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Cefadroxil

A Review of its Antibacterial, Pharmacokinetic and Therapeutic Properties in Comparison with Cephalexin and Cephradine

Summary

Cefadroxil is an oral cephalosporin which is similar to cephalexin and cephradine in structure and spectrum of antibacterial activity, but has different pharmacokinetic properties. Not only does cefadroxil exhibit a longer serum half-life, and thus a prolonged duration of activity, but it is virtually unaffected by simultaneous food intake. The concentrations of cefadroxil attained in body tissues and fluids are also higher and more sustained than those of cephalexin and cephradine. These characteristics permit the administration of cefadroxil during meals on a once-daily or twice-daily basis, thus encouraging patient compliance which often determines the successful management of outpatient infections. Many studies have established the efficacy of the administration of once- or twice-daily cefadroxil, compared with regimens of cephalexin or cephradine given 4 times daily, in the management of infections in the respiratory tract, urinary tract, skin and soft tissues, and bones and joints.

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References

  • Adam D, Krentle O. Investigation on the diffusion of cefadroxil and cephalexin into tonsil tissues. Infection 5: 580–583, 1980

    Article  Google Scholar 

  • Anon. Cefadroxil treatment in sinusitis. Multicenter study. Data on BMCID file

  • Albertal J. Cefadroxil tissue levels concentration in lungs following thoracotomies. Data on BMCID file (Study No. 31-190)

  • Ayvazian LF, Rock FM, Ramisetti K. Cefadroxil in the treatment of bronchopneumonia. Journal of International Medical Research 8 (Suppl.): 94–97, 1980

    PubMed  CAS  Google Scholar 

  • Baert L. Cefadroxil concentration in prostatic tissue. Data on BMCID file (Study No. 31-97)

  • Ballantyne F. Cefadroxil in the treatment of skin and soft tissue infection. Journal of Antimicrobial Chemotherapy 10(Suppl. B): 143–147, 1982

    PubMed  Google Scholar 

  • Bernhardt LL. Cefadroxil in the treatment of lobar pneumonia. Journal of International Medical Research 8(Suppl. 1): 98–100, 1980

    PubMed  CAS  Google Scholar 

  • Bernhardt LL. Tissue and fluid concentration of cefadroxil mono-hydrate. Journal of International Medical Research 8(Suppl.1): 58–63, 1980

    PubMed  CAS  Google Scholar 

  • Bidart-Ramos B, et al. Cefadroxil levels in human aqueous humors. Data on BMCID file (Special study), 1979

    Google Scholar 

  • Bolding OT. Clinical comparison of cefadroxil, new oral cephalosporin and cephalexin in uncomplicated urinary tract infections. Urology 12: 321–324, 1978

    PubMed  Article  CAS  Google Scholar 

  • Bolding OT. Comparison of the efficacy and safety of cefadroxil and cephalexin in treating acute urinary tract infection in women. Journal of International Medical Research 8(Suppl.1): 34–39, 1980

    PubMed  CAS  Google Scholar 

  • Boyle GI, et al. Intraocular penetration of cephalexin in man. American Journal of Ophthalmology 69: 868, 1970

    PubMed  CAS  Google Scholar 

  • Brusch JL, Bergeron MG, Barza M. Pharmacological comparison of amoxycillin and ampicillin. American Journal of Medical Science 267: 41, 1974

    Article  CAS  Google Scholar 

  • Buck RE, Price KE. Cefadroxil, a new broad-spectrum cephalosporin. Antimicrobial Agents and Chemotherapy 11: 324–330, 1977

    PubMed  Article  CAS  Google Scholar 

  • Castro M. Cefadroxil sputum concentration. Data on BMCID file (Study No. 31-113)

  • Catz CS, Giacoia GD. Drugs and breast milk. Pediatric Clinics of North America 19: 151–166, 1972

    PubMed  CAS  Google Scholar 

  • Cedrato A. Cefadroxil treatment in Gonorr. A. Ther. Pharm. Data on BMCID file (Study No. 31-162)

  • Chisholm DR, Dekegis RG, Behr D. Therapeutic efficacy of cefadroxil and cephalexin for pneumonia in a rat test model. Antimicrobial Agents and Chemotherapy 30: 105–109, 1986

    PubMed  Article  CAS  Google Scholar 

  • Chow M, Quintiliani R, Cunha BA, Thompson M, Finkelstein E, et al. Pharmacokinetics of high-dose cephalosporins. Journal of Clinical Pharmacology 19: 185–194, 1979

    PubMed  CAS  Google Scholar 

  • Cutler RE, Blair AD, Kelly MR. Cefadroxil kinetics in patients with renal insufficiency. Clinical Pharmacology and Therapeutics 25: 514–521, 1979

    PubMed  CAS  Google Scholar 

  • Daenen W, Lauwers P. Cefadroxil concentration in respiratory tract. Data on BMCID file (Study No. 31-96)

  • Daschner R, Goller F. Data on BMCID file (Study No. 31-139)

  • Diaz, Gomez, et al. Cefadroxil serum and pleural fluid levels, presented 18th ICAAC. Abstract (223), 1978

  • Eichenwald H. Antimicrobial therapy in infants and children update 1976–85. Journal of Pediatrics 107: 161–168, 1985

    PubMed  Article  CAS  Google Scholar 

  • Elder MG, Bywater MJ. Concentration achieved in serum and pelvic tissue after various antibiotic regimens given preoperatively. Current Chemotherapy 1: 404–406, 1977

    Google Scholar 

  • Flores E, Hochberg K, Rangel-Guerra R. Evaluation of cefadroxil in complicated and uncomplicated infection of the upper and lower urinary tract infections. Journal of Antimicrobial Chemotherapy 10(Suppl. 8): 65–72, 1982

    PubMed  Google Scholar 

  • Gallegos-Torres J, et al. Tissue and urine levels during terminal stages of pregnancy. Presented at 18th ICAAC Atlantic, Georgia, 1978

    Google Scholar 

  • Gastanaduy AS, Kaplan EW, Hume BB, McKay C, Wannamaker LW. Failure of penicillin to eradicate group A streptococci during an outbreak of pharyngitis. Lancet 2: 498–501, 1980

    PubMed  Article  CAS  Google Scholar 

  • Ginsburg CM, McCracken Jr GH, Steinberg JG, Crow SD, Dildy BF et al. Treatment of group A streptococcal pharyngitis in children. Clinical Pediatrics 21: 83–88, 1982

    PubMed  Article  CAS  Google Scholar 

  • Ginsburg CM, McCracken Jr GH. Clinical pharmacology of cefadroxil in infants and children. Antimicrobial Agents and Chemotherapy 13: 845–848, 1978

    PubMed  Article  CAS  Google Scholar 

  • Ginsburg CM, McCracken GH, Petruska M. Once-daily cefadroxil versus twice-daily cefaclor for treatment of acute urinary tract infections in children. Journal of Antimicrobial Chemotherapy 10(Suppl. B): 53–56, 1982

    PubMed  Google Scholar 

  • Gordon RC, Regamey C, Kirby WMM. Comparative clinical pharmacology of amoxicillin and ampicillin administered orally. Antimicrobial Agents and Chemotherapy 1: 504–507, 1972

    PubMed  Article  CAS  Google Scholar 

  • Grim H. Bacteriological study on cefadroxil in-vitro correlation between diameter of inhibition zone and inhibitory concentration. Arzneimittel-Førschung 30: 301–303, 1980

    Google Scholar 

  • Handsfield HH, Wallace JF. Amoxycillin, a new penicillin antibiotic. Antimicrobial Agents and Chemotherapy 3: 262, 1973

    PubMed  Article  CAS  Google Scholar 

  • Harris RE. Antibiotic therapy of antepartum urinary tract infection. Journal of International Medical Research 8(Suppl. 1): 40–44, 1980

    PubMed  CAS  Google Scholar 

  • Hartstein AI, Patrick KE, Jones SR, Miller MJ, Bryant RE. Comparison of pharmacological and antimicrobial properties of cefadroxil and cephalexin. Antimicrobial Agents and Chemotherapy 12: 93–97, 1977

    PubMed  Article  CAS  Google Scholar 

  • Hausman MS. Treatment of urinary infection with cefadroxil, controlled comparison of high-compliance oral dosage regimen. Urology 15: 40–43, 1980a

    PubMed  Article  CAS  Google Scholar 

  • Hausman MS. Treatment of urinary tract infections with cefadroxil, a new cephalosporin. Journal of International Medical Research 8(Suppl. 1): 21–28, 1980b

    PubMed  CAS  Google Scholar 

  • Hendricks J, Trimpeneers I. Cefadroxil penetration with various body tissues. Data on BMCID file (Study No. 127-127A)

  • Hendricks J, Trimpeneers J, Pijck J, Baert T. Clinical evaluation of cefadroxil. A multicenter trial — acute lower respiratory tract infections. Drugs Under Experimental and Clinical Research 4: 89–93, 1978

    Google Scholar 

  • Henness DM. Treatment of urinary tract infections with cefadroxil: comparative evaluation of three high-compliance dosage regimens. Postgraduate Medical Communications (June): 36–40, 1979

    Google Scholar 

  • Henness DM. A clinical experience with cefadroxil in upper respiratory tract infections. Journal of Antimicrobial Chemotherapy 10(Suppl. B): 125–136, 1982

    PubMed  Google Scholar 

  • Henness DM, Gordon WE. Effective once or twice-daily treatment of skin and structure infections with a new cephalosporin (cefadroxil). Postgraduate Medical Communications (June): 41–47, 1979

    Google Scholar 

  • Henness DM, Richards D. Clinical comparison of cefadroxil and cephalexin in uncomplicated urinary tract infections. Current Therapeutic Research 23: 547–554, 1978

    Google Scholar 

  • Henness DM, Richards D, Santella PJ, Rubenfeld J. Oral bio-availability of cefadroxil, a new semisynthetic cephalosporin. Clinical Therapeutics 1: 263–273, 1978

    CAS  Google Scholar 

  • Holm SE, Ekedahl C. Comparative study of the penetration of penicillin V and cefadroxil into tonsils in man. Journal of Antimicrobial Chemotherapy 10(Suppl. B): 121–123, 1982

    PubMed  Google Scholar 

  • Howie VM, Ploussard JH. Treatment of group A streptococcal pharyngitis in children. American Journal of Diseases of Children 121: 477, 1977

    Google Scholar 

  • Humbert G, Leroy A, Fillastre JP, Godin M. Pharmacokinetics of cefadroxil in normal subjects and in patients with renal insufficiency. Chemotherapy 25: 189–195, 1979

    PubMed  Article  CAS  Google Scholar 

  • Hungria JS. Cefadroxil tissue levels concentration in orthopedic tissue. Data on BMCID file (Study No. 31-95)

  • Hunter P, Rolins GN. Bactericidal effect of amoxycillin in vitro compared with ampicillin. 8th International Congress of Chemotherapy p. 113, 1974

  • Jimenez-Shehab M, Barragan A. Oral cefadroxil in the treatment of bone and joint infection in children and adults. Journal of Antimicrobial Chemotherapy 10(Suppl. B): 149–152, 1982

    PubMed  Google Scholar 

  • Jimenez-Shehab M, et al. Acute and chronic osteomyelitis in well-nourished and undernourished 28 children treatment with cefadroxil. 17th Interscience Conference on Antimicrobial Agents and Chemotherapy. Abstract No. 339, October, 1977

  • Kafetzis DA, Siafas CA, Georgakopoulos PA, Papadatos CJ. Passage of cephalosporins and amoxicillin into the breast milk. Acta Paediatrica Scandinavica 70: 285–288, 1981

    PubMed  Article  CAS  Google Scholar 

  • Kjaer TB, Hallynck T, Hess J, Agger P. Cefadroxil and cephalexin concentration in prostatic tissue: comparison of tissues obtained by transurethral resection and transvesical prostatectomy. In Nelson & Grassi (Eds) Chemotherapy and infectious disease, Vol. 1, pp. 667–669, American Society for Microbiology, Washington, 1980

    Google Scholar 

  • Klighley MRB, et al. Antibiotic treatment of biliary sepsis. Surgical Clinics of North America 55: 1379, 1975

    Google Scholar 

  • Krause PJ, Owens NJ, Nightingale CH, Klimek JJ, Lehmann WB, et al. Penetration of amoxicillin, cefaclor, erythromycin-sulfisoxazole and trimethoprim-sulfamethoxazole into the middle ear fluid. Journal of Infectious Diseases 145: 815–821, 1982

    PubMed  Article  CAS  Google Scholar 

  • Kune GA, Burden JGW. Are antibiotics necessary in acute cholecystitis. Medical Journal of Australia 2: 627–630, 1975

    PubMed  CAS  Google Scholar 

  • Lazzareschi M. Cefadroxil tissue levels concentration in orthopedic tissue. Data on BMCID file (Study No. 31-94)

  • Leitner F, Goodhines RA, Buck RE, Price KE. Bactericidal activity of cefadroxil, cephalexin and cephradine in an in vitro pharmacokinetic model. Journal of Antibiotics 32: 718–726, 1979

    PubMed  Article  CAS  Google Scholar 

  • Levine RL. Quantitative comparison of adverse reactions to cefaclor vs amoxicillin. Pediatric Infectious Disease 4: 358–361, 1985

    PubMed  Article  CAS  Google Scholar 

  • Lewis G. Treatment of acute urinary tract infection with cefadroxil administered once daily. Journal of International Medical Research 8(Suppl. 1): 29–33, 1980

    PubMed  CAS  Google Scholar 

  • Litvak AS, Franks CD, Vaught SK, et al. Cefazolin and cephalexin levels in prostatic tissue and sera. Urology 7: 497–499, 1976

    PubMed  Article  CAS  Google Scholar 

  • Lode H, Stahlman R, Koeppe P. Comparative pharmacokinetics of cephalexin, cefadroxil, cefaclor and GGP9000. Antimicrobial Agents and Chemotherapy 16: 1–6, 1979

    PubMed  Article  CAS  Google Scholar 

  • Malaka-Zafiriou K, Papadopoular F, Augustidousavvopoulon P, Papachristos F, Cassimos C. Once daily cefadroxil compared with ampicillin in the treatment of urinary tract infections in children. Journal of Antimicrobial Chemotherapy 10(Suppl. B): 47–51, 1982

    Google Scholar 

  • Marino EL, Dominguez-Gil AA, Cepeda M, Otero MJ, Dominguez-Gil A. Effect of experimentally reduced renal impairment in the pharmacokinetic of cefadroxil in rabbits. Arzneimittel-Forschung 31: 478–481, 1981

    PubMed  CAS  Google Scholar 

  • Martinelli EM. High dose oral cefadroxil pharmacokinetics study N. HL-80-83. Data on file Bristol-Myers, International Division Medical Department

  • McCracken Jr GH, Ginsberg CM, Clahsen JC, Thomas ML. Pharmacologic evaluation of orally administered antibiotics in infants and children. Effect of feeding on bioavailability. Pediatrics 62: 738–743, 1978

    PubMed  Google Scholar 

  • Meares Jr EM. Prostatis syndromes: new perspectives about old woes. Journal of Urology 123: 141–147, 1980

    PubMed  Google Scholar 

  • Millan EA. Multicenter evaluation of cefadroxil in lower respiratory tract infections. Current Therapeutic Research 31: 467–474, 1982

    Google Scholar 

  • Murray BE, Moellering Jr RC. Cephalosporins. Annual Review of Medicine 32: 559–581, 1981

    PubMed  Article  CAS  Google Scholar 

  • Nauman P. The value of antibiotic levels in tissue and in urine in the treatment of urinary tract infections. Journal of Antimicrobial Chemotherapy 4: 9–17, 1978

    Article  Google Scholar 

  • Nelson JD, Howard JB, Shelton S. Oral antibiotic therapy for skeletal infection in children. Journal of Pediatrics 92: 131–134, 1978

    PubMed  Article  CAS  Google Scholar 

  • Nightingale CH. Pharmacokinetics of the oral cephalosporins in adults. Journal of International Medical Research 8(Suppl. 1): 2–8, 1980

    PubMed  CAS  Google Scholar 

  • Nightingale CH, Greene DS, Quintiliani R. Pharmacokinetics and clinical use of cephalosporins. Journal of Pharmaceutical Sciences 64: 1899–1927, 1975

    PubMed  Article  CAS  Google Scholar 

  • Otacilio LF. Therapeutic effectiveness of cefadroxil in infants and children with acute bacteria otitis media. Data on BMCID file (Special study report), 1981

    Google Scholar 

  • Palmu A, Järvinen H, Hallynck T, Pijk PJ. Cefadroxil levels in bile in biliary infections: In Nelson & Grassi (Eds) Chemotherapy and infectious disease, Vol. 1, pp. 643–644, American Society for Microbiology, Washington, 1980

    Google Scholar 

  • Pfeffer M, Jackson A, Ximeres J, Perche de Menezes J. Comparative human oral clinical pharmacology of cefadroxil, cefalexin and cephradine. Antimicrobial Agents and Chemotherapy 11: 331–338, 1977

    PubMed  Article  CAS  Google Scholar 

  • Puhakka H, Virolainen E, Eskola J, Holm S. Cefadroxil in the treatment of acute otitis media in children. Journal of Antimicrobial Chemotherapy 10(Suppl. B): 99–103, 1982

    PubMed  Google Scholar 

  • Quintiliani R. Treatment of urinary tract infections with cephalosporins: an overview. Special report, Mead Johnson Pharmaceutical Division, 1980

    Google Scholar 

  • Quintiliani R. A review of the penetration of cefadroxil into human tissue. Journal of Antimicrobial Chemotherapy 10(Suppl. B): 33–38, 1982

    PubMed  CAS  Google Scholar 

  • Randolph MA. Recurrence rates in Streptococcal pharyngitis with b.i.d. cefadroxil or t.i.d. penicillin VK. Today’s Therapeutic Trends 2: 1–6, 1985

    Google Scholar 

  • Ripa S, Penna M. Laboratory studies with BL-S578 (cefadroxil) a new broad spectrum orally active cephalosporin. Chemotherapy 25: 9–13, 1979

    PubMed  Article  CAS  Google Scholar 

  • Rubi R. Cefadroxil concentration in the prostatic tissues. Data on BMCID file (Study No. 31-81)

  • Rugendorff EW. Randomized comparative open study of cefadroxil administered once to twice daily in urinary tract infections. Journal of Antimicrobial Chemotherapy 10(Suppl. B): 57–63, 1982

    PubMed  Google Scholar 

  • Santella PJ, Tanrisever B. Treatment of upper and lower respiratory tract infections with cefadroxil, a totally new cephalosporin. Current Therapeutic Research 25: 210–220, 1979

    Google Scholar 

  • Santella PJ, et al. Clinical evaluation of cefadroxil, a new oral cephalosporin. Current Chemotherapy and Infectious Disease 2: 1040–1049, 1978a

    Google Scholar 

  • Santella PJ, Tannisever B, Berman E. An overview of results of worldwide clinical trials with cefadroxil. Journal of International Medical Research 6(6): 441–451, 1978b

    PubMed  CAS  Google Scholar 

  • Schwartz RH, Wientzen Jr RL, Pedreira F, Feroli EJ, Mella GW, et al. Penicillin V for group A streptococcal pharyngitis. Journal of the American Medical Association 1790-1795: 246, 1981

    Google Scholar 

  • Schwob M. Cefadroxil in the treatment of otitis media. Journal of International Medical Research 8(Suppl. 1): 103–105, 1980

    PubMed  CAS  Google Scholar 

  • Schwob M, Jimenez-Shehab M. Cefadroxil in the treatment of osteomyelitis in children. Journal of International Medical Research 8(Suppl. 1): 106–110, 1980

    PubMed  CAS  Google Scholar 

  • Schwob M, Trujillo H, Mimica I. Cefadroxil monohydrate suspension in the treatment of streptococcal pharyngitis in children. Current Therapeutic Research 29: 992–996, 1981

    Google Scholar 

  • Simon C. Serum and skin blister levels of cefadroxil in comparison to cephalexin. Infection 8(Suppl. 5): 584–587, 1980

    Article  CAS  Google Scholar 

  • Stamey TA, Govan DE, Palmer JM. The localization and treatment of urinary tract infections: the role of bactericidal levels as opposed to serum levels. Medicine 44: 1–36, 1965

    PubMed  Article  CAS  Google Scholar 

  • Stillerman M, Isenberg HD. Streptococcal pharyngitis therapy. American Journal of Diseases of Children 123: 457, 1972

    PubMed  CAS  Google Scholar 

  • Symes JM, Janvis JD, Tresidder GC. An appraisal of cephalexin monohydrate levels in semen and prostatic tissue. Chemotherapy 20: 257–262 1974

    PubMed  Article  CAS  Google Scholar 

  • Tanrisever B, Cedrato AE, Trujillo H. Cefadroxil monohydrate compared with cephradine in bacterial respiratory infections in children. Current Therapeutic Research 29: 452–462, 1981

    Google Scholar 

  • Trujillo H. Plasma and tissue (tonsil) concentration of cefadroxil versus cephalexin. Data on BMCID file (Study No. 31-66)

  • Trujillo H. Cefadroxil treatment of Group A streptococcal pharyngitis. Data on BMCID file (Study No. 31-102)

  • Vercruysse J. Serum and tissue levels of cefadroxil in human fallopian tissue. Data on BMCID file

  • Weingarten C. Randomized, comparative study of oral cefadroxil and cephalexin in lower respiratory tract infections in adults. Journal of Antimicrobial Chemotherapy 10(Suppl. B): 109–113, 1982

    PubMed  Google Scholar 

  • Weinstein AS. The cephalosporins activity and clinical use. Drugs 19: 137–154, 1980

    Article  Google Scholar 

  • Wilber RB, De Regis RG, Fox EJ. The role of cefadroxil in therapy of urinary tract infections. Journal of Antimicrobial Chemotherapy 10(Suppl. 8): 77–84, 1982

    PubMed  Google Scholar 

  • Windorfer A. Cefadroxil treatment of Group A streptococcal pharyngitis. Data on BMCID file (Study No. 31-123)

  • Windorfer A, Trujillo H, Bauer P. Comparison of twice-daily cefadroxil with four-times-daily cephalexin in pediatric respiratory infection. Journal of Antimicrobial Chemotherapy (Suppl. B): 10: 93–98, 1982

    PubMed  Google Scholar 

  • Wise R. Penicillins and cephalosporins. Antimicrobial and pharmacological properties. Lancet 2: 140–143, 1982

    PubMed  Article  CAS  Google Scholar 

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Tanrisever, B., Santella, P.J. Cefadroxil. Drugs 32 (Suppl 3), 1–16 (1986). https://doi.org/10.2165/00003495-198600323-00003

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Keywords

  • Cephalosporin
  • Acute Otitis Medium
  • Cephalexin
  • Cefaclor
  • Antimicrobial Chemotherapy