-pig trachea in vivo. American Review of Respiratory Diseases 135: A160, 1987
Schleimer RP, MacGlashan DW, Peters SP, Pinckard RN, Adkinson NF, et al. Characterization of inflammatory mediator release from purified human lung mast cells. American Review of Respiratory Diseases 133: 614–617, 1986
Shen TY, Huang S-B, Chang MN, Doebber TW, Lam M-H, et al. Characterization of platelet-activating factor receptor antagonist isolated for haifenteng (Piper futokoedsura): specific inhibition of in vitro and in vivo platelet-activating factor-induced effects. Proceedings of the National Academy of Science 82: 672–676, 1985
Shukla SD, Hanahan DJ. AGEPC (platelet activating factor) induced stimulation of rabbit platelets: effects on phosphatidylinositol, di and triphosphoinositides. Biochemical and Biophysical Research Communications 106: 697–703, 1982
Sly RM. Increases in death from asthma. Annals of Allergy 53: 20–25, 1984
Smith AP, Cuthbert MF, Dunlop LS. Effects of inhaled prostaglandins E1, E2, and p2α on the airway resistance of healthy and asthmatic man. Clinical Science and Molecular Medicine 48: 421–430, 1975
Snyder F. Chemical and biochemical aspects of platelet activating factor: a novel class of acetylated ether-linked choline phospholipids. Medical Research Reviews 5: 107–140, 1985
Soter NA, Lewis RA, Corey EJ, Auster KF. Local effects of synthetic leukotrienes (LTC4, LTD4, LTE4 and LTB4) in human skin. Journal of Investigative Dermatology 80: 115–119, 1983
Stevenson JS, Tallet M, Blinder B, Abraham WM. Modification of antigen-induced late responses with an antagonist of platelet-activating factor (WEB 2086). Abstract. Federation Proceedings 46: 1454, 1987
Stewart CJ, Nunn AJ. Are asthma mortality rates changing? British Journal of Diseases of the Chest 79: 229–234, 1985
Terashita Z, Tsushima S, Yoshioka Y, Nomura H, Inada Y, et al. CV-3988, a specific antagonist of platelet activating factor (PAF). Life Sciences 32: 1975–1982, 1983
Touvay C, Etienne A, Braquet P. Inhibition of antigen-induced lung anaphylaxis in the guinea-pig by BN 52021 a new specific PAF-acether receptor antagonist isolated from Ginkgo biloba. Agents and Actions 17: 371–372, 1985
Udaka K, Tatenchi Y, Movat H. Simple method for quantitation of enhanced vascular permeability. Proceedings of the Society for Experimental Biology and Medicine 133: 1384–1387, 1970
Valonne FH, Coles E, Reinhold VR, Goetzl EJ. Specific binding of phospholipid platelet-activating factor by human platelets. Journal of Immunology 129: 1637–1641, 1982
Valonne FH, Goetzl EJ. Specific binding by human polymorphonuclear leucocytes of the immunological mediator 1-o-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphorylcholine. Immunology 48: 141–149, 1983
Vargaftig BB, Lefort J, Chignard M, Benveniste J. Platelet-activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives. European Journal of Pharmacology 65: 185–192, 1980
Vargaftig BB, Lefort J, Wal F, Chignard M, Medeiros MC. Interference of non-steroidal anti-inflammatory drugs associated to anti-histamine and anti-serotonin agents with the bronchial and platelet effects of‘platelet-activating factor’ (PAF-acether). European Journal of Pharmacology 82: 121–130, 1982
Walters EH, Parrish RW, Bevan C, Smith AP. Induction of bronchial hypersensitivity: evidence for a role of prostaglandins. Thorax 36: 571–574, 1981
Wardlaw AJ, Moqbel R, Cromwell O, Kay AB. Platelet-activating factor: a potent chemotactic and chemokinetic factor for human eosinophils. Journal of Clinical Investigation 78: 1701–1706, 1986
White J, Eiser NM. The role of histamine and its receptors in the pathogenesis of asthma. British Journal of Diseases of the Chest 77: 215–226, 1983
Williams BD, O’Sullivan MM, Saggu GS, Williams SKE, Williams LA, et al. Imaging in rheumatoid arthritis using liposomes labelled with technetium. British Medical Journal 293: 1143–1144, 1986
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Chung, K.F., Barnes, P.J. PAF Antagonists. Drugs 35, 93–103 (1988). https://doi.org/10.2165/00003495-198835020-00001
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DOI: https://doi.org/10.2165/00003495-198835020-00001