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A Regional Survey of the Resistance to β-Lactam Antibiotics in Clinical Isolates of (Facultative) Aerobic Micro-organisms

  • Section 1: The Current Situation on Bacterial Resistance to Third Generation Cephalosporins
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Summary

From 1980 to 1986 a regional survey was performed to investigate the susceptibility of β-lactam antibiotics in clinical isolates of Escherichia coli, Proteus mirabilis, Klebsieila pneumoniae, Enterobacter cloacae and Pseudomonas aeruginosa in 6 hospitals located in the southern part of the Netherlands. Each year 300 to 400 strains were tested. The susceptibility to representatives of the older and the newer β-lactam antibiotics was determined by a microbroth dilution assay using an inoculum size of 105 colony forming units (CFU)/ml in ISO-Sensitest broth (Oxoid). No significant differences in antibiotic sensitivity of the micro-organisms from the different hospitals were found. There was no evidence for an increase in antibiotic resistance of the strains during the sampling period. In contrast, there was a general tendency to an increase in antibiotic sensitivity.

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Authors and Affiliations

  1. Department of Medical Microbiology, University of Limburg, P.O. Box 616, 6200 MD, Maastricht, The Netherlands

    E. E. Stobberingh, J. M. H. Philips, A. W. Houben & C. P. A. van Boven

Authors
  1. E. E. Stobberingh
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  2. J. M. H. Philips
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  3. A. W. Houben
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  4. C. P. A. van Boven
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Stobberingh, E.E., Philips, J.M.H., Houben, A.W. et al. A Regional Survey of the Resistance to β-Lactam Antibiotics in Clinical Isolates of (Facultative) Aerobic Micro-organisms. Drugs 35 (Suppl 2), 41–44 (1988). https://doi.org/10.2165/00003495-198800352-00010

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  • DOI: https://doi.org/10.2165/00003495-198800352-00010

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