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Amoxycillin-Clavulanic Acid Combination in Bronchopulmonary Infection due to β-Lactamase-producing Branhamella catarrhalis

Preliminary Report

  • Section 3: Therapeutic Aspects: Part 1
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Summary

Since 1978 we have taken an interest in lower respiratory tract infections associated with Branhamella catarrhalis in Christchurch, New Zealand. In a preliminary trial, 20 patients with bronchopulmonary infection caused by β-lactamase-producing B. catarrhalis were treated with a combination tablet of amoxycillin 500mg and clavulanic acid 125mg (‘Augmentin’) 3 times daily for 5 days. Sputum cultures were negative for B. catarrhalis within 3 days in all patients. Two of 7 patients whose sputum cultures were positive for this organism at a review 2 to 4 weeks later were successfully treated with a further course of amoxycillin/clavulanic acid.

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References

  • Aitken JM, Thornley PE. Isolation of Branhamella catarrhalis from sputum and tracheal aspirate. Journal of Clinical Microbiology 18: 1262–1263, 1983

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Authors and Affiliations

  1. Departments of Respiratory Medicine and Microbiology, The Princess Margaret Hospital, Christchurch, New Zealand

    Peter E. Thornley, John M. Aitken, Geoffrey M. Nichol & Nicholas J. Slevin

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  1. Peter E. Thornley
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  2. John M. Aitken
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  3. Geoffrey M. Nichol
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  4. Nicholas J. Slevin
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Thornley, P.E., Aitken, J.M., Nichol, G.M. et al. Amoxycillin-Clavulanic Acid Combination in Bronchopulmonary Infection due to β-Lactamase-producing Branhamella catarrhalis . Drugs 31 (Suppl 3), 113–114 (1986). https://doi.org/10.2165/00003495-198600313-00024

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  • DOI: https://doi.org/10.2165/00003495-198600313-00024

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