Summary
Acute infectious diarrhoea is the major killer of children in the Third World. It is also the principal cause of malnutrition in children under 5 years of age. More than 4 million children die each year of diarrhoea and its complications. Acute diarrhoea kills by causing dehydration, which leads to hypovolaemia and metabolic acidosis. Recurrent episodes of diarrhoea lead to malnutrition as the result of anorexia, catabolism from infection, and lack of adequate caloric and protein intake because of the widespread custom of ‘starving’ diarrhoea.
Oral rehydration therapy (ORT) is effective in the prevention and treatment of dehydration caused by diarrhoea. Because it is cheap, easy to administer and very effective, ORT has the potential to allow substantial reductions in the morbidity and mortality of acute diarrhoea in children living in less developed countries. The major obstacles to achieving its potential are the social ones of production and distribution of oral rehydration solutions and of educating parents in how to use ORT.
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References
Cash RA, Nalin DR, Rochat R, et al. A clinical trial of oral therapy in a rural cholera-treatment center. American Journal of Tropical Medicine and Hygiene 19: 653–656, 1970a
Cash RA, Forrest JN, Nalin DR, et al. Rapid correction of acidosis and dehydration of cholera with oral electrolyte and glucose solution. Lancet 2: 549–550, 1970b
Editorial. Water with sugar and salt. Lancet 2: 300, 1978
Garthright WE, Archer DL, Kvenberg JE. Estimates of incidence and costs of intestinal infectious diseases in the United States. Public Health Reports 103: 107–115, 1988
Guerrant RL, McAuliffe JR. Special problems in developing countries. In Gorbach SL (Ed.) Infectious diarrhea, pp. 287–307, Blackwell Scientific Publications, Boston, 1986
Kumate J, Isibasi A. Pediatric diarrheal disease: a global perspective. Pediatric Infectious Disease 5: S21–S28, 1986
Levine MM, Losonsky G, Herrington D, Kaper JB, Tacket C, et al. Pediatric diarrhea: the challenge of prevention. Pediatric Infectious Disease 5: S29–S43, 1986
Mason JO. Enteric disease and health for all: a public health perspective. Pediatric Infectious Disease 5: S7–S10, 1986
Phillips RA. Cholera in perspective of 1966. Annals of Internal Medicine 78: 922–930, 1966
Rhode JE. Selective primary health care: strategies for control of disease in the developing world. XV. Acute diarrhea. Reviews of Infectious Diseases 6: 840–854, 1984
Rhode JE, Northrup RS. Taking science where the diarrhoea is. In Elliott & Knight (Eds) Acute diarrhoea in childhood, Ciba Foundation Symposium 42 (new series), pp. 339–358, Elsevier, Amsterdam, 1976
Snow J. On the mode of communication of cholera, 2nd ed. John Churchill, London, 1854
Stanton BF, Rowland MGM, Clemens JD. Oral rehydration solution — too little or too much. Lancet 1: 33–34, 1987
UNICEF. II Lifelines: oral rehydration therapy. In The state of the world’s children 1986. Oxford University Press for UNICEF, pp. 90–95, 1985a
UNICEF. I The state of the world’s children. In The state of the world’s children 1986. Oxford University Press for UNICEF, pp. 20–27, 1985b
Watten RH, et al. Water and electrolyte studies in cholera. Journal of Clinical Investigation 38: 1879–1889, 1959
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Gold, R. Overview of the Worldwide Problem of Diarrhoea. Drugs 36 (Suppl 4), 1–5 (1988). https://doi.org/10.2165/00003495-198800364-00003
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DOI: https://doi.org/10.2165/00003495-198800364-00003