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Effects of Long Term Oral Administration of Ketanserin and Trichlormethiazide on Blood Pressure in Stroke-Prone Spontaneously Hypertensive Rats

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  • Poster Presentations: Pharmacology of Serotonin Antagonists
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References

  • Cantalamessa F, De Caro G, Massi M, Micossi LG. Ketanserin, a new selective 5-HT2 receptor blocking agent, inhibits the antidiuretic effect of 5-hydroxytryptamine (5-HT) in Wistar rats. Archives Internationales de Pharmacodynamie 162: 302–307, 1983

    Google Scholar 

  • Dustan HP. Causes of inadequate response to antihypertensive drugs. Volume factors. Hypertension 5(Suppl. III): III–26–III–30, 1983

    Google Scholar 

  • Erspamer V. Peripheral physiological and pharmacological actions of indolealkylamines. In Erspamer V (Ed.) Handbook of experimental pharmacology: 5-hydroxytryptamine and related indolealkylamines, vol. 19, pp. 245–359, Springer Verlag, Berlin, 1966

    Chapter  Google Scholar 

  • Fagard R, Cattaert A, Lijnen P, Staessen J, Vanhees L, et al. Responses of the systemic circulation and of the renin-angiotensin-aldosterone system to ketanserin at rest and exercise in normal man. Clinical Science 66: 17–25, 1984

    CAS  PubMed  Google Scholar 

  • Minami M, Yasuda H, Yamazaki N, Kojima S, Nishijima H, et al. Plasma norepinephrine concentration and plasma dopamine-beta-hydroxylase activity in patients with congestive heart failure. Circulation 67: 1324–1329, 1983

    Article  CAS  PubMed  Google Scholar 

  • Minami M, Togashi H, Sano M, Yoshioka M, Saito I, et al. Effects of a new antihypertensive agent, 2-[4-(n-butyryl)-homo-piperazine-1-ul]-4-amino-6, 7-dimethoxy-quinazoline (E-643), on blood pressure, urinary sodium excretion and urinary norepinephrine excretion rate in stroke-prone spontaneously hypertensive rats (in Japanese). Hokkaido Journal of Medical Science 60: 536–543, 1985

    CAS  PubMed  Google Scholar 

  • Mulvihil-Wilson J, Graham RM, Pettinger WA, Mucklerog C, Anderson S, et al. Comparative effects of prazosin and phenoxybenzamine on arterial blood pressure, heart rate and plasma catecholamine in essential hypertension. Journal of Cardiovascular Pharmacology 1 (Suppl.): 1–7, 1979

    Article  Google Scholar 

  • Okamoto K, Yamori Y, Nagaoka A. Establishment of the strokeprone SHR. Circulation Research 34(Suppl. 1): 143–153, 1974

    Google Scholar 

  • Rahman MK, Nagatsu T, Kato T. Aromatic L-amino acid decarboxylase activity in central and peripheral tissues and serum of rats with L-dopa and L-5-hydroxytryptophan as substrates. Biochemical Pharmacology 30: 645–649, 1981

    Article  CAS  PubMed  Google Scholar 

  • Reimann IW, Frölich JC. Is ketanserin a D receptor antagonist? Lancet 1: 703–704, 1983

    Google Scholar 

  • Sano M, Minami M, Togashi H, Yoshioka M, Tochihara M, et al. Effect of ketanserin on blood pressure in rats (in Japanese). Folia Pharmacologics Japonica 86: 401–409, 1985

    Article  CAS  Google Scholar 

  • Senjo M, Yamazaki N, Minami M, Hirokami M, Saito H, et al. Decreased monoamine oxidase activity in stroke-prone spontaneously hypertensive rat kidney. Research Communications in Chemical Pathology and Pharmacology 52: 207–216, 1986

    CAS  PubMed  Google Scholar 

  • Van Nueten JM, Janssen PAJ, Van Beek J, Xhonneux R, Verbeuren TJ, et al. Vascular effects of ketanserin (R41 468), a novel antagonist of 5-HT2 serotonergic receptors. Journal of Pharmacology and Experimental Therapeutics 218: 217–230, 1981

    PubMed  Google Scholar 

  • Wallenstein S, Zucker CL, Fleiss JL. Some statistical methods useful in circulation research. Circulation Research 47: 1–9, 1980

    Article  CAS  PubMed  Google Scholar 

  • Yoshioka M, Matsumoto M, Togashi H, Minami M, Saito H. Central sympathoinhibitory action of ketanserin in rats. Journal of Pharmacology and Experimental Therapeutics 243: 1174–1178, 1987

    CAS  PubMed  Google Scholar 

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Minami, M., Hamaue, N., Togashi, H. et al. Effects of Long Term Oral Administration of Ketanserin and Trichlormethiazide on Blood Pressure in Stroke-Prone Spontaneously Hypertensive Rats. Drugs 36 (Suppl 1), 92–96 (1988). https://doi.org/10.2165/00003495-198800361-00016

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