Skip to main content
Log in

Otitis Media and Sinusitis in Children

Role of Branhamella catarrhalis

  • Section 4: Therapeutic Aspects: Part 2
  • Published:
Drugs Aims and scope Submit manuscript

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Summary

Otitis media and sinusitis are among the most common diseases of childhood and various treatment approaches have been advocated. This review focuses on current experience in Pittsburgh, both in terms of our methods of patient management and the changing aetiology of the underlying diseases. Special reference is made to the role played by Branhamella catarrhalis and the emergence of β-lactamase-producing strains. Results from recently completed clinical trials would suggest that antibacterial therapy should be administered to children with these infections, to reduce morbidity and prevent the ever-present supportive complications associated with both diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Bluestone CD. Recent advances in the pathogenesis, diagnosis, and management of otitis media. In Stool (Ed.) The pediatric clinics of North America, pp. 727–755, W.B. Saunders, Philadelphia, 1981

    Google Scholar 

  • Bluestone CD. Otitis media in children: to treat or not to treat? New England Journal of Medicine 306: 1399–1404, 1982

    Article  PubMed  CAS  Google Scholar 

  • Bluestone CD. The ear. In Vaughan and Behrman (Eds) Nelson textbook of pediatrics, 12th ed., pp. 1022–1031, W.B. Saunders, Philadelphia, 1983

    Google Scholar 

  • Bluestone CD. Augmentin therapy for acute otitis media in children: summary of presentation of four clinical trials. In Progress and perspectives on beta-lactamase inhibition: a review of augmentin, pp. 137–139, Postgraduate Medicine, Custom Communications, 1984

    Google Scholar 

  • Bluestone CD, Klein JO. Otitis media with effusion, atelectasis, and Eustachian tube dysfunction. In Bluestone and Stool (Eds) Pediatric otolaryngology, pp. 356–512, WB Saunders, Philadelphia, 1983a

    Google Scholar 

  • Bluestone CD, Klein JO. Intratemporal complications and sequelae of otitis media. In Bluestone and Stool (Eds) Pediatric otolaryngology, pp. 513–564, WB Saunders, Philadelphia, 1983b

    Google Scholar 

  • Cantekin EI, Mandel EM, Bluestone CD, Rockette HE, Paradise JL, et al. Lack of efficacy of a decongestant-antihistamine combination for otitis media with effusion (secretory otitis media) in children. New England Journal of Medicine 308: 297–301, 1983

    Article  PubMed  CAS  Google Scholar 

  • Casselbrant ML, Brostoff L, Cantekin EI, Flaherty MR, Doyle WJ, et al. Otitis media in preschool children. Laryngoscope 95 (Suppl.): 428–436, 1985

    Article  PubMed  CAS  Google Scholar 

  • Chapnik JS, Bach MC. Bacterial and fungal infections of the maxillary sinus. Otolaryngologic Clinics of North America 9: 43–54, 1976

    PubMed  CAS  Google Scholar 

  • Eliasson R, Mossberg B, Camner P, et al. The immotile cilia syndrome. A congenital ciliary abnormality as an etiologic factor in chronic airway infections and male sterility. New England Journal of Medicine 297: 1–6, 1977

    Article  PubMed  CAS  Google Scholar 

  • Fireman P. Allergic rhinitis. In Bluestone and Stool (Eds) Pediatric otolaryngology, pp. 849–862, W.B. Saunders, Philadelphia, 1983

    Google Scholar 

  • Frederick J, Braude AI. Anaerobic infection of the paranasal sinuses. New England Journal of Medicine 290: 135–137, 1974

    Article  PubMed  CAS  Google Scholar 

  • Kovatch A, Wald E, Ledesma-Medina J, et al. Sinus radiographs in normal children. Paper presented at the 22nd Interscience Conference on Antimicrobial Agents and Chemotherapy, Miami 1982

  • Kovatch AL, Wald ER, Michaels RH. β-Lactamase-producing Branhamella catarrhalis causing otitis media in children. Journal of Pediatrics 102: 261–264, 1983

    Article  PubMed  CAS  Google Scholar 

  • Odio CM, Kusmiesz H, Shelton S, Nelson JD. Comparative treatment trial of augmentin versus cefaclor for acute otitis media with effusion. Pediatrics 75: 819–826, 1985

    PubMed  CAS  Google Scholar 

  • Rachelefsky GS, Goldberg M, Katz RM, et al. Sinus disease in children with respiratory allergy. Journal of Allergy and Clinical Immunology 61: 310–314, 1978

    Article  PubMed  CAS  Google Scholar 

  • Riding KH, Bluestone CD, Michaels RH, Cantekin EI, Doyle WJ, et al. Microbiology of recurrent and chronic otitis media with effusion. Journal of Pediatrics 93: 739–743, 1978

    Article  PubMed  CAS  Google Scholar 

  • Rohn DD, Vatman F, Cantekin EI. Incidence of organisms in otitis media. Studies in Otitis Media, Pittsburgh Otitis Media Research Center Progress Report, 1982. Annals of Otology, Rhinology and Laryngology 92 (Suppl.): 17, 1983

    Google Scholar 

  • Rohn DD, Wald ER, Bluestone CD. Unpublished data from Pittsburgh Otitis Media Research Center.

  • Shapiro ED, Milmoe GJ, Wald ER, Rodnan JB, Bowen AD. Bacteriology of the maxillary sinuses in patients with cystic fibrosis. Journal of Infectious Diseases 146: 589–593, 1982

    Article  PubMed  CAS  Google Scholar 

  • Shurin PA, Marchant CD, Kim CH, Van Hare GF, Johnson CE, et al. Emergence of beta-lactamase-producing strains of Branhamella catarrhalis as important agents of acute otitis media. Pediatric Infectious Disease 2: 34–38, 1983

    Article  PubMed  CAS  Google Scholar 

  • Wald ER, Reilly JS, Casselbrant ML, Ledesma-Medina J, Milmoe GJ, et al. Treatment of acute maxillary sinusitis in childhood: A comparative study of amoxicillin and cefaclor. Journal of Pediatrics 104: 297–302, 1984

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bluestone, C.D. Otitis Media and Sinusitis in Children. Drugs 31 (Suppl 3), 132–141 (1986). https://doi.org/10.2165/00003495-198600313-00029

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00003495-198600313-00029

Keywords

Navigation