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Renal Function before and after Withdrawal of Long Term Antihypertensive Treatment in Primary Hypertension

  • Section 2: The Pathogenic Role of the Kidney
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Summary

Glomerular filtration rate (GFR) and renal plasma flow (inulin and para-aminohippurate clearance) were measured in a random sample of 17 normotensive and 20 untreated patients with primary hypertension. At the 7-year follow-up, 19 patients were on metoprolol (as the sole drug or in combination with either hydrochlorothiazide or hydralazine) and 1 patient was on hydrochlorothiazide. They were re-examined after withdrawal of treatment and return of hypertension. At the 7-year follow-up GFR was more reduced in the hypertensive (−17%) than in the normotensive group (−9%). The percentage decrease in renal blood flow was the same in both groups. No significant renal function changes appeared after withdrawal of treatment.

In conclusion, there was a slightly greater deterioration in GFR in the hypertensive patients after long term treatment with metoprolol than can be explained by normal ageing.

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Authors and Affiliations

  1. Departments of Nephrology, Medicine I and Clinical Physiology, Sahlgrenska Hospital, University of Göteborg, S-413 45, Göteborg, Sweden

    Susanne Ljungman, Mattias Aurell, Marianne Hartford, John Wikstrand & Göran Berglund

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  1. Susanne Ljungman
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  2. Mattias Aurell
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  3. Marianne Hartford
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  4. John Wikstrand
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  5. Göran Berglund
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Ljungman, S., Aurell, M., Hartford, M. et al. Renal Function before and after Withdrawal of Long Term Antihypertensive Treatment in Primary Hypertension. Drugs 35 (Suppl 5), 55–58 (1988). https://doi.org/10.2165/00003495-198800355-00009

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  • DOI: https://doi.org/10.2165/00003495-198800355-00009

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