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Activity of Cefotaxime and Amikacin against 14,272 Gram-Negative Bacteria from Clinical Samples in the Period 1980 to 1985

  • Section 1: The Current Situation on Bacterial Resistance to Third Generation Cephalosporins
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Summary

The sensitivity to cefotaxime and amikacin of 14,272 Gram-negative bacilli (Enterobacteriaceae and non-fermenting Gram-negative bacilli) isolated from clinical samples was studied during the period 1980 to 1985.

The minimum inhibitory concentration (MIC) was determined by means of diffusion in agar. Strains were considered resistant to cefotaxime and amikacin if the MIC values were >16 mg/L and >8 mg/L, respectively.

The MIC 90 reached the critical value for cefotaxime in the case of Citrobacter spp., Escherichia coli, Klebsiella spp., Proteus mirabilis, Salmonella spp. and Shigella spp., and for amikacin in the case of Citrobacter spp., Enterobacter spp., E. coli, Klebsiella spp., P. mirabilis, Proteus vulgaris, Salmonella spp. and Serratia spp.

Only Shigella spp. were sensitive to cefotaxime but not to amikacin, and only strains of Enterobacter spp. and Serratia spp. were sensitive to amikacin but not to cefotaxime.

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Authors and Affiliations

  1. Servicio de Microbiología, Clinica Puerta de Hierro, C/-San Martin de Porres, 4, 28035, Madrid, Spain

    Diego Dámaso, M. P. Sánchez-Moreno, L. Martínez-Martínez, E. Mesa, F. Portero, P. Mendaza & R. M. Daza

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  1. Diego Dámaso
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  2. M. P. Sánchez-Moreno
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  3. L. Martínez-Martínez
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  4. E. Mesa
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  5. F. Portero
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  6. P. Mendaza
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  7. R. M. Daza
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Dámaso, D., Sánchez-Moreno, M.P., Martínez-Martínez, L. et al. Activity of Cefotaxime and Amikacin against 14,272 Gram-Negative Bacteria from Clinical Samples in the Period 1980 to 1985. Drugs 35 (Suppl 2), 1–5 (1988). https://doi.org/10.2165/00003495-198800352-00003

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  • DOI: https://doi.org/10.2165/00003495-198800352-00003

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