Summary
Increased urinary excretion of β2-microglobulin and certain enzymes, for example leucine aminopeptidase (LAP) and N-acetyl-β-D-glucosaminidase (NAG), produces sensitive markers of damage to renal tubular cells. These markers were monitored in patients undergoing obstetric and gynaecological surgery who received cefotaxime for 5 days. Slight increased activity in NAG and β2-microglobulin was observed in some patients 3 to 5 days after surgery. However, no changes of significance were found in levels of urinary LAP and NAG. During cefotaxime treatment, urinary β2-microglobulin in the group of abdominal hysterectomy increased slightly. In most cases renal side effects are negligible and cannot be detected by these tests. These results indicate that administration of cefotaxime in obstetric and gynaecological surgery does not produce cumulative renal tubular toxicity.
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Ishikawa, M., Yamashita, K. & Shimizu, T. Studies of Enzymuria and β2-Microglobulinuria in Patients Receiving Prophylactic Cefotaxime in Obstetric and Gynaecological Surgery. Drugs 35 (Suppl 2), 178–180 (1988). https://doi.org/10.2165/00003495-198800352-00037
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DOI: https://doi.org/10.2165/00003495-198800352-00037