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Classification of β-Lactamases from Branhamella catarrhalis in Relation to Penicillinases Produced by Other Bacterial Species

  • Section 2: β-Lactamases of Branhamella catarrhalis
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Summary

Branhamella catarrhalis strains resistant to commonly used penicillins, and presently isolated, produce a β-lactamase. Most of these enzymes are chromosomally mediated, but a plasmid-mediated β-lactamase has been described (enzyme BRO-1). With reference to isoelectric points, 7 different enzymes have been identified: 6 chromosomally mediated and 1 plasmid-mediated. Nevertheless, they have many common properties, such as being biosynthesised constitutively but with a low level of production. They have a penicillinasetype profile, and are strongly inhibited by clavulanic acid.

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Authors and Affiliations

  1. Muséum National d’Histoire Naturelle, 63 rue Buffon, 75005, Paris, France

    Roger Labia, Michel Barthelemy, Chantal Brive Le Bouguennec & Annie Buu Hoi-Dang Van

  2. Institut Pasteur, Paris, France

    Roger Labia, Michel Barthelemy, Chantal Brive Le Bouguennec & Annie Buu Hoi-Dang Van

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  1. Roger Labia
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  2. Michel Barthelemy
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  3. Chantal Brive Le Bouguennec
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  4. Annie Buu Hoi-Dang Van
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Labia, R., Barthelemy, M., Le Bouguennec, C.B. et al. Classification of β-Lactamases from Branhamella catarrhalis in Relation to Penicillinases Produced by Other Bacterial Species. Drugs 31 (Suppl 3), 40–47 (1986). https://doi.org/10.2165/00003495-198600313-00011

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  • DOI: https://doi.org/10.2165/00003495-198600313-00011

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