Summary
The present in vitro antibacterial activities of cefotaxime and 8 other cephalosporins (cefoperazone, cefmenoxime, cefpiramide, latamoxef cefamandole, cefmetazole, cefotiam and cephazolin) were evaluated simultaneously in 384 strains of Gram-positive cocci, 595 strains of Enterobacteriaceae, 240 strains of non-fermenters and 143 strains of anaerobes and miscellaneous organisms. The results were expressed as minimum inhibitory concentration (MIC) range, MIC90 and MIC90. Of the β-lactams, cefotaxime and latamoxef exhibited the highest activity against a wide variety of Gram-positive and Gram-negative bacteria. MIC90 of cefotaxime, however, for species of Pseudomonas aeruginosa, Xanthomonas maltophilia, enterococci, Bacteroides sp. and Clostridium difficile were more than 100 mg/L. Cefpiramide and cefoperazone were generally less active than these 2 agents. All strains were tested for β-lactamase production by the cefinase disc method and the relationship of susceptibility to β-lactams was evaluated in each species. The need was demonstrated for periodic susceptibility testing to be performed to better guide empirical antimicrobial therapy.
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Nakashio, S., Nakamura, M. In Vitro Activity of Cefotaxime against Clinically Significant Pathogens. Drugs 35 (Suppl 2), 14–21 (1988). https://doi.org/10.2165/00003495-198800352-00006
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DOI: https://doi.org/10.2165/00003495-198800352-00006